Abstract

A novel miniature integrated-optical sensor for versatile multichannel applications is described. Wavelength-modulation techniques using laser diodes (vertical-cavity surface-emitting lasers) are used to interrogate multiple-waveguide sensing regions on a single integrated-optical chip for accurate measurement of effective refractive-index changes at a high data rate. With the experimental miniature sensor system, a resolution of ΔNPP = 10-7 (short term, peak to peak) of the effective refractive index was demonstrated. In terms of surface-mass coverage, this resolution corresponds to ΔΓPP = 130 fg/mm2.

© 2000 Optical Society of America

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  1. BIOS-1 input grating-coupler instrument, Artificial Sensing Instruments AG, Zurich Switzerland.
  2. J. Dübendorfer and R. E. Kunz, Appl. Opt. 37, 1890 (1998).
  3. R. Karlsson and R. Stahlberg, Anal. Biochem. 228, 274 (1995).
  4. BIAcore and BIAlite surface-plasmon resonance biosensors; Biocore, Uppsala, Sweden.
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  8. R. G. Heideman, R. P. H. Kooyman, and J. Greve, Sensors Actuators B 10, 209 (1993).
  9. A. Brandenburg, Sensors Actuators B 38–39, 266 (1997).
  10. J. Dübendorfer and R. E. Kunz, Sensors Actuators B 38–39, 116 (1996).
  11. K. Gulden, M. Moser, and S. Lüscher, Proc. SPIE 2682, 125 (1996).
  12. Ph. M. Nellen and W. Lukosz, Sensors Actuators B 1, 592 (1990).
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  14. Europlex 99510, Roehm Darmstadt, Germany.
  15. R. E. Kunz, J. Edlinger, P. Sixt, and M. T. Gale, Sensors Actuators A 47, 482 (1995).
  16. BPY 11P, Siemens Munich, Germany.
  17. LIA-BVD-150-H, Femto, Berlin.

1998

1997

A. Brandenburg, Sensors Actuators B 38–39, 266 (1997).

1996

J. Dübendorfer and R. E. Kunz, Sensors Actuators B 38–39, 116 (1996).

K. Gulden, M. Moser, and S. Lüscher, Proc. SPIE 2682, 125 (1996).

W. Lukosz, Ch. Stamm, H. R. Moser, R. Ryf, and J. Dübendorfer, Sensors Actuators B 31, 203 (1996).

1995

R. Karlsson and R. Stahlberg, Anal. Biochem. 228, 274 (1995).

R. E. Kunz, J. Edlinger, P. Sixt, and M. T. Gale, Sensors Actuators A 47, 482 (1995).

1993

R. E. Kunz, Sensors Actuators B 11, 167 (1993).

R. Cush, J. M. Cronin, W. J. Stewart, C. H. Maule, J. Molloy, and N. J. Goddard, Biosensors Bioelectron. 8, 347 (1993).

R. G. Heideman, R. P. H. Kooyman, and J. Greve, Sensors Actuators B 10, 209 (1993).

1990

Ph. M. Nellen and W. Lukosz, Sensors Actuators B 1, 592 (1990).

Brandenburg, A.

A. Brandenburg, Sensors Actuators B 38–39, 266 (1997).

Cronin, J. M.

R. Cush, J. M. Cronin, W. J. Stewart, C. H. Maule, J. Molloy, and N. J. Goddard, Biosensors Bioelectron. 8, 347 (1993).

Cush, R.

R. Cush, J. M. Cronin, W. J. Stewart, C. H. Maule, J. Molloy, and N. J. Goddard, Biosensors Bioelectron. 8, 347 (1993).

Dübendorfer, J.

J. Dübendorfer and R. E. Kunz, Appl. Opt. 37, 1890 (1998).

W. Lukosz, Ch. Stamm, H. R. Moser, R. Ryf, and J. Dübendorfer, Sensors Actuators B 31, 203 (1996).

J. Dübendorfer and R. E. Kunz, Sensors Actuators B 38–39, 116 (1996).

Edlinger, J.

R. E. Kunz, J. Edlinger, P. Sixt, and M. T. Gale, Sensors Actuators A 47, 482 (1995).

Gale, M. T.

R. E. Kunz, J. Edlinger, P. Sixt, and M. T. Gale, Sensors Actuators A 47, 482 (1995).

Goddard, N. J.

R. Cush, J. M. Cronin, W. J. Stewart, C. H. Maule, J. Molloy, and N. J. Goddard, Biosensors Bioelectron. 8, 347 (1993).

Greve, J.

R. G. Heideman, R. P. H. Kooyman, and J. Greve, Sensors Actuators B 10, 209 (1993).

Gulden, K.

K. Gulden, M. Moser, and S. Lüscher, Proc. SPIE 2682, 125 (1996).

Heideman, R. G.

R. G. Heideman, R. P. H. Kooyman, and J. Greve, Sensors Actuators B 10, 209 (1993).

Karlsson, R.

R. Karlsson and R. Stahlberg, Anal. Biochem. 228, 274 (1995).

Kooyman, R. P. H.

R. G. Heideman, R. P. H. Kooyman, and J. Greve, Sensors Actuators B 10, 209 (1993).

Kunz, R. E.

J. Dübendorfer and R. E. Kunz, Appl. Opt. 37, 1890 (1998).

J. Dübendorfer and R. E. Kunz, Sensors Actuators B 38–39, 116 (1996).

R. E. Kunz, J. Edlinger, P. Sixt, and M. T. Gale, Sensors Actuators A 47, 482 (1995).

R. E. Kunz, Sensors Actuators B 11, 167 (1993).

Lukosz, W.

W. Lukosz, Ch. Stamm, H. R. Moser, R. Ryf, and J. Dübendorfer, Sensors Actuators B 31, 203 (1996).

Ph. M. Nellen and W. Lukosz, Sensors Actuators B 1, 592 (1990).

Lüscher, S.

K. Gulden, M. Moser, and S. Lüscher, Proc. SPIE 2682, 125 (1996).

Maule, C. H.

R. Cush, J. M. Cronin, W. J. Stewart, C. H. Maule, J. Molloy, and N. J. Goddard, Biosensors Bioelectron. 8, 347 (1993).

Molloy, J.

R. Cush, J. M. Cronin, W. J. Stewart, C. H. Maule, J. Molloy, and N. J. Goddard, Biosensors Bioelectron. 8, 347 (1993).

Moser, H. R.

W. Lukosz, Ch. Stamm, H. R. Moser, R. Ryf, and J. Dübendorfer, Sensors Actuators B 31, 203 (1996).

Moser, M.

K. Gulden, M. Moser, and S. Lüscher, Proc. SPIE 2682, 125 (1996).

Nellen, Ph. M.

Ph. M. Nellen and W. Lukosz, Sensors Actuators B 1, 592 (1990).

Ryf, R.

W. Lukosz, Ch. Stamm, H. R. Moser, R. Ryf, and J. Dübendorfer, Sensors Actuators B 31, 203 (1996).

Sixt, P.

R. E. Kunz, J. Edlinger, P. Sixt, and M. T. Gale, Sensors Actuators A 47, 482 (1995).

Stahlberg, R.

R. Karlsson and R. Stahlberg, Anal. Biochem. 228, 274 (1995).

Stamm, Ch.

W. Lukosz, Ch. Stamm, H. R. Moser, R. Ryf, and J. Dübendorfer, Sensors Actuators B 31, 203 (1996).

Stewart, W. J.

R. Cush, J. M. Cronin, W. J. Stewart, C. H. Maule, J. Molloy, and N. J. Goddard, Biosensors Bioelectron. 8, 347 (1993).

Anal. Biochem.

R. Karlsson and R. Stahlberg, Anal. Biochem. 228, 274 (1995).

Appl. Opt.

Biosensors Bioelectron.

R. Cush, J. M. Cronin, W. J. Stewart, C. H. Maule, J. Molloy, and N. J. Goddard, Biosensors Bioelectron. 8, 347 (1993).

Proc. SPIE

K. Gulden, M. Moser, and S. Lüscher, Proc. SPIE 2682, 125 (1996).

Sensors Actuators A

R. E. Kunz, J. Edlinger, P. Sixt, and M. T. Gale, Sensors Actuators A 47, 482 (1995).

Sensors Actuators B

Ph. M. Nellen and W. Lukosz, Sensors Actuators B 1, 592 (1990).

R. E. Kunz, Sensors Actuators B 11, 167 (1993).

W. Lukosz, Ch. Stamm, H. R. Moser, R. Ryf, and J. Dübendorfer, Sensors Actuators B 31, 203 (1996).

R. G. Heideman, R. P. H. Kooyman, and J. Greve, Sensors Actuators B 10, 209 (1993).

A. Brandenburg, Sensors Actuators B 38–39, 266 (1997).

J. Dübendorfer and R. E. Kunz, Sensors Actuators B 38–39, 116 (1996).

Other

IAsys resonant mirror biosensor sytem, Affinity Sensors, Cambridge, UK.

BIAcore and BIAlite surface-plasmon resonance biosensors; Biocore, Uppsala, Sweden.

Europlex 99510, Roehm Darmstadt, Germany.

BPY 11P, Siemens Munich, Germany.

LIA-BVD-150-H, Femto, Berlin.

BIOS-1 input grating-coupler instrument, Artificial Sensing Instruments AG, Zurich Switzerland.

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