Abstract

A simple instrument is demonstrated for high-resolution simultaneous imaging of total hemoglobin concentration and oxygenation and blood flow in the brain by combining rapid multiwavelength imaging with laser speckle contrast imaging. The instrument was used to image changes in oxyhemoglobin and deoxyhemoglobin and blood flow during cortical spreading depression and single whisker stimulation in rats through a thinned skull. The ability to image blood flow and hemoglobin concentration changes simultaneously with high resolution will permit detailed quantitative analysis of the spatiotemporal hemodynamics of functional brain activation, including imaging of oxygen metabolism. This is of significance to the neuroscience community and will lead to a better understanding of the interrelationship of neural, metabolic, and hemodynamic processes in normal and diseased brains.

© 2003 Optical Society of America

Full Article  |  PDF Article
Related Articles
Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation

Turgut Durduran, Guoqiang Yu, Mark G. Burnett, John A. Detre, Joel H. Greenberg, Jiongjiong Wang, Chao Zhou, and Arjun G. Yodh
Opt. Lett. 29(15) 1766-1768 (2004)

Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging

Shuai Yuan, Anna Devor, David A. Boas, and Andrew K. Dunn
Appl. Opt. 44(10) 1823-1830 (2005)

Computational hyperspectral interferometry for studies of brain function: proof of concept

Douglas J. Fox, Jr., Hana Tysver Velde, Chrysanthe Preza, Joseph A. O'Sullivan, William H. Smith, and Thomas A. Woolsey
Appl. Opt. 45(13) 3009-3021 (2006)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription