Abstract

A recently developed analytical optical coherence tomography (OCT) model [Thrane et al., J. Opt. Soc. Am. A 17, 484 (2000)] allows the extraction of optical scattering parameters from OCT images, thereby permitting attenuation compensation in those images. By expanding this theoretical model, we have developed a new method for extracting optical scattering parameters from multilayered tissue structures in vivo. To verify this, we used a Monte Carlo (MC) OCT model as a numerical phantom to simulate the OCT signal for heterogeneous multilayered tissue. Excellent agreement between the extracted values of the optical scattering properties of the different layers and the corresponding input reference values of the MC simulation was obtained, which demonstrates the feasibility of the method for in vivo applications. This is to our knowledge the first time such verification has been obtained, and the results hold promise for expanding the functional imaging capabilities of OCT.

© 2004 Optical Society of America

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References

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2003

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

2002

N. M. Shakhova, V. M. Gelikonov, V. A. Kamensky, R. V. Kuranov, and I. V. Turchin, Laser Phys. 12, 617 (2002).

L. Thrane, T. M. Jørgensen, P. E. Andersen, and H. T. Yura, Proc. SPIE 4619, 36 (2002).
[CrossRef]

A. Tycho, T. M. Jørgensen, H. T. Yura, and P. E. Andersen, Appl. Opt. 41, 6676 (2002).
[CrossRef] [PubMed]

2001

2000

1997

D. I. Hughes and F. A. Duck, Ultrasound Med. Biol. 23, 651 (1997).
[CrossRef]

1993

1991

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

1987

1974

M. Stone, J. Royal. Statzs. Soc. B 36, 111 (1974).

Andersen, C. B.

Andersen, P. E.

Andersson-Engels, S.

Bonner, R. F.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Drexler, W.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Duck, F. A.

D. I. Hughes and F. A. Duck, Ultrasound Med. Biol. 23, 651 (1997).
[CrossRef]

Esenaliev, R. O.

Fercher, A. F.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Frosz, M. H.

Fujimoto, J. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Gelikonov, V. M.

N. M. Shakhova, V. M. Gelikonov, V. A. Kamensky, R. V. Kuranov, and I. V. Turchin, Laser Phys. 12, 617 (2002).

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Hansen, P. R.

Hanson, S. G.

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Hitzenberger, C. K.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Hughes, D. I.

D. I. Hughes and F. A. Duck, Ultrasound Med. Biol. 23, 651 (1997).
[CrossRef]

Jørgensen, T. M.

L. Thrane, T. M. Jørgensen, P. E. Andersen, and H. T. Yura, Proc. SPIE 4619, 36 (2002).
[CrossRef]

A. Tycho, T. M. Jørgensen, H. T. Yura, and P. E. Andersen, Appl. Opt. 41, 6676 (2002).
[CrossRef] [PubMed]

Kamensky, V. A.

N. M. Shakhova, V. M. Gelikonov, V. A. Kamensky, R. V. Kuranov, and I. V. Turchin, Laser Phys. 12, 617 (2002).

Knüttel, A.

Kuranov, R. V.

N. M. Shakhova, V. M. Gelikonov, V. A. Kamensky, R. V. Kuranov, and I. V. Turchin, Laser Phys. 12, 617 (2002).

Larin, K. V.

Larina, I. V.

Lasser, T.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Levitz, D.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Motamedi, M.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Schmitt, J. M.

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Shakhova, N. M.

N. M. Shakhova, V. M. Gelikonov, V. A. Kamensky, R. V. Kuranov, and I. V. Turchin, Laser Phys. 12, 617 (2002).

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Stone, M.

M. Stone, J. Royal. Statzs. Soc. B 36, 111 (1974).

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Swartling, J.

Thrane, L.

Turchin, I. V.

N. M. Shakhova, V. M. Gelikonov, V. A. Kamensky, R. V. Kuranov, and I. V. Turchin, Laser Phys. 12, 617 (2002).

Tycho, A.

Valanciunaite, J.

Yura, H. T.

Appl. Opt.

J. Opt. Soc. Am. A

J. Royal. Statzs. Soc. B

M. Stone, J. Royal. Statzs. Soc. B 36, 111 (1974).

Laser Phys.

N. M. Shakhova, V. M. Gelikonov, V. A. Kamensky, R. V. Kuranov, and I. V. Turchin, Laser Phys. 12, 617 (2002).

Opt. Express

Opt. Lett.

Proc. SPIE

L. Thrane, T. M. Jørgensen, P. E. Andersen, and H. T. Yura, Proc. SPIE 4619, 36 (2002).
[CrossRef]

Rep. Prog. Phys.

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, Rep. Prog. Phys. 66, 239 (2003).
[CrossRef]

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
[CrossRef] [PubMed]

Ultrasound Med. Biol.

D. I. Hughes and F. A. Duck, Ultrasound Med. Biol. 23, 651 (1997).
[CrossRef]

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Figures (2)

Fig. 1
Fig. 1

Heterodyne efficiency factor as a function of μs for a fixed probe depth (0.5 mm) in a homogeneous sample obtained by use of the MC OCT model and experiments presented in Ref. 9. The typical standard deviation for the measurements (open circles) is ±7.8%. The dotted line is the prediction of the single-scattering OCT model3 (λ=814 nm, g=0.929 (θrms=0.38 rad), n=1.33, f=16 mm, w0=0.125 mm).

Fig. 2
Fig. 2

MC simulation of the OCT signal for a two-layer sample with μs2=10.0 mm-1, EHF fit to the first and second layers, and the MC simulation of the OCT signal after use of the true-reflection algorithm.

Tables (1)

Tables Icon

Table 1 Input Parameters of the MC Simulation, Together with the Extracted Parameters Obtained by Use of the EHF Model and the Relative Difference (Rel. Diff.)a

Equations (3)

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i2z=i20exp-2μsz+4 exp-μsz1-exp-μsz1+wS2/wH2+1-exp-μsz2wH2wS2,
ρ01z1=3μs1z1λπθrms1n1fz1,
ρ02z2=3πλn2Δ1+λn1z2+n2f-Δ1n1-z2n22n22Δ1Δ12+3Δ1z2+3z22θrms12μs1+n12z23θrms22μs21/2.

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