Abstract

We introduce an imaging technique that combines complementary features of ultrasound and near-infrared diffusive light imaging. We achieve the combined technology experimentally by mounting an ultrasound array together with multiple laser source and optical detector fibers upon a hand-held probe. The technique is demonstrated with tissue phantoms wherein both acoustic and optical sensors image the volume underneath the probe. Coregistration of acoustic and optical images is achieved with an accuracy of 0.27±0.20 cm, approximately half of the image pixel size of our prototype. Accurate determination of target optical absorption is also achieved by use of image segmentation on the ultrasound reconstruction. The combined technique may provide improved breast-cancer detection sensitivity and specificity.

© 1999 Optical Society of America

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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  6. R. J. Grable, D. P. Rohler, and S. Kla, Proc. SPIE 2979, 197 (1997).
    [CrossRef]
  7. B. Chance, S. Nioka, S. Zhou, and E. Conant, “Simple, fast, breast-tumor hypoxia imager,” Proc. SPIE3597 (to be published).
  8. A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
    [CrossRef]
  9. Q. Zhu, D. Sullivan, B. Chance, and T. Dambro, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 665 (1999).
    [CrossRef]
  10. B. J. Tromberg, University of California, Irvine, Irvine, Calif. 92612 (personal communication, 1999).
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    [CrossRef] [PubMed]
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    [CrossRef]
  13. R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, Photochem. Photobiol. 67, 33 (1998).
    [CrossRef] [PubMed]
  14. Y. Yao, Y. Wang, Y. Pei, W. Zhu, and R. L. Barbour, J. Opt. Soc. Am. A 14, 325 (1997).
    [CrossRef]
  15. N. Ramanujam, C. Du, H. Y. Ma, and B. Chance, Rev. Sci. Instrum. 69, 3042 (1998).
    [CrossRef]

1999

Q. Zhu, D. Sullivan, B. Chance, and T. Dambro, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 665 (1999).
[CrossRef]

S. Leveque, A. C. Boccara, M. Lebec, and H. Saint-Jalmes, Opt. Lett. 24, 181 (1999).
[CrossRef]

1998

R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, Photochem. Photobiol. 67, 33 (1998).
[CrossRef] [PubMed]

N. Ramanujam, C. Du, H. Y. Ma, and B. Chance, Rev. Sci. Instrum. 69, 3042 (1998).
[CrossRef]

1997

Y. Yao, Y. Wang, Y. Pei, W. Zhu, and R. L. Barbour, J. Opt. Soc. Am. A 14, 325 (1997).
[CrossRef]

R. J. Grable, D. P. Rohler, and S. Kla, Proc. SPIE 2979, 197 (1997).
[CrossRef]

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

J. B. Fishkin, O. Coquoz, E. R. Anderson, M. Brenner, and B. J. Tromberg, Appl. Opt. 36, 10 (1997).
[CrossRef] [PubMed]

1996

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

1995

T. A. Stavros, D. Thickman, and C. Rapp, Radiology 196, 123 (1995).
[CrossRef] [PubMed]

A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
[CrossRef]

L. Wang, S. L. Steven, and X. Zhao, Opt. Lett. 20, 629 (1995); L. Wang and G. Ku, Opt. Lett. 23, 975 (1998).
[CrossRef] [PubMed]

1994

B. B. Goldberg, J. B. Liu, and F. Forsberg, Ultrasound Med. Biol. 20, 319 (1994).
[CrossRef]

Anderson, E. R.

Barbour, R. L.

Boccara, A. C.

Brenner, M.

Chance, B.

Q. Zhu, D. Sullivan, B. Chance, and T. Dambro, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 665 (1999).
[CrossRef]

N. Ramanujam, C. Du, H. Y. Ma, and B. Chance, Rev. Sci. Instrum. 69, 3042 (1998).
[CrossRef]

A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
[CrossRef]

B. Chance, S. Nioka, S. Zhou, and E. Conant, “Simple, fast, breast-tumor hypoxia imager,” Proc. SPIE3597 (to be published).

Conant, E.

B. Chance, S. Nioka, S. Zhou, and E. Conant, “Simple, fast, breast-tumor hypoxia imager,” Proc. SPIE3597 (to be published).

Coquoz, O.

Dambro, T.

Q. Zhu, D. Sullivan, B. Chance, and T. Dambro, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 665 (1999).
[CrossRef]

Danen, R. M.

R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, Photochem. Photobiol. 67, 33 (1998).
[CrossRef] [PubMed]

Du, C.

N. Ramanujam, C. Du, H. Y. Ma, and B. Chance, Rev. Sci. Instrum. 69, 3042 (1998).
[CrossRef]

Fantini, S.

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Fishkin, J. B.

Forsberg, F.

B. B. Goldberg, J. B. Liu, and F. Forsberg, Ultrasound Med. Biol. 20, 319 (1994).
[CrossRef]

Franceschini, M. A.

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Gaida, G.

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Goldberg, B. B.

B. B. Goldberg, J. B. Liu, and F. Forsberg, Ultrasound Med. Biol. 20, 319 (1994).
[CrossRef]

Grable, R. J.

R. J. Grable, D. P. Rohler, and S. Kla, Proc. SPIE 2979, 197 (1997).
[CrossRef]

Gratton, E.

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Jess, H.

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Kashke, M.

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Kla, S.

R. J. Grable, D. P. Rohler, and S. Kla, Proc. SPIE 2979, 197 (1997).
[CrossRef]

Lebec, M.

Leveque, S.

Li, X. D.

R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, Photochem. Photobiol. 67, 33 (1998).
[CrossRef] [PubMed]

Liu, J. B.

B. B. Goldberg, J. B. Liu, and F. Forsberg, Ultrasound Med. Biol. 20, 319 (1994).
[CrossRef]

Ma, H. Y.

N. Ramanujam, C. Du, H. Y. Ma, and B. Chance, Rev. Sci. Instrum. 69, 3042 (1998).
[CrossRef]

Moesta, K. T.

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Nioka, S.

B. Chance, S. Nioka, S. Zhou, and E. Conant, “Simple, fast, breast-tumor hypoxia imager,” Proc. SPIE3597 (to be published).

Page, D. L.

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

Pei, Y.

Ramanujam, N.

N. Ramanujam, C. Du, H. Y. Ma, and B. Chance, Rev. Sci. Instrum. 69, 3042 (1998).
[CrossRef]

Rapp, C.

T. A. Stavros, D. Thickman, and C. Rapp, Radiology 196, 123 (1995).
[CrossRef] [PubMed]

Rohler, D. P.

R. J. Grable, D. P. Rohler, and S. Kla, Proc. SPIE 2979, 197 (1997).
[CrossRef]

Saint-Jalmes, H.

Schlag, P. M.

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Seeber, M.

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Sevick-Muraca, E. M.

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

Stavros, T. A.

T. A. Stavros, D. Thickman, and C. Rapp, Radiology 196, 123 (1995).
[CrossRef] [PubMed]

Steven, S. L.

Sullivan, D.

Q. Zhu, D. Sullivan, B. Chance, and T. Dambro, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 665 (1999).
[CrossRef]

Thayer, W. S.

R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, Photochem. Photobiol. 67, 33 (1998).
[CrossRef] [PubMed]

Thickman, D.

T. A. Stavros, D. Thickman, and C. Rapp, Radiology 196, 123 (1995).
[CrossRef] [PubMed]

Tromberg, B. J.

J. B. Fishkin, O. Coquoz, E. R. Anderson, M. Brenner, and B. J. Tromberg, Appl. Opt. 36, 10 (1997).
[CrossRef] [PubMed]

B. J. Tromberg, University of California, Irvine, Irvine, Calif. 92612 (personal communication, 1999).

Troy, T. L.

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

Wang, L.

Wang, Y.

R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, Photochem. Photobiol. 67, 33 (1998).
[CrossRef] [PubMed]

Y. Yao, Y. Wang, Y. Pei, W. Zhu, and R. L. Barbour, J. Opt. Soc. Am. A 14, 325 (1997).
[CrossRef]

Yao, Y.

Yodh, A.

A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
[CrossRef]

Yodh, A. G.

R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, Photochem. Photobiol. 67, 33 (1998).
[CrossRef] [PubMed]

Zhao, X.

Zhou, S.

B. Chance, S. Nioka, S. Zhou, and E. Conant, “Simple, fast, breast-tumor hypoxia imager,” Proc. SPIE3597 (to be published).

Zhu, Q.

Q. Zhu, D. Sullivan, B. Chance, and T. Dambro, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 665 (1999).
[CrossRef]

Zhu, W.

Appl. Opt.

IEEE Trans. Ultrason. Ferroelectr. Freq. Control

Q. Zhu, D. Sullivan, B. Chance, and T. Dambro, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 665 (1999).
[CrossRef]

J. Biomed. Opt.

T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A

Opt. Lett.

Photochem. Photobiol.

R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, Photochem. Photobiol. 67, 33 (1998).
[CrossRef] [PubMed]

Phys. Today

A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
[CrossRef]

Proc. Natl. Acad. Sci. USA

M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
[CrossRef]

Proc. SPIE

R. J. Grable, D. P. Rohler, and S. Kla, Proc. SPIE 2979, 197 (1997).
[CrossRef]

Radiology

T. A. Stavros, D. Thickman, and C. Rapp, Radiology 196, 123 (1995).
[CrossRef] [PubMed]

Rev. Sci. Instrum.

N. Ramanujam, C. Du, H. Y. Ma, and B. Chance, Rev. Sci. Instrum. 69, 3042 (1998).
[CrossRef]

Ultrasound Med. Biol.

B. B. Goldberg, J. B. Liu, and F. Forsberg, Ultrasound Med. Biol. 20, 319 (1994).
[CrossRef]

Other

B. Chance, S. Nioka, S. Zhou, and E. Conant, “Simple, fast, breast-tumor hypoxia imager,” Proc. SPIE3597 (to be published).

B. J. Tromberg, University of California, Irvine, Irvine, Calif. 92612 (personal communication, 1999).

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Figures (3)

Fig. 1
Fig. 1

(a) Sketch and (b) photograph of the combined probe (front view). An ultrasound array made from 20 crystals in a rectangular 2 cm×1.6 cm grid is located at the center of the probe. An optical array made from 12 source fibers (smaller, darker filled circles) and 4 APD light detector fibers (larger, lighter filled circles) is located at the periphery of the probe. The coordinate axes are shown in (a).

Fig. 2
Fig. 2

Electronic configuration of the ultrasound data-acquisition system.

Fig. 3
Fig. 3

Optical absorption (left) and ultrasound (right) images of the same target embedded inside an Intralipid solution.

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