Abstract

A novel technique for the noninvasive measurement of tissue optical properties simultaneously at all visible and near-infrared wavelengths is presented. The technique is based on the time-resolved detection of multicolor diffusely scattered light. Short pulses of white light are produced by using self-phase modulation by focusing the light from a short-pulsed high-power laser into a cuvette filled with water. After spectral dispersion in a polychromator and temporal dispersion in a streak tube, a two-dimensional CCD camera was used as a detector, with one dimension used for time resolution and the other one for wavelength separation.

© 1993 Optical Society of America

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References

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  1. P. Å. Öberg, Crit. Rev. Biomed. Eng. 18, 125 (1990).
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  2. B. Chance, Proc. Natl. Acad. Sci. USA 85, 4971 (1988).
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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  15. S. Svanberg, J. Larsson, A. Persson, C.-G. Wahlström, “Lund high power laser facility—systems and first results,”Phys. Scr. (to be published).

1993 (2)

1992 (3)

T. B. Norris, Opt. Lett. 17, 1009 (1992).
[CrossRef] [PubMed]

S. Andersson-Engels, B. C. Wilson, J. Cell. Pharmacol. 3, 48 (1992).

S. Andersson-Engels, R. Berg, S. Svanberg, J. Photochem. Photobiol. B16, 155 (1992).

1990 (2)

P. Å. Öberg, Crit. Rev. Biomed. Eng. 18, 125 (1990).
[PubMed]

B. C. Wilson, T. J. Farrell, M. S. Patterson, SPIE Inst. Ser. IS-6, 219 (1990).

1989 (3)

1988 (1)

B. Chance, Proc. Natl. Acad. Sci. USA 85, 4971 (1988).
[CrossRef] [PubMed]

1986 (1)

B. C. Wilson, M. S. Patterson, Phys. Med. Biol. 31, 327 (1986).
[CrossRef] [PubMed]

1983 (1)

Andersson-Engels, S.

S. Andersson-Engels, R. Berg, S. Svanberg, J. Photochem. Photobiol. B16, 155 (1992).

S. Andersson-Engels, B. C. Wilson, J. Cell. Pharmacol. 3, 48 (1992).

Andreola, S.

Beek, J. F.

Berg, R.

R. Berg, O. Jarlman, S. Svanberg, Appl. Opt. 32, 574 (1993).
[CrossRef] [PubMed]

S. Andersson-Engels, R. Berg, S. Svanberg, J. Photochem. Photobiol. B16, 155 (1992).

Bertoni, A.

Boyd, R. W.

R. W. Boyd, in Nonlinear Optics (Academic, San Diego, Calif., 1992), Chap. 6.

Chance, B.

Farrell, T. J.

B. C. Wilson, T. J. Farrell, M. S. Patterson, SPIE Inst. Ser. IS-6, 219 (1990).

Flock, S. T.

S. T. Flock, B. C. Wilson, M. S. Patterson, IEEE Trans. Biomed. Eng. 36, 1169 (1989).
[CrossRef] [PubMed]

Fork, R. L.

Hirlimann, C.

Jarlman, O.

Larsson, J.

S. Svanberg, J. Larsson, A. Persson, C.-G. Wahlström, “Lund high power laser facility—systems and first results,”Phys. Scr. (to be published).

Marchesini, R.

Melloni, E.

Norris, T. B.

Öberg, P. Å.

P. Å. Öberg, Crit. Rev. Biomed. Eng. 18, 125 (1990).
[PubMed]

Patterson, M. S.

B. C. Wilson, T. J. Farrell, M. S. Patterson, SPIE Inst. Ser. IS-6, 219 (1990).

S. T. Flock, B. C. Wilson, M. S. Patterson, IEEE Trans. Biomed. Eng. 36, 1169 (1989).
[CrossRef] [PubMed]

M. S. Patterson, B. Chance, B. C. Wilson, Appl. Opt. 28, 2331 (1989).
[CrossRef] [PubMed]

B. C. Wilson, M. S. Patterson, Phys. Med. Biol. 31, 327 (1986).
[CrossRef] [PubMed]

Persson, A.

S. Svanberg, J. Larsson, A. Persson, C.-G. Wahlström, “Lund high power laser facility—systems and first results,”Phys. Scr. (to be published).

Pickering, J. W.

Prahl, S. A.

Shank, C. V.

Sichirollo, E.

Sterenborg, H. J. C. M.

Svanberg, S.

R. Berg, O. Jarlman, S. Svanberg, Appl. Opt. 32, 574 (1993).
[CrossRef] [PubMed]

S. Andersson-Engels, R. Berg, S. Svanberg, J. Photochem. Photobiol. B16, 155 (1992).

S. Svanberg, J. Larsson, A. Persson, C.-G. Wahlström, “Lund high power laser facility—systems and first results,”Phys. Scr. (to be published).

Tomlinson, W. J.

van Gemert, M. J. C.

van Wieringen, N.

Wahlström, C.-G.

S. Svanberg, J. Larsson, A. Persson, C.-G. Wahlström, “Lund high power laser facility—systems and first results,”Phys. Scr. (to be published).

Wilson, B. C.

S. Andersson-Engels, B. C. Wilson, J. Cell. Pharmacol. 3, 48 (1992).

B. C. Wilson, T. J. Farrell, M. S. Patterson, SPIE Inst. Ser. IS-6, 219 (1990).

S. T. Flock, B. C. Wilson, M. S. Patterson, IEEE Trans. Biomed. Eng. 36, 1169 (1989).
[CrossRef] [PubMed]

M. S. Patterson, B. Chance, B. C. Wilson, Appl. Opt. 28, 2331 (1989).
[CrossRef] [PubMed]

B. C. Wilson, M. S. Patterson, Phys. Med. Biol. 31, 327 (1986).
[CrossRef] [PubMed]

Yen, R.

Appl. Opt. (4)

Crit. Rev. Biomed. Eng. (1)

P. Å. Öberg, Crit. Rev. Biomed. Eng. 18, 125 (1990).
[PubMed]

IEEE Trans. Biomed. Eng. (1)

S. T. Flock, B. C. Wilson, M. S. Patterson, IEEE Trans. Biomed. Eng. 36, 1169 (1989).
[CrossRef] [PubMed]

J. Cell. Pharmacol. (1)

S. Andersson-Engels, B. C. Wilson, J. Cell. Pharmacol. 3, 48 (1992).

J. Photochem. Photobiol. (1)

S. Andersson-Engels, R. Berg, S. Svanberg, J. Photochem. Photobiol. B16, 155 (1992).

Opt. Lett. (2)

Phys. Med. Biol. (1)

B. C. Wilson, M. S. Patterson, Phys. Med. Biol. 31, 327 (1986).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. USA (1)

B. Chance, Proc. Natl. Acad. Sci. USA 85, 4971 (1988).
[CrossRef] [PubMed]

SPIE Inst. Ser. (1)

B. C. Wilson, T. J. Farrell, M. S. Patterson, SPIE Inst. Ser. IS-6, 219 (1990).

Other (2)

R. W. Boyd, in Nonlinear Optics (Academic, San Diego, Calif., 1992), Chap. 6.

S. Svanberg, J. Larsson, A. Persson, C.-G. Wahlström, “Lund high power laser facility—systems and first results,”Phys. Scr. (to be published).

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Figures (3)

Fig. 1
Fig. 1

Experimental setup for multispectral measurements of tissue optical properties.

Fig. 2
Fig. 2

Recording image through 14 mm of porcine muscle in vitro.

Fig. 3
Fig. 3

Image obtained by recording diffuse light transmitted through a 12-mm-thick finger in vivo. The time-dispersion curves at two selected wavelengths are shown (solid curves) with the apparatus function at that wavelength (dashed curves). The final slopes of the curves obtained at different wavelengths are also shown (lower-left plot).

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