Abstract

The principles of laser photothermal (PT) imaging beyond the diffraction limit are discussed. Algorithms for obtaining information on the sizes and the shapes of nanotargets are analyzed. Spectral PT lifetime imaging is suggested to provide spatial localization of nanotargets overlapping inside the diffraction volume.

© 2003 Optical Society of America

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References

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  1. T. D. Lacoste, X. Michalet, F. Pinaud, D. S. Chemla, A. P. Alivisatos, and S. Weiss, Proc. Natl. Acad. Sci. USA 97, 9461 (2000).
    [CrossRef]
  2. A. M. van Oijen, J. Köhler, J. Schmidt, M. Müller, and G. J. Brakenhoff, J. Opt. Soc. Am. A 16, 909 (1999).
    [CrossRef]
  3. V. P. Zharov, D. Lapotko, and T. Romanovskaya, Proc. SPIE 4623, 384 (2002).
    [CrossRef]
  4. D. Lapotko, T. Romanovskaya, and V. Zharov, J. Biomed. Opt. 7, 425 (2002).
    [CrossRef] [PubMed]
  5. D. O. Lapotko, T. R. Romanovskaya, A. Shnip, and V. P. Zharov, Lasers Surg. Med. 31, 53 (2002).
    [CrossRef]
  6. M. Born and E. Wolf, Principles of Optics, 2nd ed. (Macmillan, New York, 1964).
  7. V. P. Zharov and V. S. Letokhov, Laser Optoacoustic Spectroscopy (Springer-Verlag, Berlin, 1986).
    [CrossRef]
  8. V. S. Letokhov, Nuovo Cimento D13, 939 (1991).
    [CrossRef]
  9. A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
    [CrossRef]
  10. V. P. Zharov and D. O. Lapotko, Rev. Sci. Instrum. 74, 785 (2003).
    [CrossRef]
  11. V. P. Zharov and D. O. Lapotko, Proc. SPIE 4960, 455 (2003).

2003 (2)

V. P. Zharov and D. O. Lapotko, Rev. Sci. Instrum. 74, 785 (2003).
[CrossRef]

V. P. Zharov and D. O. Lapotko, Proc. SPIE 4960, 455 (2003).

2002 (3)

V. P. Zharov, D. Lapotko, and T. Romanovskaya, Proc. SPIE 4623, 384 (2002).
[CrossRef]

D. Lapotko, T. Romanovskaya, and V. Zharov, J. Biomed. Opt. 7, 425 (2002).
[CrossRef] [PubMed]

D. O. Lapotko, T. R. Romanovskaya, A. Shnip, and V. P. Zharov, Lasers Surg. Med. 31, 53 (2002).
[CrossRef]

2000 (1)

T. D. Lacoste, X. Michalet, F. Pinaud, D. S. Chemla, A. P. Alivisatos, and S. Weiss, Proc. Natl. Acad. Sci. USA 97, 9461 (2000).
[CrossRef]

1999 (1)

1994 (1)

A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
[CrossRef]

1991 (1)

V. S. Letokhov, Nuovo Cimento D13, 939 (1991).
[CrossRef]

1986 (1)

V. P. Zharov and V. S. Letokhov, Laser Optoacoustic Spectroscopy (Springer-Verlag, Berlin, 1986).
[CrossRef]

1964 (1)

M. Born and E. Wolf, Principles of Optics, 2nd ed. (Macmillan, New York, 1964).

Alivisatos, A. P.

T. D. Lacoste, X. Michalet, F. Pinaud, D. S. Chemla, A. P. Alivisatos, and S. Weiss, Proc. Natl. Acad. Sci. USA 97, 9461 (2000).
[CrossRef]

Babin, A. A.

A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
[CrossRef]

Belyaeva, N. N.

A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
[CrossRef]

Born, M.

M. Born and E. Wolf, Principles of Optics, 2nd ed. (Macmillan, New York, 1964).

Brakenhoff, G. J.

Bubis, E. L.

A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
[CrossRef]

Chemla, D. S.

T. D. Lacoste, X. Michalet, F. Pinaud, D. S. Chemla, A. P. Alivisatos, and S. Weiss, Proc. Natl. Acad. Sci. USA 97, 9461 (2000).
[CrossRef]

Feldshtein, F. I.

A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
[CrossRef]

Freidman, G. I.

A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
[CrossRef]

Köhler, J.

Lacoste, T. D.

T. D. Lacoste, X. Michalet, F. Pinaud, D. S. Chemla, A. P. Alivisatos, and S. Weiss, Proc. Natl. Acad. Sci. USA 97, 9461 (2000).
[CrossRef]

Lapotko, D.

V. P. Zharov, D. Lapotko, and T. Romanovskaya, Proc. SPIE 4623, 384 (2002).
[CrossRef]

D. Lapotko, T. Romanovskaya, and V. Zharov, J. Biomed. Opt. 7, 425 (2002).
[CrossRef] [PubMed]

Lapotko, D. O.

V. P. Zharov and D. O. Lapotko, Rev. Sci. Instrum. 74, 785 (2003).
[CrossRef]

V. P. Zharov and D. O. Lapotko, Proc. SPIE 4960, 455 (2003).

D. O. Lapotko, T. R. Romanovskaya, A. Shnip, and V. P. Zharov, Lasers Surg. Med. 31, 53 (2002).
[CrossRef]

Letokhov, V. S.

V. S. Letokhov, Nuovo Cimento D13, 939 (1991).
[CrossRef]

V. P. Zharov and V. S. Letokhov, Laser Optoacoustic Spectroscopy (Springer-Verlag, Berlin, 1986).
[CrossRef]

Michalet, X.

T. D. Lacoste, X. Michalet, F. Pinaud, D. S. Chemla, A. P. Alivisatos, and S. Weiss, Proc. Natl. Acad. Sci. USA 97, 9461 (2000).
[CrossRef]

Müller, M.

Pinaud, F.

T. D. Lacoste, X. Michalet, F. Pinaud, D. S. Chemla, A. P. Alivisatos, and S. Weiss, Proc. Natl. Acad. Sci. USA 97, 9461 (2000).
[CrossRef]

Romanovskaya, T.

V. P. Zharov, D. Lapotko, and T. Romanovskaya, Proc. SPIE 4623, 384 (2002).
[CrossRef]

D. Lapotko, T. Romanovskaya, and V. Zharov, J. Biomed. Opt. 7, 425 (2002).
[CrossRef] [PubMed]

Romanovskaya, T. R.

D. O. Lapotko, T. R. Romanovskaya, A. Shnip, and V. P. Zharov, Lasers Surg. Med. 31, 53 (2002).
[CrossRef]

Schmidt, J.

Shnip, A.

D. O. Lapotko, T. R. Romanovskaya, A. Shnip, and V. P. Zharov, Lasers Surg. Med. 31, 53 (2002).
[CrossRef]

Shubin, S. V.

A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
[CrossRef]

van Oijen, A. M.

Weiss, S.

T. D. Lacoste, X. Michalet, F. Pinaud, D. S. Chemla, A. P. Alivisatos, and S. Weiss, Proc. Natl. Acad. Sci. USA 97, 9461 (2000).
[CrossRef]

Wolf, E.

M. Born and E. Wolf, Principles of Optics, 2nd ed. (Macmillan, New York, 1964).

Yakovlev, I. V.

A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
[CrossRef]

Zharov, V.

D. Lapotko, T. Romanovskaya, and V. Zharov, J. Biomed. Opt. 7, 425 (2002).
[CrossRef] [PubMed]

Zharov, V. P.

V. P. Zharov and D. O. Lapotko, Proc. SPIE 4960, 455 (2003).

V. P. Zharov and D. O. Lapotko, Rev. Sci. Instrum. 74, 785 (2003).
[CrossRef]

D. O. Lapotko, T. R. Romanovskaya, A. Shnip, and V. P. Zharov, Lasers Surg. Med. 31, 53 (2002).
[CrossRef]

V. P. Zharov, D. Lapotko, and T. Romanovskaya, Proc. SPIE 4623, 384 (2002).
[CrossRef]

V. P. Zharov and V. S. Letokhov, Laser Optoacoustic Spectroscopy (Springer-Verlag, Berlin, 1986).
[CrossRef]

J. Biomed. Opt. (1)

D. Lapotko, T. Romanovskaya, and V. Zharov, J. Biomed. Opt. 7, 425 (2002).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Lasers Surg. Med. (1)

D. O. Lapotko, T. R. Romanovskaya, A. Shnip, and V. P. Zharov, Lasers Surg. Med. 31, 53 (2002).
[CrossRef]

Nuovo Cimento (1)

V. S. Letokhov, Nuovo Cimento D13, 939 (1991).
[CrossRef]

Proc. Natl. Acad. Sci. USA (1)

T. D. Lacoste, X. Michalet, F. Pinaud, D. S. Chemla, A. P. Alivisatos, and S. Weiss, Proc. Natl. Acad. Sci. USA 97, 9461 (2000).
[CrossRef]

Proc. SPIE (3)

V. P. Zharov and D. O. Lapotko, Proc. SPIE 4960, 455 (2003).

A. A. Babin, N. N. Belyaeva, E. L. Bubis, F. I. Feldshtein, G. I. Freidman, S. V. Shubin, and I. V. Yakovlev, Proc. SPIE 2205, 454 (1994).
[CrossRef]

V. P. Zharov, D. Lapotko, and T. Romanovskaya, Proc. SPIE 4623, 384 (2002).
[CrossRef]

Rev. Sci. Instrum. (1)

V. P. Zharov and D. O. Lapotko, Rev. Sci. Instrum. 74, 785 (2003).
[CrossRef]

Other (2)

M. Born and E. Wolf, Principles of Optics, 2nd ed. (Macmillan, New York, 1964).

V. P. Zharov and V. S. Letokhov, Laser Optoacoustic Spectroscopy (Springer-Verlag, Berlin, 1986).
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

Schematic of laser PT phase-contrast microscopy.

Fig. 2
Fig. 2

Thermal fields (solid curves) around a nano-object: A, temperature profile along axis X; B, margin of temperature distribution for a cylindrical target.

Fig. 3
Fig. 3

PT analysis of two nano-objects: Positions of A, two nano-objects (n1 and n2) inside the diffraction pattern and B, the diffraction pattern from each object.

Equations (5)

Equations on this page are rendered with MathJax. Learn more.

τT=R2/6.75k,
τT=Rc2/4k,
τT=d2/8k,
Tr,t=ΔTRT2/R2-3/2 exp-r2/RT2,
RT=4kt+R21/2,

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