Abstract

We compare two geometries of sources and detectors for optimizing the diffuse optical imaging resolution of brain activation in humans. Because of limitations in the instruments’ dynamic range, most diffuse optical brain activation images have used only nonoverlapping measurements. We demonstrate theoretically and with a human experiment that a simple geometry of sources and detectors can provide overlapping measurements within the limitation of instrumentation dynamic range and produce an image resolution and localization accuracy that is twofold better.

© 2004 Optical Society of America

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References

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  1. A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, Neurosci. Lett. 154, 101 (1993).
    [CrossRef] [PubMed]
  2. Y. Hoshi and M. Tamura, Neurosci. Lett. 150, 5 (1993).
    [CrossRef] [PubMed]
  3. A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, Med. Phys. 22, 1997 (1995).
    [CrossRef] [PubMed]
  4. M. A. Franceschini, V. Toronov, M. Filiaci, E. Gratton, and S. Fantini, Opt. Express 6, 49 (2000), http://www.opticsexpress.org .
    [CrossRef] [PubMed]
  5. S. R. Arridge, Inverse Probl. 15, R41 (1999).
    [CrossRef]
  6. A. M. Siegel, J. J. A. Marota, and D. A. Boas, Opt. Express 4, 287 (1999), http://www.opticsexpress.org .
    [CrossRef] [PubMed]
  7. A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
    [CrossRef] [PubMed]
  8. J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
    [CrossRef] [PubMed]
  9. J. P. Culver, A. M. Siegel, J. J. Stott, and D. A. Boas, Opt. Lett. 28, 2061 (2003).
    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef] [PubMed]
  17. S. A. Walker, S. Fantini, and E. Gratton, Appl. Opt. 36, 170 (1997).
    [CrossRef] [PubMed]

2003 (5)

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

M. A. Franceschini, S. Fantini, J. H. Thompson, J. P. Culver, and D. A. Boas, Psychophysiology 40, 548 (2003).
[CrossRef] [PubMed]

H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, and J. F. Dunn, J. Biomed. Opt. 8, 102 (2003).
[CrossRef] [PubMed]

J. P. Culver, A. M. Siegel, J. J. Stott, and D. A. Boas, Opt. Lett. 28, 2061 (2003).
[CrossRef] [PubMed]

2002 (1)

T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi, Phys. Med. Biol. 47, 3429 (2002).
[CrossRef] [PubMed]

2001 (3)

2000 (2)

1999 (2)

1997 (1)

1995 (1)

A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, Med. Phys. 22, 1997 (1995).
[CrossRef] [PubMed]

1993 (2)

A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, Neurosci. Lett. 154, 101 (1993).
[CrossRef] [PubMed]

Y. Hoshi and M. Tamura, Neurosci. Lett. 150, 5 (1993).
[CrossRef] [PubMed]

Abdoulaev, G.

Andronica, R.

Arif, I.

Arridge, S. R.

S. R. Arridge, Inverse Probl. 15, R41 (1999).
[CrossRef]

Barbour, R.

Barbour, R. L.

Barbour, S.

Benaron, D. A.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, and D. A. Boas, J. Perinat. Med. 29, 335 (2001).
[CrossRef]

Bluestone, A.

Boas, D. A.

J. P. Culver, A. M. Siegel, J. J. Stott, and D. A. Boas, Opt. Lett. 28, 2061 (2003).
[CrossRef] [PubMed]

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

M. A. Franceschini, S. Fantini, J. H. Thompson, J. P. Culver, and D. A. Boas, Psychophysiology 40, 548 (2003).
[CrossRef] [PubMed]

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, and D. A. Boas, J. Perinat. Med. 29, 335 (2001).
[CrossRef]

A. M. Siegel, J. J. A. Marota, and D. A. Boas, Opt. Express 4, 287 (1999), http://www.opticsexpress.org .
[CrossRef] [PubMed]

Cheung, C.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Culver, J. P.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

M. A. Franceschini, S. Fantini, J. H. Thompson, J. P. Culver, and D. A. Boas, Psychophysiology 40, 548 (2003).
[CrossRef] [PubMed]

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

J. P. Culver, A. M. Siegel, J. J. Stott, and D. A. Boas, Opt. Lett. 28, 2061 (2003).
[CrossRef] [PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, and A. G. Yodh, Opt. Lett. 26, 701 (2001).
[CrossRef]

Dehghani, H.

H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, and J. F. Dunn, J. Biomed. Opt. 8, 102 (2003).
[CrossRef] [PubMed]

Dirnagl, U.

A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, Neurosci. Lett. 154, 101 (1993).
[CrossRef] [PubMed]

Dunn, J. F.

H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, and J. F. Dunn, J. Biomed. Opt. 8, 102 (2003).
[CrossRef] [PubMed]

Durduran, T.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Fantini, S.

Filiaci, M.

Franceschini, M. A.

M. A. Franceschini, S. Fantini, J. H. Thompson, J. P. Culver, and D. A. Boas, Psychophysiology 40, 548 (2003).
[CrossRef] [PubMed]

M. A. Franceschini, V. Toronov, M. Filiaci, E. Gratton, and S. Fantini, Opt. Express 6, 49 (2000), http://www.opticsexpress.org .
[CrossRef] [PubMed]

Furuya, D.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Graber, H. L.

Gratton, E.

Greenberg, J. H.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Hielscher, A.

Hintz, S. R.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, and D. A. Boas, J. Perinat. Med. 29, 335 (2001).
[CrossRef]

Hira, J.

Hock, C.

A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, Neurosci. Lett. 154, 101 (1993).
[CrossRef] [PubMed]

Holboke, M. J.

Hoshi, Y.

Y. Hoshi and M. Tamura, Neurosci. Lett. 150, 5 (1993).
[CrossRef] [PubMed]

Ito, Y.

A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, Med. Phys. 22, 1997 (1995).
[CrossRef] [PubMed]

Kadoya, T.

T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi, Phys. Med. Biol. 47, 3429 (2002).
[CrossRef] [PubMed]

Koizumi, H.

T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi, Phys. Med. Biol. 47, 3429 (2002).
[CrossRef] [PubMed]

A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, Med. Phys. 22, 1997 (1995).
[CrossRef] [PubMed]

Luo, H.

Maki, A.

T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi, Phys. Med. Biol. 47, 3429 (2002).
[CrossRef] [PubMed]

A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, Med. Phys. 22, 1997 (1995).
[CrossRef] [PubMed]

Mandeville, J. B.

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

Marota, J. J. A.

Mayanagi, Y.

A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, Med. Phys. 22, 1997 (1995).
[CrossRef] [PubMed]

Ntziachristos, V.

Okada, E.

T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi, Phys. Med. Biol. 47, 3429 (2002).
[CrossRef] [PubMed]

Paulsen, K. D.

H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, and J. F. Dunn, J. Biomed. Opt. 8, 102 (2003).
[CrossRef] [PubMed]

Pei, Y.

Planck, J.

A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, Neurosci. Lett. 154, 101 (1993).
[CrossRef] [PubMed]

Pogue, B. W.

H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, and J. F. Dunn, J. Biomed. Opt. 8, 102 (2003).
[CrossRef] [PubMed]

Ramirez, N.

Schleinkofer, L.

A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, Neurosci. Lett. 154, 101 (1993).
[CrossRef] [PubMed]

Schmitz, C.

Schmitz, C. H.

Siegel, A. M.

J. P. Culver, A. M. Siegel, J. J. Stott, and D. A. Boas, Opt. Lett. 28, 2061 (2003).
[CrossRef] [PubMed]

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, and D. A. Boas, J. Perinat. Med. 29, 335 (2001).
[CrossRef]

A. M. Siegel, J. J. A. Marota, and D. A. Boas, Opt. Express 4, 287 (1999), http://www.opticsexpress.org .
[CrossRef] [PubMed]

Soller, I.

Springett, R.

H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, and J. F. Dunn, J. Biomed. Opt. 8, 102 (2003).
[CrossRef] [PubMed]

Stevenson, D. K.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, and D. A. Boas, J. Perinat. Med. 29, 335 (2001).
[CrossRef]

Stott, J. J.

Tamura, M.

Y. Hoshi and M. Tamura, Neurosci. Lett. 150, 5 (1993).
[CrossRef] [PubMed]

Tanikawa, Y.

T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi, Phys. Med. Biol. 47, 3429 (2002).
[CrossRef] [PubMed]

Thompson, J. H.

M. A. Franceschini, S. Fantini, J. H. Thompson, J. P. Culver, and D. A. Boas, Psychophysiology 40, 548 (2003).
[CrossRef] [PubMed]

Toronov, V.

Villringer, A.

A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, Neurosci. Lett. 154, 101 (1993).
[CrossRef] [PubMed]

Walker, S. A.

Watanabe, E.

A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, Med. Phys. 22, 1997 (1995).
[CrossRef] [PubMed]

Xu, H.

H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, and J. F. Dunn, J. Biomed. Opt. 8, 102 (2003).
[CrossRef] [PubMed]

Yamada, Y.

T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi, Phys. Med. Biol. 47, 3429 (2002).
[CrossRef] [PubMed]

Yamamoto, T.

T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi, Phys. Med. Biol. 47, 3429 (2002).
[CrossRef] [PubMed]

Yamashita, Y.

A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, Med. Phys. 22, 1997 (1995).
[CrossRef] [PubMed]

Yodh, A. G.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, and A. G. Yodh, Opt. Lett. 26, 701 (2001).
[CrossRef]

Zhong, S.

Zourabian, A.

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, and D. A. Boas, J. Perinat. Med. 29, 335 (2001).
[CrossRef]

Appl. Opt. (2)

Inverse Probl. (1)

S. R. Arridge, Inverse Probl. 15, R41 (1999).
[CrossRef]

J. Biomed. Opt. (1)

H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, and J. F. Dunn, J. Biomed. Opt. 8, 102 (2003).
[CrossRef] [PubMed]

J. Cereb. Blood Flow Metab. (1)

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

J. Perinat. Med. (1)

S. R. Hintz, D. A. Benaron, A. M. Siegel, A. Zourabian, D. K. Stevenson, and D. A. Boas, J. Perinat. Med. 29, 335 (2001).
[CrossRef]

Med. Phys. (1)

A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayanagi, and H. Koizumi, Med. Phys. 22, 1997 (1995).
[CrossRef] [PubMed]

Neurosci. Lett. (2)

A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, Neurosci. Lett. 154, 101 (1993).
[CrossRef] [PubMed]

Y. Hoshi and M. Tamura, Neurosci. Lett. 150, 5 (1993).
[CrossRef] [PubMed]

Opt. Express (3)

Opt. Lett. (2)

Phys. Med. Biol. (2)

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

T. Yamamoto, A. Maki, T. Kadoya, Y. Tanikawa, Y. Yamada, E. Okada, and H. Koizumi, Phys. Med. Biol. 47, 3429 (2002).
[CrossRef] [PubMed]

Psychophysiology (1)

M. A. Franceschini, S. Fantini, J. H. Thompson, J. P. Culver, and D. A. Boas, Psychophysiology 40, 548 (2003).
[CrossRef] [PubMed]

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Figures (3)

Fig. 1
Fig. 1

Localization error for (a), (b) the rectangular and (c), (d) the hexagonal geometries compared for (a), (c) backprojection and (b), (d) DOT image reconstructions. The sources (crosses) and detectors (open circles) are shown in (a) and (c). The scale goes to 1 cm, where white indicates greater than 1-cm localization error.

Fig. 2
Fig. 2

Comparison of backprojection images obtained from first- and second-nearest-neighbor measurements with the DOT image. The positions of sources (crosses) and detectors (open circles) are indicated by the numbers in the reconstructed images. Solid curves, half-maximum contours.

Fig. 3
Fig. 3

Resolution for (a), (b) rectangular and (c), (d) hexagonal geometries compared for (a), (c) backprojection and (b), (d) DOT image reconstructions. The sources (crosses) and detectors (open circles) are shown in (a) and (c). The scale ranges from 1 to 5 cm2, where white indicates greater than 5 cm2.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

xˆ=ATAAT+αsmaxI-1y,
xˆ=ASTy,
R=ATAAT+αsmaxI-1A.

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