Abstract

We present what is believed to be the first simultaneous reconstruction of the internal scattering and absorbing properties of a highly scattering medium by use of purely temporal data. These results are also the first acquired with the multichannel time-resolved imaging system developed at University College London.

© 1999 Optical Society of America

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References

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  1. B. Chance and R. R. Alfano, eds., Proc. SPIE2979, (1997).
  2. S. R. Arridge and J. C. Hebden, Phys. Med. Biol. 42, 841 (1997).
    [CrossRef] [PubMed]
  3. S. R. Arridge and M. Schweiger, “A general framework for iterative reconstructive algorithms in optical tomography using a finite element method,” in Computational Radiology and Imaging:?Therapy and Diagnosis, C. Borgers and F. Natterer, eds., Vol. 110 of IMA Volumes in Mathematics and Its Applications ( to be published).
  4. M. Schweiger, S. R. Arridge, and D. T. Delpy, J. Math. Imag. Vision 3, 263 (1993).
    [CrossRef]
  5. H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, and M. S. Patterson, Opt. Lett. 20, 2128 (1995).
    [CrossRef] [PubMed]
  6. H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
    [CrossRef] [PubMed]
  7. B. W. Pogue, M. S. Patterson, H. Jiang, and K. D. Paulsen, Phys. Med. Biol. 40, 1709 (1995).
    [CrossRef] [PubMed]
  8. S. R. Arridge and M. Schweiger, Opt. Express 2, 213 (1998), www.osa.org .
    [CrossRef] [PubMed]
  9. S. R. Arridge, Appl. Opt. 34, 7395 (1995).
    [CrossRef] [PubMed]
  10. M. A. O’Leary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett. 20, 426 (1995).
    [CrossRef] [PubMed]
  11. S. R. Arridge and W. R. B. Lionheart, Opt. Lett. 23, 882 (1998).
    [CrossRef]
  12. Y. Ueda, K. Ohta, M. Oda, M. Miwa, Y. Yamashita, and Y. Tsuchiya, Jpn. J. Appl. Phys. 27, 2717 (1998).
    [CrossRef]
  13. K. Wells, J. C. Hebden, F. E. W. Schmidt, and D. T. Delpy, Proc. SPIE 2979, 599 (1997).
    [CrossRef]
  14. J. C. Hebden and D. T. Delpy, Opt. Lett. 19, 311 (1994).
    [CrossRef] [PubMed]
  15. M. Schweiger and S. R. Arridge, Appl. Opt. 37, 7419 (1998).
    [CrossRef]

1998 (5)

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

S. R. Arridge and W. R. B. Lionheart, Opt. Lett. 23, 882 (1998).
[CrossRef]

Y. Ueda, K. Ohta, M. Oda, M. Miwa, Y. Yamashita, and Y. Tsuchiya, Jpn. J. Appl. Phys. 27, 2717 (1998).
[CrossRef]

S. R. Arridge and M. Schweiger, Opt. Express 2, 213 (1998), www.osa.org .
[CrossRef] [PubMed]

M. Schweiger and S. R. Arridge, Appl. Opt. 37, 7419 (1998).
[CrossRef]

1997 (2)

K. Wells, J. C. Hebden, F. E. W. Schmidt, and D. T. Delpy, Proc. SPIE 2979, 599 (1997).
[CrossRef]

S. R. Arridge and J. C. Hebden, Phys. Med. Biol. 42, 841 (1997).
[CrossRef] [PubMed]

1995 (4)

1994 (1)

1993 (1)

M. Schweiger, S. R. Arridge, and D. T. Delpy, J. Math. Imag. Vision 3, 263 (1993).
[CrossRef]

Arridge, S. R.

S. R. Arridge and M. Schweiger, Opt. Express 2, 213 (1998), www.osa.org .
[CrossRef] [PubMed]

S. R. Arridge and W. R. B. Lionheart, Opt. Lett. 23, 882 (1998).
[CrossRef]

M. Schweiger and S. R. Arridge, Appl. Opt. 37, 7419 (1998).
[CrossRef]

S. R. Arridge and J. C. Hebden, Phys. Med. Biol. 42, 841 (1997).
[CrossRef] [PubMed]

S. R. Arridge, Appl. Opt. 34, 7395 (1995).
[CrossRef] [PubMed]

M. Schweiger, S. R. Arridge, and D. T. Delpy, J. Math. Imag. Vision 3, 263 (1993).
[CrossRef]

S. R. Arridge and M. Schweiger, “A general framework for iterative reconstructive algorithms in optical tomography using a finite element method,” in Computational Radiology and Imaging:?Therapy and Diagnosis, C. Borgers and F. Natterer, eds., Vol. 110 of IMA Volumes in Mathematics and Its Applications ( to be published).

Boas, D. A.

Chance, B.

Delpy, D. T.

K. Wells, J. C. Hebden, F. E. W. Schmidt, and D. T. Delpy, Proc. SPIE 2979, 599 (1997).
[CrossRef]

J. C. Hebden and D. T. Delpy, Opt. Lett. 19, 311 (1994).
[CrossRef] [PubMed]

M. Schweiger, S. R. Arridge, and D. T. Delpy, J. Math. Imag. Vision 3, 263 (1993).
[CrossRef]

Hebden, J. C.

S. R. Arridge and J. C. Hebden, Phys. Med. Biol. 42, 841 (1997).
[CrossRef] [PubMed]

K. Wells, J. C. Hebden, F. E. W. Schmidt, and D. T. Delpy, Proc. SPIE 2979, 599 (1997).
[CrossRef]

J. C. Hebden and D. T. Delpy, Opt. Lett. 19, 311 (1994).
[CrossRef] [PubMed]

Jiang, H.

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, and M. S. Patterson, Opt. Lett. 20, 2128 (1995).
[CrossRef] [PubMed]

B. W. Pogue, M. S. Patterson, H. Jiang, and K. D. Paulsen, Phys. Med. Biol. 40, 1709 (1995).
[CrossRef] [PubMed]

Lionheart, W. R. B.

Miwa, M.

Y. Ueda, K. Ohta, M. Oda, M. Miwa, Y. Yamashita, and Y. Tsuchiya, Jpn. J. Appl. Phys. 27, 2717 (1998).
[CrossRef]

O’Leary, M. A.

Oda, M.

Y. Ueda, K. Ohta, M. Oda, M. Miwa, Y. Yamashita, and Y. Tsuchiya, Jpn. J. Appl. Phys. 27, 2717 (1998).
[CrossRef]

Ohta, K.

Y. Ueda, K. Ohta, M. Oda, M. Miwa, Y. Yamashita, and Y. Tsuchiya, Jpn. J. Appl. Phys. 27, 2717 (1998).
[CrossRef]

Osterberg, U. L.

Patterson, M. S.

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, and M. S. Patterson, Opt. Lett. 20, 2128 (1995).
[CrossRef] [PubMed]

B. W. Pogue, M. S. Patterson, H. Jiang, and K. D. Paulsen, Phys. Med. Biol. 40, 1709 (1995).
[CrossRef] [PubMed]

Paulsen, K. D.

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, and M. S. Patterson, Opt. Lett. 20, 2128 (1995).
[CrossRef] [PubMed]

B. W. Pogue, M. S. Patterson, H. Jiang, and K. D. Paulsen, Phys. Med. Biol. 40, 1709 (1995).
[CrossRef] [PubMed]

Pogue, B. W.

B. W. Pogue, M. S. Patterson, H. Jiang, and K. D. Paulsen, Phys. Med. Biol. 40, 1709 (1995).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, and M. S. Patterson, Opt. Lett. 20, 2128 (1995).
[CrossRef] [PubMed]

Schmidt, F. E. W.

K. Wells, J. C. Hebden, F. E. W. Schmidt, and D. T. Delpy, Proc. SPIE 2979, 599 (1997).
[CrossRef]

Schweiger, M.

M. Schweiger and S. R. Arridge, Appl. Opt. 37, 7419 (1998).
[CrossRef]

S. R. Arridge and M. Schweiger, Opt. Express 2, 213 (1998), www.osa.org .
[CrossRef] [PubMed]

M. Schweiger, S. R. Arridge, and D. T. Delpy, J. Math. Imag. Vision 3, 263 (1993).
[CrossRef]

S. R. Arridge and M. Schweiger, “A general framework for iterative reconstructive algorithms in optical tomography using a finite element method,” in Computational Radiology and Imaging:?Therapy and Diagnosis, C. Borgers and F. Natterer, eds., Vol. 110 of IMA Volumes in Mathematics and Its Applications ( to be published).

Tsuchiya, Y.

Y. Ueda, K. Ohta, M. Oda, M. Miwa, Y. Yamashita, and Y. Tsuchiya, Jpn. J. Appl. Phys. 27, 2717 (1998).
[CrossRef]

Ueda, Y.

Y. Ueda, K. Ohta, M. Oda, M. Miwa, Y. Yamashita, and Y. Tsuchiya, Jpn. J. Appl. Phys. 27, 2717 (1998).
[CrossRef]

Wells, K.

K. Wells, J. C. Hebden, F. E. W. Schmidt, and D. T. Delpy, Proc. SPIE 2979, 599 (1997).
[CrossRef]

Yamashita, Y.

Y. Ueda, K. Ohta, M. Oda, M. Miwa, Y. Yamashita, and Y. Tsuchiya, Jpn. J. Appl. Phys. 27, 2717 (1998).
[CrossRef]

Yodh, A. G.

Appl. Opt. (2)

J. Math. Imag. Vision (1)

M. Schweiger, S. R. Arridge, and D. T. Delpy, J. Math. Imag. Vision 3, 263 (1993).
[CrossRef]

Jpn. J. Appl. Phys. (1)

Y. Ueda, K. Ohta, M. Oda, M. Miwa, Y. Yamashita, and Y. Tsuchiya, Jpn. J. Appl. Phys. 27, 2717 (1998).
[CrossRef]

Med. Phys. (1)

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, Med. Phys. 25, 183 (1998).
[CrossRef] [PubMed]

Opt. Express (1)

Opt. Lett. (4)

Phys. Med. Biol. (2)

S. R. Arridge and J. C. Hebden, Phys. Med. Biol. 42, 841 (1997).
[CrossRef] [PubMed]

B. W. Pogue, M. S. Patterson, H. Jiang, and K. D. Paulsen, Phys. Med. Biol. 40, 1709 (1995).
[CrossRef] [PubMed]

Proc. SPIE (1)

K. Wells, J. C. Hebden, F. E. W. Schmidt, and D. T. Delpy, Proc. SPIE 2979, 599 (1997).
[CrossRef]

Other (2)

B. Chance and R. R. Alfano, eds., Proc. SPIE2979, (1997).

S. R. Arridge and M. Schweiger, “A general framework for iterative reconstructive algorithms in optical tomography using a finite element method,” in Computational Radiology and Imaging:?Therapy and Diagnosis, C. Borgers and F. Natterer, eds., Vol. 110 of IMA Volumes in Mathematics and Its Applications ( to be published).

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Figures (3)

Fig. 1
Fig. 1

32-channel time-resolved imaging system.

Fig. 2
Fig. 2

Solid tissue-equivalent phantom and the fan-beam acquisition geometry.

Fig. 3
Fig. 3

Reconstructed maps of absorption (left) and scatter (right).

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