Abstract

Fluorescence diffuse optical tomography (FDOT) is a biomedical imaging modality that can be used for localization and quantification of fluorescent molecules inside turbid media. In this ill-posed problem, the reconstruction quality is directly determined by the amount and quality of the information obtained from the boundary measurements. Regularly, more information can be obtained by increasing the number of excitation positions in an FDOT system. However, the maximum number of excitation positions is limited by the finite size of the excitation beam. In the present work, we demonstrate a method in FDOT to exploit the unique nonlinear power dependence of upconverting nanoparticles to further increase the amount of information in a raster-scanning setup by including excitation with two beams simultaneously. We show that the additional information can be used to obtain more accurate reconstructions.

© 2010 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. Hielscher, Curr. Opin. Biotechnol. 16, 79 (2005).
    [CrossRef] [PubMed]
  2. A. Corlu, R. Choe, T. Durduran, M. A. Rosen, M. Schweiger, S. R. Arridge, M. D. Schnall, and A. G. Yodh, Opt. Express 15, 6696 (2007).
    [CrossRef] [PubMed]
  3. V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, Nat. Med. 8, 757 (2002).
    [CrossRef] [PubMed]
  4. V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
    [CrossRef] [PubMed]
  5. S. R. Arridge, Inverse Probl. 15, R41 (1999).
    [CrossRef]
  6. A. Soubret and V. Ntziachristos, Phys. Med. Biol. 51, 3983 (2006).
    [CrossRef] [PubMed]
  7. D. C. Comsa, T. J. Farrell, and M. S. Patterson, Phys. Med. Biol. 53, 5797 (2008).
    [CrossRef] [PubMed]
  8. J. R. Mansfield, K. W. Gossage, C. C. Hoyt, and R. M. Levenson, J. Biomed. Opt. 10, 041207 (2005).
    [CrossRef]
  9. G. Y. Panasyuk, Z.-M. Wang, J. C. Schotland, and V. A. Markel, Opt. Lett. 33, 1744 (2008).
    [CrossRef] [PubMed]
  10. S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
    [CrossRef] [PubMed]
  11. S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
    [CrossRef] [PubMed]
  12. C. Vinegoni, D. Razansky, S. A. Hilderbrand, F. Shao, V. Ntziachristos, and R. Weissleder, Opt. Lett. 34, 2566 (2009).
    [CrossRef] [PubMed]
  13. C. T. Xu, J. Axelsson, and S. Andersson-Engels, Appl. Phys. Lett. 94, 251107 (2009).
    [CrossRef]
  14. H. J. Liang, G. Y. Chen, L. Li, Y. Liu, F. Qin, and Z. G. Zhang, Opt. Commun. 282, 3028 (2009).
    [CrossRef]
  15. C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
    [CrossRef]
  16. H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
    [CrossRef]
  17. J. P. Culver, V. Ntziachristos, M. J. Holboke, and A. G. Yodh, Opt. Lett. 26, 701 (2001).
    [CrossRef]
  18. E. Alerstam, S. Andersson-Engels, and T. Svensson, J. Biomed. Opt. 13, 041304 (2008).
    [CrossRef] [PubMed]

2009 (4)

C. Vinegoni, D. Razansky, S. A. Hilderbrand, F. Shao, V. Ntziachristos, and R. Weissleder, Opt. Lett. 34, 2566 (2009).
[CrossRef] [PubMed]

C. T. Xu, J. Axelsson, and S. Andersson-Engels, Appl. Phys. Lett. 94, 251107 (2009).
[CrossRef]

H. J. Liang, G. Y. Chen, L. Li, Y. Liu, F. Qin, and Z. G. Zhang, Opt. Commun. 282, 3028 (2009).
[CrossRef]

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

2008 (5)

G. Y. Panasyuk, Z.-M. Wang, J. C. Schotland, and V. A. Markel, Opt. Lett. 33, 1744 (2008).
[CrossRef] [PubMed]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

D. C. Comsa, T. J. Farrell, and M. S. Patterson, Phys. Med. Biol. 53, 5797 (2008).
[CrossRef] [PubMed]

E. Alerstam, S. Andersson-Engels, and T. Svensson, J. Biomed. Opt. 13, 041304 (2008).
[CrossRef] [PubMed]

2007 (1)

2006 (2)

A. Soubret and V. Ntziachristos, Phys. Med. Biol. 51, 3983 (2006).
[CrossRef] [PubMed]

S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
[CrossRef] [PubMed]

2005 (2)

A. Hielscher, Curr. Opin. Biotechnol. 16, 79 (2005).
[CrossRef] [PubMed]

J. R. Mansfield, K. W. Gossage, C. C. Hoyt, and R. M. Levenson, J. Biomed. Opt. 10, 041207 (2005).
[CrossRef]

2004 (1)

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

2002 (1)

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, Nat. Med. 8, 757 (2002).
[CrossRef] [PubMed]

2001 (1)

1999 (1)

S. R. Arridge, Inverse Probl. 15, R41 (1999).
[CrossRef]

Alerstam, E.

E. Alerstam, S. Andersson-Engels, and T. Svensson, J. Biomed. Opt. 13, 041304 (2008).
[CrossRef] [PubMed]

Andersson-Engels, S.

C. T. Xu, J. Axelsson, and S. Andersson-Engels, Appl. Phys. Lett. 94, 251107 (2009).
[CrossRef]

E. Alerstam, S. Andersson-Engels, and T. Svensson, J. Biomed. Opt. 13, 041304 (2008).
[CrossRef] [PubMed]

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Arridge, S. R.

Austin, R. H.

S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
[CrossRef] [PubMed]

Axelsson, J.

C. T. Xu, J. Axelsson, and S. Andersson-Engels, Appl. Phys. Lett. 94, 251107 (2009).
[CrossRef]

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Bogdanov, A.

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

Bremer, C.

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, Nat. Med. 8, 757 (2002).
[CrossRef] [PubMed]

Carpenter, C. M.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

Chen, G. Y.

H. J. Liang, G. Y. Chen, L. Li, Y. Liu, F. Qin, and Z. G. Zhang, Opt. Commun. 282, 3028 (2009).
[CrossRef]

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Choe, R.

Comsa, D. C.

D. C. Comsa, T. J. Farrell, and M. S. Patterson, Phys. Med. Biol. 53, 5797 (2008).
[CrossRef] [PubMed]

Corlu, A.

Culver, J. P.

Davis, S. C.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Dehghani, H.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Durduran, T.

Eames, M. E.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

Farrell, T. J.

D. C. Comsa, T. J. Farrell, and M. S. Patterson, Phys. Med. Biol. 53, 5797 (2008).
[CrossRef] [PubMed]

Gibbs-Strauss, S. L.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Gossage, K. W.

J. R. Mansfield, K. W. Gossage, C. C. Hoyt, and R. M. Levenson, J. Biomed. Opt. 10, 041207 (2005).
[CrossRef]

Graves, E.

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

Hielscher, A.

A. Hielscher, Curr. Opin. Biotechnol. 16, 79 (2005).
[CrossRef] [PubMed]

Hilderbrand, S. A.

Holboke, M. J.

Hoyt, C. C.

J. R. Mansfield, K. W. Gossage, C. C. Hoyt, and R. M. Levenson, J. Biomed. Opt. 10, 041207 (2005).
[CrossRef]

Jiang, S. S.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Josephson, L.

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

Khanarian, N.

S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
[CrossRef] [PubMed]

Leussler, C.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Levenson, R. M.

J. R. Mansfield, K. W. Gossage, C. C. Hoyt, and R. M. Levenson, J. Biomed. Opt. 10, 041207 (2005).
[CrossRef]

Li, L.

H. J. Liang, G. Y. Chen, L. Li, Y. Liu, F. Qin, and Z. G. Zhang, Opt. Commun. 282, 3028 (2009).
[CrossRef]

Liang, H. J.

H. J. Liang, G. Y. Chen, L. Li, Y. Liu, F. Qin, and Z. G. Zhang, Opt. Commun. 282, 3028 (2009).
[CrossRef]

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Lim, S. F.

S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
[CrossRef] [PubMed]

Liu, H. C.

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Liu, Y.

H. J. Liang, G. Y. Chen, L. Li, Y. Liu, F. Qin, and Z. G. Zhang, Opt. Commun. 282, 3028 (2009).
[CrossRef]

Mansfield, J. R.

J. R. Mansfield, K. W. Gossage, C. C. Hoyt, and R. M. Levenson, J. Biomed. Opt. 10, 041207 (2005).
[CrossRef]

Markel, V. A.

Mazurkewitz, P.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Ntziachristos, V.

C. Vinegoni, D. Razansky, S. A. Hilderbrand, F. Shao, V. Ntziachristos, and R. Weissleder, Opt. Lett. 34, 2566 (2009).
[CrossRef] [PubMed]

A. Soubret and V. Ntziachristos, Phys. Med. Biol. 51, 3983 (2006).
[CrossRef] [PubMed]

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, Nat. Med. 8, 757 (2002).
[CrossRef] [PubMed]

J. P. Culver, V. Ntziachristos, M. J. Holboke, and A. G. Yodh, Opt. Lett. 26, 701 (2001).
[CrossRef]

Panasyuk, G. Y.

Patterson, M. S.

D. C. Comsa, T. J. Farrell, and M. S. Patterson, Phys. Med. Biol. 53, 5797 (2008).
[CrossRef] [PubMed]

Paulsen, K. D.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Pogue, B. W.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Qin, F.

H. J. Liang, G. Y. Chen, L. Li, Y. Liu, F. Qin, and Z. G. Zhang, Opt. Commun. 282, 3028 (2009).
[CrossRef]

Razansky, D.

Riehn, R.

S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
[CrossRef] [PubMed]

Ripoll, J.

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

Rosen, M. A.

Ryu, W. S.

S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
[CrossRef] [PubMed]

Schellenberger, E. A.

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

Schnall, M. D.

Schotland, J. C.

Schweiger, M.

Shao, F.

Somesfalean, G.

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Soubret, A.

A. Soubret and V. Ntziachristos, Phys. Med. Biol. 51, 3983 (2006).
[CrossRef] [PubMed]

Springett, R.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Srinivasan, S.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

Svenmarker, P.

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Svensson, N.

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Svensson, T.

E. Alerstam, S. Andersson-Engels, and T. Svensson, J. Biomed. Opt. 13, 041304 (2008).
[CrossRef] [PubMed]

Tank, D.

S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
[CrossRef] [PubMed]

Tung, C.-H.

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, Nat. Med. 8, 757 (2002).
[CrossRef] [PubMed]

Tung, C.-K.

S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
[CrossRef] [PubMed]

Tuttle, S. B.

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Vinegoni, C.

Wang, Z.-M.

Weissleder, R.

C. Vinegoni, D. Razansky, S. A. Hilderbrand, F. Shao, V. Ntziachristos, and R. Weissleder, Opt. Lett. 34, 2566 (2009).
[CrossRef] [PubMed]

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, Nat. Med. 8, 757 (2002).
[CrossRef] [PubMed]

Xu, C. T.

C. T. Xu, J. Axelsson, and S. Andersson-Engels, Appl. Phys. Lett. 94, 251107 (2009).
[CrossRef]

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Yalavarthy, P. K.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

Yessayan, D.

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

Yodh, A. G.

Zhang, Z. G.

H. J. Liang, G. Y. Chen, L. Li, Y. Liu, F. Qin, and Z. G. Zhang, Opt. Commun. 282, 3028 (2009).
[CrossRef]

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Appl. Phys. Lett. (2)

C. T. Xu, J. Axelsson, and S. Andersson-Engels, Appl. Phys. Lett. 94, 251107 (2009).
[CrossRef]

C. T. Xu, N. Svensson, J. Axelsson, P. Svenmarker, G. Somesfalean, G. Y. Chen, H. J. Liang, H. C. Liu, Z. G. Zhang, and S. Andersson-Engels, Appl. Phys. Lett. 93, 171103 (2008).
[CrossRef]

Commun. Numer. Methods Eng. (1)

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009).
[CrossRef]

Curr. Opin. Biotechnol. (1)

A. Hielscher, Curr. Opin. Biotechnol. 16, 79 (2005).
[CrossRef] [PubMed]

Inverse Probl. (1)

S. R. Arridge, Inverse Probl. 15, R41 (1999).
[CrossRef]

J. Biomed. Opt. (2)

J. R. Mansfield, K. W. Gossage, C. C. Hoyt, and R. M. Levenson, J. Biomed. Opt. 10, 041207 (2005).
[CrossRef]

E. Alerstam, S. Andersson-Engels, and T. Svensson, J. Biomed. Opt. 13, 041304 (2008).
[CrossRef] [PubMed]

Nano Lett. (1)

S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C.-K. Tung, D. Tank, and R. H. Austin, Nano Lett. 6, 169 (2006).
[CrossRef] [PubMed]

Nat. Med. (1)

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, Nat. Med. 8, 757 (2002).
[CrossRef] [PubMed]

Opt. Commun. (1)

H. J. Liang, G. Y. Chen, L. Li, Y. Liu, F. Qin, and Z. G. Zhang, Opt. Commun. 282, 3028 (2009).
[CrossRef]

Opt. Express (1)

Opt. Lett. (3)

Phys. Med. Biol. (2)

A. Soubret and V. Ntziachristos, Phys. Med. Biol. 51, 3983 (2006).
[CrossRef] [PubMed]

D. C. Comsa, T. J. Farrell, and M. S. Patterson, Phys. Med. Biol. 53, 5797 (2008).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. USA (1)

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, L. Josephson, and R. Weissleder, Proc. Natl. Acad. Sci. USA 101, 12294 (2004).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (1)

S. C. Davis, B. W. Pogue, R. Springett, C. Leussler, P. Mazurkewitz, S. B. Tuttle, S. L. Gibbs-Strauss, S. S. Jiang, H. Dehghani, and K. D. Paulsen, Rev. Sci. Instrum. 79, 064302 (2008).
[CrossRef] [PubMed]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1
Fig. 1

Singular-value distribution of W.

Fig. 2
Fig. 2

Three-dimensional reconstruction of upconverting nanoparticles. (a) Reconstruction using only type-S images. (b) Reconstruction using the combined data from type-S and type-D images.

Fig. 3
Fig. 3

Cross-sectional slices of the reconstructed relative nanoparticle distribution at x = 17 mm . (a) Reconstruction with only type-S images. (b) Reconstruction with both type-S and type-D images.

Fig. 4
Fig. 4

Cross-sectional slices of the reconstructed relative rhodamine 6G distribution at x = 17 mm . (a) Reconstruction with only type-S images. (b) Reconstruction with both type-S and type-D images.

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

Γ k = i = 1 N U f * ( r d , r i ) n ( r i ) [ U e ( r s k , r i ) ] 2 Δ V i ,
Γ k & j = i = 1 N U f * ( r d , r i ) n ( r i ) [ U e ( r s k , r i ) + U e ( r s j , r i ) ] 2 Δ V i = 2 i = 1 N U f * ( r d , r i ) n ( r i ) U e ( r s k , r i ) U e ( r s j , r i ) Δ V i + Γ k + Γ j ,
W ( s , d ) , i = U f * ( r d , r i ) [ U e ( r s , r i ) ] γ Δ V i ,
W = U Σ V * ,

Metrics