Abstract

Optical coherence tomography (OCT) images of biological tissues often have low contrast. Spectroscopic optical coherence tomography (SOCT) methods have been developed to enhance contrast but remain limited because most tissues are not spectrally active in the frequency bands of laser sources commonly used in OCT. Near-infrared (NIR) dyes with absorption spectra features within the OCT source spectrum can be used for enhancing contrast in this situation. We introduce and demonstrate the use of NIR dyes as contrast agents for SOCT. Contrast-enhanced images are compared with fluorescence microscopy, demonstrating a link between SOCT and fluorescence imaging.

© 2004 Optical Society of America

Full Article  |  PDF Article
More Like This
Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent

Changhuei Yang, Laura E. L. McGuckin, John D. Simon, Michael A. Choma, Brian E. Applegate, and Joseph A. Izatt
Opt. Lett. 29(17) 2016-2018 (2004)

Engineered microsphere contrast agents for optical coherence tomography

Tin Man Lee, Amy L. Oldenburg, Shoeb Sitafalwalla, Daniel L. Marks, Wei Luo, Farah Jean-Jacques Toublan, Kenneth S. Suslick, and Stephen A. Boppart
Opt. Lett. 28(17) 1546-1548 (2003)

Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent

Xueding Wang, Geng Ku, Malgorzata A. Wegiel, Darryl J. Bornhop, George Stoica, and Lihong V. Wang
Opt. Lett. 29(7) 730-732 (2004)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (2)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription