Experimental verification of the ability to alter the sensitivity to fluorophore layers in turbid media by varying illumination-collection geometry is presented. Fiber-optic probes and two-layer, fluorophore-doped, turbid phantoms are used to elucidate the roles of spot size, illumination–collection fiber separation, and probe–sample spacing. Variations in single- and multiple-fiber probe design parameters produce significant changes in the relative sensitivity to sample layers in a manner that agrees with prior computational studies.
© 2003 Optical Society of AmericaFull Article | PDF Article
T. Joshua Pfefer, Kevin T. Schomacker, Marwood N. Ediger, and Norman S. Nishioka
Appl. Opt. 41(22) 4712-4721 (2002)
Thanassis Papaioannou, Norris W. Preyer, Qiyin Fang, Adam Brightwell, Michael Carnohan, Greg Cottone, Russel Ross, Linda R. Jones, and Laura Marcu
Appl. Opt. 43(14) 2846-2860 (2004)
Richard A. Schwarz, Dizem Arifler, Sung K. Chang, Ina Pavlova, Insiya A. Hussain, Vivian Mack, Bob Knight, Rebecca Richards-Kortum, and Ann M. Gillenwater
Opt. Lett. 30(10) 1159-1161 (2005)