Volumetric diffuse optical tomography of brain activity

Abstract

We present three-dimensional diffuse optical tomography of the hemodynamic response to somatosensory stimulation in a rat. These images show the feasibility of volumetrically imaging the functional response to brain activity with diffuse light. A combination of positional optode calibration and contrast-to-noise ratio weighting was found to improve imaging performance.

© 2003 Optical Society of America

Simulation study of magnetic resonance imaging–guided cortically constrained diffuse optical tomography of human brain function

David A. Boas and Anders M. Dale
Appl. Opt. 44(10) 1957-1968 (2005)

Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging

Danny K. Joseph, Theodore J. Huppert, Maria Angela Franceschini, and David A. Boas
Appl. Opt. 45(31) 8142-8151 (2006)

Simultaneous integrated diffuse optical tomography and functional magnetic resonance imaging of the human brain

Xiaofeng Zhang, Vladislav Y. Toronov, and Andrew G. Webb
Opt. Express 13(14) 5513-5521 (2005)

Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation

Turgut Durduran, Guoqiang Yu, Mark G. Burnett, John A. Detre, Joel H. Greenberg, Jiongjiong Wang, Chao Zhou, and Arjun G. Yodh
Opt. Lett. 29(15) 1766-1768 (2004)

Optimization of probe geometry for diffuse optical brain imaging based on measurement density and distribution

Fenghua Tian, George Alexandrakis, and Hanli Liu
Appl. Opt. 48(13) 2496-2504 (2009)