Abstract

An experimental validation of an inversion procedure for retrieving the optical properties of layered media from multidistance time-resolved reflectance measurements is presented. The results cover a wide range of optical properties, showing excellent effectiveness and reliability of the procedure in reconstructing the optical properties of a two-layered medium. The optical properties of the first layer and the absorption of the second layer could be retrieved with excellent precision, whereas the reduced scattering coefficient of the second layer was reconstructed with a large error. The first layer thickness could be retrieved with an error less than 50%. An example of retrieval of the optical properties of muscle from in vivo measurements during an arterial occlusion is shown.

© 2004 Optical Society of America

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References

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  1. F. Martelli, S. Del Bianco, and G. Zaccanti, Opt. Lett. 28, 1236 (2003).
    [CrossRef] [PubMed]
  2. R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, Appl. Phys. Lett. 74, 874 (1999).
    [CrossRef]
  3. A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, J. Biomed. Opt. 8, 512 (2003).
    [CrossRef] [PubMed]
  4. F. Martelli, A. Sassaroli, S. Del Bianco, Y. Yamada, and G. Zaccanti, Phys. Rev. E 67, 056623 (2003).
    [CrossRef]
  5. A. Pifferi, A. Torricelli, P. Taroni, and R. Cubeddu, Opt. Lett. 26, 1963 (2001).
    [CrossRef]
  6. A. Kienle, T. Glanzmann, G. Wagnieres, and H. van den Berg, Appl. Opt. 37, 6852 (1998).
    [CrossRef]
  7. A. Kienle and T. Glanzmann, Phys. Med. Biol. 44, 2689 (1999).
    [CrossRef] [PubMed]

2003 (3)

A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, J. Biomed. Opt. 8, 512 (2003).
[CrossRef] [PubMed]

F. Martelli, A. Sassaroli, S. Del Bianco, Y. Yamada, and G. Zaccanti, Phys. Rev. E 67, 056623 (2003).
[CrossRef]

F. Martelli, S. Del Bianco, and G. Zaccanti, Opt. Lett. 28, 1236 (2003).
[CrossRef] [PubMed]

2001 (1)

1999 (2)

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, Appl. Phys. Lett. 74, 874 (1999).
[CrossRef]

A. Kienle and T. Glanzmann, Phys. Med. Biol. 44, 2689 (1999).
[CrossRef] [PubMed]

1998 (1)

Cubeddu, R.

A. Pifferi, A. Torricelli, P. Taroni, and R. Cubeddu, Opt. Lett. 26, 1963 (2001).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, Appl. Phys. Lett. 74, 874 (1999).
[CrossRef]

Del Bianco, S.

F. Martelli, A. Sassaroli, S. Del Bianco, Y. Yamada, and G. Zaccanti, Phys. Rev. E 67, 056623 (2003).
[CrossRef]

F. Martelli, S. Del Bianco, and G. Zaccanti, Opt. Lett. 28, 1236 (2003).
[CrossRef] [PubMed]

Glanzmann, T.

Grosenick, D.

A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, J. Biomed. Opt. 8, 512 (2003).
[CrossRef] [PubMed]

Kienle, A.

Liebert, A.

A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, J. Biomed. Opt. 8, 512 (2003).
[CrossRef] [PubMed]

Macdonald, R.

A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, J. Biomed. Opt. 8, 512 (2003).
[CrossRef] [PubMed]

Martelli, F.

F. Martelli, A. Sassaroli, S. Del Bianco, Y. Yamada, and G. Zaccanti, Phys. Rev. E 67, 056623 (2003).
[CrossRef]

F. Martelli, S. Del Bianco, and G. Zaccanti, Opt. Lett. 28, 1236 (2003).
[CrossRef] [PubMed]

Pifferi, A.

A. Pifferi, A. Torricelli, P. Taroni, and R. Cubeddu, Opt. Lett. 26, 1963 (2001).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, Appl. Phys. Lett. 74, 874 (1999).
[CrossRef]

Sassaroli, A.

F. Martelli, A. Sassaroli, S. Del Bianco, Y. Yamada, and G. Zaccanti, Phys. Rev. E 67, 056623 (2003).
[CrossRef]

Taroni, P.

A. Pifferi, A. Torricelli, P. Taroni, and R. Cubeddu, Opt. Lett. 26, 1963 (2001).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, Appl. Phys. Lett. 74, 874 (1999).
[CrossRef]

Torricelli, A.

A. Pifferi, A. Torricelli, P. Taroni, and R. Cubeddu, Opt. Lett. 26, 1963 (2001).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, Appl. Phys. Lett. 74, 874 (1999).
[CrossRef]

Valentini, G.

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, Appl. Phys. Lett. 74, 874 (1999).
[CrossRef]

van den Berg, H.

Wabnitz, H.

A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, J. Biomed. Opt. 8, 512 (2003).
[CrossRef] [PubMed]

Wagnieres, G.

Yamada, Y.

F. Martelli, A. Sassaroli, S. Del Bianco, Y. Yamada, and G. Zaccanti, Phys. Rev. E 67, 056623 (2003).
[CrossRef]

Zaccanti, G.

F. Martelli, A. Sassaroli, S. Del Bianco, Y. Yamada, and G. Zaccanti, Phys. Rev. E 67, 056623 (2003).
[CrossRef]

F. Martelli, S. Del Bianco, and G. Zaccanti, Opt. Lett. 28, 1236 (2003).
[CrossRef] [PubMed]

Appl. Opt. (1)

Appl. Phys. Lett. (1)

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, Appl. Phys. Lett. 74, 874 (1999).
[CrossRef]

J. Biomed. Opt. (1)

A. Liebert, H. Wabnitz, D. Grosenick, and R. Macdonald, J. Biomed. Opt. 8, 512 (2003).
[CrossRef] [PubMed]

Opt. Lett. (2)

Phys. Med. Biol. (1)

A. Kienle and T. Glanzmann, Phys. Med. Biol. 44, 2689 (1999).
[CrossRef] [PubMed]

Phys. Rev. E (1)

F. Martelli, A. Sassaroli, S. Del Bianco, Y. Yamada, and G. Zaccanti, Phys. Rev. E 67, 056623 (2003).
[CrossRef]

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Figures (3)

Fig. 1
Fig. 1

Retrieved optical properties versus measurement number. Curves, calibration values of the optical properties; points, values retrieved from fits based on a two-layered model. Fit A, fitting results when s0 was kept constant at the true value of 9 mm; Fit B, values retrieved when s0 was fitted.

Fig. 2
Fig. 2

Comparison of different types of fit based on the solution of the diffusion equation for a homogeneous medium. Curves, calibration values of the optical properties of the two layers (solid curve, first layer; dotted curve, second layer); points, values retrieved from the fit.

Fig. 3
Fig. 3

Time course of the retrieved absorption coefficient of muscle from in vivo time-resolved reflectance measurements at 720 nm during a 4-min (t=26 min) arterial occlusion (250 mmHg) on a human forearm.

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