Abstract

Near-infrared (NIR) optical image reconstruction that incorporates magnetic resonance image (MRI) structural data was tested in a series of simulated reconstructions. NIR diffuse tomography generally suffers from comparatively low spatial resolution. By using the fine structural detail that is available with MRI, combined with the functional information of NIR spectroscopy, it is possible to design a new image-reconstruction methodology that provides high-resolution images that are correlated with hemoglobin concentration and oxygen saturation. To test this concept a MRI spin-echo image of a rat cranium was used to obtain an outline of the bone, brain, and muscle tissues, and this information was incorporated into an iterative-based diffuse tomography reconstruction. These simulations represent what is believed to be the first attempt at evaluating a spatially constrained iterative-reconstruction MRI–NIR imaging modality for brain tissue.

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  1. B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).
  2. M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel, Cancer Res. 56, 4509 (1996).
  3. B. K. Siesjo, J. Neurosurg. 77, 169 (1992).
  4. M. Cope and D. T. Delpy, Med. Biol. Eng. Comp. 26, 289 (1988).
  5. B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).
  6. J. Chang, H. L. Graber, P. C. Koo, R. Aronson, S. S. Barbour, and R. L. Barbour, IEEE Trans. Med. Imag. 16, 68 (1997).
  7. J. F. Dunn, Y. Z. Wadghiri, B. Pogue, and I. Kida, “BOLD vs. NIR spectroscopy: will the best technique come forward?” Adv. Exp. Med. Biol. (to be published).
  8. G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).
  9. D. T. Delpy, M. Cope, P. Van der Zee, S. R. Arridge, S. Wray, and J. S. Wyatt, Phys. Med. Biol. 33, 1433 (1988).
  10. M. S. Patterson, B. Chance, and B. C. Wilson, Appl. Opt. 28, 2331 (1989).
  11. J. R. Singer, F. A. Grunbaum, P. D. Kohn, and J. P. Zubelli, Science 248, 990 (1990).
  12. S. R. Arridge, P. van der Zee, M. Cope, and D. T. Delpy, Proc. SPIE 1431, 204 (1991).
  13. K. D. Paulsen and H. Jiang, Med. Phys. 22, 691 (1995).
  14. K. D. Paulsen and H. Jiang, Appl. Opt. 35, 3447 (1996).
  15. H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, Appl. Opt. 36, 52 (1997).
  16. K. D. Paulsen, M. J. Moskowitz, and T. P. Ryan, Int. J. Hyperthermia 10, 209 (1994).
  17. S. R. Arridge and M. Schweiger, Proc. SPIE 2389, 378 (1995).

1997

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).

J. Chang, H. L. Graber, P. C. Koo, R. Aronson, S. S. Barbour, and R. L. Barbour, IEEE Trans. Med. Imag. 16, 68 (1997).

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, Appl. Opt. 36, 52 (1997).

1996

K. D. Paulsen and H. Jiang, Appl. Opt. 35, 3447 (1996).

M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel, Cancer Res. 56, 4509 (1996).

1995

K. D. Paulsen and H. Jiang, Med. Phys. 22, 691 (1995).

S. R. Arridge and M. Schweiger, Proc. SPIE 2389, 378 (1995).

1994

K. D. Paulsen, M. J. Moskowitz, and T. P. Ryan, Int. J. Hyperthermia 10, 209 (1994).

1992

B. K. Siesjo, J. Neurosurg. 77, 169 (1992).

1991

S. R. Arridge, P. van der Zee, M. Cope, and D. T. Delpy, Proc. SPIE 1431, 204 (1991).

1990

J. R. Singer, F. A. Grunbaum, P. D. Kohn, and J. P. Zubelli, Science 248, 990 (1990).

1989

1988

B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).

M. Cope and D. T. Delpy, Med. Biol. Eng. Comp. 26, 289 (1988).

D. T. Delpy, M. Cope, P. Van der Zee, S. R. Arridge, S. Wray, and J. S. Wyatt, Phys. Med. Biol. 33, 1433 (1988).

Alsop, D. C.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).

Aral, B.

M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel, Cancer Res. 56, 4509 (1996).

Aronson, R.

J. Chang, H. L. Graber, P. C. Koo, R. Aronson, S. S. Barbour, and R. L. Barbour, IEEE Trans. Med. Imag. 16, 68 (1997).

Arridge, S. R.

S. R. Arridge and M. Schweiger, Proc. SPIE 2389, 378 (1995).

S. R. Arridge, P. van der Zee, M. Cope, and D. T. Delpy, Proc. SPIE 1431, 204 (1991).

D. T. Delpy, M. Cope, P. Van der Zee, S. R. Arridge, S. Wray, and J. S. Wyatt, Phys. Med. Biol. 33, 1433 (1988).

Barbour, R. L.

J. Chang, H. L. Graber, P. C. Koo, R. Aronson, S. S. Barbour, and R. L. Barbour, IEEE Trans. Med. Imag. 16, 68 (1997).

Barbour, S. S.

J. Chang, H. L. Graber, P. C. Koo, R. Aronson, S. S. Barbour, and R. L. Barbour, IEEE Trans. Med. Imag. 16, 68 (1997).

Chance, B.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).

M. S. Patterson, B. Chance, and B. C. Wilson, Appl. Opt. 28, 2331 (1989).

B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).

Chang, J.

J. Chang, H. L. Graber, P. C. Koo, R. Aronson, S. S. Barbour, and R. L. Barbour, IEEE Trans. Med. Imag. 16, 68 (1997).

Cope, M.

S. R. Arridge, P. van der Zee, M. Cope, and D. T. Delpy, Proc. SPIE 1431, 204 (1991).

D. T. Delpy, M. Cope, P. Van der Zee, S. R. Arridge, S. Wray, and J. S. Wyatt, Phys. Med. Biol. 33, 1433 (1988).

M. Cope and D. T. Delpy, Med. Biol. Eng. Comp. 26, 289 (1988).

Corballis, P. M.

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Delpy, D. T.

S. R. Arridge, P. van der Zee, M. Cope, and D. T. Delpy, Proc. SPIE 1431, 204 (1991).

D. T. Delpy, M. Cope, P. Van der Zee, S. R. Arridge, S. Wray, and J. S. Wyatt, Phys. Med. Biol. 33, 1433 (1988).

M. Cope and D. T. Delpy, Med. Biol. Eng. Comp. 26, 289 (1988).

Detre, J. A.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).

Dunn, J. F.

J. F. Dunn, Y. Z. Wadghiri, B. Pogue, and I. Kida, “BOLD vs. NIR spectroscopy: will the best technique come forward?” Adv. Exp. Med. Biol. (to be published).

Fabiani, M.

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Fountain, M.

B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).

Friedman, D.

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Goodman-Wood, M. R.

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Graber, H. L.

J. Chang, H. L. Graber, P. C. Koo, R. Aronson, S. S. Barbour, and R. L. Barbour, IEEE Trans. Med. Imag. 16, 68 (1997).

Gratton, E.

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Gratton, G.

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Greenfield, R.

B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).

Grunbaum, F. A.

J. R. Singer, F. A. Grunbaum, P. D. Kohn, and J. P. Zubelli, Science 248, 990 (1990).

Hirsch, J.

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Hockel, M.

M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel, Cancer Res. 56, 4509 (1996).

Holtom, G.

B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).

Hood, D. C.

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Jiang, H.

Kent, J.

B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).

Kida, I.

J. F. Dunn, Y. Z. Wadghiri, B. Pogue, and I. Kida, “BOLD vs. NIR spectroscopy: will the best technique come forward?” Adv. Exp. Med. Biol. (to be published).

Kim, K.

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Kohn, P. D.

J. R. Singer, F. A. Grunbaum, P. D. Kohn, and J. P. Zubelli, Science 248, 990 (1990).

Koo, P. C.

J. Chang, H. L. Graber, P. C. Koo, R. Aronson, S. S. Barbour, and R. L. Barbour, IEEE Trans. Med. Imag. 16, 68 (1997).

Luo, Q.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).

McCully, K.

B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).

Mitze, M.

M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel, Cancer Res. 56, 4509 (1996).

Moskowitz, M. J.

K. D. Paulsen, M. J. Moskowitz, and T. P. Ryan, Int. J. Hyperthermia 10, 209 (1994).

Nioka, S.

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).

B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).

Osterberg, U. L.

Patterson, M. S.

Paulsen, K. D.

H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, Appl. Opt. 36, 52 (1997).

K. D. Paulsen and H. Jiang, Appl. Opt. 35, 3447 (1996).

K. D. Paulsen and H. Jiang, Med. Phys. 22, 691 (1995).

K. D. Paulsen, M. J. Moskowitz, and T. P. Ryan, Int. J. Hyperthermia 10, 209 (1994).

Pogue, B.

J. F. Dunn, Y. Z. Wadghiri, B. Pogue, and I. Kida, “BOLD vs. NIR spectroscopy: will the best technique come forward?” Adv. Exp. Med. Biol. (to be published).

Ryan, T. P.

K. D. Paulsen, M. J. Moskowitz, and T. P. Ryan, Int. J. Hyperthermia 10, 209 (1994).

Schaffer, U.

M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel, Cancer Res. 56, 4509 (1996).

Schlenger, K.

M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel, Cancer Res. 56, 4509 (1996).

Schweiger, M.

S. R. Arridge and M. Schweiger, Proc. SPIE 2389, 378 (1995).

Siesjo, B. K.

B. K. Siesjo, J. Neurosurg. 77, 169 (1992).

Singer, J. R.

J. R. Singer, F. A. Grunbaum, P. D. Kohn, and J. P. Zubelli, Science 248, 990 (1990).

van der Zee, P.

S. R. Arridge, P. van der Zee, M. Cope, and D. T. Delpy, Proc. SPIE 1431, 204 (1991).

D. T. Delpy, M. Cope, P. Van der Zee, S. R. Arridge, S. Wray, and J. S. Wyatt, Phys. Med. Biol. 33, 1433 (1988).

Vaupel, P.

M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel, Cancer Res. 56, 4509 (1996).

Wadghiri, Y. Z.

J. F. Dunn, Y. Z. Wadghiri, B. Pogue, and I. Kida, “BOLD vs. NIR spectroscopy: will the best technique come forward?” Adv. Exp. Med. Biol. (to be published).

Wilson, B. C.

Wray, S.

D. T. Delpy, M. Cope, P. Van der Zee, S. R. Arridge, S. Wray, and J. S. Wyatt, Phys. Med. Biol. 33, 1433 (1988).

Wyatt, J. S.

D. T. Delpy, M. Cope, P. Van der Zee, S. R. Arridge, S. Wray, and J. S. Wyatt, Phys. Med. Biol. 33, 1433 (1988).

Zubelli, J. P.

J. R. Singer, F. A. Grunbaum, P. D. Kohn, and J. P. Zubelli, Science 248, 990 (1990).

Adv. Exp. Med. Biol.

J. F. Dunn, Y. Z. Wadghiri, B. Pogue, and I. Kida, “BOLD vs. NIR spectroscopy: will the best technique come forward?” Adv. Exp. Med. Biol. (to be published).

Anal. Biochem.

B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfield, and G. Holtom, Anal. Biochem. 174, 698 (1988).

Appl. Opt.

Cancer Res.

M. Hockel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer, and P. Vaupel, Cancer Res. 56, 4509 (1996).

IEEE Trans. Med. Imag.

J. Chang, H. L. Graber, P. C. Koo, R. Aronson, S. S. Barbour, and R. L. Barbour, IEEE Trans. Med. Imag. 16, 68 (1997).

Int. J. Hyperthermia

K. D. Paulsen, M. J. Moskowitz, and T. P. Ryan, Int. J. Hyperthermia 10, 209 (1994).

J. Neurosurg.

B. K. Siesjo, J. Neurosurg. 77, 169 (1992).

Med. Biol. Eng. Comp.

M. Cope and D. T. Delpy, Med. Biol. Eng. Comp. 26, 289 (1988).

Med. Phys.

K. D. Paulsen and H. Jiang, Med. Phys. 22, 691 (1995).

Neuroimage

G. Gratton, M. Fabiani, P. M. Corballis, D. C. Hood, M. R. Goodman-Wood, J. Hirsch, K. Kim, D. Friedman, and E. Gratton, Neuroimage 6, 168 (1997).

Philos. Trans. R. Soc. London Ser. B

B. Chance, Q. Luo, S. Nioka, D. C. Alsop, and J. A. Detre, Philos. Trans. R. Soc. London Ser. B 352, 707 (1997).

Phys. Med. Biol.

D. T. Delpy, M. Cope, P. Van der Zee, S. R. Arridge, S. Wray, and J. S. Wyatt, Phys. Med. Biol. 33, 1433 (1988).

Proc. SPIE

S. R. Arridge and M. Schweiger, Proc. SPIE 2389, 378 (1995).

S. R. Arridge, P. van der Zee, M. Cope, and D. T. Delpy, Proc. SPIE 1431, 204 (1991).

Science

J. R. Singer, F. A. Grunbaum, P. D. Kohn, and J. P. Zubelli, Science 248, 990 (1990).

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