Abstract

A novel two-step reconstruction scheme using a combined near-infrared and ultrasound technique and its utility in imaging distributions of optical absorption and hemoglobin concentration of breast lesions are demonstrated. In the first-step image reconstruction, the entire tissue volume is segmented based on initial coregistered ultrasound measurements into lesion and background regions. Reconstruction is performed by use of a finer grid for lesion region and a coarse grid for the background tissue. As a result, the total number of voxels with unknown absorption can be maintained on the same order of total measurements, and the matrix with unknown total absorption distribution is appropriately scaled for inversion. In the second step, image reconstruction is refined by optimization of lesion parameters measured from ultrasound images. It is shown that detailed distributions of wavelength-dependent absorption and hemoglobin concentration of breast carcinoma can be obtained with the new reconstruction scheme.

© 2003 Optical Society of America

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References

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  1. B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
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2001

B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

N. G. Chen, P. Y. Guo, S. K. Yan, D. Q. Piao, and Q. Zhu, Appl. Opt. 40, 6367 (2001).
[CrossRef]

2000

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

1999

1989

P. Vaupel, F. Kallinowski, and P. Okunieff, Cancer Res. 49, 6449 (1989).
[PubMed]

Butler, J.

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

Cerussi, A.

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

Chen, N. G.

Durduran, T.

Espinoza, J.

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

Guo, P. Y.

Holboke, M.

Kallinowski, F.

P. Vaupel, F. Kallinowski, and P. Okunieff, Cancer Res. 49, 6449 (1989).
[PubMed]

Lanning, R.

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

McBride, T. O.

B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Ntziachristos, V.

Okunieff, P.

P. Vaupel, F. Kallinowski, and P. Okunieff, Cancer Res. 49, 6449 (1989).
[PubMed]

Osterberg, U.

B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Osterman, K. S.

B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Paulsen, K. D.

B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Pham, T.

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

Piao, D. Q.

Pogue, B.

B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Poplack, S. P.

B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Shah, N.

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

Svaasand, L.

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

Tromberg, B.

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

Vaupel, P.

P. Vaupel, F. Kallinowski, and P. Okunieff, Cancer Res. 49, 6449 (1989).
[PubMed]

Wells, W. A.

B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Yan, S. K.

Yodh, A.

Zhu, Q.

Appl. Opt.

Cancer Res.

P. Vaupel, F. Kallinowski, and P. Okunieff, Cancer Res. 49, 6449 (1989).
[PubMed]

Neoplasia

B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, Neoplasia 2, 26 (2000).
[CrossRef] [PubMed]

Opt. Lett.

Radiology

B. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

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Figures (2)

Fig. 1
Fig. 1

(a) Hand-held combined probe and a frequency-domain NIR imager. (b) Sensor distribution of the combined probe (diameter, 10 cm). The smaller circles are optical source fibers, and the bigger circles are detector fibers. A commercial ultrasound probe is located at the center and its dimensions are 5.6 cm by 1 cm.

Fig. 2
Fig. 2

(a) Gray-scale ultrasound image of a palpable lump of a 44-year-old woman. Ultrasound showed an irregular poorly defined hypoechoic mass, and the lesion was considered as highly suspicious for malignancy. Reconstructed optical absorption maps at (b) 780 nm and (c) 830 nm. The vertical color bars are the absorption coefficient [cm-1]. (d) Total hemoglobin concentration map. The vertical color bars are μmol. The NIR data were simultaneously acquired with the ultrasound image shown in (a). Each image consists of seven slices obtained in 0.5-cm spacing from 0.5 to 3.5 cm in depth. The vertical and horizontal axes correspond to x and y dimensions of 9 cm by 9 cm.

Equations (2)

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Uscrsi,rdi,ω-1D¯×LjGrvj,rdiUincrvj,rsijΔμard3r+BkGrvk,rdiUincrvk,rsikΔμard3r,
UsdMX1=WL,WBMXNML,MBT,

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