Abstract

We demonstrate significant differences in the propagation of polarized light through biological tissue compared with two common tissue phantoms. Depolarization of linearly and circularly polarized light was measured versus propagation distance by use of two independent measurement techniques. The measurements were performed on adipose and myocardial tissues and on tissue phantoms that consisted of polystyrene microsphere suspensions and Intralipid. The results indicate that, in contrast with results obtained in tissue phantoms, linearly polarized light survives through longer propagation distances than circularly polarized light in biological tissue.

© 1999 Optical Society of America

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References

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  1. J. M. Schmitt, A. H. Gandbakhche, and R. F. Bonner, Appl. Opt. 31, 6535 (1992).
    [CrossRef] [PubMed]
  2. O. Emile, F. Bretenaker, and A. Le Floch, Opt. Lett. 21, 1706 (1996).
    [CrossRef] [PubMed]
  3. S. P. Morgan, M. P. Khong, and M. G. Somekh, Appl. Opt. 36, 1560 (1997).
    [CrossRef] [PubMed]
  4. F. C. MacKintosh, J. X. Zhu, D. J. Pine, and D. A. Weitz, Phys. Rev. B 40, 9342 (1989).
    [CrossRef]
  5. D. Bicout, C. Brosseau, A. S. Martinez, and J. M. Schmitt, Phys. Rev. E 49, 1767 (1994).
    [CrossRef]
  6. E. Collett, Opt. Commun. 52, 77 (1984).
    [CrossRef]
  7. V. Sankaran, D. J. Maitland, and J. T. Walsh, Proc. SPIE 3598, 158 (1999).
    [CrossRef]
  8. W.-F. Cheong, in Optical-Thermal Response of Laser-Irradiated Tissue, A. J. Welch and M. J. C. van Gemert, eds. (Plenum, New York, 1985), pp. 275–303.
  9. H. J. van Staveren, C. J. M. Moes, J. van Marle, S. A. Prahl, and M. J. C. van Gemert, Appl. Opt. 30, 4507 (1991).
    [CrossRef] [PubMed]
  10. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983).
  11. J. A. G. Rhodin, Histology:?A Text and Atlas (Oxford University, New York, 1974).
  12. R. G. Kessel, Basic Medical Histology: The Biology of Cells, Tissues, and Organs (Oxford University, New York, 1998).
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    [CrossRef]
  14. S. Bosman, Appl. Opt. 32, 461 (1993).
    [CrossRef] [PubMed]
  15. R. C. Haskell, F. D. Carlson, and P. S. Blank, Bio-phys. J. 56, 401 (1989).

1999 (1)

V. Sankaran, D. J. Maitland, and J. T. Walsh, Proc. SPIE 3598, 158 (1999).
[CrossRef]

1997 (1)

1996 (2)

O. Emile, F. Bretenaker, and A. Le Floch, Opt. Lett. 21, 1706 (1996).
[CrossRef] [PubMed]

A. Dunn and R. Richards-Kortum, IEEE J. Sel. Top. Quantum Electron. 2, 898 (1996).
[CrossRef]

1994 (1)

D. Bicout, C. Brosseau, A. S. Martinez, and J. M. Schmitt, Phys. Rev. E 49, 1767 (1994).
[CrossRef]

1993 (1)

1992 (1)

1991 (1)

1989 (2)

F. C. MacKintosh, J. X. Zhu, D. J. Pine, and D. A. Weitz, Phys. Rev. B 40, 9342 (1989).
[CrossRef]

R. C. Haskell, F. D. Carlson, and P. S. Blank, Bio-phys. J. 56, 401 (1989).

1984 (1)

E. Collett, Opt. Commun. 52, 77 (1984).
[CrossRef]

Bicout, D.

D. Bicout, C. Brosseau, A. S. Martinez, and J. M. Schmitt, Phys. Rev. E 49, 1767 (1994).
[CrossRef]

Blank, P. S.

R. C. Haskell, F. D. Carlson, and P. S. Blank, Bio-phys. J. 56, 401 (1989).

Bohren, C. F.

C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983).

Bonner, R. F.

Bosman, S.

Bretenaker, F.

Brosseau, C.

D. Bicout, C. Brosseau, A. S. Martinez, and J. M. Schmitt, Phys. Rev. E 49, 1767 (1994).
[CrossRef]

Carlson, F. D.

R. C. Haskell, F. D. Carlson, and P. S. Blank, Bio-phys. J. 56, 401 (1989).

Cheong, W.-F.

W.-F. Cheong, in Optical-Thermal Response of Laser-Irradiated Tissue, A. J. Welch and M. J. C. van Gemert, eds. (Plenum, New York, 1985), pp. 275–303.

Collett, E.

E. Collett, Opt. Commun. 52, 77 (1984).
[CrossRef]

Dunn, A.

A. Dunn and R. Richards-Kortum, IEEE J. Sel. Top. Quantum Electron. 2, 898 (1996).
[CrossRef]

Emile, O.

Gandbakhche, A. H.

Haskell, R. C.

R. C. Haskell, F. D. Carlson, and P. S. Blank, Bio-phys. J. 56, 401 (1989).

Huffman, D. R.

C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983).

Kessel, R. G.

R. G. Kessel, Basic Medical Histology: The Biology of Cells, Tissues, and Organs (Oxford University, New York, 1998).

Khong, M. P.

Le Floch, A.

MacKintosh, F. C.

F. C. MacKintosh, J. X. Zhu, D. J. Pine, and D. A. Weitz, Phys. Rev. B 40, 9342 (1989).
[CrossRef]

Maitland, D. J.

V. Sankaran, D. J. Maitland, and J. T. Walsh, Proc. SPIE 3598, 158 (1999).
[CrossRef]

Martinez, A. S.

D. Bicout, C. Brosseau, A. S. Martinez, and J. M. Schmitt, Phys. Rev. E 49, 1767 (1994).
[CrossRef]

Moes, C. J. M.

Morgan, S. P.

Pine, D. J.

F. C. MacKintosh, J. X. Zhu, D. J. Pine, and D. A. Weitz, Phys. Rev. B 40, 9342 (1989).
[CrossRef]

Prahl, S. A.

Rhodin, J. A. G.

J. A. G. Rhodin, Histology:?A Text and Atlas (Oxford University, New York, 1974).

Richards-Kortum, R.

A. Dunn and R. Richards-Kortum, IEEE J. Sel. Top. Quantum Electron. 2, 898 (1996).
[CrossRef]

Sankaran, V.

V. Sankaran, D. J. Maitland, and J. T. Walsh, Proc. SPIE 3598, 158 (1999).
[CrossRef]

Schmitt, J. M.

D. Bicout, C. Brosseau, A. S. Martinez, and J. M. Schmitt, Phys. Rev. E 49, 1767 (1994).
[CrossRef]

J. M. Schmitt, A. H. Gandbakhche, and R. F. Bonner, Appl. Opt. 31, 6535 (1992).
[CrossRef] [PubMed]

Somekh, M. G.

van Gemert, M. J. C.

van Marle, J.

van Staveren, H. J.

Walsh, J. T.

V. Sankaran, D. J. Maitland, and J. T. Walsh, Proc. SPIE 3598, 158 (1999).
[CrossRef]

Weitz, D. A.

F. C. MacKintosh, J. X. Zhu, D. J. Pine, and D. A. Weitz, Phys. Rev. B 40, 9342 (1989).
[CrossRef]

Zhu, J. X.

F. C. MacKintosh, J. X. Zhu, D. J. Pine, and D. A. Weitz, Phys. Rev. B 40, 9342 (1989).
[CrossRef]

Appl. Opt. (4)

Bio-phys. J. (1)

R. C. Haskell, F. D. Carlson, and P. S. Blank, Bio-phys. J. 56, 401 (1989).

IEEE J. Sel. Top. Quantum Electron. (1)

A. Dunn and R. Richards-Kortum, IEEE J. Sel. Top. Quantum Electron. 2, 898 (1996).
[CrossRef]

Opt. Commun. (1)

E. Collett, Opt. Commun. 52, 77 (1984).
[CrossRef]

Opt. Lett. (1)

Phys. Rev. B (1)

F. C. MacKintosh, J. X. Zhu, D. J. Pine, and D. A. Weitz, Phys. Rev. B 40, 9342 (1989).
[CrossRef]

Phys. Rev. E (1)

D. Bicout, C. Brosseau, A. S. Martinez, and J. M. Schmitt, Phys. Rev. E 49, 1767 (1994).
[CrossRef]

Proc. SPIE (1)

V. Sankaran, D. J. Maitland, and J. T. Walsh, Proc. SPIE 3598, 158 (1999).
[CrossRef]

Other (4)

W.-F. Cheong, in Optical-Thermal Response of Laser-Irradiated Tissue, A. J. Welch and M. J. C. van Gemert, eds. (Plenum, New York, 1985), pp. 275–303.

C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983).

J. A. G. Rhodin, Histology:?A Text and Atlas (Oxford University, New York, 1974).

R. G. Kessel, Basic Medical Histology: The Biology of Cells, Tissues, and Organs (Oxford University, New York, 1998).

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Figures (2)

Fig. 1
Fig. 1

Degree of 1, linear and 2, circular polarization in (a) an Intralipid suspension, (b) a polystyrene microsphere suspension, (c) porcine adipose tissue, and (d) porcine myocardial tissue as a function of the reduced optical thickness of the sample, τ. Each point is an average of three measurements. The error bars represent the standard deviation; points with nonvisible error bars have errors that are smaller than the symbol. These results were taken from measurement of the Stokes vectors.

Fig. 2
Fig. 2

Same as Fig. 1 but obtained with the RA method.

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