Rapid acquisition of in vivo biological images by use of optical coherence tomography

Abstract

The development of techniques for high-speed image acquisition in optical coherence tomography (OCT) systems is essential for suppressing motion artifacts when one is imaging living systems. We describe a new OCT system for performing micrometer-scale, cross-sectional optical imaging at four images/s. To achieve OCT image-acquisition times of less than 1 s, we use a piezoelectric fiber stretcher to vary the reference arm delay. A Kerr-lens mode-locked chromium-doped forsterite laser is employed as the low-coherence source for the highspeed OCT system. Dynamic, motion-artifact-free in vivo imaging of a beating Xenopus laevis (African frog) heart is demonstrated.

© 1996 Optical Society of America

High resolution imaging of in vivo cardiac dynamics using color Doppler optical coherence tomography

Siavash Yazdanfar, Manish D. Kulkarni, and Joseph A. Izatt
Opt. Express 1(13) 424-431 (1997)

In vivo video rate optical coherence tomography

Andrew M. Rollins, Manish D. Kulkarni, Siavash Yazdanfar, Rujchai Ung-arunyawee, and Joseph A. Izatt
Opt. Express 3(6) 219-229 (1998)

Magnetomotive contrast for in vivo optical coherence tomography

Amy L. Oldenburg, Farah Jean-Jacques Toublan, Kenneth S. Suslick, Alexander Wei, and Stephen A. Boppart
Opt. Express 13(17) 6597-6614 (2005)

In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography

Joseph A. Izatt, Manish D. Kulkarni, Siavash Yazdanfar, Jennifer K. Barton, and Ashley J. Welch
Opt. Lett. 22(18) 1439-1441 (1997)

Doppler optical cardiogram gated 2D color flow imaging at 1000 fps and 4D in vivo visualization of embryonic heart at 45 fps on a swept source OCT system

Adrian Mariampillai, Beau A. Standish, Nigel R. Munce, Cristina Randall, George Liu, James Y. Jiang, Alex E. Cable, I. Alex Vitkin, and Victor X.D. Yang
Opt. Express 15(4) 1627-1638 (2007)