Abstract

We propose a novel method for measuring time-dependent optical quantities. A train of excitation pulses modulated by a pseudorandom bit sequence is used as the light source, and a cross-correlation scheme is used to retrieve the impulse response. Simulation results of the temporal point-spread function of a diffusive wave are provided, as well as experimental results of a fluorescence decay profile. It is demonstrated that our new time-resolved technique can lead to high signal-to-noise ratios and short data acquisition times. A fluorescence-time-dependent suppression process was also been discovered.

© 2002 Optical Society of America

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References

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  1. A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
    [CrossRef]
  2. F. Gao, H. J. Zhao, and Y. Yamada, Appl. Opt. 41, 778 (2002).
    [CrossRef] [PubMed]
  3. N. G. Chen and J. Bai, Phys. Med. Biol. 44, 1669 (1999).
    [CrossRef] [PubMed]
  4. N. G. Chen and Q. Zhu, Proc. SPIE 4250, 37 (2001).
    [CrossRef]
  5. Y. C. Lee, Anal. Biochem. 297, 123 (2001).
    [CrossRef] [PubMed]
  6. C. J. de Grauw and H. C. Gerritsen, Appl. Spectrosc. 55, 670 (2001).
    [CrossRef]
  7. H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
    [CrossRef]
  8. F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, Rev. Sci. Instrum. 71, 256 (2000).
    [CrossRef]
  9. R. C. Dixon, Spread Spectrum Systems (Wiley, New York, 1976).

2002

2001

C. J. de Grauw and H. C. Gerritsen, Appl. Spectrosc. 55, 670 (2001).
[CrossRef]

N. G. Chen and Q. Zhu, Proc. SPIE 4250, 37 (2001).
[CrossRef]

Y. C. Lee, Anal. Biochem. 297, 123 (2001).
[CrossRef] [PubMed]

2000

F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, Rev. Sci. Instrum. 71, 256 (2000).
[CrossRef]

1999

N. G. Chen and J. Bai, Phys. Med. Biol. 44, 1669 (1999).
[CrossRef] [PubMed]

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
[CrossRef]

1995

A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
[CrossRef]

Bai, J.

N. G. Chen and J. Bai, Phys. Med. Biol. 44, 1669 (1999).
[CrossRef] [PubMed]

Chance, B.

A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
[CrossRef]

Chen, N. G.

N. G. Chen and Q. Zhu, Proc. SPIE 4250, 37 (2001).
[CrossRef]

N. G. Chen and J. Bai, Phys. Med. Biol. 44, 1669 (1999).
[CrossRef] [PubMed]

de Grauw, C. J.

Delpy, D. T.

F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, Rev. Sci. Instrum. 71, 256 (2000).
[CrossRef]

Dixon, R. C.

R. C. Dixon, Spread Spectrum Systems (Wiley, New York, 1976).

Eda, H.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
[CrossRef]

Fry, M. E.

F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, Rev. Sci. Instrum. 71, 256 (2000).
[CrossRef]

Gao, F.

Gerritsen, H. C.

Hebden, J. C.

F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, Rev. Sci. Instrum. 71, 256 (2000).
[CrossRef]

Hillman, E. M. C.

F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, Rev. Sci. Instrum. 71, 256 (2000).
[CrossRef]

Ito, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
[CrossRef]

Lee, Y. C.

Y. C. Lee, Anal. Biochem. 297, 123 (2001).
[CrossRef] [PubMed]

Oda, I.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
[CrossRef]

Oikawa, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
[CrossRef]

Schmidt, F. E. W.

F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, Rev. Sci. Instrum. 71, 256 (2000).
[CrossRef]

Takada, M.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
[CrossRef]

Tsunazawa, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
[CrossRef]

Wada, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
[CrossRef]

Yamada, Y.

Yodh, A.

A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
[CrossRef]

Zhao, H. J.

Zhu, Q.

N. G. Chen and Q. Zhu, Proc. SPIE 4250, 37 (2001).
[CrossRef]

Anal. Biochem.

Y. C. Lee, Anal. Biochem. 297, 123 (2001).
[CrossRef] [PubMed]

Appl. Opt.

Appl. Spectrosc.

Phys. Med. Biol.

N. G. Chen and J. Bai, Phys. Med. Biol. 44, 1669 (1999).
[CrossRef] [PubMed]

Phys. Today

A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
[CrossRef]

Proc. SPIE

N. G. Chen and Q. Zhu, Proc. SPIE 4250, 37 (2001).
[CrossRef]

Rev. Sci. Instrum.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, Rev. Sci. Instrum. 70, 3595 (1999).
[CrossRef]

F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, Rev. Sci. Instrum. 71, 256 (2000).
[CrossRef]

Other

R. C. Dixon, Spread Spectrum Systems (Wiley, New York, 1976).

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Figures (2)

Fig. 1
Fig. 1

Impulse response representing the TPSF of a diffusive photon density wave. Thin curve, theoretical prediction; thick curve, reconstruction from noisy environments.

Fig. 2
Fig. 2

Florescence decay temporal profile of the solution of eropium chelate, Quantum Dye.

Equations (6)

Equations on this page are rendered with MathJax. Learn more.

Rt=AIt*Pt,
gτ=ptpt-τ=1τ/T0=0-1/Nτ/T0=1,2,,N/2;-1,-2,,  -N/2,
fτ=RtPt-τ=Iτ*gτ.
Mt=AVt*Pt+nsR1t+ndR2t,
It=1.33 exp-t/T1-0.389 exp-t/T2,
err=T1CΔ,

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