Abstract

We present a label-free, nondestructive and high sensitivity biosensor by using the phase information of a gold nanoparticles enhanced ellipsometry signal. The refractive index (RI) resolution from ellipsometric phase information is of the order of 1.6×106 RI units. Furthermore, spectroscopic and dynamic measurements show substantial change in the phase signal when biomolecules are coated on gold nanoparticles. The detection limit of our proposed technique is up to 18pM concentration of the target biomolecules.

© 2011 Optical Society of America

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2010 (2)

2009 (1)

2008 (2)

J. Y. Lee, T. K. Chou, and H. C. Shih, Opt. Lett. 33, 434 (2008).
[CrossRef] [PubMed]

R. A. Sperling, P. R. Gil, F. Zhang, M. Zanella, and W. J. Parak, Chem. Soc. Rev. 37, 1896 (2008).
[CrossRef] [PubMed]

2007 (1)

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

2005 (2)

I. H. El-Sayed, X. Huang, and M. A. El-Sayed, Nano Lett. 5, 829 (2005).
[CrossRef] [PubMed]

M. M. Miller and A. A. Lazarides, J. Phys. Chem. B 109, 21556 (2005).
[CrossRef]

2004 (1)

N. Nath and A. Chilkoti, Anal. Chem. 76, 5370 (2004).
[CrossRef] [PubMed]

2003 (1)

N. L. Dmitruk, T. R. Barlas, O. S. Kondratenko, and V. R. Romanyuk, Mater. Sci. Eng., C 23, 159 (2003).
[CrossRef]

2000 (1)

1999 (2)

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, Appl. Phys. Lett. 75, 3917 (1999).
[CrossRef]

1973 (1)

G. Frens, Nature 241, 20 (1973).

Baptista, P.

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

Barlas, T. R.

N. L. Dmitruk, T. R. Barlas, O. S. Kondratenko, and V. R. Romanyuk, Mater. Sci. Eng., C 23, 159 (2003).
[CrossRef]

Chang, C. H.

Chilkoti, A.

N. Nath and A. Chilkoti, Anal. Chem. 76, 5370 (2004).
[CrossRef] [PubMed]

Chou, T. K.

Dmitruk, N. L.

N. L. Dmitruk, T. R. Barlas, O. S. Kondratenko, and V. R. Romanyuk, Mater. Sci. Eng., C 23, 159 (2003).
[CrossRef]

Doria, G.

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

Eaton, P.

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

El-Sayed, I. H.

I. H. El-Sayed, X. Huang, and M. A. El-Sayed, Nano Lett. 5, 829 (2005).
[CrossRef] [PubMed]

El-Sayed, M. A.

I. H. El-Sayed, X. Huang, and M. A. El-Sayed, Nano Lett. 5, 829 (2005).
[CrossRef] [PubMed]

Franco, R.

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

Frens, G.

G. Frens, Nature 241, 20 (1973).

Fujiwara, H.

H. Fujiwara, Spectroscopic Ellipsometry: Principles and Applications (Wiley, 2007).

Gauglitz, G.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Gil, P. R.

R. A. Sperling, P. R. Gil, F. Zhang, M. Zanella, and W. J. Parak, Chem. Soc. Rev. 37, 1896 (2008).
[CrossRef] [PubMed]

Gomes, I.

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

Grigorenko, A. N.

Homola, J.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Huang, X.

I. H. El-Sayed, X. Huang, and M. A. El-Sayed, Nano Lett. 5, 829 (2005).
[CrossRef] [PubMed]

Kabashin, A. V.

Karvets, V. G.

Kobayashi, T.

Kondratenko, O. S.

N. L. Dmitruk, T. R. Barlas, O. S. Kondratenko, and V. R. Romanyuk, Mater. Sci. Eng., C 23, 159 (2003).
[CrossRef]

Kuo, W. K.

Lazarides, A. A.

M. M. Miller and A. A. Lazarides, J. Phys. Chem. B 109, 21556 (2005).
[CrossRef]

Lee, J. Y.

Miller, M. M.

M. M. Miller and A. A. Lazarides, J. Phys. Chem. B 109, 21556 (2005).
[CrossRef]

Miranda, A.

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

Nath, N.

N. Nath and A. Chilkoti, Anal. Chem. 76, 5370 (2004).
[CrossRef] [PubMed]

Nikitin, P. I.

A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, Appl. Phys. Lett. 75, 3917 (1999).
[CrossRef]

Okamoto, T.

Parak, W. J.

R. A. Sperling, P. R. Gil, F. Zhang, M. Zanella, and W. J. Parak, Chem. Soc. Rev. 37, 1896 (2008).
[CrossRef] [PubMed]

Patskovsky, S.

Pereira, E.

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

Quaresma, P.

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

Romanyuk, V. R.

N. L. Dmitruk, T. R. Barlas, O. S. Kondratenko, and V. R. Romanyuk, Mater. Sci. Eng., C 23, 159 (2003).
[CrossRef]

Schedin, F.

Shih, H. C.

Sperling, R. A.

R. A. Sperling, P. R. Gil, F. Zhang, M. Zanella, and W. J. Parak, Chem. Soc. Rev. 37, 1896 (2008).
[CrossRef] [PubMed]

Yamaguchi, I.

Yee, S. S.

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Zanella, M.

R. A. Sperling, P. R. Gil, F. Zhang, M. Zanella, and W. J. Parak, Chem. Soc. Rev. 37, 1896 (2008).
[CrossRef] [PubMed]

Zhang, F.

R. A. Sperling, P. R. Gil, F. Zhang, M. Zanella, and W. J. Parak, Chem. Soc. Rev. 37, 1896 (2008).
[CrossRef] [PubMed]

Anal. Bioanal. Chem. (1)

P. Baptista, E. Pereira, P. Eaton, G. Doria, A. Miranda, I. Gomes, P. Quaresma, and R. Franco, Anal. Bioanal. Chem. 391, 943 (2007).
[CrossRef] [PubMed]

Anal. Chem. (1)

N. Nath and A. Chilkoti, Anal. Chem. 76, 5370 (2004).
[CrossRef] [PubMed]

Appl. Phys. Lett. (1)

A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, Appl. Phys. Lett. 75, 3917 (1999).
[CrossRef]

Chem. Soc. Rev. (1)

R. A. Sperling, P. R. Gil, F. Zhang, M. Zanella, and W. J. Parak, Chem. Soc. Rev. 37, 1896 (2008).
[CrossRef] [PubMed]

J. Phys. Chem. B (1)

M. M. Miller and A. A. Lazarides, J. Phys. Chem. B 109, 21556 (2005).
[CrossRef]

Mater. Sci. Eng., C (1)

N. L. Dmitruk, T. R. Barlas, O. S. Kondratenko, and V. R. Romanyuk, Mater. Sci. Eng., C 23, 159 (2003).
[CrossRef]

Nano Lett. (1)

I. H. El-Sayed, X. Huang, and M. A. El-Sayed, Nano Lett. 5, 829 (2005).
[CrossRef] [PubMed]

Nature (1)

G. Frens, Nature 241, 20 (1973).

Opt. Express (2)

Opt. Lett. (3)

Sens. Actuators B (1)

J. Homola, S. S. Yee, and G. Gauglitz, Sens. Actuators B 54, 3 (1999).
[CrossRef]

Other (1)

H. Fujiwara, Spectroscopic Ellipsometry: Principles and Applications (Wiley, 2007).

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Figures (3)

Fig. 1
Fig. 1

(a) Schematic diagram of our experimental setup and (b) SEM image of AuNPs on glass substrate.

Fig. 2
Fig. 2

Spectral response of the ellipsometric parameters for (a) Ψ and (b) Δ for glycerol–water mixtures with various RIs; (c) changes of phase signal, Δ, and (d) dynamic response measured at fixed wavelength ( 575 nm ) with varying RIs ( δ n ) of glycerol–water mixtures. Error bars in Fig. 2c were determined from five independent measurements at the same spot for a given sample, and slopes with the standard deviation obtained from linear fitting of the data points are also given.

Fig. 3
Fig. 3

Spectral response of the ellipsometric parameters for (a) Ψ and (b) Δfor various configurations with respect to the addition of BSA and anti-BSA; (c) reproducibility of the measurement on three different samples and error bar over three different regions on the sample surface [atomic force microscopy images of the AuNPs with uncoated and coated biomolecules are shown in insets in (a) and (b)]. (d) Dynamic response of Δ.

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