Abstract

A new resolution-enhanced surface plasmon resonance (SPR) biosensor offers a tenfold improvement in resolution compared with conventional SPR biosensors in the detection of the surface coverage of biomaterials. The proposed optical biosensor, based on the attenuated total-reflection method, excites both the surface plasmons and particle plasmons to enhance the local electromagnetic field by control of the size and volume fraction of embedded Au nanoparticles to increase the resolution of the device. The SPR biosensor design is based on the Maxwell-Garnett model and the Fresnel equations, and the device is fabricated with a cosputtering deposition system.

© 2004 Optical Society of America

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References

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  1. H. Raether, Surface Plasmons on Smooth and Rough Surfaces and on Gratings (Springer-Verlag, Berlin, 1988).
  2. B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
    [CrossRef]
  3. J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
    [CrossRef]
  4. M. J. O’Brien, V. H. Perez-Luna, S. R. Brueck, and G. P. Lopez, Biosens. Bioelectron. 16, 97 (2001).
    [CrossRef] [PubMed]
  5. P.-T. Leung, D. Pollard-Knight, G. P. Malan, and M. F. Finlan, Sens. Actuators B 22, 175 (1994).
    [CrossRef]
  6. H. Xu and M. Kall, Sens. Actuators B 87, 244 (2002).
    [CrossRef]
  7. K. C. Lee, S. T. Pai, Y. C. Chang, M. C. Chen, and W.-H. Li, Mater. Sci. Eng. B 52, 189 (1998).
    [CrossRef]
  8. G. Kalyuzhny, A. Vaskevich, M. A. Schneeweiss, and I. Rubinstein, Chem.-Eur. J. 8, 3849 (2002).
  9. D. Kambhampati, P. E. Nielsen, and W. Knoll, Biosens. Bioelectron. 16, 1109 (2001).
    [CrossRef] [PubMed]
  10. J. C. Maxwell-Garnett, Philos. Trans. R Soc. London 203, 385 (1904).
    [CrossRef]
  11. T. Ung, L. M. Liz-Marzan, and P. Mulvaney, Colloids Surf. A 202, 119 (2002).
    [CrossRef]

2002 (3)

H. Xu and M. Kall, Sens. Actuators B 87, 244 (2002).
[CrossRef]

G. Kalyuzhny, A. Vaskevich, M. A. Schneeweiss, and I. Rubinstein, Chem.-Eur. J. 8, 3849 (2002).

T. Ung, L. M. Liz-Marzan, and P. Mulvaney, Colloids Surf. A 202, 119 (2002).
[CrossRef]

2001 (2)

D. Kambhampati, P. E. Nielsen, and W. Knoll, Biosens. Bioelectron. 16, 1109 (2001).
[CrossRef] [PubMed]

M. J. O’Brien, V. H. Perez-Luna, S. R. Brueck, and G. P. Lopez, Biosens. Bioelectron. 16, 97 (2001).
[CrossRef] [PubMed]

1999 (1)

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

1998 (1)

K. C. Lee, S. T. Pai, Y. C. Chang, M. C. Chen, and W.-H. Li, Mater. Sci. Eng. B 52, 189 (1998).
[CrossRef]

1994 (1)

P.-T. Leung, D. Pollard-Knight, G. P. Malan, and M. F. Finlan, Sens. Actuators B 22, 175 (1994).
[CrossRef]

1983 (1)

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

1904 (1)

J. C. Maxwell-Garnett, Philos. Trans. R Soc. London 203, 385 (1904).
[CrossRef]

Brueck, S. R.

M. J. O’Brien, V. H. Perez-Luna, S. R. Brueck, and G. P. Lopez, Biosens. Bioelectron. 16, 97 (2001).
[CrossRef] [PubMed]

Chang, Y. C.

K. C. Lee, S. T. Pai, Y. C. Chang, M. C. Chen, and W.-H. Li, Mater. Sci. Eng. B 52, 189 (1998).
[CrossRef]

Chen, M. C.

K. C. Lee, S. T. Pai, Y. C. Chang, M. C. Chen, and W.-H. Li, Mater. Sci. Eng. B 52, 189 (1998).
[CrossRef]

Finlan, M. F.

P.-T. Leung, D. Pollard-Knight, G. P. Malan, and M. F. Finlan, Sens. Actuators B 22, 175 (1994).
[CrossRef]

Gauglitz, G.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Homola, J.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Kall, M.

H. Xu and M. Kall, Sens. Actuators B 87, 244 (2002).
[CrossRef]

Kalyuzhny, G.

G. Kalyuzhny, A. Vaskevich, M. A. Schneeweiss, and I. Rubinstein, Chem.-Eur. J. 8, 3849 (2002).

Kambhampati, D.

D. Kambhampati, P. E. Nielsen, and W. Knoll, Biosens. Bioelectron. 16, 1109 (2001).
[CrossRef] [PubMed]

Knoll, W.

D. Kambhampati, P. E. Nielsen, and W. Knoll, Biosens. Bioelectron. 16, 1109 (2001).
[CrossRef] [PubMed]

Lee, K. C.

K. C. Lee, S. T. Pai, Y. C. Chang, M. C. Chen, and W.-H. Li, Mater. Sci. Eng. B 52, 189 (1998).
[CrossRef]

Leung, P.-T.

P.-T. Leung, D. Pollard-Knight, G. P. Malan, and M. F. Finlan, Sens. Actuators B 22, 175 (1994).
[CrossRef]

Li, W.-H.

K. C. Lee, S. T. Pai, Y. C. Chang, M. C. Chen, and W.-H. Li, Mater. Sci. Eng. B 52, 189 (1998).
[CrossRef]

Liedberg, B.

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

Liz-Marzan, L. M.

T. Ung, L. M. Liz-Marzan, and P. Mulvaney, Colloids Surf. A 202, 119 (2002).
[CrossRef]

Lopez, G. P.

M. J. O’Brien, V. H. Perez-Luna, S. R. Brueck, and G. P. Lopez, Biosens. Bioelectron. 16, 97 (2001).
[CrossRef] [PubMed]

Lundström, I.

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

Malan, G. P.

P.-T. Leung, D. Pollard-Knight, G. P. Malan, and M. F. Finlan, Sens. Actuators B 22, 175 (1994).
[CrossRef]

Maxwell-Garnett, J. C.

J. C. Maxwell-Garnett, Philos. Trans. R Soc. London 203, 385 (1904).
[CrossRef]

Mulvaney, P.

T. Ung, L. M. Liz-Marzan, and P. Mulvaney, Colloids Surf. A 202, 119 (2002).
[CrossRef]

Nielsen, P. E.

D. Kambhampati, P. E. Nielsen, and W. Knoll, Biosens. Bioelectron. 16, 1109 (2001).
[CrossRef] [PubMed]

Nylander, C.

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

O’Brien, M. J.

M. J. O’Brien, V. H. Perez-Luna, S. R. Brueck, and G. P. Lopez, Biosens. Bioelectron. 16, 97 (2001).
[CrossRef] [PubMed]

Pai, S. T.

K. C. Lee, S. T. Pai, Y. C. Chang, M. C. Chen, and W.-H. Li, Mater. Sci. Eng. B 52, 189 (1998).
[CrossRef]

Perez-Luna, V. H.

M. J. O’Brien, V. H. Perez-Luna, S. R. Brueck, and G. P. Lopez, Biosens. Bioelectron. 16, 97 (2001).
[CrossRef] [PubMed]

Pollard-Knight, D.

P.-T. Leung, D. Pollard-Knight, G. P. Malan, and M. F. Finlan, Sens. Actuators B 22, 175 (1994).
[CrossRef]

Raether, H.

H. Raether, Surface Plasmons on Smooth and Rough Surfaces and on Gratings (Springer-Verlag, Berlin, 1988).

Rubinstein, I.

G. Kalyuzhny, A. Vaskevich, M. A. Schneeweiss, and I. Rubinstein, Chem.-Eur. J. 8, 3849 (2002).

Schneeweiss, M. A.

G. Kalyuzhny, A. Vaskevich, M. A. Schneeweiss, and I. Rubinstein, Chem.-Eur. J. 8, 3849 (2002).

Ung, T.

T. Ung, L. M. Liz-Marzan, and P. Mulvaney, Colloids Surf. A 202, 119 (2002).
[CrossRef]

Vaskevich, A.

G. Kalyuzhny, A. Vaskevich, M. A. Schneeweiss, and I. Rubinstein, Chem.-Eur. J. 8, 3849 (2002).

Xu, H.

H. Xu and M. Kall, Sens. Actuators B 87, 244 (2002).
[CrossRef]

Yee, S. S.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Biosens. Bioelectron. (2)

M. J. O’Brien, V. H. Perez-Luna, S. R. Brueck, and G. P. Lopez, Biosens. Bioelectron. 16, 97 (2001).
[CrossRef] [PubMed]

D. Kambhampati, P. E. Nielsen, and W. Knoll, Biosens. Bioelectron. 16, 1109 (2001).
[CrossRef] [PubMed]

Chem.-Eur. J. (1)

G. Kalyuzhny, A. Vaskevich, M. A. Schneeweiss, and I. Rubinstein, Chem.-Eur. J. 8, 3849 (2002).

Colloids Surf. A (1)

T. Ung, L. M. Liz-Marzan, and P. Mulvaney, Colloids Surf. A 202, 119 (2002).
[CrossRef]

Mater. Sci. Eng. B (1)

K. C. Lee, S. T. Pai, Y. C. Chang, M. C. Chen, and W.-H. Li, Mater. Sci. Eng. B 52, 189 (1998).
[CrossRef]

Philos. Trans. R Soc. London (1)

J. C. Maxwell-Garnett, Philos. Trans. R Soc. London 203, 385 (1904).
[CrossRef]

Sens. Actuators (1)

B. Liedberg, C. Nylander, and I. Lundström, Sens. Actuators 4, 299 (1983).
[CrossRef]

Sens. Actuators B (3)

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

P.-T. Leung, D. Pollard-Knight, G. P. Malan, and M. F. Finlan, Sens. Actuators B 22, 175 (1994).
[CrossRef]

H. Xu and M. Kall, Sens. Actuators B 87, 244 (2002).
[CrossRef]

Other (1)

H. Raether, Surface Plasmons on Smooth and Rough Surfaces and on Gratings (Springer-Verlag, Berlin, 1988).

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Figures (3)

Fig. 1
Fig. 1

Reflectivity of SPR sensors as a function of the angle of incidence calculated for three different configurations. Dashed curve, conventional SPR; solid curve, waveguide-coupled SPR; dotted–dashed curve, nanoparticle-enhanced SPR.

Fig. 2
Fig. 2

Schematic illustration of the differential metrology system for SPR biosensors.

Fig. 3
Fig. 3

Dynamic DNA hybridization observed with conventional and nanoparticle-enhanced SPR biosensors. Solid curve, nanoparticle-enhanced SPR biosensor; dashed curve, conventional SPR biosensor.

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

Ee=1-ϕEm+ϕEi,
Pe=1-ϕεm-1ε0Em+ϕεi-1ε0Ei=εe-1ε0Ee,
Ee=1-ϕEm+3ϕεmεi+2εmEm.
εe=εmεi1+2ϕ+2εm1-ϕεi1-ϕ+εm2+ϕ.

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