Abstract

We present the results of a feasibility study with spatial frequency domain imaging (SFDI) to produce quantitative measurements of optical property and chromophore concentration maps of three porcine kidneys utilizing a renal occlusion model at the near-infrared wavelengths of 658, 730, and 850 nm. Using SFDI, we examined the dynamics of absolute oxygen saturation (StO2). The mean StO2 for the kidneys varied from approximately 60% before occlusion, to 20% during occlusion, to 55% after reperfusion. We also present, for the first time to the best of our knowledge, reduced scattering coefficient (μs) maps of the kidney during occlusion. We observed a substantial decrease in the wavelength dependence of scattering (i.e., scattering power) in the three kidneys, with a mean decrease of 18%±2.6%, which is indicative of an increase in scatterer size, and is likely due to tissue changes such as edema that follow from occlusion and inflammation.

© 2013 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Quantification of in vivo autofluorescence dynamics during renal ischemia and reperfusion under 355 nm excitation

Rajesh N. Raman, Christopher D. Pivetti, Dennis L. Matthews, Christoph Troppmann, and Stavros G. Demos
Opt. Express 16(7) 4930-4944 (2008)

Highly sensitive imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography

Zhongwei Zhi, Yeongri Jung, Yali Jia, Lin An, and Ruikang K. Wang
Biomed. Opt. Express 2(5) 1059-1068 (2011)

Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach

Dirk Grosenick, Kathleen Cantow, Karen Arakelyan, Heidrun Wabnitz, Bert Flemming, Angela Skalweit, Mechthild Ladwig, Rainer Macdonald, Thoralf Niendorf, and Erdmann Seeliger
Biomed. Opt. Express 6(2) 309-323 (2015)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription