Abstract

We demonstrate the fabrication of a Vernier effect SU8/PMATRIFE polymer optical biosensor with high homogeneous sensitivity using a standard photolithography process. The sensor is based on one micro-resonator embedded on each arm of a Mach-Zehnder interferometer. Measurements are based on the refractive index variation of the optical waveguide superstrate with different concentrations of glucose solutions. The sensitivity of the sensor has been measured as 17558 nm/RIU and the limit of detection has been estimated to 1.1.10−6 RIU.

© 2017 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

1. Introduction

The increasing demand for ultra-sensitive and compact sensors for rapid and specific detection of various biochemical analytes has induced a large development of integrated optical waveguide-based label free sensors. Unlike optical fiber sensors, integrated optical sensors can be easily miniaturized and thus have the potential to be integrated in large numbers over a small area in order to implement laboratories-on-chip (LOC) [1]. Multi-detection is possible since integrated optical sensor arrays for the detection of different molecules from the same sample can be fabricated on the same chip [2].

Several configurations of integrated optical sensors using bulk materials have been demonstrated with the objective of increasing the sensitivity as well as reducing the limit of detection as in, for example, Mach-Zehnder (MZ) interferometers [3], surface Plasmon sensors [4], grating couplers [5], photonic crystal [6] and micro-resonators (MR) [7]...

One solution for increasing the sensitivity of an integrated interferometer based on an optical sensor such as the Mach-Zehnder is to increase the length interaction between the target molecules and the light, but this however reduces the capacity for miniaturization. MR-based sensors have been extensively researched the last few years to exploit their resonant properties [8] which makes it possible to overcome the increase in the interaction length.

To further increase the sensitivity of such an integrated optical sensor, Vernier effect configurations based on cascaded MRs or using both MZ and MR, are now widely recognized in integrated optics applications not only for filtering applications [9] but also increasingly for the detection of various substances [10]. Sensitivities are enhanced by a factor, up to several hundred times that of a single MR, which can then reduce the sensor limit of detection or ease the detection of low concentration analytes using simplified experimental setups. State of the art Vernier effect devices and performances have been described in [11-12]. Various Vernier effect configurations in silicon-on-insulator (SOI) or in silicon nitride (SiN) have been proposed experimentally as, for example, the commonly used cascaded MR [11–14], a MR cascaded with a MZ [15], two cascaded MZs [16] and very recently, three cascaded MRs [17]. A structure with one MR embedded on each arm of a MZ has also been studied theoretically [18].

In this work, the advantage of the last configuration is investigated theoretically and experimentally using polymer materials as they offer both low cost mass production with standard clean room setups and low propagation losses [19]. PMATRIFE (Poly(2,2,2 MethAcrylate of TRIFluoro-Ethyl)) polymer is used as optical confinement layer for both cladding and superstrate and SU8 is used for the waveguide core. The novelty consists in taking advantage of these low cost polymer materials to implement a Vernier effect biosensor, based on MR embedded on each arm of a MZ, which achieves very high sensitivity in agreement with a theoretical study. After the presentation of the design and the fabrication of the Vernier effect sensor, theoretical and experimental results of sensing are presented and discussed.

2. Design of Vernier effect polymer optical transducer

The MZ pass configuration sensor studied is represented in Fig. 1(a). It is made up of a sensor MR on the sensing arm and a reference MR on the reference arm, both based on SU8/PMATRIFE waveguides. The sensor MR is directly exposed to the solution to be detected by means of a reservoir (white rectangle) etched in the PMATRIFE superstrate covering the reference part of the sensor. The transmission function of this sensor is given by the expression [18]:

T(λ)=14(|Esens.|2+|Eref.|2)+12|Esens.||Eref.|cos(arg(|Esens.|)arg(|Eref.|))
with Eref. and Esens., the expression of the electromagnetic field at the output of the sensor MR and the reference MR respectively for a unit amplitude TE polarization electromagnetic field excitation. The expression of the electromagnetic field at the output of the reference and sensor MR are given by the reference [20]:
Eref.,sens.=τref.,sens.eαref.,sens.Lref.,sens.ejφ1τref.,sens.eαref.,sens.Lref.,sens.ejφEin
with Ein the amplitude of the incident field at the input of the Vernier effect transducer. Lref. and Lsens. noticed as Lref.,sens. in Eq. (2), are the length of the reference and sensor MR respectively. Similarly, αref. and αsens. noticed as αref.,sens. are the propagation losses in the reference and sensor MR respectively. Likewise, τref. and τsens., expressed as τref.,sens., are the self-coupling coefficient of the reference and sensor MR respectively. In this study, lossless coupling is considered, so the relation between self-coupling τ and cross coupling coefficient κ is τref.,sens.2+κref.,sens.2=1. The single pass phase shift is defined as φ=Lref.,sens.neffref.,sens.β with β the propagation constant, neffreff.and neffsens.are the respective effective indices of the reference MR and the sensor MR as calculated by P.Girault et.al. for SU8/PMATRIFE waveguides [19-20].

 figure: Fig. 1

Fig. 1 a) Representation of the Vernier effect MZ-pass configuration sensor, b) Dependence of the curvature losses with the radius for the reference waveguides and the sensor waveguides, c) Coupling region of the MR

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In order to design the Vernier effect transducer, the length of each MR must be carefully calculated to achieve both high sensitivity and measurable envelope period in the range of detection. Indeed, the Vernier sensitivity Sv is defined as [13]:

SV=SMRGV=SMRFSRref.|FSRsens.FSRref.|
with SMR the sensitivity of a single polymer MR and Gv the amelioration factor between single MR sensor and Vernier sensor sensitivity. FSRref and FSRsens. are the free spectral range of the reference MR or of the sensor MR and are given by:
FSRref.,sens.=λres2Lref.,sens.neffreff.,sens.
the sensitivity of one MR (sensor MR) is then given by:
SMR(nm/RIU)=λneffsens.neffsens.nssens.=λresneffsens.Δneffsens.Δnssens.
with ns,sens, the refractive index of the superstrate (solution in the sensing reservoir) and neffsens./nssens.the variation of the effective index of the MR sensor waveguide with the variation of the superstrate refractive index in the reservoir. The period of the Vernier transmission function envelope is defined as [13]:

TV=FSRref.FSRsens.|FSRsens.FSRref.|

The MR perimeter has been calculated as 5500 μm and 5559 μm for the sensor MR and reference MR respectively to achieve both high sensitivity and measurable envelope period, taking into account Eq. (1) and Eq. (4) and experimental tunable laser source range limitation of 100 nm between 1500 nm and 1600 nm.

The overall losses for SU8/PMATRIFE polymer waveguides have been estimated previously for the determination of a single MR characteristics as αref. = 2 dB/cm [19] for the reference part of the MR and αsens. = 6 dB/cm for the waveguide exposed to the analyte solution (glucose solubilized in deionized water) [20]. A radius R = 100 μm is defined in Fig. 1(c) in all bend radii in the device to minimize curvature losses calculated with FIMMWAVE commercial software and represented in Fig. 1(b). This radius limits the curvature losses for both sensor and reference waveguides compared to the overall losses as polymer waveguide mode confinement is low compared to SOI waveguides.

For these values of MR perimeters and propagation losses, evanescent coupling has been calculated for MR critical symmetrical coupling conditions with a gap g = 0.6 μm between the access waveguide and the MR waveguide and coupling lengths of Lc = 17 µm and Lc = 34 μm for the sensor MR and reference MR respectively. For these coupling conditions the self-coupling coefficients has been calculated by the marcatili’s method [21] to τsens. = 0.6 and τref. = 0.694 at 1500 nm with a positive slope of 0.09 on the range 1500-1625 nm for both MRs.

The structure has been designed to simplify the photomask fabrication, however, a folded structure with spiral MRs presented in reference [22] could be considered to further reduce the transducer footprint without reduction of the radius of curvature.

From the refractive index of the material as defined in [19], the effective refractive index of the SU8/PMATRIFE polymer waveguides have been calculated as a function of the wavelength in [20] for a PMATRIFE superstrate and for a water superstrate using the commercial FIMMWAVE software. Then, by calculating the effective refractive index variation (Δneff,sens) induced by a small variation of refractive index superstrate (Δns,sens) in the reservoir, the sensor MR theoretical sensitivity has been estimated using the expression defined in Eq. (5) as 70 nm/RIU.

From these geometrical parameters, and using the expressions given by Eq. (3) and Eq. (6), a Vernier gain Gv and Tv the theoretical period of the transmission function has been calculated respectively as 250 and 55 nm at 1550 nm. A very promising Vernier sensitivity Sv of 17500 nm/RIU has been deduced from the relation given by Eq. (3) with the sensor MR theoretical sensitivity SMR of 70 nm/RIU calculated before.

3. Fabrication of the transducer

The transducer is fabricated using SU8 2000 polymer as the core waveguide material and PMATRIFE polymer as both cladding layer and superstrate for the reference part of the sensor (Fig. 1(a)). Fabrication steps are detailed in Fig. 2. In step 1, the Si wafer is cleaned and dehydrated. In step 2, a 5 μm thick cladding layer is fabricated with PMATRIFE diluted in THF (TetraHydroFuran) to 500 g/L concentration, is spin coated onto the wafer. Then, in step 3, a 1.5 μm thick SU8 2000 polymer layer is spin coated onto the cladding and polymerized with thermal treatment and UV exposure. In step 4, a 50 nm thick layer of SiO2 is deposited by PECVD (Plasma Enhanced Chemical Vapor Deposition) and standard photolithography is performed with SPR700 positive resin. In step 5, the waveguides are etched in three steps: firstly, the SiO2 is etched for 20 seconds with a SF6 plasma treatment, then the SU8 waveguides are etched for 10 minutes with 150 nm/min etching speed and the remaining SiO2 under the resin mask is etched with a SF6 plasma. In step 6, a 50 nm thick layer of SiNx is deposited onto the waveguides by PECVD, to ease superstrate adherence. In step 7, PMATRIFE with a concentration of 300g/L is deposited as a superstrate in order to cover the waveguides. This superstrate has a maximum thickness of 2 μm in order to limit its etching time in step 9. In step 8, a 50 nm thick layer of SiO2 is deposited as etching stop layer. After this, the reservoir of the sensor MR, which will be sensitive to the solution, is defined using SU8 negative resist photolithography. Finally in step 9, the reservoir is etched with the same etching process as used for the SU8 waveguides.

 figure: Fig. 2

Fig. 2 Fabrication steps of the sensor

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The X5 magnification optical microscope image in Fig. 3(a) shows a top view of the whole made up of MRs embedded on each arm of a MZ; the darker part corresponds to the reference part of the MR sensor covered by the PMATRIFE polymer superstrate while in the lighter part, the MR sensing part of the sensor in the reservoir is open to the air and will be covered by glucose/water solutions. In Fig. 3(b), the gap opening is observed with X50 times optical magnification. Cross-section view of the cleaved surface with the SU8 and the PMATRIFE cladding and superstrate can be seen in the Scanning Electronic Microscope (SEM) image shown in Fig. 3(c). The dimensions of the SU8 waveguides are 1.5 µm2 square in cross section, with less than 0.1 μm variation in the size of the waveguide measured at different wafer positions.

 figure: Fig. 3

Fig. 3 a) Optical microscope image of the polymer Vernier effect sensor with the reference MR on the upper arm and the sensor MR in the reservoir in the lower arm. b) Optical microscope image of the directional coupler of the sensor MR c) Scanning electronic microscope (SEM) cross section of the optical waveguide at the input of the sensor

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4. Experiment and results

The sensor is characterized with a fibered broadband 1500-1625nm tunable laser source (Yenista Tunics T100S-HP). Its 10 mW output power is coupled into the SU8 waveguide using a lensed fiber with a mode radius of 2.5 μm mounted on micro-alignment bench fabricated in the lab [23]. A second lensed single mode fiber is used to couple the output of the waveguide to a power-meter. Piezo-controlled stages are used to position the input and output fibers with the help of an infra-red camera. A polarization controller is placed between the laser and the input micro-lensed single mode fiber to select the TE polarization mode. A temperature controller is also used to maintain the sample at room temperature and to reduce the impact of temperature fluctuation on the spectral responses. The spectral responses of the structure, made up of one MR embedded on each arm of a MZ, was measured over the full wavelength range of the laser in steps of 1 pm.

The characterization of the sensor is performed with glucose solutions of 2.5 g/L, 5 g/L and 7.5 g/L with an accuracy of 0.25g/L and the reference transmission spectra is registered with deionized water after each measurement with the glucose/water solution. The experimental spectra are shown near the peak of the envelope in the range 1530-1565nm in Fig. 4(a). The envelope spectra characteristic of the Vernier effect appears at the output with up to 20 dB contrast, which eases the sensor characterizations and the envelope is extracted by peak detection of the maximum values of the spectra.

 figure: Fig. 4

Fig. 4 a) Shift of the envelope function with different concentrations of the glucose solution spectra of glucose water solutions ; the envelopes are translated by 20dB for representation b) Lorentzian fit of the envelope function maximum values with glucose solution refractive index variation c) Linear fit of the resonant wavelength shift with the refractive index variation of the solution d) Comparison between theoretical and experimental transmission spectra; the envelopes are translated for representation e) fit of the experimental spectra with the theoretical spectra

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A shift of the envelope appears when glucose concentrations vary. A linear fit can be applied on the Lorentzian fit of the envelope function of the resonance peaks of the transmission spectra represented in Fig. 4.b. and then, the sensitivity can be calculated from the slope of the linear fit of the maximum position of the fitted Lorentzian peaks and the variation of the solution refractive index as represented in Fig. 4(c). The dependence of the solution refractive index variation on the concentration of glucose has been calculated to 1.189.10−4 RIU/(g/L) by Ciminelli.et.al [7]. The experimental sensitivity obtained here is 17558 nm/RIU with a standard error on the slope of less than 5%. The period of the experimental envelope is 55 nm which corresponds to a maximum variation of refractive index of 3.1 10−3 or a glucose concentration of 27 g/l.

The theoretical transmission function of the Vernier MZ pass sensor calculated with Eq. (1) can be simulated according to the geometry defined in part 2 and from the optical parameters defined in [19-20]. The experimental spectra is compared to theoretical spectra for the fundamental mode TE polarization over the full wavelength range of measurement in Fig. 4(d), and the superposition of the resonant peaks is represented over the range 1540-1544 nm in Fig. 4(e). The sensitivity and the Vernier envelope period of the theoretical and experimental spectra compare well. The slight difference to the theoretical sensitivity can be attributed to fabrication tolerances on the size of the polymer waveguides and polarization dependence of the tunable laser source. The difference in contrast between the theoretical and experimental spectra can be explained by coupling coefficient and loss variations with the wavelength. Taking into account the minimum detectable wavelength shift value of 0.02 nm of our experimental setup, the transducer limit of detection is calculated as 1.1.10−6 which corresponds to a glucose concentration of 9.10−3 g/L.

5. Discussion and conclusion

A new optical transducer based on the Vernier effect has been developed for glucose detection. The transducer is based on one MR embedded on each arm of a MZ interferometer and has been fabricated with polymer materials using standard photolithography process. This work demonstrates the ability to develop a highly sensitive and low cost polymer optical transducer for biological detection with several interferometers. The sensitivity of the transducer developed in this work is more than 250 times higher than that of a single SU8/PMATRIFE polymer MR with similar fabrication process which demonstrates the advantage of Vernier effect sensor over to a single MR in achieving high sensitivity [20].

The obtained experimental transducer sensitivity of 17558 nm/RIU in the RIU range of [1.1.10−6 - 3.1 10−3] is greatly increased compared to 5866 nm/RIU and 6317 nm/RIU sensitivity obtained with other Vernier effect transducers based on cascaded MRs developed by Y.Liu.et.al [17]. using SOI materials or by V.Zamora.et.al [11] using SiN material. The advantage of the use of polymers in this work is their low cost and the ease standard technological process compared to e-beam technology. Additionally, the 20dB contrast of the envelope function of the transducer eases detection and longer interferometers could be developed to surpass the extremely high sensitivity of 21500 nm/RIU reached by Jiang.et.al. with SOI MR cascaded with a MZ [15].

Funding

Lannion Trégor Communauté; Conseil Régional de Bretagne (501100004584); French government.

References and links

1. M. C. Estevez, M. Alvarez, and L. M. Lechuga, “Integrated optical devices for lab-on-chip biosensing applications,” Laser Photonics Rev. 6(4), 463–487 (2012).

2. D. Duval and L. M. Lechuga, “Breakthroughs in photonics 2012: 2012 breakthroughs in lab-on-a-chip and optical biosensors,” IEEE Photonics J. 5(2), 0700906 (2013).

3. Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

4. J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

5. J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009). [PubMed]  

6. S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013). [PubMed]  

7. C. Ciminelli, F. Dell’Olio, D. Conteduca, C. M. Campanella, and M. N. Armenise, “High performance SOI microring resonator for biochemical sensing,” Opt. Laser Technol. 59, 60–67 (2014).

8. C. Ciminelli, F. Dell’Olio, C. E. Campanella, and M. N. Armenise, “Label-free optical resonant sensors for biochemical applications,” Prog. Quantum Electron. 37(2), 51–107 (2013).

9. R. Boeck, N. A. Jaeger, N. Rouger, and L. Chrostowski, “Series-coupled silicon racetrack resonators and the Vernier effect: theory and measurement,” Opt. Express 18(24), 25151–25157 (2010). [PubMed]  

10. M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014). [PubMed]  

11. V. Zamora, P. Lützow, M. Weiland, and D. Pergande, “A highly sensitive refractometric sensor based on cascaded SiN microring resonators,” Sensors (Basel) 13(11), 14601–14610 (2013). [PubMed]  

12. B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015). [PubMed]  

13. T. Claes, W. Bogaerts, and P. Bienstman, “Experimental characterization of a silicon photonic biosensor consisting of two cascaded ring resonators based on the Vernier-effect and introduction of a curve fitting method for an improved detection limit,” Opt. Express 18(22), 22747–22761 (2010). [PubMed]  

14. J. Hu and D. Dai, “Cascaded-ring optical sensor with enhanced sensitivity by using suspended si-nanowires,” IEEE Photonics Technol. Lett. 23(13), 842–844 (2011).

15. X. Jiang, Y. Chen, F. Yu, L. Tang, M. Li, and J. J. He, “High-sensitivity optical biosensor based on cascaded Mach-Zehnder interferometer and ring resonator using Vernier effect,” Opt. Lett. 39(22), 6363–6366 (2014). [PubMed]  

16. X. Tu, J. Song, T.-Y. Liow, M. K. Park, J. Q. Yiying, J. S. Kee, M. Yu, and G.-Q. Lo, “Thermal independent silicon-nitride slot waveguide biosensor with high sensitivity,” Opt. Express 20(3), 2640–2648 (2012). [PubMed]  

17. Y. Liu, Y. Li, M. Li, and J. J. He, “High-sensitivity and wide-range optical sensor based on three cascaded ring resonators,” Opt. Express 25(2), 972–978 (2017). [PubMed]  

18. H. Yi, D. S. Citrin, Y. Chen, and Z. Zhou, “Dual-microring-resonator interference sensor,” Appl. Phys. Lett. 95, 191112 (2012).

19. P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

20. P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

21. E. A. J. Marcatili, “Dielectric Rectangular waveguide and directional coupler for integrated optics,” Bell syst. Tech. 48, 2071 (1969).

22. D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express 16(19), 15137–15148 (2008). [PubMed]  

23. S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

References

  • View by:

  1. M. C. Estevez, M. Alvarez, and L. M. Lechuga, “Integrated optical devices for lab-on-chip biosensing applications,” Laser Photonics Rev. 6(4), 463–487 (2012).
  2. D. Duval and L. M. Lechuga, “Breakthroughs in photonics 2012: 2012 breakthroughs in lab-on-a-chip and optical biosensors,” IEEE Photonics J. 5(2), 0700906 (2013).
  3. Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).
  4. J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).
  5. J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
    [PubMed]
  6. S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
    [PubMed]
  7. C. Ciminelli, F. Dell’Olio, D. Conteduca, C. M. Campanella, and M. N. Armenise, “High performance SOI microring resonator for biochemical sensing,” Opt. Laser Technol. 59, 60–67 (2014).
  8. C. Ciminelli, F. Dell’Olio, C. E. Campanella, and M. N. Armenise, “Label-free optical resonant sensors for biochemical applications,” Prog. Quantum Electron. 37(2), 51–107 (2013).
  9. R. Boeck, N. A. Jaeger, N. Rouger, and L. Chrostowski, “Series-coupled silicon racetrack resonators and the Vernier effect: theory and measurement,” Opt. Express 18(24), 25151–25157 (2010).
    [PubMed]
  10. M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014).
    [PubMed]
  11. V. Zamora, P. Lützow, M. Weiland, and D. Pergande, “A highly sensitive refractometric sensor based on cascaded SiN microring resonators,” Sensors (Basel) 13(11), 14601–14610 (2013).
    [PubMed]
  12. B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
    [PubMed]
  13. T. Claes, W. Bogaerts, and P. Bienstman, “Experimental characterization of a silicon photonic biosensor consisting of two cascaded ring resonators based on the Vernier-effect and introduction of a curve fitting method for an improved detection limit,” Opt. Express 18(22), 22747–22761 (2010).
    [PubMed]
  14. J. Hu and D. Dai, “Cascaded-ring optical sensor with enhanced sensitivity by using suspended si-nanowires,” IEEE Photonics Technol. Lett. 23(13), 842–844 (2011).
  15. X. Jiang, Y. Chen, F. Yu, L. Tang, M. Li, and J. J. He, “High-sensitivity optical biosensor based on cascaded Mach-Zehnder interferometer and ring resonator using Vernier effect,” Opt. Lett. 39(22), 6363–6366 (2014).
    [PubMed]
  16. X. Tu, J. Song, T.-Y. Liow, M. K. Park, J. Q. Yiying, J. S. Kee, M. Yu, and G.-Q. Lo, “Thermal independent silicon-nitride slot waveguide biosensor with high sensitivity,” Opt. Express 20(3), 2640–2648 (2012).
    [PubMed]
  17. Y. Liu, Y. Li, M. Li, and J. J. He, “High-sensitivity and wide-range optical sensor based on three cascaded ring resonators,” Opt. Express 25(2), 972–978 (2017).
    [PubMed]
  18. H. Yi, D. S. Citrin, Y. Chen, and Z. Zhou, “Dual-microring-resonator interference sensor,” Appl. Phys. Lett. 95, 191112 (2012).
  19. P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).
  20. P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).
  21. E. A. J. Marcatili, “Dielectric Rectangular waveguide and directional coupler for integrated optics,” Bell syst. Tech. 48, 2071 (1969).
  22. D.-X. Xu, A. Densmore, A. Delâge, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, “Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding,” Opt. Express 16(19), 15137–15148 (2008).
    [PubMed]
  23. S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

2017 (1)

2016 (1)

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

2015 (2)

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
[PubMed]

2014 (4)

X. Jiang, Y. Chen, F. Yu, L. Tang, M. Li, and J. J. He, “High-sensitivity optical biosensor based on cascaded Mach-Zehnder interferometer and ring resonator using Vernier effect,” Opt. Lett. 39(22), 6363–6366 (2014).
[PubMed]

C. Ciminelli, F. Dell’Olio, D. Conteduca, C. M. Campanella, and M. N. Armenise, “High performance SOI microring resonator for biochemical sensing,” Opt. Laser Technol. 59, 60–67 (2014).

M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014).
[PubMed]

P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

2013 (5)

V. Zamora, P. Lützow, M. Weiland, and D. Pergande, “A highly sensitive refractometric sensor based on cascaded SiN microring resonators,” Sensors (Basel) 13(11), 14601–14610 (2013).
[PubMed]

C. Ciminelli, F. Dell’Olio, C. E. Campanella, and M. N. Armenise, “Label-free optical resonant sensors for biochemical applications,” Prog. Quantum Electron. 37(2), 51–107 (2013).

D. Duval and L. M. Lechuga, “Breakthroughs in photonics 2012: 2012 breakthroughs in lab-on-a-chip and optical biosensors,” IEEE Photonics J. 5(2), 0700906 (2013).

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

2012 (3)

X. Tu, J. Song, T.-Y. Liow, M. K. Park, J. Q. Yiying, J. S. Kee, M. Yu, and G.-Q. Lo, “Thermal independent silicon-nitride slot waveguide biosensor with high sensitivity,” Opt. Express 20(3), 2640–2648 (2012).
[PubMed]

H. Yi, D. S. Citrin, Y. Chen, and Z. Zhou, “Dual-microring-resonator interference sensor,” Appl. Phys. Lett. 95, 191112 (2012).

M. C. Estevez, M. Alvarez, and L. M. Lechuga, “Integrated optical devices for lab-on-chip biosensing applications,” Laser Photonics Rev. 6(4), 463–487 (2012).

2011 (1)

J. Hu and D. Dai, “Cascaded-ring optical sensor with enhanced sensitivity by using suspended si-nanowires,” IEEE Photonics Technol. Lett. 23(13), 842–844 (2011).

2010 (2)

2009 (1)

J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
[PubMed]

2008 (1)

2001 (1)

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

1969 (1)

E. A. J. Marcatili, “Dielectric Rectangular waveguide and directional coupler for integrated optics,” Bell syst. Tech. 48, 2071 (1969).

Adrian, J.

J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
[PubMed]

Alvarez, M.

M. C. Estevez, M. Alvarez, and L. M. Lechuga, “Integrated optical devices for lab-on-chip biosensing applications,” Laser Photonics Rev. 6(4), 463–487 (2012).

Armenise, M. N.

C. Ciminelli, F. Dell’Olio, D. Conteduca, C. M. Campanella, and M. N. Armenise, “High performance SOI microring resonator for biochemical sensing,” Opt. Laser Technol. 59, 60–67 (2014).

C. Ciminelli, F. Dell’Olio, C. E. Campanella, and M. N. Armenise, “Label-free optical resonant sensors for biochemical applications,” Prog. Quantum Electron. 37(2), 51–107 (2013).

Azuelos, P.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Bienstman, P.

Bodiou, L.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Boeck, R.

Bogaerts, W.

Bosc, D.

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

Brynda, E.

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Campanella, C. E.

M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014).
[PubMed]

C. Ciminelli, F. Dell’Olio, C. E. Campanella, and M. N. Armenise, “Label-free optical resonant sensors for biochemical applications,” Prog. Quantum Electron. 37(2), 51–107 (2013).

Campanella, C. M.

C. Ciminelli, F. Dell’Olio, D. Conteduca, C. M. Campanella, and M. N. Armenise, “High performance SOI microring resonator for biochemical sensing,” Opt. Laser Technol. 59, 60–67 (2014).

Carré, C.

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

Chakravarty, S.

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

Charrier, J.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Chartier, T.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Cheben, P.

Chen, R. T.

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

Chen, Y.

Chin, S. H.

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

Chrostowski, L.

Ciminelli, C.

C. Ciminelli, F. Dell’Olio, D. Conteduca, C. M. Campanella, and M. N. Armenise, “High performance SOI microring resonator for biochemical sensing,” Opt. Laser Technol. 59, 60–67 (2014).

C. Ciminelli, F. Dell’Olio, C. E. Campanella, and M. N. Armenise, “Label-free optical resonant sensors for biochemical applications,” Prog. Quantum Electron. 37(2), 51–107 (2013).

Citrin, D. S.

H. Yi, D. S. Citrin, Y. Chen, and Z. Zhou, “Dual-microring-resonator interference sensor,” Appl. Phys. Lett. 95, 191112 (2012).

Claes, T.

Claudot, S.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Conteduca, D.

C. Ciminelli, F. Dell’Olio, D. Conteduca, C. M. Campanella, and M. N. Armenise, “High performance SOI microring resonator for biochemical sensing,” Opt. Laser Technol. 59, 60–67 (2014).

Ctyroky, J.

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Dai, D.

J. Hu and D. Dai, “Cascaded-ring optical sensor with enhanced sensitivity by using suspended si-nanowires,” IEEE Photonics Technol. Lett. 23(13), 842–844 (2011).

De Leonardis, F.

M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014).
[PubMed]

Delâge, A.

Delcourt, E.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Dell’Olio, F.

C. Ciminelli, F. Dell’Olio, D. Conteduca, C. M. Campanella, and M. N. Armenise, “High performance SOI microring resonator for biochemical sensing,” Opt. Laser Technol. 59, 60–67 (2014).

C. Ciminelli, F. Dell’Olio, C. E. Campanella, and M. N. Armenise, “Label-free optical resonant sensors for biochemical applications,” Prog. Quantum Electron. 37(2), 51–107 (2013).

Densmore, A.

Diserens, J. M.

J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
[PubMed]

Dostalek, J.

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Drabkin, H. A.

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

Dumeige, Y.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Duval, D.

D. Duval and L. M. Lechuga, “Breakthroughs in photonics 2012: 2012 breakthroughs in lab-on-a-chip and optical biosensors,” IEEE Photonics J. 5(2), 0700906 (2013).

Estevez, M. C.

M. C. Estevez, M. Alvarez, and L. M. Lechuga, “Integrated optical devices for lab-on-chip biosensing applications,” Laser Photonics Rev. 6(4), 463–487 (2012).

Gadonna, M.

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

Gao, H.

J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
[PubMed]

Gemmill, R. M.

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

Girault, P.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

Goujon, J.-M.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Guendouz, M.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

Gutierrez-Arroyo, A.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Han, K.

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

Hardy, I.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

He, J. J.

Homola, J.

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Hu, J.

J. Hu and D. Dai, “Cascaded-ring optical sensor with enhanced sensitivity by using suspended si-nanowires,” IEEE Photonics Technol. Lett. 23(13), 842–844 (2011).

Hu, Y.

B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
[PubMed]

Jaeger, N. A.

Janz, S.

Jiang, X.

Kee, J. S.

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

X. Tu, J. Song, T.-Y. Liow, M. K. Park, J. Q. Yiying, J. S. Kee, M. Yu, and G.-Q. Lo, “Thermal independent silicon-nitride slot waveguide biosensor with high sensitivity,” Opt. Express 20(3), 2640–2648 (2012).
[PubMed]

Khokhar, A. Z.

B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
[PubMed]

Kim, K. W.

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

La Notte, M.

M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014).
[PubMed]

Lai, W. C.

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

Lapointe, J.

Le, S. D.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Lechuga, L. M.

D. Duval and L. M. Lechuga, “Breakthroughs in photonics 2012: 2012 breakthroughs in lab-on-a-chip and optical biosensors,” IEEE Photonics J. 5(2), 0700906 (2013).

M. C. Estevez, M. Alvarez, and L. M. Lechuga, “Integrated optical devices for lab-on-chip biosensing applications,” Laser Photonics Rev. 6(4), 463–487 (2012).

Lemaitre, J.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

Li, M.

Li, Y.

Liow, T.-Y.

Liu, Q.

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

Liu, Y.

Lo, G. Q.

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

Lo, G.-Q.

Lopinski, G.

Lorrain, N.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

Lützow, P.

V. Zamora, P. Lützow, M. Weiland, and D. Pergande, “A highly sensitive refractometric sensor based on cascaded SiN microring resonators,” Sensors (Basel) 13(11), 14601–14610 (2013).
[PubMed]

Marcatili, E. A. J.

E. A. J. Marcatili, “Dielectric Rectangular waveguide and directional coupler for integrated optics,” Bell syst. Tech. 48, 2071 (1969).

Marco, M. P.

J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
[PubMed]

Mashanovich, G. Z.

B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
[PubMed]

McKinnon, R.

Mischki, T.

Muciaccia, T.

M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014).
[PubMed]

Nedeljkovic, M.

B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
[PubMed]

Nekvindova, P.

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Park, M. K.

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

X. Tu, J. Song, T.-Y. Liow, M. K. Park, J. Q. Yiying, J. S. Kee, M. Yu, and G.-Q. Lo, “Thermal independent silicon-nitride slot waveguide biosensor with high sensitivity,” Opt. Express 20(3), 2640–2648 (2012).
[PubMed]

Pasche, S.

J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
[PubMed]

Passaro, V. M. N.

B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
[PubMed]

M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014).
[PubMed]

Pergande, D.

V. Zamora, P. Lützow, M. Weiland, and D. Pergande, “A highly sensitive refractometric sensor based on cascaded SiN microring resonators,” Sensors (Basel) 13(11), 14601–14610 (2013).
[PubMed]

Pirasteh, P.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Poffo, L.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

Post, E.

Quétel, L.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Reynolds, S. A.

B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
[PubMed]

Rochard, P.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Rouger, N.

Sánchez-Baeza, F.

J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
[PubMed]

Schmid, J. H.

Schrofel, J.

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Shin, Y.

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

Simon, G. R.

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

Skalsky, M.

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Skvor, J.

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Song, J.

Spirkova, J.

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Tang, L.

Thual, M.

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

Troia, B.

B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
[PubMed]

M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014).
[PubMed]

Tu, X.

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

X. Tu, J. Song, T.-Y. Liow, M. K. Park, J. Q. Yiying, J. S. Kee, M. Yu, and G.-Q. Lo, “Thermal independent silicon-nitride slot waveguide biosensor with high sensitivity,” Opt. Express 20(3), 2640–2648 (2012).
[PubMed]

Vignaud, G.

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

Voirin, G.

J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
[PubMed]

Waldron, P.

Weiland, M.

V. Zamora, P. Lützow, M. Weiland, and D. Pergande, “A highly sensitive refractometric sensor based on cascaded SiN microring resonators,” Sensors (Basel) 13(11), 14601–14610 (2013).
[PubMed]

Xu, D.-X.

Yi, H.

H. Yi, D. S. Citrin, Y. Chen, and Z. Zhou, “Dual-microring-resonator interference sensor,” Appl. Phys. Lett. 95, 191112 (2012).

Yiying, J. Q.

Yoon, Y. J.

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

Yu, F.

Yu, M.

Zamora, V.

V. Zamora, P. Lützow, M. Weiland, and D. Pergande, “A highly sensitive refractometric sensor based on cascaded SiN microring resonators,” Sensors (Basel) 13(11), 14601–14610 (2013).
[PubMed]

Zhou, Z.

H. Yi, D. S. Citrin, Y. Chen, and Z. Zhou, “Dual-microring-resonator interference sensor,” Appl. Phys. Lett. 95, 191112 (2012).

Zou, Y.

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

Appl. Phys. Lett. (1)

H. Yi, D. S. Citrin, Y. Chen, and Z. Zhou, “Dual-microring-resonator interference sensor,” Appl. Phys. Lett. 95, 191112 (2012).

Bell syst. Tech. (1)

E. A. J. Marcatili, “Dielectric Rectangular waveguide and directional coupler for integrated optics,” Bell syst. Tech. 48, 2071 (1969).

Biosens. Bioelectron. (2)

J. Adrian, S. Pasche, J. M. Diserens, F. Sánchez-Baeza, H. Gao, M. P. Marco, and G. Voirin, “Waveguide interrogated optical immunosensor (WIOS) for detection of sulfonamide antibiotics in milk,” Biosens. Bioelectron. 24(11), 3340–3346 (2009).
[PubMed]

S. Chakravarty, W. C. Lai, Y. Zou, H. A. Drabkin, R. M. Gemmill, G. R. Simon, S. H. Chin, and R. T. Chen, “Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors,” Biosens. Bioelectron. 43, 50–55 (2013).
[PubMed]

Commun. Phys. (1)

S. D. Le, E. Delcourt, P. Girault, A. Gutierrez-Arroyo, P. Azuelos, N. Lorrain, L. Bodiou, L. Poffo, J.-M. Goujon, Y. Dumeige, I. Hardy, P. Rochard, J. Lemaitre, P. Pirasteh, M. Guendouz, T. Chartier, L. Quétel, S. Claudot, J. Charrier, and M. Thual, “Study of optimized coupling based on micro-lensed fibers for fibers and photonic integrated circuits in the framework of telecommunications and sensing applications,” Commun. Phys. 26(4), 325–334 (2016).

IEEE Photonics J. (1)

D. Duval and L. M. Lechuga, “Breakthroughs in photonics 2012: 2012 breakthroughs in lab-on-a-chip and optical biosensors,” IEEE Photonics J. 5(2), 0700906 (2013).

IEEE Photonics Technol. Lett. (1)

J. Hu and D. Dai, “Cascaded-ring optical sensor with enhanced sensitivity by using suspended si-nanowires,” IEEE Photonics Technol. Lett. 23(13), 842–844 (2011).

J. Appl. Phys. (1)

P. Girault, N. Lorrain, L. Poffo, M. Guendouz, J. Lemaitre, C. Carré, M. Gadonna, D. Bosc, and G. Vignaud, “Integrated polymer micro-ring resonators for optical sensing applications,” J. Appl. Phys. 117, 104504 (2015).

Laser Photonics Rev. (1)

M. C. Estevez, M. Alvarez, and L. M. Lechuga, “Integrated optical devices for lab-on-chip biosensing applications,” Laser Photonics Rev. 6(4), 463–487 (2012).

Opt. Express (5)

Opt. Laser Technol. (1)

C. Ciminelli, F. Dell’Olio, D. Conteduca, C. M. Campanella, and M. N. Armenise, “High performance SOI microring resonator for biochemical sensing,” Opt. Laser Technol. 59, 60–67 (2014).

Opt. Lett. (1)

Proc. SPIE (1)

P. Girault, J. Lemaitre, M. Guendouz, N. Lorrain, L. Poffo, M. Gadonna, and D. Bosc, “Micro-resonators based on integrated polymer technology for optical sensing,” Proc. SPIE 9141, 914121 (2014).

Prog. Quantum Electron. (1)

C. Ciminelli, F. Dell’Olio, C. E. Campanella, and M. N. Armenise, “Label-free optical resonant sensors for biochemical applications,” Prog. Quantum Electron. 37(2), 51–107 (2013).

Sens. Actuator B-Chem. (2)

Q. Liu, X. Tu, K. W. Kim, J. S. Kee, Y. Shin, K. Han, Y. J. Yoon, G. Q. Lo, and M. K. Park, “Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide,” Sens. Actuator B-Chem. 188, 681–688 (2013).

J. Dostalek, J. Ctyroky, J. Homola, E. Brynda, M. Skalsky, P. Nekvindova, J. Spirkova, J. Skvor, and J. Schrofel, “Surface plasmon resonance biosensor based on integrated optical waveguide,” Sens. Actuator B-Chem. 76(1–3), 8–12 (2001).

Sensors (Basel) (3)

M. La Notte, B. Troia, T. Muciaccia, C. E. Campanella, F. De Leonardis, and V. M. N. Passaro, “Recent advances in gas and chemical detection by Vernier effect-based photonic sensors,” Sensors (Basel) 14(3), 4831–4855 (2014).
[PubMed]

V. Zamora, P. Lützow, M. Weiland, and D. Pergande, “A highly sensitive refractometric sensor based on cascaded SiN microring resonators,” Sensors (Basel) 13(11), 14601–14610 (2013).
[PubMed]

B. Troia, A. Z. Khokhar, M. Nedeljkovic, S. A. Reynolds, Y. Hu, G. Z. Mashanovich, and V. M. N. Passaro, “Design procedure and fabrication of reproducible silicon Vernier devices for high-performance refractive index sensing,” Sensors (Basel) 15(6), 13548–13567 (2015).
[PubMed]

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Figures (4)

Fig. 1
Fig. 1 a) Representation of the Vernier effect MZ-pass configuration sensor, b) Dependence of the curvature losses with the radius for the reference waveguides and the sensor waveguides, c) Coupling region of the MR
Fig. 2
Fig. 2 Fabrication steps of the sensor
Fig. 3
Fig. 3 a) Optical microscope image of the polymer Vernier effect sensor with the reference MR on the upper arm and the sensor MR in the reservoir in the lower arm. b) Optical microscope image of the directional coupler of the sensor MR c) Scanning electronic microscope (SEM) cross section of the optical waveguide at the input of the sensor
Fig. 4
Fig. 4 a) Shift of the envelope function with different concentrations of the glucose solution spectra of glucose water solutions ; the envelopes are translated by 20dB for representation b) Lorentzian fit of the envelope function maximum values with glucose solution refractive index variation c) Linear fit of the resonant wavelength shift with the refractive index variation of the solution d) Comparison between theoretical and experimental transmission spectra; the envelopes are translated for representation e) fit of the experimental spectra with the theoretical spectra

Equations (6)

Equations on this page are rendered with MathJax. Learn more.

T ( λ ) = 1 4 ( | E s e n s . | 2 + | E r e f . | 2 ) + 1 2 | E s e n s . | | E r e f . | cos ( arg ( | E s e n s . | ) arg ( | E r e f . | ) )
E r e f . , s e n s . = τ r e f . , s e n s . e α r e f . , s e n s . L r e f . , s e n s . e j φ 1 τ r e f . , s e n s . e α r e f . , s e n s . L r e f . , s e n s . e j φ E i n
S V = S M R G V = S M R F S R r e f . | F S R s e n s . F S R r e f . |
F S R r e f . , s e n s . = λ r e s 2 L r e f . , s e n s . n e f f r e f f . , s e n s .
S M R ( n m / R I U ) = λ n e f f s e n s . n e f f s e n s . n s s e n s . = λ r e s n e f f s e n s . Δ n e f f s e n s . Δ n s s e n s .
T V = F S R r e f . F S R s e n s . | F S R s e n s . F S R r e f . |

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