Abstract

Contrast agents are utilized in virtually every imaging modality to enhance diagnostic capabilities. We introduce a novel class of optical contrast agent, namely, encapsulating microspheres, that are based not on fluorescence but on scattering nanoparticles within the shell or core. The agents are suitable for reflection- or scattering-based techniques such as optical coherence tomography, light microscopy, and reflectance confocal microscopy. We characterize the optical properties of gold-, melanin-, and carbon-shelled contrast agents and demonstrate enhancement of optical coherence tomography imaging after intravenous injection of such an agent into a mouse.

© 2003 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Near-infrared dyes as contrast-enhancing agents for spectroscopic optical coherence tomography

Chenyang Xu, Jian Ye, Daniel L. Marks, and Stephen A. Boppart
Opt. Lett. 29(14) 1647-1649 (2004)

In vivo photothermal optical coherence tomography of gold nanorod contrast agents

J. M. Tucker-Schwartz, T. A. Meyer, C. A. Patil, C. L. Duvall, and M. C. Skala
Biomed. Opt. Express 3(11) 2881-2895 (2012)

Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent

Changhuei Yang, Laura E. L. McGuckin, John D. Simon, Michael A. Choma, Brian E. Applegate, and Joseph A. Izatt
Opt. Lett. 29(17) 2016-2018 (2004)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (2)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription