Abstract

Laminar optical tomography (LOT) is a new technique that combines the advantages of diffuse optical tomography image reconstruction and a microscopy-based setup to allow noncontact imaging with 100200µm resolution effective over depths of 0–2.5 mm. LOT is being developed primarily for multispectral imaging of rat cortex, for which resolving functional dynamics in various layers of the brain’s cortex (to depths of 1500 µm) is of increasing interest to neurophysiologists. System design and image reconstruction techniques are described, along with simulation and phantom results that demonstrate the characteristics and limitations of system accuracy and resolution.

© 2004 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
High-dynamic-range fluorescence laminar optical tomography (HDR-FLOT)

Qinggong Tang, Yi Liu, Vassiliy Tsytsarev, Jonathan Lin, Bohan Wang, Udayakumar Kanniyappan, Zhifang Li, and Yu Chen
Biomed. Opt. Express 8(4) 2124-2137 (2017)

Transport-based image reconstruction in turbid media with small source–detector separations

Andrew Dunn and David Boas
Opt. Lett. 25(24) 1777-1779 (2000)

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

Qinggong Tang, Jianting Wang, Aaron Frank, Jonathan Lin, Zhifang Li, Chao-wei Chen, Lily Jin, Tongtong Wu, Bruce D. Greenwald, Hiroshi Mashimo, and Yu Chen
Biomed. Opt. Express 7(12) 5218-5232 (2016)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (2)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription