Abstract

This study presents a methodology to accurately extract the absorption coefficient from single fiber reflectance spectra measured in turbid media without a priori knowledge of either the reduced scattering coefficient or the phase function. This novel approach accounts for the interrelated effects these properties have on the photon path length, yielding estimates of an absorption coefficient on average within <7.5% of true values over a wide range of biologically relevant optical properties.

© 2011 Optical Society of America

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References

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  1. S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
    [CrossRef] [PubMed]
  2. S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
    [CrossRef] [PubMed]
  3. F. Bevilacqua and C. Depeursinge, J. Opt. Soc. Am. A 16, 2935 (1999).
    [CrossRef]
  4. J. R. Mourant, J. Boyer, A. H. Hielscher, and I. J. Bigio, Opt. Lett. 21, 546 (1996).
    [CrossRef] [PubMed]
  5. S. C. Kanick, U. A. Gamm, M. Schouten, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, Biomed. Opt. Express 2, 1687 (2011).
    [CrossRef] [PubMed]
  6. P. R. Bargo, S. A. Prahl, and S. L. Jacques, Appl. Opt. 42, 3187 (2003).
    [CrossRef] [PubMed]
  7. A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
    [CrossRef] [PubMed]

2011

2010

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
[CrossRef] [PubMed]

2009

S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
[CrossRef] [PubMed]

2008

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

2003

1999

1996

Aerts, J. G. J. V.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
[CrossRef] [PubMed]

Amelink, A.

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, Biomed. Opt. Express 2, 1687 (2011).
[CrossRef] [PubMed]

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
[CrossRef] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
[CrossRef] [PubMed]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

Bargo, P. R.

Bevilacqua, F.

Bigio, I. J.

Boyer, J.

Depeursinge, C.

Gamm, U. A.

Hielscher, A. H.

Hoogsteden, H. C.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
[CrossRef] [PubMed]

Jacques, S. L.

Kanick, S. C.

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, Biomed. Opt. Express 2, 1687 (2011).
[CrossRef] [PubMed]

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
[CrossRef] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
[CrossRef] [PubMed]

Kašcáková, S.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
[CrossRef] [PubMed]

Mourant, J. R.

Prahl, S. A.

Robinson, D. J.

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, Biomed. Opt. Express 2, 1687 (2011).
[CrossRef] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
[CrossRef] [PubMed]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

Schouten, M.

Sterenborg, H. J. C. M.

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, Biomed. Opt. Express 2, 1687 (2011).
[CrossRef] [PubMed]

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
[CrossRef] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
[CrossRef] [PubMed]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

van der Leest, C.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
[CrossRef] [PubMed]

Appl. Opt.

Biomed. Opt. Express

J. Biomed. Opt.

S. C. Kanick, C. van der Leest, J. G. J. V. Aerts, H. C. Hoogsteden, S. Kaščáková, H. J. C. M. Sterenborg, and A. Amelink, J. Biomed. Opt. 15, 017004 (2010).
[CrossRef] [PubMed]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A

Opt. Lett.

Phys. Med. Biol.

S. C. Kanick, D. J. Robinson, H. J. C. M. Sterenborg, and A. Amelink, Phys. Med. Biol. 54, 6991 (2009).
[CrossRef] [PubMed]

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Figures (2)

Fig. 1
Fig. 1

Residual plots of L SF for four scenarios: A, B, C, and D. See text for details.

Fig. 2
Fig. 2

Relationship between R SF o and μ s d fiber for three PFs with different γ and g values. Indicated are the C PF values associated with these PFs and the effect of (mis-)specification of the PF on the estimation of μ s based on a measured R SF o ( real ) .

Equations (3)

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L SF model d fiber = C PF 1.54 ( μ s d fiber ) 0.18 ( 0.64 + ( μ a d fiber ) 0.64 ) ,
p MHG ( θ ) = α p HG ( θ , g HG ) + ( 1 α ) 3 4 π cos 2 ( θ ) .
R SF o = η limit ( 1 + ρ 3 e ( ρ 1 μ s d fiber ) ) [ ( μ s d fiber ) ρ 2 ρ 1 + ( μ s d fiber ) ρ 2 ] ,

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