Abstract

Monte Carlo simulations have been conducted to investigate the effect of surface roughness on the inverse determination of bulk optical parameters. Results show that μs, μa, and g can be overestimated by an order of magnitude for thin slab tissue samples with a moderate index mismatch at the interfaces if typical surface roughness is neglected. Measurements of Intralipid samples between glass windows with smooth and rough surfaces have been carried out and agreement was found between the numerical and the experimental data. This study suggests that the surface roughness should be taken into account for both in vitro and in vivo determination of bulk tissue optical parameters.

© 2003 Optical Society of America

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2001

Y. Du, X. H. Hu, M. Cariveau, X. Ma, G. W. Kalmus, and J. Q. Lu, Phys. Med. Biol. 46, 167 (2001).
[CrossRef] [PubMed]

G. Zonios, J. Bykowski, and N. Kollias, J. Invest. Dermatol. 117, 1452 (2001).
[CrossRef]

2000

1999

1998

C. R. Simpson, M. Kohl, M. Essenpreis, and M. Cope, Phys. Med. Biol. 43, 2465 (1998).
[CrossRef] [PubMed]

1997

J. F. Beek, H. J. van Staveren, P. Posthumus, H. J. Sterenborg, and M. J. van Gemert, Phys. Med. Biol. 42, 2263 (1997).
[CrossRef] [PubMed]

1996

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

1995

L. Wang, S. L. Jacques, and L. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

1993

1992

T. J. Farrell, M. S. Patterson, and B. Wilson, Med. Phys. 19, 879 (1992).
[CrossRef] [PubMed]

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, Lasers Surg. Med. 12, 510 (1992).
[CrossRef]

1990

V. G. Peters, D. R. Wyman, M. S. Patterson, and G. L. Frank, Phys. Med. Biol. 35, 1317 (1990).
[CrossRef] [PubMed]

1983

B. C. Wilson and G. Adam, Med. Phys. 10, 824 (1983).
[CrossRef] [PubMed]

Aarnoudse, J. G.

Adam, G.

B. C. Wilson and G. Adam, Med. Phys. 10, 824 (1983).
[CrossRef] [PubMed]

Beek, J. F.

J. F. Beek, H. J. van Staveren, P. Posthumus, H. J. Sterenborg, and M. J. van Gemert, Phys. Med. Biol. 42, 2263 (1997).
[CrossRef] [PubMed]

J. W. Pickering, S. A. Prahl, N. Vanwieringen, J. F. Beek, H. J. C. M. Sterenborg, and M. J. C. Vangemert, Appl. Opt. 32, 399 (1993).
[CrossRef] [PubMed]

Bykowski, J.

G. Zonios, J. Bykowski, and N. Kollias, J. Invest. Dermatol. 117, 1452 (2001).
[CrossRef]

Cariveau, M.

Y. Du, X. H. Hu, M. Cariveau, X. Ma, G. W. Kalmus, and J. Q. Lu, Phys. Med. Biol. 46, 167 (2001).
[CrossRef] [PubMed]

Cope, M.

C. R. Simpson, M. Kohl, M. Essenpreis, and M. Cope, Phys. Med. Biol. 43, 2465 (1998).
[CrossRef] [PubMed]

Dassel, A. C. M.

de Mul, F. F. M.

Dong, K.

Du, Y.

Y. Du, X. H. Hu, M. Cariveau, X. Ma, G. W. Kalmus, and J. Q. Lu, Phys. Med. Biol. 46, 167 (2001).
[CrossRef] [PubMed]

Essenpreis, M.

C. R. Simpson, M. Kohl, M. Essenpreis, and M. Cope, Phys. Med. Biol. 43, 2465 (1998).
[CrossRef] [PubMed]

Farrell, T. J.

T. J. Farrell, M. S. Patterson, and B. Wilson, Med. Phys. 19, 879 (1992).
[CrossRef] [PubMed]

Flock, S. T.

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, Lasers Surg. Med. 12, 510 (1992).
[CrossRef]

Frank, G. L.

V. G. Peters, D. R. Wyman, M. S. Patterson, and G. L. Frank, Phys. Med. Biol. 35, 1317 (1990).
[CrossRef] [PubMed]

Graaff, R.

Hu, X. H.

Jacques, S. L.

L. Wang, S. L. Jacques, and L. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, Lasers Surg. Med. 12, 510 (1992).
[CrossRef]

Kalmus, G. W.

Y. Du, X. H. Hu, M. Cariveau, X. Ma, G. W. Kalmus, and J. Q. Lu, Phys. Med. Biol. 46, 167 (2001).
[CrossRef] [PubMed]

Koelink, M. H.

Kohl, M.

C. R. Simpson, M. Kohl, M. Essenpreis, and M. Cope, Phys. Med. Biol. 43, 2465 (1998).
[CrossRef] [PubMed]

Kollias, N.

G. Zonios, J. Bykowski, and N. Kollias, J. Invest. Dermatol. 117, 1452 (2001).
[CrossRef]

Lu, J. Q.

Ma, X.

Y. Du, X. H. Hu, M. Cariveau, X. Ma, G. W. Kalmus, and J. Q. Lu, Phys. Med. Biol. 46, 167 (2001).
[CrossRef] [PubMed]

Page, D. L.

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

Patterson, M. S.

T. J. Farrell, M. S. Patterson, and B. Wilson, Med. Phys. 19, 879 (1992).
[CrossRef] [PubMed]

V. G. Peters, D. R. Wyman, M. S. Patterson, and G. L. Frank, Phys. Med. Biol. 35, 1317 (1990).
[CrossRef] [PubMed]

Peters, V. G.

V. G. Peters, D. R. Wyman, M. S. Patterson, and G. L. Frank, Phys. Med. Biol. 35, 1317 (1990).
[CrossRef] [PubMed]

Pickering, J. W.

Posthumus, P.

J. F. Beek, H. J. van Staveren, P. Posthumus, H. J. Sterenborg, and M. J. van Gemert, Phys. Med. Biol. 42, 2263 (1997).
[CrossRef] [PubMed]

Prahl, S. A.

Sevick-Muraca, E. M.

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

Simpson, C. R.

C. R. Simpson, M. Kohl, M. Essenpreis, and M. Cope, Phys. Med. Biol. 43, 2465 (1998).
[CrossRef] [PubMed]

Song, Z.

Star, W. M.

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, Lasers Surg. Med. 12, 510 (1992).
[CrossRef]

Sterenborg, H. J.

J. F. Beek, H. J. van Staveren, P. Posthumus, H. J. Sterenborg, and M. J. van Gemert, Phys. Med. Biol. 42, 2263 (1997).
[CrossRef] [PubMed]

Sterenborg, H. J. C. M.

Troy, T. L.

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

van Gemert, M. J.

J. F. Beek, H. J. van Staveren, P. Posthumus, H. J. Sterenborg, and M. J. van Gemert, Phys. Med. Biol. 42, 2263 (1997).
[CrossRef] [PubMed]

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, Lasers Surg. Med. 12, 510 (1992).
[CrossRef]

van Staveren, H. J.

J. F. Beek, H. J. van Staveren, P. Posthumus, H. J. Sterenborg, and M. J. van Gemert, Phys. Med. Biol. 42, 2263 (1997).
[CrossRef] [PubMed]

Vangemert, M. J. C.

Vanwieringen, N.

Wang, L.

L. Wang, S. L. Jacques, and L. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

Wilson, B.

T. J. Farrell, M. S. Patterson, and B. Wilson, Med. Phys. 19, 879 (1992).
[CrossRef] [PubMed]

Wilson, B. C.

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, Lasers Surg. Med. 12, 510 (1992).
[CrossRef]

B. C. Wilson and G. Adam, Med. Phys. 10, 824 (1983).
[CrossRef] [PubMed]

Wyman, D. R.

V. G. Peters, D. R. Wyman, M. S. Patterson, and G. L. Frank, Phys. Med. Biol. 35, 1317 (1990).
[CrossRef] [PubMed]

Zheng, L.

L. Wang, S. L. Jacques, and L. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

Zijlstra, W. G.

Zonios, G.

G. Zonios, J. Bykowski, and N. Kollias, J. Invest. Dermatol. 117, 1452 (2001).
[CrossRef]

Appl. Opt.

Comput. Methods Programs Biomed.

L. Wang, S. L. Jacques, and L. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
[CrossRef] [PubMed]

J. Biomed. Opt.

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

J. Invest. Dermatol.

G. Zonios, J. Bykowski, and N. Kollias, J. Invest. Dermatol. 117, 1452 (2001).
[CrossRef]

Lasers Surg. Med.

S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, Lasers Surg. Med. 12, 510 (1992).
[CrossRef]

Med. Phys.

B. C. Wilson and G. Adam, Med. Phys. 10, 824 (1983).
[CrossRef] [PubMed]

T. J. Farrell, M. S. Patterson, and B. Wilson, Med. Phys. 19, 879 (1992).
[CrossRef] [PubMed]

Phys. Med. Biol.

V. G. Peters, D. R. Wyman, M. S. Patterson, and G. L. Frank, Phys. Med. Biol. 35, 1317 (1990).
[CrossRef] [PubMed]

J. F. Beek, H. J. van Staveren, P. Posthumus, H. J. Sterenborg, and M. J. van Gemert, Phys. Med. Biol. 42, 2263 (1997).
[CrossRef] [PubMed]

Y. Du, X. H. Hu, M. Cariveau, X. Ma, G. W. Kalmus, and J. Q. Lu, Phys. Med. Biol. 46, 167 (2001).
[CrossRef] [PubMed]

C. R. Simpson, M. Kohl, M. Essenpreis, and M. Cope, Phys. Med. Biol. 43, 2465 (1998).
[CrossRef] [PubMed]

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Figures (3)

Fig. 1
Fig. 1

Definitions of optical signals, with the dashed circles indicating the two positions of the integrating sphere.

Fig. 2
Fig. 2

Dependence of μa, μs, and g on δ/a. The bulk parameters of the sample for the reference configuration are μa0=0.2 mm-1 and g0=0.90; (a)–(c), μs0=15 mm-1; (d)–(f), μs0=5 mm-1. Other parameters are 0.20-mm, 14-mm diameter, n=1.41 for the sample, and 3 mm, 22 mm, and 1.51 for the holder plates, respectively. Insets in (c) and (f) indicate μs as functions of δ/a. Two groups of data are compared in each figure with either δ or a kept as a constant. The solid curves are to guide the eye.

Fig. 3
Fig. 3

Contour plot of error function Σ versus surface parameters δ and a for the Intralipid sample between rough windows.

Equations (1)

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Σ=Rd-Rd0Rd02+Td-Td0Td02+Tc-Tc0Tc02,

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