Abstract

Optical low-coherence reflectometry is applied for the first time to our knowledge to investigate diffusive biological tissues with a single-mode fiber probe. Samples of fresh arteries are studied, using the backscattered light from the tissue. The probed volume in the vicinity of the fiber tip is estimated to be below 6.7 × 10−10 cm3. This noninvasive method allows one to determine optical parameters, such as the index of refraction and the transmission properties, and the tissue thickness.

© 1992 Optical Society of America

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References

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    [CrossRef]

1989

H. H. Gilgen, R. P. Novàk, R. P. Salathé, W. Hodel, P. Beaud, IEEE J. Lightwave Technol. 7, 1225 (1989).
[CrossRef]

F. P. Bolin, L. E. Preuss, R. C. Taylor, R. J. Ference, Appl. Opt. 28, 2297 (1989).
[CrossRef] [PubMed]

1988

A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, R. Paoletti, Atherosclerosis 70, 253 (1988).
[CrossRef] [PubMed]

A. F. Fercher, K. Mengedoht, W. Werner, Opt. Lett. 13, 186 (1988).
[CrossRef] [PubMed]

1987

1973

Beaud, P.

H. H. Gilgen, R. P. Novàk, R. P. Salathé, W. Hodel, P. Beaud, IEEE J. Lightwave Technol. 7, 1225 (1989).
[CrossRef]

R. P. Novàk, H. H. Gilgen, P. Beaud, W. Hodel, in Digest of Symposium on Optical Fiber Measurements (National Institute of Standards and Technology, Boulder, Colo., 1990), p. 35.

Bolin, F. P.

Carro, C. G.

C. G. Carro, T. J. Pedley, R. C. Schroter, W. A. Seed, The Mechanics of the Circulation (Oxford U. Press, London, 1978), p. 91.

Chida, K.

Colombo, A.

A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, R. Paoletti, Atherosclerosis 70, 253 (1988).
[CrossRef] [PubMed]

Danielson, B. L.

Fercher, A. F.

Ference, R. J.

Fujimoto, J. G.

E. Swanson, D. Huang, J. G. Fujimoto, C. P. Lin, C. A. Puliafito, in Digest of Conference on Lasers and Electro-Optics (Optical Society of America, Washington, D.C., 1991), p. 150.

Gilgen, H. H.

H. H. Gilgen, R. P. Novàk, R. P. Salathé, W. Hodel, P. Beaud, IEEE J. Lightwave Technol. 7, 1225 (1989).
[CrossRef]

R. P. Novàk, H. H. Gilgen, P. Beaud, W. Hodel, in Digest of Symposium on Optical Fiber Measurements (National Institute of Standards and Technology, Boulder, Colo., 1990), p. 35.

Hale, G. M.

Hodel, W.

H. H. Gilgen, R. P. Novàk, R. P. Salathé, W. Hodel, P. Beaud, IEEE J. Lightwave Technol. 7, 1225 (1989).
[CrossRef]

R. P. Novàk, H. H. Gilgen, P. Beaud, W. Hodel, in Digest of Symposium on Optical Fiber Measurements (National Institute of Standards and Technology, Boulder, Colo., 1990), p. 35.

Huang, D.

E. Swanson, D. Huang, J. G. Fujimoto, C. P. Lin, C. A. Puliafito, in Digest of Conference on Lasers and Electro-Optics (Optical Society of America, Washington, D.C., 1991), p. 150.

Lin, C. P.

E. Swanson, D. Huang, J. G. Fujimoto, C. P. Lin, C. A. Puliafito, in Digest of Conference on Lasers and Electro-Optics (Optical Society of America, Washington, D.C., 1991), p. 150.

Mengedoht, K.

Noda, J.

Novàk, R. P.

H. H. Gilgen, R. P. Novàk, R. P. Salathé, W. Hodel, P. Beaud, IEEE J. Lightwave Technol. 7, 1225 (1989).
[CrossRef]

R. P. Novàk, H. H. Gilgen, P. Beaud, W. Hodel, in Digest of Symposium on Optical Fiber Measurements (National Institute of Standards and Technology, Boulder, Colo., 1990), p. 35.

Paoletti, R.

A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, R. Paoletti, Atherosclerosis 70, 253 (1988).
[CrossRef] [PubMed]

Pedley, T. J.

C. G. Carro, T. J. Pedley, R. C. Schroter, W. A. Seed, The Mechanics of the Circulation (Oxford U. Press, London, 1978), p. 91.

Pignoli, P.

A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, R. Paoletti, Atherosclerosis 70, 253 (1988).
[CrossRef] [PubMed]

Poli, A.

A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, R. Paoletti, Atherosclerosis 70, 253 (1988).
[CrossRef] [PubMed]

Preuss, L. E.

Puliafito, C. A.

E. Swanson, D. Huang, J. G. Fujimoto, C. P. Lin, C. A. Puliafito, in Digest of Conference on Lasers and Electro-Optics (Optical Society of America, Washington, D.C., 1991), p. 150.

Querry, M. R.

Salathé, R. P.

H. H. Gilgen, R. P. Novàk, R. P. Salathé, W. Hodel, P. Beaud, IEEE J. Lightwave Technol. 7, 1225 (1989).
[CrossRef]

Schroter, R. C.

C. G. Carro, T. J. Pedley, R. C. Schroter, W. A. Seed, The Mechanics of the Circulation (Oxford U. Press, London, 1978), p. 91.

Seed, W. A.

C. G. Carro, T. J. Pedley, R. C. Schroter, W. A. Seed, The Mechanics of the Circulation (Oxford U. Press, London, 1978), p. 91.

Sirtori, M.

A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, R. Paoletti, Atherosclerosis 70, 253 (1988).
[CrossRef] [PubMed]

Swanson, E.

E. Swanson, D. Huang, J. G. Fujimoto, C. P. Lin, C. A. Puliafito, in Digest of Conference on Lasers and Electro-Optics (Optical Society of America, Washington, D.C., 1991), p. 150.

Takada, K.

Taylor, R. C.

Tremoli, E.

A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, R. Paoletti, Atherosclerosis 70, 253 (1988).
[CrossRef] [PubMed]

Werner, W.

Whittenberg, C. D.

Yokohama, I.

Appl. Opt.

Atherosclerosis

A. Poli, E. Tremoli, A. Colombo, M. Sirtori, P. Pignoli, R. Paoletti, Atherosclerosis 70, 253 (1988).
[CrossRef] [PubMed]

IEEE J. Lightwave Technol.

H. H. Gilgen, R. P. Novàk, R. P. Salathé, W. Hodel, P. Beaud, IEEE J. Lightwave Technol. 7, 1225 (1989).
[CrossRef]

Opt. Lett.

Other

E. Swanson, D. Huang, J. G. Fujimoto, C. P. Lin, C. A. Puliafito, in Digest of Conference on Lasers and Electro-Optics (Optical Society of America, Washington, D.C., 1991), p. 150.

R. P. Novàk, H. H. Gilgen, P. Beaud, W. Hodel, in Digest of Symposium on Optical Fiber Measurements (National Institute of Standards and Technology, Boulder, Colo., 1990), p. 35.

C. G. Carro, T. J. Pedley, R. C. Schroter, W. A. Seed, The Mechanics of the Circulation (Oxford U. Press, London, 1978), p. 91.

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Figures (3)

Fig. 1
Fig. 1

Schematic of the experimental setup for OLCR measurements.

Fig. 2
Fig. 2

Reflection signal as a function of the optical depth for three different interfaces: fiber–air, fiber–pure water, and fiber–arterial wall

Fig. 3
Fig. 3

Reflection signal as a function of the optical depth in a logarithmic representation. Dotted curve, reference curve from the bare fiber in air (normalized); solid curve, arterial wall in contact with the fiber end.

Equations (2)

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P i ( τ ) = 2 P o k ( 1 k ) β i A i R i | γ 12 ( τ τ i ) | cos θ i , θ i = 2 π ν ( τ τ i ) + ξ .
I water I air = n water n fiber n water + n fiber n air + n fiber n air n fiber

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