Depth-resolved NADH autofluorescence images are shown to differentiate between normal and precancerous engineered tissues. An inverse power law behavior of the power spectral density (PSD) of these images is observed, indicating a self-affine organization of mitochondrial NADH at length scales 1–. Power exponents of the PSD functions vary significantly with tissue depth and precancerous state, giving insight into the morphological changes associated with precancerous lesions and providing substantial potential for noninvasive clinical diagnosis of squamous epithelial lesions and tumors.
© 2007 Optical Society of AmericaFull Article | PDF Article
A. Podshyvalov, R. K. Sahu, S. Mark, K. Kantarovich, H. Guterman, J. Goldstein, R. Jagannathan, S. Argov, and S. Mordechai
Appl. Opt. 44(18) 3725-3734 (2005)
Joanna Xylas, Addy Alt-Holland, Jonathan Garlick, Martin Hunter, and Irene Georgakoudi
Biomed. Opt. Express 1(5) 1387-1400 (2010)
Jonathan A. Palero, Arjen N. Bader, Henriëtte S. de Bruijn, Angélique van der Ploeg van den Heuvel, Henricus J. C. M. Sterenborg, and Hans C. Gerritsen
Biomed. Opt. Express 2(5) 1030-1039 (2011)