Abstract

We developed second-generation (G2) optical-resolution photoacoustic microscopy (OR-PAM). Incorporation of a novel acoustic detection scheme improved upon the sensitivity of our first-generation (G1) system by 18.4dB, deepening the in vivo tissue penetration to 1.2mm at 570nm. Moreover, translating the imaging head instead of the living object accelerated the scanning speed by a factor of 5, widening the field of view within the same acquisition time. Mouse ears, as well as mouse brains with intact craniums, were imaged in vivo in both total concentration and oxygen saturation of hemoglobin.

© 2011 Optical Society of America

Full Article  |  PDF Article
More Like This
Near-infrared optical-resolution photoacoustic microscopy

Pengfei Hai, Junjie Yao, Konstantin I. Maslov, Yong Zhou, and Lihong V. Wang
Opt. Lett. 39(17) 5192-5195 (2014)

Multifocal optical-resolution photoacoustic microscopy in vivo

Liang Song, Konstantin Maslov, and Lihong V. Wang
Opt. Lett. 36(7) 1236-1238 (2011)

Fully motorized optical-resolution photoacoustic microscopy

Lei Li, Chenghung Yeh, Song Hu, Lidai Wang, Brian T. Soetikno, Ruimin Chen, Qifa Zhou, K. Kirk Shung, Konstantin I. Maslov, and Lihong V. Wang
Opt. Lett. 39(7) 2117-2120 (2014)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription