Abstract

Ultrasound tagging of light provides a unique way to probe photon density inside turbid media. We show that this technique allows one to probe the well-known banana-shaped photon density noninvasively, giving rise to a new tool for modeling diffusive photon propagation. Moreover, we show that this technique is quantitative and allows one to get a precise determination of the absorbing constituents inside the turbid medium.

© 2002 Optical Society of America

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References

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  1. W. Cui, C. Kumar, and B. Chance, Proc. SPIE 1431, 180 (1991).
    [CrossRef]
  2. D. Dolfi and F. Micheron, International Patent Application, PCT number W 89/00278 (1989).
  3. L. Wang, Phys. Rev. Lett. 87, 4 (2001).
  4. L. Wang, S. L. Jacques, and X. Zhao, Opt. Lett. 20, 629 (1995).
    [CrossRef] [PubMed]
  5. M. Kempe, M. Larionov, D. Zaslavski, and A. Z. Genack, J. Opt. Soc. Am. A 14, 1151 (1997).
    [CrossRef]
  6. S. Leveque, A. C. Boccara, M. Lebec, and H. Saint-Jalmes, Opt. Lett. 24, 181 (1999).
    [CrossRef]
  7. A. Lev, Z. Kotler, and B. Sfez, Opt. Lett. 25, 378 (2000).
    [CrossRef]
  8. E. Granot, A. Lev, Z. Kotler, B. G. Sfez, and H. Taitelbaum, J. Opt. Soc. Am. A 18, 1962 (2001).
    [CrossRef]
  9. S. C. Feng, F. Zeng, and B. Chance, Proc. SPIE 2389, 54 (1995).
    [CrossRef]
  10. S. Suzuki, S. Takasaki, T. Ozaki, and Y. Kobayashi, Proc. SPIE 3597, 582 (1999).
    [CrossRef]
  11. http://olmc.ogi.edu/spectra/Hemoglobin/ .

2001 (2)

2000 (1)

1999 (2)

S. Leveque, A. C. Boccara, M. Lebec, and H. Saint-Jalmes, Opt. Lett. 24, 181 (1999).
[CrossRef]

S. Suzuki, S. Takasaki, T. Ozaki, and Y. Kobayashi, Proc. SPIE 3597, 582 (1999).
[CrossRef]

1997 (1)

1995 (2)

L. Wang, S. L. Jacques, and X. Zhao, Opt. Lett. 20, 629 (1995).
[CrossRef] [PubMed]

S. C. Feng, F. Zeng, and B. Chance, Proc. SPIE 2389, 54 (1995).
[CrossRef]

1991 (1)

W. Cui, C. Kumar, and B. Chance, Proc. SPIE 1431, 180 (1991).
[CrossRef]

Boccara, A. C.

Chance, B.

S. C. Feng, F. Zeng, and B. Chance, Proc. SPIE 2389, 54 (1995).
[CrossRef]

W. Cui, C. Kumar, and B. Chance, Proc. SPIE 1431, 180 (1991).
[CrossRef]

Cui, W.

W. Cui, C. Kumar, and B. Chance, Proc. SPIE 1431, 180 (1991).
[CrossRef]

Dolfi, D.

D. Dolfi and F. Micheron, International Patent Application, PCT number W 89/00278 (1989).

Feng, S. C.

S. C. Feng, F. Zeng, and B. Chance, Proc. SPIE 2389, 54 (1995).
[CrossRef]

Genack, A. Z.

Granot, E.

Jacques, S. L.

Kempe, M.

Kobayashi, Y.

S. Suzuki, S. Takasaki, T. Ozaki, and Y. Kobayashi, Proc. SPIE 3597, 582 (1999).
[CrossRef]

Kotler, Z.

Kumar, C.

W. Cui, C. Kumar, and B. Chance, Proc. SPIE 1431, 180 (1991).
[CrossRef]

Larionov, M.

Lebec, M.

Lev, A.

Leveque, S.

Micheron, F.

D. Dolfi and F. Micheron, International Patent Application, PCT number W 89/00278 (1989).

Ozaki, T.

S. Suzuki, S. Takasaki, T. Ozaki, and Y. Kobayashi, Proc. SPIE 3597, 582 (1999).
[CrossRef]

Saint-Jalmes, H.

Sfez, B.

Sfez, B. G.

Suzuki, S.

S. Suzuki, S. Takasaki, T. Ozaki, and Y. Kobayashi, Proc. SPIE 3597, 582 (1999).
[CrossRef]

Taitelbaum, H.

Takasaki, S.

S. Suzuki, S. Takasaki, T. Ozaki, and Y. Kobayashi, Proc. SPIE 3597, 582 (1999).
[CrossRef]

Wang, L.

Zaslavski, D.

Zeng, F.

S. C. Feng, F. Zeng, and B. Chance, Proc. SPIE 2389, 54 (1995).
[CrossRef]

Zhao, X.

J. Opt. Soc. Am. A (2)

Opt. Lett. (3)

Phys. Rev. Lett. (1)

L. Wang, Phys. Rev. Lett. 87, 4 (2001).

Proc. SPIE (3)

W. Cui, C. Kumar, and B. Chance, Proc. SPIE 1431, 180 (1991).
[CrossRef]

S. C. Feng, F. Zeng, and B. Chance, Proc. SPIE 2389, 54 (1995).
[CrossRef]

S. Suzuki, S. Takasaki, T. Ozaki, and Y. Kobayashi, Proc. SPIE 3597, 582 (1999).
[CrossRef]

Other (2)

http://olmc.ogi.edu/spectra/Hemoglobin/ .

D. Dolfi and F. Micheron, International Patent Application, PCT number W 89/00278 (1989).

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Figures (3)

Fig. 1
Fig. 1

Setup of the optical measurement. Light from both lasers is combined and coupled to an optical multimode fiber that is plugged into the phantom. A collecting fiber sends the signal to a photomultiplier. The signal is then processed as described in Ref. 7.

Fig. 2
Fig. 2

(a) Mapping of the photon density obtained by scanning the ultrasound transducer over the sample (contour plot). (b) Mathematical derivation by use of the experimental values of the absorption and scattering, as well as the experimental geometric dimensions.

Fig. 3
Fig. 3

Transversal cross section of the banana shape in the absorbing medium described in the text. The circles correspond to the experimental points. The solid curve corresponds to a fit with Eq. (3) in the text.

Equations (5)

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Em,ex2=ASfUSSfUS+δfUS1/2-12,
Qrs,rd,rUS=BrUS·z2i=s,d1+μeffλrUS-rirUS-ri3×exp-μeffλrUS-ri,
Em,th2rs,rd,rUS=ACQrs,rd,rUSdrUS,
x=γ6O-μeff,6μeff,8γ8Oγ8H-γ8O-μeff,6μeff,8γ6H-γ6O,
κ=μa,6Mγ6Hx+1-xγ6Oln10,

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