Abstract

Optical tomography of turbid media has so far been limited by systems that require fixed geometries or measurements employing fibers. We present a system that records noncontact optical measurements from diffuse media of arbitrary shapes and retrieves the three-dimensional surface information of the diffuse medium. We further present a novel method of combining this composite data set and obtain accurate fluorescence reconstructions. This approach offers significant experimental simplicity and yields high-information-content datasets. The performance of this novel tomographic approach is demonstrated with experimental reconstructions of phantoms.

© 2003 Optical Society of America

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  1. Biomedical Topical Meetings, Vol. 71 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2002).
  2. J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).
  3. A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, Opt. Express 9, 272 (2001), http://www.opticsexpress.org.
  4. J. Ripoll, M. Nieto-Vesperinas, R. Weissleder, and V. Ntziachristos, Opt. Lett. 27, 527 (2002).
  5. M. Firbank, S. Arridge, M. Schweiger, and D. Delpy, Phys. Med. Biol. 41, 767 (1996).
  6. V. Ntziachristos and R. Weissleder, Opt. Lett. 26, 893 (2001).
  7. M. A. Oleary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett. 20, 428 (1995).
  8. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, Med. Phys. 30, 901 (2003).

2003 (1)

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, Med. Phys. 30, 901 (2003).

2002 (3)

J. Ripoll, M. Nieto-Vesperinas, R. Weissleder, and V. Ntziachristos, Opt. Lett. 27, 527 (2002).

Biomedical Topical Meetings, Vol. 71 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2002).

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

2001 (1)

1996 (1)

M. Firbank, S. Arridge, M. Schweiger, and D. Delpy, Phys. Med. Biol. 41, 767 (1996).

1995 (1)

M. A. Oleary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett. 20, 428 (1995).

Abdoulaev, G.

A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, Opt. Express 9, 272 (2001), http://www.opticsexpress.org.

Arridge, S.

M. Firbank, S. Arridge, M. Schweiger, and D. Delpy, Phys. Med. Biol. 41, 767 (1996).

Arridge, S. R.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Austin, T.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Barbour, R. L.

A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, Opt. Express 9, 272 (2001), http://www.opticsexpress.org.

Bluestone, A. Y.

A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, Opt. Express 9, 272 (2001), http://www.opticsexpress.org.

Boas, D. A.

M. A. Oleary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett. 20, 428 (1995).

Chance, B.

M. A. Oleary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett. 20, 428 (1995).

Delpy, D.

M. Firbank, S. Arridge, M. Schweiger, and D. Delpy, Phys. Med. Biol. 41, 767 (1996).

Delpy, D. T.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Everdell, N.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Firbank, M.

M. Firbank, S. Arridge, M. Schweiger, and D. Delpy, Phys. Med. Biol. 41, 767 (1996).

Gibson, A.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Graves, E.

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, Med. Phys. 30, 901 (2003).

Hebden, J. C.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Hielscher, A. H.

A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, Opt. Express 9, 272 (2001), http://www.opticsexpress.org.

Hillman, E. M. C.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Meek, J. H.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Nieto-Vesperinas, M.

Ntziachristos, V.

Oleary, M. A.

M. A. Oleary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett. 20, 428 (1995).

Ripoll, J.

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, Med. Phys. 30, 901 (2003).

J. Ripoll, M. Nieto-Vesperinas, R. Weissleder, and V. Ntziachristos, Opt. Lett. 27, 527 (2002).

Schmitz, C. H.

A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, Opt. Express 9, 272 (2001), http://www.opticsexpress.org.

Schweiger, M.

M. Firbank, S. Arridge, M. Schweiger, and D. Delpy, Phys. Med. Biol. 41, 767 (1996).

Weissleder, R.

Wyatt, J. S.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Yodh, A. G.

M. A. Oleary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett. 20, 428 (1995).

Yusof, R. M.

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

Med. Phys. (1)

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, Med. Phys. 30, 901 (2003).

Opt. Express (1)

A. Y. Bluestone, G. Abdoulaev, C. H. Schmitz, R. L. Barbour, and A. H. Hielscher, Opt. Express 9, 272 (2001), http://www.opticsexpress.org.

Opt. Lett. (3)

OSA Trends in Optics and Photonics Series (1)

Biomedical Topical Meetings, Vol. 71 of OSA Trends in Optics and Photonics Series (Optical Society of America, Washington, D.C., 2002).

Phys. Med. Biol. (2)

J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, Phys. Med. Biol. 47, 4155 (2002).

M. Firbank, S. Arridge, M. Schweiger, and D. Delpy, Phys. Med. Biol. 41, 767 (1996).

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