Abstract

Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from β-emitting radiotracers such as F18-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.

© 2010 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Multispectral Cerenkov luminescence tomography for small animal optical imaging

Antonello E Spinelli, Chaincy Kuo, Brad W Rice, Riccardo Calandrino, Pasquina Marzola, Andrea Sbarbati, and Federico Boschi
Opt. Express 19(13) 12605-12618 (2011)

Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation

Zhenhua Hu, Jimin Liang, Weidong Yang, Weiwei Fan, Congye Li, Xiaowei Ma, Xueli Chen, Xiaopeng Ma, Xiangsi Li, Xiaochao Qu, Jing Wang, Feng Cao, and Jie Tian
Opt. Express 18(24) 24441-24450 (2010)

Persistent luminescence tomography for small animal imaging

Xu Cao, Yuzhu Gong, Yang Li, Shouping Zhu, Xuanxuan Zhang, Yonghua Zhan, Fei Kang, Jing Wang, and Jimin Liang
Biomed. Opt. Express 8(3) 1466-1476 (2017)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription