Abstract

We have demonstrated functional optical coherence tomography (fOCT) for neural imaging by detecting scattering changes during the propagation of action potentials through neural tissue. OCT images of nerve fibers from the abdominal ganglion of the sea slug Aplysia californica were taken before, during, and after electrical stimulation. Images acquired during stimulation showed localized reversible increases in scattering compared with those acquired before stimulation. Motion-mode OCT images of nerve fibers showed transient scattering changes from spontaneous action potentials. These results demonstrate that OCT is sensitive to the optical changes in electrically active nerve fibers.

© 2003 Optical Society of America

Full Article  |  PDF Article
More Like This
Detecting intrinsic scattering changes correlated to neuron action potentials using optical coherence imaging

Benedikt W. Graf, Tyler S. Ralston, Han-Jo Ko, and Stephen A. Boppart
Opt. Express 17(16) 13447-13457 (2009)

Optical stimulation of neural tissue in vivo

Jonathon Wells, Chris Kao, Karthik Mariappan, Jeffrey Albea, E. Duco Jansen, Peter Konrad, and Anita Mahadevan-Jansen
Opt. Lett. 30(5) 504-506 (2005)

Complete optical neurophysiology: toward optical stimulation and recording of neural tissue

Fred A. Wininger, Jennifer L. Schei, and David M. Rector
Appl. Opt. 48(10) D218-D224 (2009)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription