Abstract

Simultaneously recovered absorption and scattering images that separate these optical property features within the female breast are demonstrated from frequency-domain measurements. A study of known absorbing and scattering objects is presented as a foundation for interpreting these in vivo images once the contrast space has been fully characterized. No measurable influence of absorbing-object contrast appears in the scattering images, whereas localized scattering contrast enhances the corresponding region within the absorption image by approximately 30% (e.g., a 2:1 scatterer also reconstructs as an 1.3:1 absorber). Scattering and absorption images of a female volunteer with a 3.4-cm fibroadenoma show a clear 2:1 localized increase in absorption coefficient with little or no evidence of scattering enhancement in the lesion.

© 2001 Optical Society of America

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  1. B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
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2001 (2)

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

T. O. McBride, S. Jiang, B. W. Pogue, U. L. Österberg, and K. D. Paulsen, Rev. Sci. Instrum. 72, 1817 (2001).
[CrossRef]

2000 (1)

B. W. Pogue, C. Willscher, T. O. McBride, U. L. Österberg, and K. D. Paulsen, Med. Phys. 27, 2693 (2000).
[CrossRef]

1999 (1)

1998 (2)

1997 (2)

S. R. Arridge and M. Schweiger, Philos. Trans. R. Soc. London Ser. B 352, 717 (1997).
[CrossRef]

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).
[CrossRef]

1996 (1)

1995 (1)

M. Firbank, M. Oda, and D. T. Delpy, Phys. Med. Biol. 40, 955 (1995).
[CrossRef] [PubMed]

1989 (1)

A. Profio and G. Navarro, Med. Phys. 16, 60 (1989).
[CrossRef] [PubMed]

Alsop, D. C.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).
[CrossRef]

Arridge, S. R.

Chance, B.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).
[CrossRef]

Delpy, D. T.

Detre, J. A.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).
[CrossRef]

Fantini, S.

Firbank, M.

M. Firbank, M. Oda, and D. T. Delpy, Phys. Med. Biol. 40, 955 (1995).
[CrossRef] [PubMed]

Franceschini, M. A.

Fry, M. E.

Hebden, J. C.

Hillman, E. M. C.

Jiang, H.

Jiang, H. B.

H. B. Jiang, K. D. Paulsen, U. L. Österberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

Jiang, S.

T. O. McBride, S. Jiang, B. W. Pogue, U. L. Österberg, and K. D. Paulsen, Rev. Sci. Instrum. 72, 1817 (2001).
[CrossRef]

Kaschke, M.

Luo, Q.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).
[CrossRef]

McBride, T. O.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

T. O. McBride, S. Jiang, B. W. Pogue, U. L. Österberg, and K. D. Paulsen, Rev. Sci. Instrum. 72, 1817 (2001).
[CrossRef]

B. W. Pogue, C. Willscher, T. O. McBride, U. L. Österberg, and K. D. Paulsen, Med. Phys. 27, 2693 (2000).
[CrossRef]

Moesta, K. T.

Navarro, G.

A. Profio and G. Navarro, Med. Phys. 16, 60 (1989).
[CrossRef] [PubMed]

Nioka, S.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).
[CrossRef]

Oda, M.

M. Firbank, M. Oda, and D. T. Delpy, Phys. Med. Biol. 40, 955 (1995).
[CrossRef] [PubMed]

Österberg, U. L.

T. O. McBride, S. Jiang, B. W. Pogue, U. L. Österberg, and K. D. Paulsen, Rev. Sci. Instrum. 72, 1817 (2001).
[CrossRef]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

B. W. Pogue, C. Willscher, T. O. McBride, U. L. Österberg, and K. D. Paulsen, Med. Phys. 27, 2693 (2000).
[CrossRef]

H. B. Jiang, K. D. Paulsen, U. L. Österberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Österberg, B. W. Pogue, and M. S. Patterson, J. Opt. Soc. Am. A 13, 253 (1996).
[CrossRef]

Osterman, K. S.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Patterson, M. S.

H. B. Jiang, K. D. Paulsen, U. L. Österberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Österberg, B. W. Pogue, and M. S. Patterson, J. Opt. Soc. Am. A 13, 253 (1996).
[CrossRef]

Paulsen, K. D.

T. O. McBride, S. Jiang, B. W. Pogue, U. L. Österberg, and K. D. Paulsen, Rev. Sci. Instrum. 72, 1817 (2001).
[CrossRef]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

B. W. Pogue, C. Willscher, T. O. McBride, U. L. Österberg, and K. D. Paulsen, Med. Phys. 27, 2693 (2000).
[CrossRef]

H. B. Jiang, K. D. Paulsen, U. L. Österberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Österberg, B. W. Pogue, and M. S. Patterson, J. Opt. Soc. Am. A 13, 253 (1996).
[CrossRef]

Pogue, B. W.

T. O. McBride, S. Jiang, B. W. Pogue, U. L. Österberg, and K. D. Paulsen, Rev. Sci. Instrum. 72, 1817 (2001).
[CrossRef]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

B. W. Pogue, C. Willscher, T. O. McBride, U. L. Österberg, and K. D. Paulsen, Med. Phys. 27, 2693 (2000).
[CrossRef]

H. Jiang, K. D. Paulsen, U. L. Österberg, B. W. Pogue, and M. S. Patterson, J. Opt. Soc. Am. A 13, 253 (1996).
[CrossRef]

Poplack, S. P.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Profio, A.

A. Profio and G. Navarro, Med. Phys. 16, 60 (1989).
[CrossRef] [PubMed]

Schlag, P. M.

Schmidt, F. E. W.

Schweiger, M.

Walker, S. A.

Wells, W. A.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Willscher, C.

B. W. Pogue, C. Willscher, T. O. McBride, U. L. Österberg, and K. D. Paulsen, Med. Phys. 27, 2693 (2000).
[CrossRef]

Appl. Opt. (1)

J. Opt. Soc. Am. A (1)

Med. Phys. (3)

H. B. Jiang, K. D. Paulsen, U. L. Österberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

B. W. Pogue, C. Willscher, T. O. McBride, U. L. Österberg, and K. D. Paulsen, Med. Phys. 27, 2693 (2000).
[CrossRef]

A. Profio and G. Navarro, Med. Phys. 16, 60 (1989).
[CrossRef] [PubMed]

Opt. Lett. (1)

Philos. Trans. R. Soc. London Ser. B (2)

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).
[CrossRef]

S. R. Arridge and M. Schweiger, Philos. Trans. R. Soc. London Ser. B 352, 717 (1997).
[CrossRef]

Phys. Med. Biol. (1)

M. Firbank, M. Oda, and D. T. Delpy, Phys. Med. Biol. 40, 955 (1995).
[CrossRef] [PubMed]

Radiology (1)

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Österberg, and K. D. Paulsen, Radiology 218, 261 (2001).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (1)

T. O. McBride, S. Jiang, B. W. Pogue, U. L. Österberg, and K. D. Paulsen, Rev. Sci. Instrum. 72, 1817 (2001).
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

Reconstructed images of (a), (c), (e) μa and (b), (d), (f) μs for contrast levels of (a), (b) 0.5:1; (c), (d) 1.5:1; and (e), (f) 2.5:1 for both coefficients are displayed. In the upper central hole, both μa and μs are increased together, whereas in the left-hand hole only μa is increased, and in the right-hand hole only μs is changed.

Fig. 2
Fig. 2

Comparison of reconstructed and expected contrast at the center of the reconstructed objects in Fig.  1. The reconstructed values for the (a) absorption and (b) scattering coefficients are plotted versus the expected results for embedded objects with contrast in (A) absorption-only, (B) scattering-only, (C) absorption and scattering. The reconstructed cross talk in terms of (c) absorption contrast for the scattering-only object and (d) scattering contrast for the absorption-only object are also displayed.

Fig. 3
Fig. 3

Reconstructed (a) μa and (b) μs tomographic images in the plane of the abnormality for a female volunteer with a 3.4-cm fibroadenoma in the upper central right breast. Images of (c) μa and (d) μs are shown for the same tomographic plane on the contralateral left breast. The images are displayed as if the reader were looking at the subject.

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