Abstract

This study utilizes experimentally validated Monte Carlo simulations to identify a mathematical formulation of the reflectance intensity collected by a single fiber probe expressed in terms of the reduced scattering coefficient (μs), fiber diameter dfiber, and a property of the first two moments of the scattering phase function (γ). This model is then utilized to accurately obtain wavelength-dependent estimates of μs(λ) and γ(λ) from multiple single fiber spectral measurements of a turbid medium obtained with different diameters. This method returns accurate descriptions (mean residual <3%) of both μs and γ across the biologically relevant range.

© 2011 Optical Society of America

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References

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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  9. P. R. Bargo, S. A. Prahl, and S. L. Jacques, Appl. Opt. 42, 3187 (2003).
    [CrossRef] [PubMed]

2011

2010

N. Boustany, S. Boppart, and V. Backman, Annu. Rev. Biomed. Eng. 12, 285 (2010).
[CrossRef] [PubMed]

2009

S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
[CrossRef] [PubMed]

S. C. Kanick, H. J. C. M. Sterenborg, and A. Amelink, Opt. Express 17, 860 (2009).
[CrossRef] [PubMed]

2008

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

2003

P. R. Bargo, S. A. Prahl, and S. L. Jacques, Appl. Opt. 42, 3187 (2003).
[CrossRef] [PubMed]

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

2001

1999

Amelink, A.

Backman, V.

N. Boustany, S. Boppart, and V. Backman, Annu. Rev. Biomed. Eng. 12, 285 (2010).
[CrossRef] [PubMed]

Bargo, P. R.

Bevilacqua, F.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

F. Bevilacqua and C. Depeursinge, J. Opt. Soc. Am. A 16, 2935 (1999).
[CrossRef]

Boppart, S.

N. Boustany, S. Boppart, and V. Backman, Annu. Rev. Biomed. Eng. 12, 285 (2010).
[CrossRef] [PubMed]

Boustany, N.

N. Boustany, S. Boppart, and V. Backman, Annu. Rev. Biomed. Eng. 12, 285 (2010).
[CrossRef] [PubMed]

Charvet, I.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

Depeursinge, C.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

F. Bevilacqua and C. Depeursinge, J. Opt. Soc. Am. A 16, 2935 (1999).
[CrossRef]

Foster, T. H.

Gamm, U. A.

Hull, E. L.

Jacques, S. L.

Kanick, S. C.

Marquet, P.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

Meda, P.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

Ory, G.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

Prahl, S. A.

Robinson, D. J.

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, Biomed. Opt. Express 2, 1687 (2011).
[CrossRef] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
[CrossRef] [PubMed]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

Schouten, M.

St. Ghislain, M.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

Sterenborg, H. J. C. M.

Thueler, P.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

Vermeulen, B.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

Annu. Rev. Biomed. Eng.

N. Boustany, S. Boppart, and V. Backman, Annu. Rev. Biomed. Eng. 12, 285 (2010).
[CrossRef] [PubMed]

Appl. Opt.

Biomed. Opt. Express

J. Biomed. Opt.

P. Thueler, I. Charvet, F. Bevilacqua, M. St. Ghislain, G. Ory, P. Marquet, P. Meda, B. Vermeulen, and C. Depeursinge, J. Biomed. Opt. 8, 495 (2003).
[CrossRef] [PubMed]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A

Opt. Express

Phys. Med. Biol.

S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
[CrossRef] [PubMed]

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Figures (2)

Fig. 1
Fig. 1

(a)  R SF o versus μ s d fiber for three different PFs: PF 1 g = 0.8 , γ = 1.4 ; PF 2 g = 0.9 ; γ = 1.6 ; PF 3 g = 0.95 , γ = 1.8 . (b) MC simulated versus model estimates.

Fig. 2
Fig. 2

(a)  R SF o ( λ ) versus λ measured by d fiber [ 0.2 , 0.4 , 0.6 , 0.8 , 1.0 ] mm differentiated by symbols in legend. (b)  μ s ( λ ) versus λ specified in MC simulation and estimated by model. (c)  γ ( λ ) versus λ specified in MC simulation and estimated by model. (d)  R SF o ( λ ) simulated by MC versus estimated by model. Left panels correspond to a wavelength-independent γ. Right panels correspond to wavelength-dependent γ.

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

R SF = R SF o e μ a L SF
R SF o = η limit ( 1 + ρ 3 e ( ρ 1 μ s d fiber ) ) [ ( μ s d fiber ) ρ 2 ρ 1 + ( μ s d fiber ) ρ 2 ] ,
p MHG ( θ ) = α p HG ( θ , g HG ) + ( 1 α ) 3 4 π cos 2 ( θ ) ,
[ ρ 1 = ξ 1 γ 2 ρ 2 = ξ 2 γ ρ 3 = ξ 3 γ 2 ]

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