Abstract

We present three-dimensional diffuse optical tomography of the hemodynamic response to somatosensory stimulation in a rat. These images show the feasibility of volumetrically imaging the functional response to brain activity with diffuse light. A combination of positional optode calibration and contrast-to-noise ratio weighting was found to improve imaging performance.

© 2003 Optical Society of America

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References

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  1. M. A. Franceschini, V. Toronov, M. E. Filiaci, E. Gratton, and S. Fantini, Opt. Express 6, 49 (2000), http://www.opticsexpress.org.
    [CrossRef] [PubMed]
  2. W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
    [CrossRef] [PubMed]
  3. P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
    [CrossRef] [PubMed]
  4. K. L. Sakai, R. Hashimoto, and F. Homae, Neurosci. Res. 39, 1 (2001).
    [PubMed]
  5. J. P. Culver, V. Ntziachristos, M. J. Holboke, and A. G. Yodh, Opt. Lett. 26, 701 (2001).
    [CrossRef]
  6. A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, Opt. Express 9, 272 (2001), http://www.opticsexpress.org.
    [CrossRef] [PubMed]
  7. J. J. Stott, J. P. Culver, S. R. Arridge, and D. A. Boas, Appl. Opt. 42, 3154 (2003).
    [CrossRef] [PubMed]
  8. A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
    [CrossRef] [PubMed]
  9. D. A. Boas, T. Gaudette, and S. R. Arridge, Opt. Express 8, 263 (2001), http://www.opticsexpress.org.
    [CrossRef] [PubMed]
  10. C. Cheung, J. P. Culver, A. G. Yodh, K. Takahashi, and J. H. Greenberg, Phys. Med. Biol. 46, 2053 (2001).
    [CrossRef] [PubMed]
  11. M. A. Oleary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett. 20, 426 (1995).
    [CrossRef]
  12. J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
    [CrossRef] [PubMed]
  13. J. B. Mandeville and J. J. Marota, Magn. Reson. Med. 42, 591 (1999).
    [CrossRef] [PubMed]

2003 (3)

J. J. Stott, J. P. Culver, S. R. Arridge, and D. A. Boas, Appl. Opt. 42, 3154 (2003).
[CrossRef] [PubMed]

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

2001 (7)

D. A. Boas, T. Gaudette, and S. R. Arridge, Opt. Express 8, 263 (2001), http://www.opticsexpress.org.
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, A. G. Yodh, K. Takahashi, and J. H. Greenberg, Phys. Med. Biol. 46, 2053 (2001).
[CrossRef] [PubMed]

W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
[CrossRef] [PubMed]

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

K. L. Sakai, R. Hashimoto, and F. Homae, Neurosci. Res. 39, 1 (2001).
[PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, and A. G. Yodh, Opt. Lett. 26, 701 (2001).
[CrossRef]

A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, Opt. Express 9, 272 (2001), http://www.opticsexpress.org.
[CrossRef] [PubMed]

2000 (1)

1999 (1)

J. B. Mandeville and J. J. Marota, Magn. Reson. Med. 42, 591 (1999).
[CrossRef] [PubMed]

1995 (1)

Abdoulaev, G.

Amigoni, A.

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

Arridge, S. R.

Barbour, R. L.

Bluestone, A. Y.

Boas, D. A.

Chance, B.

Cheung, C.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, A. G. Yodh, K. Takahashi, and J. H. Greenberg, Phys. Med. Biol. 46, 2053 (2001).
[CrossRef] [PubMed]

Chiandetti, L.

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

Colier, W.

W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
[CrossRef] [PubMed]

Culver, J. P.

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

J. J. Stott, J. P. Culver, S. R. Arridge, and D. A. Boas, Appl. Opt. 42, 3154 (2003).
[CrossRef] [PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, and A. G. Yodh, Opt. Lett. 26, 701 (2001).
[CrossRef]

C. Cheung, J. P. Culver, A. G. Yodh, K. Takahashi, and J. H. Greenberg, Phys. Med. Biol. 46, 2053 (2001).
[CrossRef] [PubMed]

Durduran, T.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Fantini, S.

Ferrari, M.

W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
[CrossRef] [PubMed]

Filiaci, M. E.

Franceschini, M. A.

Freato, F.

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

Furuya, D.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Gaudette, T.

Gratton, E.

Greenberg, J. H.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, A. G. Yodh, K. Takahashi, and J. H. Greenberg, Phys. Med. Biol. 46, 2053 (2001).
[CrossRef] [PubMed]

Hashimoto, R.

K. L. Sakai, R. Hashimoto, and F. Homae, Neurosci. Res. 39, 1 (2001).
[PubMed]

Hielscher, A. H.

Holboke, M. J.

Homae, F.

K. L. Sakai, R. Hashimoto, and F. Homae, Neurosci. Res. 39, 1 (2001).
[PubMed]

Mandeville, J. B.

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

J. B. Mandeville and J. J. Marota, Magn. Reson. Med. 42, 591 (1999).
[CrossRef] [PubMed]

Marangoni, P.

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

Marota, J. J.

J. B. Mandeville and J. J. Marota, Magn. Reson. Med. 42, 591 (1999).
[CrossRef] [PubMed]

Ntziachristos, V.

Oeseburg, B.

W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
[CrossRef] [PubMed]

Oleary, M. A.

Quaresima, V.

W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
[CrossRef] [PubMed]

Sakai, K. L.

K. L. Sakai, R. Hashimoto, and F. Homae, Neurosci. Res. 39, 1 (2001).
[PubMed]

Salvadori, S.

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

Schiavo, B.

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

Schmitz, C. H.

Siegel, A. M.

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

Stott, J. J.

Suppjei, A.

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

Takahashi, K.

C. Cheung, J. P. Culver, A. G. Yodh, K. Takahashi, and J. H. Greenberg, Phys. Med. Biol. 46, 2053 (2001).
[CrossRef] [PubMed]

Toronov, V.

van der Sluijs, M. C.

W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
[CrossRef] [PubMed]

Villringer, A.

W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
[CrossRef] [PubMed]

Wenzel, R.

W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
[CrossRef] [PubMed]

Yodh, A. G.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, A. G. Yodh, K. Takahashi, and J. H. Greenberg, Phys. Med. Biol. 46, 2053 (2001).
[CrossRef] [PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, and A. G. Yodh, Opt. Lett. 26, 701 (2001).
[CrossRef]

M. A. Oleary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett. 20, 426 (1995).
[CrossRef]

Zaramella, P.

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

Appl. Opt. (1)

J. Cereb. Blood Flow Metab. (1)

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003).
[CrossRef] [PubMed]

Magn. Reson. Med. (1)

J. B. Mandeville and J. J. Marota, Magn. Reson. Med. 42, 591 (1999).
[CrossRef] [PubMed]

Neurosci. Res. (1)

K. L. Sakai, R. Hashimoto, and F. Homae, Neurosci. Res. 39, 1 (2001).
[PubMed]

Opt. Express (3)

Opt. Lett. (2)

Pediatr. Res. (1)

P. Zaramella, F. Freato, A. Amigoni, S. Salvadori, P. Marangoni, A. Suppjei, B. Schiavo, and L. Chiandetti, Pediatr. Res. 49, 213 (2001).
[CrossRef] [PubMed]

Phys. Med. Biol. (2)

A. M. Siegel, J. P. Culver, J. B. Mandeville, and D. A. Boas, Phys. Med. Biol. 48, 1391 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, A. G. Yodh, K. Takahashi, and J. H. Greenberg, Phys. Med. Biol. 46, 2053 (2001).
[CrossRef] [PubMed]

Vision Res. (1)

W. Colier, V. Quaresima, R. Wenzel, M. C. van der Sluijs, B. Oeseburg, M. Ferrari, and A. Villringer, Vision Res. 41, 97 (2001).
[CrossRef] [PubMed]

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Figures (4)

Fig. 1
Fig. 1

DOT of rat brain function, fiber array positions, and imaging domains. Left, horizontal (xy); right, coronal (xz).

Fig. 2
Fig. 2

Image reconstruction methods were evaluated with simulations. (a) CNR in δμa with PC and SV-CNR weighting, xy slice at z=2.25 mm and xz slice at y=9.5 mm. (b) CNR in δμa without PC and without SV-CNR (e.g., constant) weighting. Color bars state CNR.

Fig. 3
Fig. 3

Experimental DOT images of CNR in δμa,λ=830 nm during rat brain activation. (a) Right forepaw, xy slice at z=1.75 mm, xz slice at y=2 mm. (b) Left forepaw, xy slice at z=2.25 mm, xz slice at y=2 mm. (c) Calibration of optode positions by use of baseline intensities. (d) Activation time traces of [HbR], HbO2, and [HbT].

Fig. 4
Fig. 4

(a) fMRI activation images (CNR of cerebral blood volume) are overlaid on MRI anatomy. (b) For illustrative comparison functional DOT (fDOT) (CNR of δμa,λ=830 nm) activations from Fig. 3 (combined right and left forepaw) are overlaid on the same MRI anatomy.

Tables (1)

Tables Icon

Table 1 Comparison of Reconstruction Methods

Equations (1)

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yi=lnΦrsi,rdi/Φorsi,rdi,Ai,j=-νh3/Do×Grsi,rjGrj,rdi/Grsi,rdi,

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