Abstract

Three-dimensional laser-induced photoacoustic tomography, also referred to as optoacoustic tomography, is developed to image animal brain structures noninvasively with the skin and skull intact. This imaging modality combines the advantages of optical contrast and ultrasonic resolution. The distribution of optical absorption in a mouse brain is imaged successfully. The intrinsic optical contrast reveals not only blood vessels but also other detailed brain structures, such as the cerebellum, hippocampus, and ventriculi lateralis. The spatial resolution is primarily diffraction limited by the received photoacoustic waves. Imaged structures of the brain at different depths match the corresponding histological pictures well.

© 2003 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Three-dimensional noninvasive imaging of the vasculature in the mouse brain using a high resolution photoacoustic scanner

Jan Laufer, Edward Zhang, Gennadij Raivich, and Paul Beard
Appl. Opt. 48(10) D299-D306 (2009)

Noninvasive in vivo monitoring of collagenase induced intracerebral hemorrhage by photoacoustic tomography

Dan Wu, Jinge Yang, Guang Zhang, and Huabei Jiang
Biomed. Opt. Express 8(4) 2276-2286 (2017)

Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging

Edward Z. Zhang, Boris Povazay, Jan Laufer, Aneesh Alex, Bernd Hofer, Barbara Pedley, Carl Glittenberg, Bradley Treeby, Ben Cox, Paul Beard, and Wolfgang Drexler
Biomed. Opt. Express 2(8) 2202-2215 (2011)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (2)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (1)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription