Abstract

We demonstrate a room-temperature-operated all-terahertz (THz) fiber-scanning near-field imaging system. The upright-type THz near-field microscope has a compact size, capable of being integrated with an optical microscope. This transmission illumination near-field system could be a promising tool to distinguish breast cancer from the normal tissue without pathologic staining.

© 2009 Optical Society of America

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2008 (2)

J.-Y. Lu, C.-M. Chiu, C.-C. Kuo, C. Lai, H.-C. Chang, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Appl. Phys. Lett. 92, 084102 (2008).
[CrossRef]

J.-Y. Lu, C.-C. Kuo, C.-M. Chiu, H.-W. Chen, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Opt. Express 16, 2494 (2008).
[CrossRef] [PubMed]

2007 (2)

2006 (4)

K. Ishihara, K. Ohashi, T. Ikari, H. Minamide, H. Yokoyama, J. Shikata, and H. Ito, Appl. Phys. Lett. 89, 201120 (2006).
[CrossRef]

A. Agrawal and A. Nahata, Opt. Express 14, 1973 (2006).
[CrossRef] [PubMed]

V. P. Wallace, E. MacPherson, A. J. Fitzgerald, T. Lo, E. Provenzano, S. Pinder, and A. Purushotham, Opt. Methods Life Sci. 6386, U183 (2006).

L.-J. Chen, H.-W. Chen, T.-F. Kao, J.-Y. Lu, and C.-K. Sun, Opt. Lett. 31, 308 (2006).
[CrossRef] [PubMed]

2004 (1)

T. Yuan, J. Z. Xu, and X.-C. Zhang, Infrared Phys. Technol. 45, 417 (2004).
[CrossRef]

2002 (1)

X.-C. Zhang, Phys. Med. Biol. 47, 3667 (2002).
[CrossRef] [PubMed]

2000 (1)

1998 (1)

S. Hunsche, M. Koch, I. Brener, and M. C. Nuss, Opt. Commun. 150, 22 (1998).
[CrossRef]

1944 (1)

H. A. Bethe, Phys. Rev. 66, 163 (1944).
[CrossRef]

Agrawal, A.

Bethe, H. A.

H. A. Bethe, Phys. Rev. 66, 163 (1944).
[CrossRef]

Brener, I.

S. Hunsche, M. Koch, I. Brener, and M. C. Nuss, Opt. Commun. 150, 22 (1998).
[CrossRef]

Chan, W. L.

W. L. Chan, J. Deibel, and D. M. Mittleman, Rep. Prog. Phys. 70, 1325 (2007).
[CrossRef]

Chang, H.-C.

J.-Y. Lu, C.-M. Chiu, C.-C. Kuo, C. Lai, H.-C. Chang, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Appl. Phys. Lett. 92, 084102 (2008).
[CrossRef]

Chen, H.-W.

Chen, L.-J.

Chen, Q.

Chiu, C.-M.

J.-Y. Lu, C.-M. Chiu, C.-C. Kuo, C. Lai, H.-C. Chang, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Appl. Phys. Lett. 92, 084102 (2008).
[CrossRef]

J.-Y. Lu, C.-C. Kuo, C.-M. Chiu, H.-W. Chen, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Opt. Express 16, 2494 (2008).
[CrossRef] [PubMed]

Deibel, J.

W. L. Chan, J. Deibel, and D. M. Mittleman, Rep. Prog. Phys. 70, 1325 (2007).
[CrossRef]

Fitzgerald, A. J.

V. P. Wallace, E. MacPherson, A. J. Fitzgerald, T. Lo, E. Provenzano, S. Pinder, and A. Purushotham, Opt. Methods Life Sci. 6386, U183 (2006).

Hunsche, S.

S. Hunsche, M. Koch, I. Brener, and M. C. Nuss, Opt. Commun. 150, 22 (1998).
[CrossRef]

Hwang, Y.-J.

J.-Y. Lu, C.-M. Chiu, C.-C. Kuo, C. Lai, H.-C. Chang, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Appl. Phys. Lett. 92, 084102 (2008).
[CrossRef]

J.-Y. Lu, C.-C. Kuo, C.-M. Chiu, H.-W. Chen, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Opt. Express 16, 2494 (2008).
[CrossRef] [PubMed]

Ikari, T.

K. Ishihara, K. Ohashi, T. Ikari, H. Minamide, H. Yokoyama, J. Shikata, and H. Ito, Appl. Phys. Lett. 89, 201120 (2006).
[CrossRef]

Ishihara, K.

K. Ishihara, K. Ohashi, T. Ikari, H. Minamide, H. Yokoyama, J. Shikata, and H. Ito, Appl. Phys. Lett. 89, 201120 (2006).
[CrossRef]

Ito, H.

K. Ishihara, K. Ohashi, T. Ikari, H. Minamide, H. Yokoyama, J. Shikata, and H. Ito, Appl. Phys. Lett. 89, 201120 (2006).
[CrossRef]

Jiang, Z. P.

Kao, T.-F.

Koch, M.

S. Hunsche, M. Koch, I. Brener, and M. C. Nuss, Opt. Commun. 150, 22 (1998).
[CrossRef]

Kuo, C.-C.

J.-Y. Lu, C.-M. Chiu, C.-C. Kuo, C. Lai, H.-C. Chang, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Appl. Phys. Lett. 92, 084102 (2008).
[CrossRef]

J.-Y. Lu, C.-C. Kuo, C.-M. Chiu, H.-W. Chen, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Opt. Express 16, 2494 (2008).
[CrossRef] [PubMed]

Kuo, J.-L.

Lai, C.

J.-Y. Lu, C.-M. Chiu, C.-C. Kuo, C. Lai, H.-C. Chang, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Appl. Phys. Lett. 92, 084102 (2008).
[CrossRef]

Li, Y.-T.

Lo, T.

V. P. Wallace, E. MacPherson, A. J. Fitzgerald, T. Lo, E. Provenzano, S. Pinder, and A. Purushotham, Opt. Methods Life Sci. 6386, U183 (2006).

Lu, J.-Y.

MacPherson, E.

V. P. Wallace, E. MacPherson, A. J. Fitzgerald, T. Lo, E. Provenzano, S. Pinder, and A. Purushotham, Opt. Methods Life Sci. 6386, U183 (2006).

Minamide, H.

K. Ishihara, K. Ohashi, T. Ikari, H. Minamide, H. Yokoyama, J. Shikata, and H. Ito, Appl. Phys. Lett. 89, 201120 (2006).
[CrossRef]

Mittleman, D. M.

W. L. Chan, J. Deibel, and D. M. Mittleman, Rep. Prog. Phys. 70, 1325 (2007).
[CrossRef]

Nahata, A.

Nuss, M. C.

S. Hunsche, M. Koch, I. Brener, and M. C. Nuss, Opt. Commun. 150, 22 (1998).
[CrossRef]

Ohashi, K.

K. Ishihara, K. Ohashi, T. Ikari, H. Minamide, H. Yokoyama, J. Shikata, and H. Ito, Appl. Phys. Lett. 89, 201120 (2006).
[CrossRef]

Pan, C.-L.

Pinder, S.

V. P. Wallace, E. MacPherson, A. J. Fitzgerald, T. Lo, E. Provenzano, S. Pinder, and A. Purushotham, Opt. Methods Life Sci. 6386, U183 (2006).

Provenzano, E.

V. P. Wallace, E. MacPherson, A. J. Fitzgerald, T. Lo, E. Provenzano, S. Pinder, and A. Purushotham, Opt. Methods Life Sci. 6386, U183 (2006).

Purushotham, A.

V. P. Wallace, E. MacPherson, A. J. Fitzgerald, T. Lo, E. Provenzano, S. Pinder, and A. Purushotham, Opt. Methods Life Sci. 6386, U183 (2006).

Shikata, J.

K. Ishihara, K. Ohashi, T. Ikari, H. Minamide, H. Yokoyama, J. Shikata, and H. Ito, Appl. Phys. Lett. 89, 201120 (2006).
[CrossRef]

Sun, C.-K.

Wallace, V. P.

V. P. Wallace, E. MacPherson, A. J. Fitzgerald, T. Lo, E. Provenzano, S. Pinder, and A. Purushotham, Opt. Methods Life Sci. 6386, U183 (2006).

Xu, G. X.

Xu, J. Z.

T. Yuan, J. Z. Xu, and X.-C. Zhang, Infrared Phys. Technol. 45, 417 (2004).
[CrossRef]

Yokoyama, H.

K. Ishihara, K. Ohashi, T. Ikari, H. Minamide, H. Yokoyama, J. Shikata, and H. Ito, Appl. Phys. Lett. 89, 201120 (2006).
[CrossRef]

Yuan, T.

T. Yuan, J. Z. Xu, and X.-C. Zhang, Infrared Phys. Technol. 45, 417 (2004).
[CrossRef]

Zhang, X.-C.

T. Yuan, J. Z. Xu, and X.-C. Zhang, Infrared Phys. Technol. 45, 417 (2004).
[CrossRef]

X.-C. Zhang, Phys. Med. Biol. 47, 3667 (2002).
[CrossRef] [PubMed]

Q. Chen, Z. P. Jiang, G. X. Xu, and X.-C. Zhang, Opt. Lett. 25, 1122 (2000).
[CrossRef]

Appl. Phys. Lett. (2)

K. Ishihara, K. Ohashi, T. Ikari, H. Minamide, H. Yokoyama, J. Shikata, and H. Ito, Appl. Phys. Lett. 89, 201120 (2006).
[CrossRef]

J.-Y. Lu, C.-M. Chiu, C.-C. Kuo, C. Lai, H.-C. Chang, Y.-J. Hwang, C.-L. Pan, and C.-K. Sun, Appl. Phys. Lett. 92, 084102 (2008).
[CrossRef]

Infrared Phys. Technol. (1)

T. Yuan, J. Z. Xu, and X.-C. Zhang, Infrared Phys. Technol. 45, 417 (2004).
[CrossRef]

Opt. Commun. (1)

S. Hunsche, M. Koch, I. Brener, and M. C. Nuss, Opt. Commun. 150, 22 (1998).
[CrossRef]

Opt. Express (2)

Opt. Lett. (3)

Opt. Methods Life Sci. (1)

V. P. Wallace, E. MacPherson, A. J. Fitzgerald, T. Lo, E. Provenzano, S. Pinder, and A. Purushotham, Opt. Methods Life Sci. 6386, U183 (2006).

Phys. Med. Biol. (1)

X.-C. Zhang, Phys. Med. Biol. 47, 3667 (2002).
[CrossRef] [PubMed]

Phys. Rev. (1)

H. A. Bethe, Phys. Rev. 66, 163 (1944).
[CrossRef]

Rep. Prog. Phys. (1)

W. L. Chan, J. Deibel, and D. M. Mittleman, Rep. Prog. Phys. 70, 1325 (2007).
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

(a) Schematic of the metallic bull’s-eye structure. (b) Calculated transmission enhancement factor of the bull’s-eye structure (normalized to an identical aperture with no grooves).

Fig. 2
Fig. 2

(a) Schematic of the all-THz fiber-scanning near-field microscope. The results of the measured (solid symbols) and simulated (open symbols) effective spatial resolution by a knife-edge method after (b) a single bare aperture and (c) an identical aperture surrounded by the bull’s-eye structure. The square symbols (circle symbols) indicate the results of X 0.9 0.1 ( Y 0.9 0.1 ) . (d) Normalized power transmission ratio measured at different fiber bending angles.

Fig. 3
Fig. 3

(a) and (b) are THz near-field absorption coefficient images of the breast tissue sections (samples 1 and 2). The insets show actual photographs of samples 1 and 2. (c) and (d) are photomicrographs of the breast tissue sections after H&E staining (samples 1 and 2).

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