Abstract

A tunable diode laser absorption spectroscopy (TDLAS) system equipped with a IV–VI mid-IR laser operating near 5.2 µm was used to measure exhaled nitric oxide (eNO) and carbon dioxide CO2 simultaneously in human breath over a single exhalation. Breath was sampled in real time, and eNO levels were measured from seven volunteers, two steroid-naive asthmatics and five nonasthmatics. Measured CO2 levels were used as an internal standard to verify correct breath collection and calculate eNO values. Calculated eNO concentrations agreed well with reported values for asthmatic and nonasthmatic individuals.

© 2002 Optical Society of America

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  1. M. Bernaraggi and G. Cremona, Pulmonary Pharmacology Therapeutics 12, 331 (1999).
    [CrossRef]
  2. S. A. Kharitonov and P. J. Barnes, Eur. Respir. J. 16, 781 (2000).
    [CrossRef] [PubMed]
  3. K. Alving, E. Weitzberg, and J. M. Lundberg, Eur. Respir. J. 6, 1368 (1993).
    [PubMed]
  4. S. A. Kharitonov, D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shineboume, and P. J. Barnes, Lancet 343, 133 (1994).
    [CrossRef] [PubMed]
  5. A. Jatakanon, S. Lim, S. A. Kharitonov, K. F. Chung, and P. J. Barnes, Thorax 53, 91 (1998).
    [CrossRef] [PubMed]
  6. P. E. Silkoff, Am. J. Respir. Crit. Care Med. 160, 2104 (1999).
  7. N. Binding, W. Muller, and P. A. Czeschinski, Eur. Respir. J. 6, 499 (2000).
    [CrossRef]
  8. V. Hampl, C. L. Walters, and S. L. Archer, in Methods in Nitric Oxide Research, M. Feelisch and J. S. Stamler, eds. (Wiley, New York, 1996), Chap. 21.
  9. A. I. Kouznetsov, Yu. G. Selivanov, Yu. A. Shulagin, E. V. Stepanov, and P. V. Zyrianov, in Proceedings of the 2nd International Conference on Tunable Diode Laser Spectroscopy (General Physics Institute, Moscow, 1998), pp. 43–44.
  10. E. V. Stepanov, P. V. Zyrianov, and V. A. Miliaev, Proc. SPIE 3829, 103 (1999).
    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef]
  14. D. H. Yates, Immun. Cell Biol. 79, 178 (2001).
    [CrossRef]

2001 (1)

D. H. Yates, Immun. Cell Biol. 79, 178 (2001).
[CrossRef]

2000 (2)

S. A. Kharitonov and P. J. Barnes, Eur. Respir. J. 16, 781 (2000).
[CrossRef] [PubMed]

N. Binding, W. Muller, and P. A. Czeschinski, Eur. Respir. J. 6, 499 (2000).
[CrossRef]

1999 (3)

E. V. Stepanov, P. V. Zyrianov, and V. A. Miliaev, Proc. SPIE 3829, 103 (1999).
[CrossRef]

P. E. Silkoff, Am. J. Respir. Crit. Care Med. 160, 2104 (1999).

M. Bernaraggi and G. Cremona, Pulmonary Pharmacology Therapeutics 12, 331 (1999).
[CrossRef]

1998 (2)

A. Jatakanon, S. Lim, S. A. Kharitonov, K. F. Chung, and P. J. Barnes, Thorax 53, 91 (1998).
[CrossRef] [PubMed]

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

1994 (1)

S. A. Kharitonov, D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shineboume, and P. J. Barnes, Lancet 343, 133 (1994).
[CrossRef] [PubMed]

1993 (1)

K. Alving, E. Weitzberg, and J. M. Lundberg, Eur. Respir. J. 6, 1368 (1993).
[PubMed]

1991 (1)

Alving, K.

K. Alving, E. Weitzberg, and J. M. Lundberg, Eur. Respir. J. 6, 1368 (1993).
[PubMed]

Archer, S. L.

V. Hampl, C. L. Walters, and S. L. Archer, in Methods in Nitric Oxide Research, M. Feelisch and J. S. Stamler, eds. (Wiley, New York, 1996), Chap. 21.

Barnes, P. J.

S. A. Kharitonov and P. J. Barnes, Eur. Respir. J. 16, 781 (2000).
[CrossRef] [PubMed]

A. Jatakanon, S. Lim, S. A. Kharitonov, K. F. Chung, and P. J. Barnes, Thorax 53, 91 (1998).
[CrossRef] [PubMed]

S. A. Kharitonov, D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shineboume, and P. J. Barnes, Lancet 343, 133 (1994).
[CrossRef] [PubMed]

Bernaraggi, M.

M. Bernaraggi and G. Cremona, Pulmonary Pharmacology Therapeutics 12, 331 (1999).
[CrossRef]

Binding, N.

N. Binding, W. Muller, and P. A. Czeschinski, Eur. Respir. J. 6, 499 (2000).
[CrossRef]

Brown, J. M.

J. J. Carr and J. M. Brown, in Introduction to Biomedical Equipment Technology, C. E. Stewart, ed. (Prentice-Hall, Englewood Cliffs, N.J., 1998), 3rd ed.

Brown, L. R.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Camy-Peyret, C.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Carr, J. J.

J. J. Carr and J. M. Brown, in Introduction to Biomedical Equipment Technology, C. E. Stewart, ed. (Prentice-Hall, Englewood Cliffs, N.J., 1998), 3rd ed.

Chance, K. V.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Chung, K. F.

A. Jatakanon, S. Lim, S. A. Kharitonov, K. F. Chung, and P. J. Barnes, Thorax 53, 91 (1998).
[CrossRef] [PubMed]

Cremona, G.

M. Bernaraggi and G. Cremona, Pulmonary Pharmacology Therapeutics 12, 331 (1999).
[CrossRef]

Czeschinski, P. A.

N. Binding, W. Muller, and P. A. Czeschinski, Eur. Respir. J. 6, 499 (2000).
[CrossRef]

Dana, V.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Drummond, J. R.

Edwards, D. P.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Flaud, J.-M.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Fox, J.

Fried, A.

Gamache, R. R.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Goldman, A.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Hampl, V.

V. Hampl, C. L. Walters, and S. L. Archer, in Methods in Nitric Oxide Research, M. Feelisch and J. S. Stamler, eds. (Wiley, New York, 1996), Chap. 21.

Henry, B.

Jatakanon, A.

A. Jatakanon, S. Lim, S. A. Kharitonov, K. F. Chung, and P. J. Barnes, Thorax 53, 91 (1998).
[CrossRef] [PubMed]

Jucks, K. W.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Kharitonov, S. A.

S. A. Kharitonov and P. J. Barnes, Eur. Respir. J. 16, 781 (2000).
[CrossRef] [PubMed]

A. Jatakanon, S. Lim, S. A. Kharitonov, K. F. Chung, and P. J. Barnes, Thorax 53, 91 (1998).
[CrossRef] [PubMed]

S. A. Kharitonov, D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shineboume, and P. J. Barnes, Lancet 343, 133 (1994).
[CrossRef] [PubMed]

Kouznetsov, A. I.

A. I. Kouznetsov, Yu. G. Selivanov, Yu. A. Shulagin, E. V. Stepanov, and P. V. Zyrianov, in Proceedings of the 2nd International Conference on Tunable Diode Laser Spectroscopy (General Physics Institute, Moscow, 1998), pp. 43–44.

Lim, S.

A. Jatakanon, S. Lim, S. A. Kharitonov, K. F. Chung, and P. J. Barnes, Thorax 53, 91 (1998).
[CrossRef] [PubMed]

Logan-Sinclair, R.

S. A. Kharitonov, D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shineboume, and P. J. Barnes, Lancet 343, 133 (1994).
[CrossRef] [PubMed]

Lundberg, J. M.

K. Alving, E. Weitzberg, and J. M. Lundberg, Eur. Respir. J. 6, 1368 (1993).
[PubMed]

Mandin, J.-Y.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Massie, S. T.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

McCann, A.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Miliaev, V. A.

E. V. Stepanov, P. V. Zyrianov, and V. A. Miliaev, Proc. SPIE 3829, 103 (1999).
[CrossRef]

Muller, W.

N. Binding, W. Muller, and P. A. Czeschinski, Eur. Respir. J. 6, 499 (2000).
[CrossRef]

Nemtchinov, V.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Perrin, A.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Rinsland, C. P.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Robbins, R. A.

S. A. Kharitonov, D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shineboume, and P. J. Barnes, Lancet 343, 133 (1994).
[CrossRef] [PubMed]

Rothman, L. S.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Schroeder, J.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Selivanov, Yu. G.

A. I. Kouznetsov, Yu. G. Selivanov, Yu. A. Shulagin, E. V. Stepanov, and P. V. Zyrianov, in Proceedings of the 2nd International Conference on Tunable Diode Laser Spectroscopy (General Physics Institute, Moscow, 1998), pp. 43–44.

Shineboume, E. A.

S. A. Kharitonov, D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shineboume, and P. J. Barnes, Lancet 343, 133 (1994).
[CrossRef] [PubMed]

Shulagin, Yu. A.

A. I. Kouznetsov, Yu. G. Selivanov, Yu. A. Shulagin, E. V. Stepanov, and P. V. Zyrianov, in Proceedings of the 2nd International Conference on Tunable Diode Laser Spectroscopy (General Physics Institute, Moscow, 1998), pp. 43–44.

Silkoff, P. E.

P. E. Silkoff, Am. J. Respir. Crit. Care Med. 160, 2104 (1999).

Stepanov, E. V.

E. V. Stepanov, P. V. Zyrianov, and V. A. Miliaev, Proc. SPIE 3829, 103 (1999).
[CrossRef]

A. I. Kouznetsov, Yu. G. Selivanov, Yu. A. Shulagin, E. V. Stepanov, and P. V. Zyrianov, in Proceedings of the 2nd International Conference on Tunable Diode Laser Spectroscopy (General Physics Institute, Moscow, 1998), pp. 43–44.

Varanasi, P.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Walters, C. L.

V. Hampl, C. L. Walters, and S. L. Archer, in Methods in Nitric Oxide Research, M. Feelisch and J. S. Stamler, eds. (Wiley, New York, 1996), Chap. 21.

Wattson, R. B.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Weitzberg, E.

K. Alving, E. Weitzberg, and J. M. Lundberg, Eur. Respir. J. 6, 1368 (1993).
[PubMed]

Yates, D.

S. A. Kharitonov, D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shineboume, and P. J. Barnes, Lancet 343, 133 (1994).
[CrossRef] [PubMed]

Yates, D. H.

D. H. Yates, Immun. Cell Biol. 79, 178 (2001).
[CrossRef]

Yoshino, K.

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Zyrianov, P. V.

E. V. Stepanov, P. V. Zyrianov, and V. A. Miliaev, Proc. SPIE 3829, 103 (1999).
[CrossRef]

A. I. Kouznetsov, Yu. G. Selivanov, Yu. A. Shulagin, E. V. Stepanov, and P. V. Zyrianov, in Proceedings of the 2nd International Conference on Tunable Diode Laser Spectroscopy (General Physics Institute, Moscow, 1998), pp. 43–44.

Am. J. Respir. Crit. Care Med. (1)

P. E. Silkoff, Am. J. Respir. Crit. Care Med. 160, 2104 (1999).

Appl. Opt. (1)

Eur. Respir. J. (3)

N. Binding, W. Muller, and P. A. Czeschinski, Eur. Respir. J. 6, 499 (2000).
[CrossRef]

S. A. Kharitonov and P. J. Barnes, Eur. Respir. J. 16, 781 (2000).
[CrossRef] [PubMed]

K. Alving, E. Weitzberg, and J. M. Lundberg, Eur. Respir. J. 6, 1368 (1993).
[PubMed]

Immun. Cell Biol. (1)

D. H. Yates, Immun. Cell Biol. 79, 178 (2001).
[CrossRef]

J. Quant. Spectrosc. Radiat. Transfer (1)

L. S. Rothman, C. P. Rinsland, A. Goldman, S. T. Massie, D. P. Edwards, J.-M. Flaud, A. Perrin, C. Camy-Peyret, V. Dana, J.-Y. Mandin, J. Schroeder, A. McCann, R. R. Gamache, R. B. Wattson, K. Yoshino, K. V. Chance, K. W. Jucks, L. R. Brown, V. Nemtchinov, and P. Varanasi, J. Quant. Spectrosc. Radiat. Transfer 60, 65 (1998).
[CrossRef]

Lancet (1)

S. A. Kharitonov, D. Yates, R. A. Robbins, R. Logan-Sinclair, E. A. Shineboume, and P. J. Barnes, Lancet 343, 133 (1994).
[CrossRef] [PubMed]

Proc. SPIE (1)

E. V. Stepanov, P. V. Zyrianov, and V. A. Miliaev, Proc. SPIE 3829, 103 (1999).
[CrossRef]

Pulmonary Pharmacology Therapeutics (1)

M. Bernaraggi and G. Cremona, Pulmonary Pharmacology Therapeutics 12, 331 (1999).
[CrossRef]

Thorax (1)

A. Jatakanon, S. Lim, S. A. Kharitonov, K. F. Chung, and P. J. Barnes, Thorax 53, 91 (1998).
[CrossRef] [PubMed]

Other (3)

V. Hampl, C. L. Walters, and S. L. Archer, in Methods in Nitric Oxide Research, M. Feelisch and J. S. Stamler, eds. (Wiley, New York, 1996), Chap. 21.

A. I. Kouznetsov, Yu. G. Selivanov, Yu. A. Shulagin, E. V. Stepanov, and P. V. Zyrianov, in Proceedings of the 2nd International Conference on Tunable Diode Laser Spectroscopy (General Physics Institute, Moscow, 1998), pp. 43–44.

J. J. Carr and J. M. Brown, in Introduction to Biomedical Equipment Technology, C. E. Stewart, ed. (Prentice-Hall, Englewood Cliffs, N.J., 1998), 3rd ed.

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Figures (3)

Fig. 1
Fig. 1

Experimental setup, including a cryostat (circle) with a laser and detector inside, an off-axis parabolic mirror (OAPM), a White cell, and control and acquisition components.

Fig. 2
Fig. 2

Second-harmonic spectrum of measured-breath NO, CO2, and H2O near 1912.79, 1912.69, and 1912.55 cm-1, respectively, with corresponding HITRAN data plotted below.

Fig. 3
Fig. 3

Trends in recorded magnitude absorption, at, plotted for eNO and CO2 during exhalation from a steroid-naive asthmatic volunteer and a normal volunteer.

Tables (1)

Tables Icon

Table 1 Measured eNO Concentrations [in ppb] from Seven Subjects

Equations (2)

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ANOACO2=aNOMAXaCO2 MAXVNO-VBLVCO2-VBL.
CeNO=ANOACO2gNOgCO2SνCO2SνNOCCO2

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