Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from β-emitting radiotracers such as -fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.
© 2010 Optical Society of AmericaFull Article | PDF Article
Wenxiang Cong, Ge Wang, Durairaj Kumar, Yi Liu, Ming Jiang, Lihong V. Wang, Eric A. Hoffman, Geoffrey McLennan, Paul B. McCray, Joseph Zabner, and Alexander Cong
Opt. Express 13(18) 6756-6771 (2005)
Chenghu Qin, Jie Tian, Xin Yang, Kai Liu, Guorui Yan, Jinchao Feng, Yujie Lv, and Min Xu
Opt. Express 16(25) 20317-20333 (2008)
Jinchao Feng, Kebin Jia, Chenghu Qin, Guorui Yan, Shouping Zhu, Xing Zhang, Junting Liu, and Jie Tian
Opt. Express 17(19) 16834-16848 (2009)