Abstract

Optical coherence tomography (OCT) has emerged as a powerful imaging instrument and technology in biomedicine. OCT imaging is predominantly performed using wavelengths in the near infrared; however, visible light (VIS) has been recently employed in OCT systems with encouraging results for high-resolution retinal imaging. Using a broadband supercontinuum VIS source, we present a sensorless adaptive optics (SAO) multimodal imaging system driven by VIS-OCT for volumetric retinal structural imaging, followed by the acquisition of fluorescence emission. The coherence-gated, depth-resolved VIS-OCT images used for image-guided SAO aberration correction enable high-resolution structural and fluorescence imaging.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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2018 (2)

2017 (5)

X. Shu, L. Beckmann, and H. F. Zhang, J. Biomed. Opt. 22, 121707 (2017).
[Crossref]

S. Chen, X. Shu, P. L. Nesper, W. Liu, A. A. Fawzi, and H. F. Zhang, Biomed. Opt. Express 8, 1415 (2017).
[Crossref]

S. P. Chong, M. Bernucci, H. Radhakrishnan, and V. J. Srinivasan, Biomed. Opt. Express 8, 323 (2017).
[Crossref]

P. L. Nesper, B. T. Soetikno, H. F. Zhang, and A. A. Fawzi, Vision Res. 139, 191 (2017).
[Crossref]

M. J. Ju, M. Heisler, D. Wahl, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 22, 121703 (2017).
[Crossref]

2016 (5)

Z. Nafar, M. Jiang, R. Wen, and S. Jiao, Biomed. Opt. Express 7, 3220 (2016).
[Crossref]

M. Cua, S. Lee, D. Miao, M. J. Ju, P. J. Mackenzie, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 21, 026007 (2016).
[Crossref]

Y. Jian, S. Lee, M. J. Ju, M. Heisler, W. Ding, R. J. Zawadzki, S. Bonora, and M. V. Sarunic, Sci. Rep. 6, 27620 (2016).
[Crossref]

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, Sci. Rep. 6, 32223 (2016).
[Crossref]

D. J. Wahl, Y. Jian, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 7, 1 (2016).
[Crossref]

2015 (4)

K. S. K. Wong, Y. Jian, M. Cua, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 6, 580 (2015).
[Crossref]

S. P. Chong, C. W. Merkle, C. Leahy, H. Radhakrishnan, and V. J. Srinivasan, Biomed. Opt. Express 6, 1422 (2015).
[Crossref]

P. Zhang, A. Zam, Y. Jian, X. Wang, Y. Li, K. S. Lam, M. E. Burns, M. V. Sarunic, E. N. Pugh, and R. J. Zawadzki, J. Biomed. Opt. 20, 126005 (2015).
[Crossref]

S. Chen, J. Yi, and H. F. Zhang, Biomed. Opt. Express 6, 2840 (2015).
[Crossref]

2014 (4)

R. P. Mcnabb, T. Blanco, D. R. Saban, J. A. Izatt, and A. N. Kuo, Invest. Ophthalmol. Vis. Sci. 55, 1779 (2014).

Y. Jian, J. Xu, M. A. Gradowski, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 5, 547 (2014).
[Crossref]

J. Yi, S. Chen, X. Shu, A. A. Fawzi, and H. F. Zhang, Ophthalmology 121, 1435 (2014).
[Crossref]

W. J. Brown, S. Kim, and A. Wax, J. Opt. Soc. Am. A 31, 2703 (2014).
[Crossref]

2013 (1)

Y. Jian, K. Wong, and M. V. Sarunic, J. Biomed. Opt. 18, 26002 (2013).
[Crossref]

2012 (2)

2011 (1)

D. R. Williams, Vision Res. 51, 1379 (2011).
[Crossref]

2004 (1)

P. F. Sharp, A. Manivannan, H. Xu, and J. V. Forrester, Phys. Med. Biol. 49, 1085 (2004).
[Crossref]

2002 (1)

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, R. Webb, V. Standards, and T. Members, J. Refract. Surg. 18, 652 (2002).

Akula, J. D.

Applegate, R. A.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, R. Webb, V. Standards, and T. Members, J. Refract. Surg. 18, 652 (2002).

Beckmann, L.

X. Shu, L. Beckmann, and H. F. Zhang, J. Biomed. Opt. 22, 121707 (2017).
[Crossref]

Bernucci, M.

Bernucci, M. T.

Blanco, T.

R. P. Mcnabb, T. Blanco, D. R. Saban, J. A. Izatt, and A. N. Kuo, Invest. Ophthalmol. Vis. Sci. 55, 1779 (2014).

Bonora, S.

Brown, W. J.

Burns, M. E.

P. Zhang, A. Zam, Y. Jian, X. Wang, Y. Li, K. S. Lam, M. E. Burns, M. V. Sarunic, E. N. Pugh, and R. J. Zawadzki, J. Biomed. Opt. 20, 126005 (2015).
[Crossref]

Chen, S.

Chong, S. P.

Chui, T. Y. P.

Cua, M.

M. Cua, S. Lee, D. Miao, M. J. Ju, P. J. Mackenzie, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 21, 026007 (2016).
[Crossref]

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, Sci. Rep. 6, 32223 (2016).
[Crossref]

K. S. K. Wong, Y. Jian, M. Cua, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 6, 580 (2015).
[Crossref]

Dai, C.

C. Dai, X. Liu, and S. Jiao, J. Biomed. Opt. 17, 080502 (2012).
[Crossref]

Daniel, F. R.

Desai, M.

Ding, W.

Y. Jian, S. Lee, M. J. Ju, M. Heisler, W. Ding, R. J. Zawadzki, S. Bonora, and M. V. Sarunic, Sci. Rep. 6, 27620 (2016).
[Crossref]

Dubra, A.

Fawzi, A. A.

S. Chen, X. Shu, P. L. Nesper, W. Liu, A. A. Fawzi, and H. F. Zhang, Biomed. Opt. Express 8, 1415 (2017).
[Crossref]

P. L. Nesper, B. T. Soetikno, H. F. Zhang, and A. A. Fawzi, Vision Res. 139, 191 (2017).
[Crossref]

J. Yi, S. Chen, X. Shu, A. A. Fawzi, and H. F. Zhang, Ophthalmology 121, 1435 (2014).
[Crossref]

Forrester, J. V.

P. F. Sharp, A. Manivannan, H. Xu, and J. V. Forrester, Phys. Med. Biol. 49, 1085 (2004).
[Crossref]

Fulton, A. B.

Gradowski, M. A.

Hammer, D. X.

Heisler, M.

M. J. Ju, M. Heisler, D. Wahl, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 22, 121703 (2017).
[Crossref]

Y. Jian, S. Lee, M. J. Ju, M. Heisler, W. Ding, R. J. Zawadzki, S. Bonora, and M. V. Sarunic, Sci. Rep. 6, 27620 (2016).
[Crossref]

Iftimia, N.

Izatt, J. A.

R. P. Mcnabb, T. Blanco, D. R. Saban, J. A. Izatt, and A. N. Kuo, Invest. Ophthalmol. Vis. Sci. 55, 1779 (2014).

Jian, Y.

M. J. Ju, M. Heisler, D. Wahl, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 22, 121703 (2017).
[Crossref]

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, Sci. Rep. 6, 32223 (2016).
[Crossref]

M. Cua, S. Lee, D. Miao, M. J. Ju, P. J. Mackenzie, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 21, 026007 (2016).
[Crossref]

Y. Jian, S. Lee, M. J. Ju, M. Heisler, W. Ding, R. J. Zawadzki, S. Bonora, and M. V. Sarunic, Sci. Rep. 6, 27620 (2016).
[Crossref]

D. J. Wahl, Y. Jian, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 7, 1 (2016).
[Crossref]

K. S. K. Wong, Y. Jian, M. Cua, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 6, 580 (2015).
[Crossref]

P. Zhang, A. Zam, Y. Jian, X. Wang, Y. Li, K. S. Lam, M. E. Burns, M. V. Sarunic, E. N. Pugh, and R. J. Zawadzki, J. Biomed. Opt. 20, 126005 (2015).
[Crossref]

Y. Jian, J. Xu, M. A. Gradowski, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 5, 547 (2014).
[Crossref]

Y. Jian, K. Wong, and M. V. Sarunic, J. Biomed. Opt. 18, 26002 (2013).
[Crossref]

Jiang, M.

Jiao, S.

Z. Nafar, M. Jiang, R. Wen, and S. Jiao, Biomed. Opt. Express 7, 3220 (2016).
[Crossref]

C. Dai, X. Liu, and S. Jiao, J. Biomed. Opt. 17, 080502 (2012).
[Crossref]

Ju, M. J.

M. J. Ju, M. Heisler, D. Wahl, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 22, 121703 (2017).
[Crossref]

Y. Jian, S. Lee, M. J. Ju, M. Heisler, W. Ding, R. J. Zawadzki, S. Bonora, and M. V. Sarunic, Sci. Rep. 6, 27620 (2016).
[Crossref]

M. Cua, S. Lee, D. Miao, M. J. Ju, P. J. Mackenzie, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 21, 026007 (2016).
[Crossref]

Kho, A.

Kim, S.

Kuo, A. N.

R. P. Mcnabb, T. Blanco, D. R. Saban, J. A. Izatt, and A. N. Kuo, Invest. Ophthalmol. Vis. Sci. 55, 1779 (2014).

Lam, K. S.

P. Zhang, A. Zam, Y. Jian, X. Wang, Y. Li, K. S. Lam, M. E. Burns, M. V. Sarunic, E. N. Pugh, and R. J. Zawadzki, J. Biomed. Opt. 20, 126005 (2015).
[Crossref]

Leahy, C.

S. P. Chong, C. W. Merkle, C. Leahy, H. Radhakrishnan, and V. J. Srinivasan, Biomed. Opt. Express 6, 1422 (2015).
[Crossref]

Lee, S.

M. Cua, S. Lee, D. Miao, M. J. Ju, P. J. Mackenzie, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 21, 026007 (2016).
[Crossref]

Y. Jian, S. Lee, M. J. Ju, M. Heisler, W. Ding, R. J. Zawadzki, S. Bonora, and M. V. Sarunic, Sci. Rep. 6, 27620 (2016).
[Crossref]

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, Sci. Rep. 6, 32223 (2016).
[Crossref]

Li, Y.

P. Zhang, A. Zam, Y. Jian, X. Wang, Y. Li, K. S. Lam, M. E. Burns, M. V. Sarunic, E. N. Pugh, and R. J. Zawadzki, J. Biomed. Opt. 20, 126005 (2015).
[Crossref]

Liu, W.

Liu, X.

C. Dai, X. Liu, and S. Jiao, J. Biomed. Opt. 17, 080502 (2012).
[Crossref]

Mackenzie, P. J.

M. Cua, S. Lee, D. Miao, M. J. Ju, P. J. Mackenzie, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 21, 026007 (2016).
[Crossref]

Manivannan, A.

P. F. Sharp, A. Manivannan, H. Xu, and J. V. Forrester, Phys. Med. Biol. 49, 1085 (2004).
[Crossref]

Mcnabb, R. P.

R. P. Mcnabb, T. Blanco, D. R. Saban, J. A. Izatt, and A. N. Kuo, Invest. Ophthalmol. Vis. Sci. 55, 1779 (2014).

Members, T.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, R. Webb, V. Standards, and T. Members, J. Refract. Surg. 18, 652 (2002).

Merkle, C. W.

S. P. Chong, C. W. Merkle, C. Leahy, H. Radhakrishnan, and V. J. Srinivasan, Biomed. Opt. Express 6, 1422 (2015).
[Crossref]

Miao, D.

M. Cua, S. Lee, D. Miao, M. J. Ju, P. J. Mackenzie, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 21, 026007 (2016).
[Crossref]

Mujat, M.

Nafar, Z.

Nesper, P. L.

S. Chen, X. Shu, P. L. Nesper, W. Liu, A. A. Fawzi, and H. F. Zhang, Biomed. Opt. Express 8, 1415 (2017).
[Crossref]

P. L. Nesper, B. T. Soetikno, H. F. Zhang, and A. A. Fawzi, Vision Res. 139, 191 (2017).
[Crossref]

Ness, S.

Patel, A.

Plumb, E.

Pugh, E. N.

P. Zhang, A. Zam, Y. Jian, X. Wang, Y. Li, K. S. Lam, M. E. Burns, M. V. Sarunic, E. N. Pugh, and R. J. Zawadzki, J. Biomed. Opt. 20, 126005 (2015).
[Crossref]

Radhakrishnan, H.

S. P. Chong, M. Bernucci, H. Radhakrishnan, and V. J. Srinivasan, Biomed. Opt. Express 8, 323 (2017).
[Crossref]

S. P. Chong, C. W. Merkle, C. Leahy, H. Radhakrishnan, and V. J. Srinivasan, Biomed. Opt. Express 6, 1422 (2015).
[Crossref]

Roy, S.

Saban, D. R.

R. P. Mcnabb, T. Blanco, D. R. Saban, J. A. Izatt, and A. N. Kuo, Invest. Ophthalmol. Vis. Sci. 55, 1779 (2014).

Sarunic, M. V.

M. J. Ju, M. Heisler, D. Wahl, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 22, 121703 (2017).
[Crossref]

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, Sci. Rep. 6, 32223 (2016).
[Crossref]

M. Cua, S. Lee, D. Miao, M. J. Ju, P. J. Mackenzie, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 21, 026007 (2016).
[Crossref]

Y. Jian, S. Lee, M. J. Ju, M. Heisler, W. Ding, R. J. Zawadzki, S. Bonora, and M. V. Sarunic, Sci. Rep. 6, 27620 (2016).
[Crossref]

D. J. Wahl, Y. Jian, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 7, 1 (2016).
[Crossref]

K. S. K. Wong, Y. Jian, M. Cua, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 6, 580 (2015).
[Crossref]

P. Zhang, A. Zam, Y. Jian, X. Wang, Y. Li, K. S. Lam, M. E. Burns, M. V. Sarunic, E. N. Pugh, and R. J. Zawadzki, J. Biomed. Opt. 20, 126005 (2015).
[Crossref]

Y. Jian, J. Xu, M. A. Gradowski, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 5, 547 (2014).
[Crossref]

Y. Jian, K. Wong, and M. V. Sarunic, J. Biomed. Opt. 18, 26002 (2013).
[Crossref]

Schwiegerling, J. T.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, R. Webb, V. Standards, and T. Members, J. Refract. Surg. 18, 652 (2002).

Shao, D.

Sharp, P. F.

P. F. Sharp, A. Manivannan, H. Xu, and J. V. Forrester, Phys. Med. Biol. 49, 1085 (2004).
[Crossref]

Shu, X.

X. Shu, L. Beckmann, and H. F. Zhang, J. Biomed. Opt. 22, 121707 (2017).
[Crossref]

S. Chen, X. Shu, P. L. Nesper, W. Liu, A. A. Fawzi, and H. F. Zhang, Biomed. Opt. Express 8, 1415 (2017).
[Crossref]

J. Yi, S. Chen, X. Shu, A. A. Fawzi, and H. F. Zhang, Ophthalmology 121, 1435 (2014).
[Crossref]

Soetikno, B. T.

P. L. Nesper, B. T. Soetikno, H. F. Zhang, and A. A. Fawzi, Vision Res. 139, 191 (2017).
[Crossref]

Song, W.

Srinivasan, V. J.

Standards, V.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, R. Webb, V. Standards, and T. Members, J. Refract. Surg. 18, 652 (2002).

Thibos, L. N.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, R. Webb, V. Standards, and T. Members, J. Refract. Surg. 18, 652 (2002).

Wahl, D.

M. J. Ju, M. Heisler, D. Wahl, Y. Jian, and M. V. Sarunic, J. Biomed. Opt. 22, 121703 (2017).
[Crossref]

Wahl, D. J.

M. Cua, D. J. Wahl, Y. Zhao, S. Lee, S. Bonora, R. J. Zawadzki, Y. Jian, and M. V. Sarunic, Sci. Rep. 6, 32223 (2016).
[Crossref]

D. J. Wahl, Y. Jian, S. Bonora, R. J. Zawadzki, and M. V. Sarunic, Biomed. Opt. Express 7, 1 (2016).
[Crossref]

Wang, X.

P. Zhang, A. Zam, Y. Jian, X. Wang, Y. Li, K. S. Lam, M. E. Burns, M. V. Sarunic, E. N. Pugh, and R. J. Zawadzki, J. Biomed. Opt. 20, 126005 (2015).
[Crossref]

Wax, A.

Webb, R.

L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, R. Webb, V. Standards, and T. Members, J. Refract. Surg. 18, 652 (2002).

Wen, R.

Williams, D. R.

D. R. Williams, Vision Res. 51, 1379 (2011).
[Crossref]

Wong, K.

Y. Jian, K. Wong, and M. V. Sarunic, J. Biomed. Opt. 18, 26002 (2013).
[Crossref]

Wong, K. S. K.

Xu, H.

P. F. Sharp, A. Manivannan, H. Xu, and J. V. Forrester, Phys. Med. Biol. 49, 1085 (2004).
[Crossref]

Xu, J.

Yi, J.

Zam, A.

P. Zhang, A. Zam, Y. Jian, X. Wang, Y. Li, K. S. Lam, M. E. Burns, M. V. Sarunic, E. N. Pugh, and R. J. Zawadzki, J. Biomed. Opt. 20, 126005 (2015).
[Crossref]

Zawadzki, R. J.

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Ophthalmology (1)

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Phys. Med. Biol. (1)

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Y. Jian, S. Lee, M. J. Ju, M. Heisler, W. Ding, R. J. Zawadzki, S. Bonora, and M. V. Sarunic, Sci. Rep. 6, 27620 (2016).
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Figures (5)

Fig. 1.
Fig. 1. Multimodal SAO-VIS-OCT and fluorescence imaging system. DM, deformable mirror); GM, 2-D galvanometer scanner; VL, variable focus lens; DG, diffraction grating; PC, polarization controller; LSC, line scan camera; DCB, dispersion compensation block; MEB, multi-edge beam splitter; MEF, multi-edge filter; M, mirror; PMT, photo-multiplier tube), { L 1 , L 2 , L 3 , L 4 , L 5 } = { 200 , 200 , 150 , and 100    mm } ; { L 5 , L 6 } = { 100 , 50 / 100 , 100 , 30 / 100 , and 35    mm } .
Fig. 2.
Fig. 2. En face VIS-OCT and fluorescence images (a), (b) before aberration correction and (c), (d) after correction. Line spread function taken across the dashed and solid lines in (b) and (d) demonstrating the performance of the correction. Scale bar, 50 μm.
Fig. 3.
Fig. 3. Single and averaged VIS-OCT B-scan images. (a), (d)  0.5    mm × 0.5    mm FOV, acquired with an NA of 0.18. (b), (e)  1.2    mm × 1.2    mm FOV, acquired with an NA of 0.18. (c)  0.7    mm × 0.7    mm FOV B-scan image and (f) en face image segmented from the dashed rectangular window in (c), acquired with an NA of 0.21. Vertical scale bar; 30 μm; horizontal scale bar, 100 μm.
Fig. 4.
Fig. 4. VIS-OCT B-scan and fluorescein angiography (a), (b) before optimization and (c), (d) after aberration correction. Scale bar, 30 μm. The Zernike coefficients selected during the optimization are demonstrated (e). Vertical scale bar, 30 μm; horizontal scale bar, 30 μm.
Fig. 5.
Fig. 5. (a)–(c) B-scan and EGFP labeled ganglion cell before optimization, and (d)–(f) the optimized images. Scale bar, 30 μm. (g) Line spread function taken across the red lines in (c) and (f). (h) Zernike coefficients selected during optimization. Vertical scale bar, 30 μm; horizontal scale bar, 30 μm.

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