Abstract

Advances in human brain imaging technologies are critical to understanding how the brain works and the diagnosis of brain disorders. Existing technologies have different drawbacks, and the human skull poses a great challenge for pure optical and ultrasound imaging technologies. Here we demonstrate the feasibility of using ultrasound-modulated optical tomography, a hybrid technology that combines both light and sound, to image through human skulls. Single-shot off-axis holography was used to measure the field of the ultrasonically tagged light. This Letter paves the way for imaging the brain noninvasively through the skull, with optical contrast and a higher spatial resolution than that of diffuse optical tomography.

© 2020 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Imaging optically scattering objects with ultrasound-modulated optical tomography

Sri-Rajasekhar Kothapalli, Sava Sakadzic, Chulhong Kim, and Lihong V. Wang
Opt. Lett. 32(16) 2351-2353 (2007)

Ultrasound-modulated optical tomography in scattering media: flux filtering based on persistent spectral hole burning in the optical diagnosis window

Caroline Venet, Maïmouna Bocoum, Jean-Baptiste Laudereau, Thierry Chaneliere, François Ramaz, and Anne Louchet-Chauvet
Opt. Lett. 43(16) 3993-3996 (2018)

High-sensitivity ultrasound-modulated optical tomography with a photorefractive polymer

Yuta Suzuki, Puxiang Lai, Xiao Xu, and Lihong Wang
Opt. Lett. 38(6) 899-901 (2013)

References

  • View by:
  • |
  • |
  • |

  1. V. Ntziachristos, Nat. Meth. 7, 603 (2010).
    [Crossref]
  2. Y. Liu, C. Zhang, and L. V. Wang, J. Biomed. Opt. 17, 126014 (2012).
    [Crossref]
  3. L. V. Wang and S. Hu, Science 335, 1458 (2012).
    [Crossref]
  4. D. S. Elson, R. Li, C. Dunsby, R. Eckersley, and M.-X. Tang, Interface Focus 1, 632 (2011).
    [Crossref]
  5. S. G. Resink, A. C. Boccara, and W. Steenbergen, J. Biomed. Opt. 17, 040901 (2012).
    [Crossref]
  6. J. Gunther and S. Andersson-Engels, Front. Optoelectron. 10, 211 (2017).
    [Crossref]
  7. C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
    [Crossref]
  8. L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 110506 (2012).
    [Crossref]
  9. Y. Huang, M. Cua, J. Brake, Y. Liu, and C. Yang, J. Biomed. Opt. 25, 025002 (2020).
    [Crossref]
  10. L. Wang and X. Zhao, Appl. Opt. 36, 7277 (1997).
    [Crossref]
  11. F. Ramaz, B. Forget, M. Atlan, A. C. Boccara, M. Gross, P. Delaye, and G. Roosen, Opt. Express 12, 5469 (2004).
    [Crossref]
  12. M. Atlan, B. C. Forget, F. Ramaz, A. C. Boccara, and M. Gross, Opt. Lett. 30, 1360 (2005).
    [Crossref]
  13. S. Farahi, G. Montemezzani, A. A. Grabar, J.-P. Huignard, and F. Ramaz, Opt. Lett. 35, 1798 (2010).
    [Crossref]
  14. H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
    [Crossref]
  15. P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
    [Crossref]
  16. S. G. Resink, E. Hondebrink, and W. Steenbergen, Opt. Express 22, 3564 (2014).
    [Crossref]
  17. S.-R. Kothapalli, S. Sakadzic, C. Kim, and L. V. Wang, Opt. Lett. 32, 2351 (2007).
    [Crossref]
  18. A. Walther, L. Rippe, L. V. Wang, S. Andersson-Engels, and S. Kröll, Biomed. Opt. Express 8, 4523 (2017).
    [Crossref]
  19. E. Cuche, P. Marquet, and C. Depeursinge, Appl. Opt. 39, 4070 (2000).
    [Crossref]
  20. T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, Rep. Prog. Phys. 73, 076701 (2010).
    [Crossref]
  21. M. M. Qureshi, J. Brake, H.-J. Jeon, H. Ruan, Y. Liu, A. M. Safi, T. J. Eom, C. Yang, and E. Chung, Biomed. Opt. Express 8, 4855 (2017).
    [Crossref]
  22. Y. Liu, P. Lai, C. Ma, X. Xu, A. A. Grabar, and L. V. Wang, Nat. Commun. 6, 5904 (2015).
    [Crossref]
  23. S. Lévêque, A. C. Boccara, M. Lebec, and H. Saint-Jalmes, Opt. Lett. 24, 181 (1999).
    [Crossref]
  24. J. Li, G. Ku, and L. V. Wang, Appl. Opt. 41, 6030 (2002).
    [Crossref]
  25. Y. Liu, Y. Shen, C. Ma, J. Shi, and L. V. Wang, Appl. Phys. Lett. 108, 231106 (2016).
    [Crossref]
  26. K. Barjean, K. Contreras, J.-B. Laudereau, É. Tinet, D. Ettori, F. Ramaz, and J.-M. Tualle, Opt. Lett. 40, 705 (2015).
    [Crossref]
  27. S. P. Morgan, C. Li, B. R. Hayes-Gill, N. B. E. Sawyer, and C. Kongsavatsak, Proc. SPIE 6086, 608615 (2006).
    [Crossref]
  28. Y. Liu, C. Ma, Y. Shen, and L. V. Wang, Opt. Lett. 41, 1321 (2016).
    [Crossref]
  29. M. Gross, P. Goy, and M. Al-Koussa, Opt. Lett. 28, 2482 (2003).
    [Crossref]
  30. K. Hynynen and F. A. Jolesz, Ultrasound Med. Biol. 24, 275 (1998).
    [Crossref]
  31. H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
    [Crossref]
  32. J.-F. Aubry, M. Tanter, M. Pernot, J.-L. Thomas, and M. Fink, J. Acoust. Soc. Am. 113, 84 (2003).
    [Crossref]
  33. D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
    [Crossref]
  34. C. Ma, F. Zhou, Y. Liu, and L. V. Wang, Optica 2, 869 (2015).
    [Crossref]

2020 (1)

Y. Huang, M. Cua, J. Brake, Y. Liu, and C. Yang, J. Biomed. Opt. 25, 025002 (2020).
[Crossref]

2017 (4)

J. Gunther and S. Andersson-Engels, Front. Optoelectron. 10, 211 (2017).
[Crossref]

A. Walther, L. Rippe, L. V. Wang, S. Andersson-Engels, and S. Kröll, Biomed. Opt. Express 8, 4523 (2017).
[Crossref]

M. M. Qureshi, J. Brake, H.-J. Jeon, H. Ruan, Y. Liu, A. M. Safi, T. J. Eom, C. Yang, and E. Chung, Biomed. Opt. Express 8, 4855 (2017).
[Crossref]

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

2016 (2)

Y. Liu, Y. Shen, C. Ma, J. Shi, and L. V. Wang, Appl. Phys. Lett. 108, 231106 (2016).
[Crossref]

Y. Liu, C. Ma, Y. Shen, and L. V. Wang, Opt. Lett. 41, 1321 (2016).
[Crossref]

2015 (3)

2014 (1)

2013 (1)

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

2012 (7)

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[Crossref]

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[Crossref]

C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
[Crossref]

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 110506 (2012).
[Crossref]

Y. Liu, C. Zhang, and L. V. Wang, J. Biomed. Opt. 17, 126014 (2012).
[Crossref]

L. V. Wang and S. Hu, Science 335, 1458 (2012).
[Crossref]

S. G. Resink, A. C. Boccara, and W. Steenbergen, J. Biomed. Opt. 17, 040901 (2012).
[Crossref]

2011 (1)

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, and M.-X. Tang, Interface Focus 1, 632 (2011).
[Crossref]

2010 (3)

V. Ntziachristos, Nat. Meth. 7, 603 (2010).
[Crossref]

S. Farahi, G. Montemezzani, A. A. Grabar, J.-P. Huignard, and F. Ramaz, Opt. Lett. 35, 1798 (2010).
[Crossref]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, Rep. Prog. Phys. 73, 076701 (2010).
[Crossref]

2007 (1)

2006 (1)

S. P. Morgan, C. Li, B. R. Hayes-Gill, N. B. E. Sawyer, and C. Kongsavatsak, Proc. SPIE 6086, 608615 (2006).
[Crossref]

2005 (1)

2004 (1)

2003 (2)

M. Gross, P. Goy, and M. Al-Koussa, Opt. Lett. 28, 2482 (2003).
[Crossref]

J.-F. Aubry, M. Tanter, M. Pernot, J.-L. Thomas, and M. Fink, J. Acoust. Soc. Am. 113, 84 (2003).
[Crossref]

2002 (1)

2000 (1)

1999 (1)

1998 (1)

K. Hynynen and F. A. Jolesz, Ultrasound Med. Biol. 24, 275 (1998).
[Crossref]

1997 (1)

Al-Koussa, M.

Anastasio, M.

C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
[Crossref]

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 110506 (2012).
[Crossref]

Andersson-Engels, S.

Atlan, M.

Aubry, J.-F.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

J.-F. Aubry, M. Tanter, M. Pernot, J.-L. Thomas, and M. Fink, J. Acoust. Soc. Am. 113, 84 (2003).
[Crossref]

Baker, W. B.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, Rep. Prog. Phys. 73, 076701 (2010).
[Crossref]

Barjean, K.

Boccara, A. C.

Boch, A.-L.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

Brake, J.

Y. Huang, M. Cua, J. Brake, Y. Liu, and C. Yang, J. Biomed. Opt. 25, 025002 (2020).
[Crossref]

M. M. Qureshi, J. Brake, H.-J. Jeon, H. Ruan, Y. Liu, A. M. Safi, T. J. Eom, C. Yang, and E. Chung, Biomed. Opt. Express 8, 4855 (2017).
[Crossref]

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

Cai, X.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 110506 (2012).
[Crossref]

Chauvet, D.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

Choe, R.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, Rep. Prog. Phys. 73, 076701 (2010).
[Crossref]

Chung, E.

Contreras, K.

Cua, M.

Y. Huang, M. Cua, J. Brake, Y. Liu, and C. Yang, J. Biomed. Opt. 25, 025002 (2020).
[Crossref]

Cuche, E.

Darrasse, L.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

Delaye, P.

Depeursinge, C.

Dunsby, C.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, and M.-X. Tang, Interface Focus 1, 632 (2011).
[Crossref]

Durduran, T.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, Rep. Prog. Phys. 73, 076701 (2010).
[Crossref]

Eckersley, R.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, and M.-X. Tang, Interface Focus 1, 632 (2011).
[Crossref]

Elson, D. S.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, and M.-X. Tang, Interface Focus 1, 632 (2011).
[Crossref]

Eom, T. J.

Ettori, D.

Farahi, S.

Fink, M.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

J.-F. Aubry, M. Tanter, M. Pernot, J.-L. Thomas, and M. Fink, J. Acoust. Soc. Am. 113, 84 (2003).
[Crossref]

Forget, B.

Forget, B. C.

Garcia-Uribe, A.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 110506 (2012).
[Crossref]

Goy, P.

Grabar, A. A.

Y. Liu, P. Lai, C. Ma, X. Xu, A. A. Grabar, and L. V. Wang, Nat. Commun. 6, 5904 (2015).
[Crossref]

S. Farahi, G. Montemezzani, A. A. Grabar, J.-P. Huignard, and F. Ramaz, Opt. Lett. 35, 1798 (2010).
[Crossref]

Gradinaru, V.

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

Gross, M.

Guillevin, R.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

Gunther, J.

J. Gunther and S. Andersson-Engels, Front. Optoelectron. 10, 211 (2017).
[Crossref]

Guo, Z.

C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
[Crossref]

Hayes-Gill, B. R.

S. P. Morgan, C. Li, B. R. Hayes-Gill, N. B. E. Sawyer, and C. Kongsavatsak, Proc. SPIE 6086, 608615 (2006).
[Crossref]

Hemmer, P. R.

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[Crossref]

Hondebrink, E.

Hu, S.

L. V. Wang and S. Hu, Science 335, 1458 (2012).
[Crossref]

Huang, C.

C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
[Crossref]

Huang, Y.

Y. Huang, M. Cua, J. Brake, Y. Liu, and C. Yang, J. Biomed. Opt. 25, 025002 (2020).
[Crossref]

Huignard, J.-P.

Hynynen, K.

K. Hynynen and F. A. Jolesz, Ultrasound Med. Biol. 24, 275 (1998).
[Crossref]

Jang, M.

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

Jeon, H.-J.

Jolesz, F. A.

K. Hynynen and F. A. Jolesz, Ultrasound Med. Biol. 24, 275 (1998).
[Crossref]

Kim, C.

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[Crossref]

S.-R. Kothapalli, S. Sakadzic, C. Kim, and L. V. Wang, Opt. Lett. 32, 2351 (2007).
[Crossref]

Kongsavatsak, C.

S. P. Morgan, C. Li, B. R. Hayes-Gill, N. B. E. Sawyer, and C. Kongsavatsak, Proc. SPIE 6086, 608615 (2006).
[Crossref]

Kothapalli, S.-R.

Kröll, S.

A. Walther, L. Rippe, L. V. Wang, S. Andersson-Engels, and S. Kröll, Biomed. Opt. Express 8, 4523 (2017).
[Crossref]

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[Crossref]

Ku, G.

Lai, P.

Y. Liu, P. Lai, C. Ma, X. Xu, A. A. Grabar, and L. V. Wang, Nat. Commun. 6, 5904 (2015).
[Crossref]

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[Crossref]

Laudereau, J.-B.

Lebec, M.

Lévêque, S.

Li, C.

S. P. Morgan, C. Li, B. R. Hayes-Gill, N. B. E. Sawyer, and C. Kongsavatsak, Proc. SPIE 6086, 608615 (2006).
[Crossref]

Li, J.

Li, R.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, and M.-X. Tang, Interface Focus 1, 632 (2011).
[Crossref]

Liu, Y.

Y. Huang, M. Cua, J. Brake, Y. Liu, and C. Yang, J. Biomed. Opt. 25, 025002 (2020).
[Crossref]

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

M. M. Qureshi, J. Brake, H.-J. Jeon, H. Ruan, Y. Liu, A. M. Safi, T. J. Eom, C. Yang, and E. Chung, Biomed. Opt. Express 8, 4855 (2017).
[Crossref]

Y. Liu, Y. Shen, C. Ma, J. Shi, and L. V. Wang, Appl. Phys. Lett. 108, 231106 (2016).
[Crossref]

Y. Liu, C. Ma, Y. Shen, and L. V. Wang, Opt. Lett. 41, 1321 (2016).
[Crossref]

Y. Liu, P. Lai, C. Ma, X. Xu, A. A. Grabar, and L. V. Wang, Nat. Commun. 6, 5904 (2015).
[Crossref]

C. Ma, F. Zhou, Y. Liu, and L. V. Wang, Optica 2, 869 (2015).
[Crossref]

Y. Liu, C. Zhang, and L. V. Wang, J. Biomed. Opt. 17, 126014 (2012).
[Crossref]

Ma, C.

Y. Liu, C. Ma, Y. Shen, and L. V. Wang, Opt. Lett. 41, 1321 (2016).
[Crossref]

Y. Liu, Y. Shen, C. Ma, J. Shi, and L. V. Wang, Appl. Phys. Lett. 108, 231106 (2016).
[Crossref]

Y. Liu, P. Lai, C. Ma, X. Xu, A. A. Grabar, and L. V. Wang, Nat. Commun. 6, 5904 (2015).
[Crossref]

C. Ma, F. Zhou, Y. Liu, and L. V. Wang, Optica 2, 869 (2015).
[Crossref]

Marquet, P.

Marsac, L.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

Maslov, K.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 110506 (2012).
[Crossref]

Montemezzani, G.

Morgan, S. P.

S. P. Morgan, C. Li, B. R. Hayes-Gill, N. B. E. Sawyer, and C. Kongsavatsak, Proc. SPIE 6086, 608615 (2006).
[Crossref]

Nie, L.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 110506 (2012).
[Crossref]

C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
[Crossref]

Ntziachristos, V.

V. Ntziachristos, Nat. Meth. 7, 603 (2010).
[Crossref]

Pernot, M.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

J.-F. Aubry, M. Tanter, M. Pernot, J.-L. Thomas, and M. Fink, J. Acoust. Soc. Am. 113, 84 (2003).
[Crossref]

Qureshi, M. M.

Ramaz, F.

Resink, S. G.

S. G. Resink, E. Hondebrink, and W. Steenbergen, Opt. Express 22, 3564 (2014).
[Crossref]

S. G. Resink, A. C. Boccara, and W. Steenbergen, J. Biomed. Opt. 17, 040901 (2012).
[Crossref]

Rippe, L.

A. Walther, L. Rippe, L. V. Wang, S. Andersson-Engels, and S. Kröll, Biomed. Opt. Express 8, 4523 (2017).
[Crossref]

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[Crossref]

Robinson, J. E.

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

Roosen, G.

Ruan, H.

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

M. M. Qureshi, J. Brake, H.-J. Jeon, H. Ruan, Y. Liu, A. M. Safi, T. J. Eom, C. Yang, and E. Chung, Biomed. Opt. Express 8, 4855 (2017).
[Crossref]

Sabooni, M.

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[Crossref]

Safi, A. M.

Saint-Jalmes, H.

Sakadzic, S.

Salameh, N.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

Sawyer, N. B. E.

S. P. Morgan, C. Li, B. R. Hayes-Gill, N. B. E. Sawyer, and C. Kongsavatsak, Proc. SPIE 6086, 608615 (2006).
[Crossref]

Schirra, C.

C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
[Crossref]

Schoonover, R.

C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
[Crossref]

Shen, Y.

Y. Liu, C. Ma, Y. Shen, and L. V. Wang, Opt. Lett. 41, 1321 (2016).
[Crossref]

Y. Liu, Y. Shen, C. Ma, J. Shi, and L. V. Wang, Appl. Phys. Lett. 108, 231106 (2016).
[Crossref]

Shi, J.

Y. Liu, Y. Shen, C. Ma, J. Shi, and L. V. Wang, Appl. Phys. Lett. 108, 231106 (2016).
[Crossref]

Souris, L.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

Steenbergen, W.

S. G. Resink, E. Hondebrink, and W. Steenbergen, Opt. Express 22, 3564 (2014).
[Crossref]

S. G. Resink, A. C. Boccara, and W. Steenbergen, J. Biomed. Opt. 17, 040901 (2012).
[Crossref]

Tang, M.-X.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, and M.-X. Tang, Interface Focus 1, 632 (2011).
[Crossref]

Tanter, M.

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

J.-F. Aubry, M. Tanter, M. Pernot, J.-L. Thomas, and M. Fink, J. Acoust. Soc. Am. 113, 84 (2003).
[Crossref]

Thomas, J.-L.

J.-F. Aubry, M. Tanter, M. Pernot, J.-L. Thomas, and M. Fink, J. Acoust. Soc. Am. 113, 84 (2003).
[Crossref]

Tinet, É.

Tualle, J.-M.

Walther, A.

Wang, L.

C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
[Crossref]

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 110506 (2012).
[Crossref]

L. Wang and X. Zhao, Appl. Opt. 36, 7277 (1997).
[Crossref]

Wang, L. V.

A. Walther, L. Rippe, L. V. Wang, S. Andersson-Engels, and S. Kröll, Biomed. Opt. Express 8, 4523 (2017).
[Crossref]

Y. Liu, Y. Shen, C. Ma, J. Shi, and L. V. Wang, Appl. Phys. Lett. 108, 231106 (2016).
[Crossref]

Y. Liu, C. Ma, Y. Shen, and L. V. Wang, Opt. Lett. 41, 1321 (2016).
[Crossref]

Y. Liu, P. Lai, C. Ma, X. Xu, A. A. Grabar, and L. V. Wang, Nat. Commun. 6, 5904 (2015).
[Crossref]

C. Ma, F. Zhou, Y. Liu, and L. V. Wang, Optica 2, 869 (2015).
[Crossref]

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[Crossref]

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[Crossref]

Y. Liu, C. Zhang, and L. V. Wang, J. Biomed. Opt. 17, 126014 (2012).
[Crossref]

L. V. Wang and S. Hu, Science 335, 1458 (2012).
[Crossref]

S.-R. Kothapalli, S. Sakadzic, C. Kim, and L. V. Wang, Opt. Lett. 32, 2351 (2007).
[Crossref]

J. Li, G. Ku, and L. V. Wang, Appl. Opt. 41, 6030 (2002).
[Crossref]

Xiao, C.

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

Xu, X.

Y. Liu, P. Lai, C. Ma, X. Xu, A. A. Grabar, and L. V. Wang, Nat. Commun. 6, 5904 (2015).
[Crossref]

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[Crossref]

Yang, C.

Y. Huang, M. Cua, J. Brake, Y. Liu, and C. Yang, J. Biomed. Opt. 25, 025002 (2020).
[Crossref]

M. M. Qureshi, J. Brake, H.-J. Jeon, H. Ruan, Y. Liu, A. M. Safi, T. J. Eom, C. Yang, and E. Chung, Biomed. Opt. Express 8, 4855 (2017).
[Crossref]

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

Yodh, A. G.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, Rep. Prog. Phys. 73, 076701 (2010).
[Crossref]

Zhang, C.

Y. Liu, C. Zhang, and L. V. Wang, J. Biomed. Opt. 17, 126014 (2012).
[Crossref]

Zhang, H.

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[Crossref]

Zhao, X.

Zhou, C.

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

Zhou, F.

Appl. Opt. (3)

Appl. Phys. Lett. (2)

Y. Liu, Y. Shen, C. Ma, J. Shi, and L. V. Wang, Appl. Phys. Lett. 108, 231106 (2016).
[Crossref]

H. Zhang, M. Sabooni, L. Rippe, C. Kim, S. Kröll, L. V. Wang, and P. R. Hemmer, Appl. Phys. Lett. 100, 131102 (2012).
[Crossref]

Biomed. Opt. Express (2)

Front. Optoelectron. (1)

J. Gunther and S. Andersson-Engels, Front. Optoelectron. 10, 211 (2017).
[Crossref]

Interface Focus (1)

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, and M.-X. Tang, Interface Focus 1, 632 (2011).
[Crossref]

J. Acoust. Soc. Am. (1)

J.-F. Aubry, M. Tanter, M. Pernot, J.-L. Thomas, and M. Fink, J. Acoust. Soc. Am. 113, 84 (2003).
[Crossref]

J. Biomed. Opt. (6)

S. G. Resink, A. C. Boccara, and W. Steenbergen, J. Biomed. Opt. 17, 040901 (2012).
[Crossref]

Y. Liu, C. Zhang, and L. V. Wang, J. Biomed. Opt. 17, 126014 (2012).
[Crossref]

C. Huang, L. Nie, R. Schoonover, Z. Guo, C. Schirra, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 066016 (2012).
[Crossref]

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. Anastasio, and L. Wang, J. Biomed. Opt. 17, 110506 (2012).
[Crossref]

Y. Huang, M. Cua, J. Brake, Y. Liu, and C. Yang, J. Biomed. Opt. 25, 025002 (2020).
[Crossref]

P. Lai, X. Xu, and L. V. Wang, J. Biomed. Opt. 17, 066006 (2012).
[Crossref]

J. Neurosurg. (1)

D. Chauvet, L. Marsac, M. Pernot, A.-L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter, and J.-F. Aubry, J. Neurosurg. 118, 1046 (2013).
[Crossref]

Nat. Commun. (1)

Y. Liu, P. Lai, C. Ma, X. Xu, A. A. Grabar, and L. V. Wang, Nat. Commun. 6, 5904 (2015).
[Crossref]

Nat. Meth. (1)

V. Ntziachristos, Nat. Meth. 7, 603 (2010).
[Crossref]

Opt. Express (2)

Opt. Lett. (7)

Optica (1)

Proc. SPIE (1)

S. P. Morgan, C. Li, B. R. Hayes-Gill, N. B. E. Sawyer, and C. Kongsavatsak, Proc. SPIE 6086, 608615 (2006).
[Crossref]

Rep. Prog. Phys. (1)

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, Rep. Prog. Phys. 73, 076701 (2010).
[Crossref]

Sci. Adv. (1)

H. Ruan, J. Brake, J. E. Robinson, Y. Liu, M. Jang, C. Xiao, C. Zhou, V. Gradinaru, and C. Yang, Sci. Adv. 3, eaao5520 (2017).
[Crossref]

Science (1)

L. V. Wang and S. Hu, Science 335, 1458 (2012).
[Crossref]

Ultrasound Med. Biol. (1)

K. Hynynen and F. A. Jolesz, Ultrasound Med. Biol. 24, 275 (1998).
[Crossref]

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1.
Fig. 1. Measuring the ultrasonic field distribution on the focal plane of a spherically focused transducer, with and without the presence of a human skull. (a) Photo of the experimental setup. (b) Normalized ultrasonic field distribution on the focal plane measured at different locations with respect to the fixed human skull. Note that the bone thickness is not uniform across the skull.
Fig. 2.
Fig. 2. Schematic of the UOT setup for imaging through highly scattering human skulls. AO, absorptive object; AOM, acousto-optic modulator; BB, beam block; BS, non-polarizing beam splitter (90% transmission, 10% reflection); CAM, camera; HWP, half-wave plate; HS, human skull; ID, iris diaphragm; ISO, isolator; L, lens; M, mirror; ND, neutral density filter; P, polarizer; PBS, polarizing beam splitter; R, reference beam; S, sample beam; UT, ultrasonic transducer; WT, water tank. The components in the water tank are enclosed in a dashed box, and a photo is shown.
Fig. 3.
Fig. 3. Reconstruction of the field of the ultrasonically tagged light from the single-shot off-axis hologram. (a) 2D Fourier transform of the recorded interferogram. The normalized magnitude is plotted in a log scale. A close-up of the sideband is shown on the right. Scale bar, 20 cycles/mm. (b) Amplitude of the reconstructed ultrasonically tagged light field. Scale bar, 1 mm. (c) Phase of the reconstructed tagged light field. (d) Histogram of intensity. (e) Histogram of phase.
Fig. 4.
Fig. 4. UOT signal as a function of the ultrasonic focus position with (blue circles) and without (red squares) the presence of an absorptive object. The blue solid curve denotes the fitting to the experimental data with the model shown in Eq. (1). Each data point is an average of four measurements. The error bar represents the standard deviation.

Equations (2)

Equations on this page are rendered with MathJax. Learn more.

$$I\!\left({\vec r} \right) = o\left({\vec r} \right) * h\left({\vec r} \right),$$
$${{\rm SNR}_{{\rm cam}}} = \frac{{{\rm UOT\, signal}}}{{\sqrt {{\rm Var}({\rm UOT\, signal})}}} = \frac{{\sqrt {{N_{\rm p}}} {{\bar N}_{\rm T}}}}{{\sqrt {4{{\bar N}_{\rm T}} + 1}}},$$

Metrics