Abstract

We interrogated whether optoacoustic tomography could be employed to study blood functional parameters and biodistribution of injected fluorescent agents in humans. Using a multichannel scanner at a frame rate of 10 images per second, we obtained cross-sectional images of the human finger in real time, before and after the administration of indocyanine green. We demonstrated that multispectral optoacoustic tomography can sense fast flow kinetics and resolve spatiotemporal characteristics of a common fluorochrome in human vasculature at clinically relevant concentrations. We further register ICG images with oxygen saturation maps and anatomical views of the proximal interphalangeal joint of a healthy volunteer.

© 2014 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistration

David J. Cuccia, Frederic Bevilacqua, Anthony J. Durkin, Sean Merritt, Bruce J. Tromberg, Gultekin Gulsen, Hon Yu, Jun Wang, and Orhan Nalcioglu
Appl. Opt. 42(16) 2940-2950 (2003)

Contrast enhanced high-resolution diffuse optical tomography of the human brain using ICG

Christina Habermehl, Christoph H. Schmitz, and Jens Steinbrink
Opt. Express 19(19) 18636-18644 (2011)

Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent

Xueding Wang, Geng Ku, Malgorzata A. Wegiel, Darryl J. Bornhop, George Stoica, and Lihong V. Wang
Opt. Lett. 29(7) 730-732 (2004)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (1)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription