Abstract

We present optical coherence tomography (OCT) measurements on fully physiologically oxygenated blood samples of varying hematocrit. We show that attenuation coefficients cannot be extracted quantitatively using the currently accepted models for the OCT signal from scattering media, because the confidence intervals obtained in the fitting procedure cannot be used as reliable uncertainty estimates of the attenuation coefficients. Better modeling of the hematocrit-dependent OCT signal is needed.

© 2009 Optical Society of America

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  1. D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Lett. 28, 1436 (2003).
    [CrossRef] [PubMed]
  2. D. J. Faber, M. C. G. Aalders, E. G. Mik, B. A. Hooper, M. J. C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
    [CrossRef] [PubMed]
  3. D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Lett. 30, 1015 (2005).
    [CrossRef] [PubMed]
  4. J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Opt. Soc. Am. A 15, 2288 (1998).
    [CrossRef]
  5. U. Morgner, W. Drexler, F. X. Kärtner, X. D. Li, C. Pitris, E. P. Ippen, and J. G. Fujimoto, Opt. Lett. 25, 111 (2000).
    [CrossRef]
  6. R. Leitgeb, M. Wojtkowski, A. Kowalczyk, C. K. Hitzenberger, M. Sticker, and A. F. Fercher, Opt. Lett. 25, 820 (2000).
    [CrossRef]
  7. C. Lu, C. Lee, M. Tsai, Y. Wang, and C. C. Yang, Opt. Lett. 33, 416 (2008).
    [CrossRef] [PubMed]
  8. L. Kagemann and G. Wollstein, J. Biomed. Opt. 12, 041212 (2007).
    [CrossRef] [PubMed]
  9. A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
    [CrossRef]
  10. M. Friebel, A. Roggan, G. Muller, and M. Meinke, J. Biomed. Opt. 11, 034021 (2006).
    [CrossRef]
  11. A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
    [CrossRef] [PubMed]
  12. D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Express 12, 4353 (2004).
    [CrossRef] [PubMed]
  13. L. Thrane, H. T. Yura, and P. E. Andersen, J. Opt. Soc. Am. A 17, 484 (2000).
    [CrossRef]
  14. D. Levitz, L. Thrane, M. H. Frosz, P. E. Andersen, C. B. Andersen, S. Andersson-Engels, J. Valanciunaite, J. Swartling, and P. R. Hansen, Opt. Express 12, 249 (2004).
    [CrossRef] [PubMed]
  15. F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005).
    [CrossRef] [PubMed]

2008 (2)

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

C. Lu, C. Lee, M. Tsai, Y. Wang, and C. C. Yang, Opt. Lett. 33, 416 (2008).
[CrossRef] [PubMed]

2007 (1)

L. Kagemann and G. Wollstein, J. Biomed. Opt. 12, 041212 (2007).
[CrossRef] [PubMed]

2006 (1)

M. Friebel, A. Roggan, G. Muller, and M. Meinke, J. Biomed. Opt. 11, 034021 (2006).
[CrossRef]

2005 (2)

F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005).
[CrossRef] [PubMed]

D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Lett. 30, 1015 (2005).
[CrossRef] [PubMed]

2004 (3)

2003 (1)

2000 (3)

1999 (1)

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

1998 (1)

Aalders, M. C. G.

Amelink, A.

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

Andersen, C. B.

Andersen, P. E.

Andersson-Engels, S.

Baraznji Sassoon, D.

F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005).
[CrossRef] [PubMed]

Dorschel, K.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Drexler, W.

Faber, D. J.

F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005).
[CrossRef] [PubMed]

D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Lett. 30, 1015 (2005).
[CrossRef] [PubMed]

D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Express 12, 4353 (2004).
[CrossRef] [PubMed]

D. J. Faber, M. C. G. Aalders, E. G. Mik, B. A. Hooper, M. J. C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
[CrossRef] [PubMed]

D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Lett. 28, 1436 (2003).
[CrossRef] [PubMed]

Fercher, A. F.

Friebel, M.

M. Friebel, A. Roggan, G. Muller, and M. Meinke, J. Biomed. Opt. 11, 034021 (2006).
[CrossRef]

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Frosz, M. H.

Fujimoto, J. G.

Hahn, A.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Hansen, P. R.

Hitzenberger, C. K.

Hooper, B. A.

D. J. Faber, M. C. G. Aalders, E. G. Mik, B. A. Hooper, M. J. C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
[CrossRef] [PubMed]

Ippen, E. P.

Kagemann, L.

L. Kagemann and G. Wollstein, J. Biomed. Opt. 12, 041212 (2007).
[CrossRef] [PubMed]

Kärtner, F. X.

Kowalczyk, A.

Lee, C.

Leitgeb, R.

Levitz, D.

Li, X. D.

Lu, C.

Meinke, M.

M. Friebel, A. Roggan, G. Muller, and M. Meinke, J. Biomed. Opt. 11, 034021 (2006).
[CrossRef]

Mik, E. G.

Morgner, U.

Muller, G.

M. Friebel, A. Roggan, G. Muller, and M. Meinke, J. Biomed. Opt. 11, 034021 (2006).
[CrossRef]

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Pasterkamp, G.

F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005).
[CrossRef] [PubMed]

Peree, J.

F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005).
[CrossRef] [PubMed]

Pitris, C.

Robinson, D. J.

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

Roggan, A.

M. Friebel, A. Roggan, G. Muller, and M. Meinke, J. Biomed. Opt. 11, 034021 (2006).
[CrossRef]

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

Schmitt, J. M.

Sterenborg, H. J. C. M.

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

Sticker, M.

Swartling, J.

Thrane, L.

Tsai, M.

Valanciunaite, J.

van der Meer, F. J.

F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005).
[CrossRef] [PubMed]

D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Express 12, 4353 (2004).
[CrossRef] [PubMed]

van Gemert, M. J. C.

D. J. Faber, M. C. G. Aalders, E. G. Mik, B. A. Hooper, M. J. C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
[CrossRef] [PubMed]

van Leeuwen, T. G.

F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005).
[CrossRef] [PubMed]

D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Lett. 30, 1015 (2005).
[CrossRef] [PubMed]

D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Express 12, 4353 (2004).
[CrossRef] [PubMed]

D. J. Faber, M. C. G. Aalders, E. G. Mik, B. A. Hooper, M. J. C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
[CrossRef] [PubMed]

D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Lett. 28, 1436 (2003).
[CrossRef] [PubMed]

Wang, Y.

Wojtkowski, M.

Wollstein, G.

L. Kagemann and G. Wollstein, J. Biomed. Opt. 12, 041212 (2007).
[CrossRef] [PubMed]

Xiang, S. H.

Yang, C. C.

Yung, K. M.

Yura, H. T.

J. Biomed. Opt. (4)

L. Kagemann and G. Wollstein, J. Biomed. Opt. 12, 041212 (2007).
[CrossRef] [PubMed]

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999).
[CrossRef]

M. Friebel, A. Roggan, G. Muller, and M. Meinke, J. Biomed. Opt. 11, 034021 (2006).
[CrossRef]

A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (2)

Lasers Med. Sci. (1)

F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005).
[CrossRef] [PubMed]

Opt. Express (2)

Opt. Lett. (5)

Phys. Rev. Lett. (1)

D. J. Faber, M. C. G. Aalders, E. G. Mik, B. A. Hooper, M. J. C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004).
[CrossRef] [PubMed]

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Figures (2)

Fig. 1
Fig. 1

Fitted attenuation coefficients versus hematocrit using the single-scattering model (○) and EHF model with θ rms as a free-running parameter (◼). Insets show representative signal profiles and fits using the single-scattering model (upper panel) and EHF model (lower panel). All fits are weighted with experimental errors.

Fig. 2
Fig. 2

Fitted scattering coefficients versus hematocrit with θ rms fixed as a values corresponding to g = 0.8 (○) and g = 0.995 (◼). Also shown are linear regressions with corresponding 95% confidence bounds. For g = 0.8 : μ t = ( 4.9 ± 0.6 ) × H , p = 0.002 . For g = 0.995 : μ t = ( 14 ± 1 ) × H , p = 0.0003 . Fits are weighted with experimental errors.

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