Abstract

Multispeckle diffusing-wave spectroscopy (DWS) is used to measure blood flow transients in the human visual cortex following stimulation by 7.5Hz full-field and checkerboard flickering. The average decay time τd characterizing the decay of the DWS autocorrelation function shows a biphasic behavior; within about 2s after stimulation onset, τd increases rapidly to about 6% above the baseline value. At later times, τd slowly decreases and reaches a steady-state value about 5% below the baseline value after about 15s. The initial increase of the DWS signal suggests a transient reduction of the cortical blood flow velocity shortly after stimulation onset. Measurements of this transient response at different positions over the primary visual cortex show a spatial pattern different from the one measured by electroencephalography.

© 2008 Optical Society of America

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