Abstract

A dual channel dual focus spectral-domain optical coherence tomography was developed for imaging the accommodation of the eye in real time. The system can provide simultaneous cross-sectional imaging of all the surfaces of the anterior segment of the eye including the cornea, anterior chamber, anterior and posterior surfaces of the crystalline lens. Thus, the modification of the curvatures of the anterior and posterior surfaces of the crystalline lens and the dimensions of the anterior segment of the eye with accommodation can be calculated. The system was successfully tested in imaging accommodation. The preliminary results demonstrated the feasibility of this novel approach.

©2009 Optical Society of America

1. Introduction

Accommodation is the act of the eye to adjust the refractive power to bring near objects into sharp focus. Accommodation occurs through possible controlled changes in the crystalline lens shape and thickness, and in distances between the major refractive surfaces. The mechanism of accommodation and its relevance to presbyopia has been debated for more than 150 years since the debut of Helmholtz’s theory of accommodation [1]. Researches into understanding accommodation and restoring accommodative function of the eye for millions of people with presbyopia and cataract surgery have attracted great interest among the ophthalmic research community [27].

A quantitative high resolution imaging technique that can image the whole anterior segment (the cornea, iris, and crystalline lens) in real time is highly desired and will greatly benefit the research in accommodation. However, currently there is no in vivo imaging technology that can meet all the needs for measuring the modifications of the anterior segment during accommodation, which we believe is one of the major hurdles for the research on accommodation and reasons why the arguments about the mechanisms are still surprisingly vehement [27]. The conventional technologies for anterior segment imaging are Scheimpflug photography, A / B scan ultrasound, UBM (Ultrasound Biomicroscopy), slit scanning topography, and Purkinje imaging [5,813]. With these technologies, it is necessary to stimulate the fellow eye in order to observe the variations of the analyzed eye. The techniques using ultrasound can only be used with contact systems or with water baths that will modify the anatomical dimensions or the pressure of the anterior segment. Geometrical reconstructions are necessary with the Scheimpflug photographic technique while it cannot be used in certain axes. The eye also needs to be dilated for Scheimpflug photography, which is not a natural condition for accommodation. MRI (magnetic resonance imaging) was also used to image the anterior segment of the eye by some authors [12]. But it may not be routinely used.

Optical coherence tomography (OCT) is a low-coherence interferometer-based noninvasive medical imaging modality that can provide high-resolution cross sectional images of biological tissues [14,15]. Anterior segment OCT (AS-OCT) provides the advantage of producing non-contact images of the anterior segment in static and dynamic conditions [1634]. AS-OCT was first reported by Izatt et al. using a time-domain system with a superluminescent diode light source at 800 nm [16]. Baikoff et al. [32,33] and Richdale et al. [34] explored the modifications of the anterior chamber and lens thickness with aging and accommodation using time-domain AS-OCT. However, simultaneous imaging of the whole anterior segment (cornea, iris, anterior chamber and crystalline lens) cannot be realized with commercial time-domain AS-OCT system because of the limitation of imaging depth as well as imaging speed. Because all the surfaces of the anterior segment cannot be imaged simultaneously, the contribution of the posterior surface curvature of the lens to accommodation, which may also play a significant role, was not discovered in their studies. Furthermore, when imaging the posterior surface of the lens with conventional AS-OCT usually only one specular reflection spot appears in the image, which makes it impossible to calculate the curvature of the surface. The accuracy of the measurement of the lens thickness is also not reliable when only one spot on the posterior surface can be detected.

The application of spectral domain OCT (SD-OCT) in imaging the anterior segment of the eye has been reported by several groups [1728]. SD-OCT provided unprecedented imaging speed, and thus made possible 3D imaging of the anterior segment of the eye. However, the limited imaging depth in SD-OCT also made imaging the whole anterior segment formidable. To improve the imaging depth in SD-OCT several groups have developed techniques to eliminate the mirror image [1922,27]. The most recent development by Grulkowski et al. [22] represents a big step toward real time imaging of the whole anterior segment of the eye using a high-speed CMOS camera. However, if only single OCT channel is used, these techniques reduce the imaging speed the same system can achieve since multiple images need to be acquired to remove the complex ambiguity in SD-OCT. Another limitation in imaging the whole anterior segment is the limited depth of focus of the objective lens. Unless dynamic focusing is employed, which is not suitable for high speed imaging, the depth of focus cannot cover the depth of the whole anterior segment. Multiple-channel [23,26] and multiple-focus OCT [3537] offer possible solutions to the problem.

In the present work, we developed a dual channel dual focus SD-OCT system to image all the surfaces of the anterior segment of the eye simultaneously for studying accommodation of the eye. This technique provides a powerful imaging tool for research on the mechanism of accommodation and presbyopia.

2. Experimental system and performance

A schematic of the experimental system is shown in Fig. 1 . The OCT system consisted of two fiber-based Michelson interferometers with two independent spectrometers for detecting the combined light from the reference and sample arms. The scanning and optical delivery system was built on a modified slit lamp with a video camera for guiding the imaging operation. The sample light beams coming out of the sample fibers were combined by a beam-splitter cube and then scanned and delivered to the eye by the same x-y galvanometer scanner and optics. The two probing beams were coaxial but focused at different depth in the eye: The light beam responsible for imaging the cornea and the anterior surface of the lens (OCT-1, consisting of light source SLD1, optics of channnel1, and spectrometer 1) was focused at the anterior chamber while the other light beam (OCT-2, consisting of light source SLD2, optics of channel 2, and spectrometer 2) was focused at the posterior surface of the lens. The spectrometer in OCT-1 was specifically designed for the study, which has a calibrated imaging depth of 5.2 mm in air. The spectrometer in OCT-2 is borrowed from our previously built machine for high resolution retinal imaging, which has a calibrated imaging depth of 2.5 mm. Two superluminescent diode-based light sources (SLD, Inphenix, USA and Superlum, Russia) with FWHM bandwidths of 50nm and 100nm were used for the two OCT systems, respectively. With the same center wavelength of 840 nm the calibrated depth resolutions are 6µm and 3.3µm in air for OCT-1 and OCT-2, respectively. The linear CCD cameras (Aviiva-SM2-CL-2014, 2048 pixels with 14 micron pixel size operating in 12-bit mode, e2V) in the two spectrometers were synchronized and operating at a rate of 24k lines per second.

 

Fig. 1 Schematic of the dual channel OCT experimental system. The inserted is the enlargement of the dual focus configuration of two sample beams.

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To tune the system we first adjust the reference arm of OCT-1 so the cornea and the anterior chamber can be imaged with the reference plane being placed in front of the cornea. We then adjust the reference arm of OCT-2 so the back surface of the lens can be imaged. The distance between the two OCT images was then measured with a mirror as a sample, which was mounted on a translation stage in the sample arm. The measured distance was 3.325 mm in air. Knowing the distance between the images a composite cross-sectional image can be constructed from them. Then all the surfaces of the anterior segment can be imaged simultaneously with the two OCT subsystems. The optimizing process is as following: (1) the objective lens was adjusted to optimize the images of OCT-1; (2) the collimating lens for OCT-2 was adjusted to optimize the image of the back surface of the lens.

The optical path length difference between the two reference arms was 11.025mm, which is the addition of the imaging depths in air of OCT-1 and OCT-2 and 3.325mm. Since the distance between the two reference arms is bigger than the sum of the imaging depths of the two OCT systems, there’s a gap between the two simultaneous OCT images. As a result, the core of the lens was not imaged. However, this has no effect in the study of accommodation.

The two OCT subsystems have a similar sensitivity of 95dB and a 20dB sensitivity drop at the maximal imaging depth. The lateral resolution and the depth-of-focus are 20µm and 3.7mm, respectively. The total exposure power at the surface of the cornea was 1.4mW, which is safe for long exposure to the eye according to ANSI Z136.1 (The light was focused on the anterior segment not the retina). The fast image acquisition speed (24k lines per second) is potentially suitable for dynamic and real time imaging of accommodation and helpful for reduction of motion error.

The optical distance of a target to the eye was changed with the movement of the target or lens L2, therefore the amplitude of accommodation can be controlled subjectively assuming that the subject could see the target as clearly as possible. Both the OCT channels are controlled by a single computer and the whole anterior segment of the eye is imaged simultaneously in real time.

3. Results and discussions

3.1 Simultaneous imaging of the anterior segment of the eye

The right eye of one of the authors (37-year old, −3.50D) was imaged. During the imaging, the same eye was fixated on a letter chart (Fixating target as shown in Fig. 1) which is movable along the optical axis in the experimental setup. The volunteer was asked to see a letter as clearly as possible when the image was acquired in real time. So the amplitude of accommodation can be determined subjectively with the optical distance of the letter chart to the cornea. The eye was imaged in relaxed status then imaged immediately with 2.00D subjective accommodation in test session 1 and 5.50D subjective accommodation in test session 2, respectively. The interval between two test sessions was about 15 minutes.

The simultaneous acquisition of the two raw images using the dual channel dual focus OCT is shown in Fig. 2 . The cross-sections (B-Scans) consisting of 2048 A-scans are shown in Fig. 2 (a) and (b). The imaging ranges in Fig. 2 (a) an (b) are 5.2mm and 2.5mm in air, respectively. The images are then constructed in scale according to the method described in section 2 (Fig. 3 ). The whole anterior segment of the eye, including cornea, anterior chamber angle, iris, anterior and posterior surfaces of the capsule and lens, is clearly visualized.

 

Fig. 2 The simultaneously acquired raw images using the dual channel dual focus OCT show the anterior chamber (a) and the posterior surface of the lens (b), respectively. These two images have a distance of 3.325mm in air in the depth direction. Pixels: 2048 × 2048; Imaging range: 5.2 (depth) × 12 (width) mm (a) and 2.5 (depth) × 12 (width) mm (b); White bar: 0.5mm.

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Fig. 3 The simultaneously acquired images were constructed in scale, but with optical correction. All the surfaces of the anterior segment of the eye including the cornea, anterior chamber, anterior and posterior surfaces of crystalline lens and capsule were clearly visualized. The white bar: 0.5mm.

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The constructed images are optically corrected for image warping with the corneal refractive index of 1.389 for 820nm light using a home-developed software (Fig. 4 ). The algorithm for the correction is based on the paper by V. Westphal, et al. [38]. The distortion to the OCT images is mainly caused by the curved boundary between the cornea and air. The difference of refractive index among the aqueous humour, lens, and vitreous body is relatively small, which cause negligible distortion of the OCT images.

 

Fig. 4 The right eye (−3.50D myopic) of the subject was imaged without accommodation (a) and with 5.5 D accommodation (b). The white bar: 0.5mm.

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The change of the shape of the iris can also be observed in the acquired images. In accommodation status the iris becomes flattened with fewer folds, and the peripheral anterior chamber becomes more spacious with the contraction of the iris sphincter muscle.

We should admit that the current system was not operating in an optimized condition. We can see that except the apex the upper part of the cornea isn’t as visible as the posterior part of the anterior chamber in the OCT-1 images. We believe the reason for the unsatisfactory image quality is the position of the focal plane. The whole lens was not imaged in the current study because the imaging depth of one of the subsystems (OCT-2) is only 2.5mm. This problem can be solved by replacing OCT-2 with a system the same as OCT-1, which has an imaging depth of 5.2mm.

3.2 Modifications of the anterior segment of the accommodated eye

The dimensions of the anterior segment of the eye, including the central thickness of cornea and lens, horizontal radii of curvature of the anterior and posterior surface of the lens, were calculated based on the acquired images. To determine the radius of curvature the boundary was first segmented manually. The data were then fitted with a circle. The changes of the dimensions were also calculated in relaxed and accommodated status (Table 1 ).

Tables Icon

Table 1. Dimensions of the anterior segment in relaxed and accommodated eye. The accommodation amplitude is 2.00D in test session 1 and 5.50D in test session 2, respectively.

Central corneal thickness didn’t change with the test sessions and with the accommodated status of the eye. The lens became thicker in the accommodated eye than in relaxed eye. And the depth of the anterior chamber (measured from the apex of cornea to anterior surface of lens) increased with accommodation. Table 1 also shows the increase of the lens curvature at both anterior and posterior surfaces of the lens. The accommodation amplitude was calculated from the distance between the fixating target and the eye.

The differences between the dimensions measured in the condition without accommodation (columns 1 and 4 of Table 1) are relatively high except that of the central corneal thickness. Since accommodation has little influence on CCT, we guess that the poor repeatability of the measurements of other parameters in the relaxed status may be caused by the following factors: 1). The subject might not be completely relaxed in the tests for the condition without accommodation: the different residual accommodation status might result in different baselines in these two test sessions. 2). The possible alignment error between the test sessions. These two factors also exist in accommodation research using other methods, the effect of which should be minimized though systematic experimental design.

4. Conclusions

In conclusion, we developed a dual channel dual focus OCT system for real-time imaging of the accommodation of the eye. This experimental system provides simultaneous imaging of the whole anterior segment. Thus the modification of the dimensions of the anterior segment, more particularly the curvatures of the anterior and posterior surface of the lens with accommodation can be studied non-invasively using high resolution OCT. The preliminary results presented in this paper demonstrated the feasibility of this approach. However, some technical details should be optimized and improved in our future work.

The merits of the technique can be summarized as follows:

  • i) Since two independent channels are used in the system, the imaging speed can be as fast as the CCD camera can reach.
  • ii) Since two channels are used the focal planes of the two channels can be in different depth and can be adjusted independently in the tissue so that the regions of interest can be selectively enhanced.
The weakness of the current system can be summarized as follows:

  • i) Since two OCT subsystems are needed the cost for the system is higher.
  • ii) The whole lens was not imaged with our current system because the imaging depth of one of the subsystems (OCT-2) is only 2.5mm. However, this problem can be solved by replacing OCT-2 with a system the same as OCT-1, which has an imaging depth of 5.2mm.
  • iii) Since a beamsplitter was used to couple the two OCT channels, the reflected light in the sample arm was attenuated 50% for each channel, which affects the signal-to-noise ratio of the system. However, this problem can be solved if we use two light sources at different bands, for example one at 840 nm and one at 1050 nm, and a dichroic mirror is used to couple the two channels.

Acknowledgment

The research was supported in part by NIH grant 1R21 EB008800-01 and “111” project from Ministry of Education, China [No. B08020].

References and links

1. H. Helmholtz, “Ueber die Accommodation des Auges,” Albrecht von Graefes Arch Ophthalmo 2(1), 1–74 (1855). [CrossRef]  

2. R. A. Schachar, “Is Helmholtz’s theory of accommodation correct?” Ann. Ophthalmol. 31, 10–17 (1999).

3. D. J. Coleman, “Unified model for accommodative mechanism,” Am. J. Ophthalmol. 69(6), 1063–1079 (1970). [PubMed]  

4. A. Glasser and P. L. Kaufman, “The mechanism of accommodation in primates,” Ophthalmology 106(5), 863–872 (1999). [CrossRef]   [PubMed]  

5. J. F. Koretz, C. A. Cook, and P. L. Kaufman, “Accommodation and presbyopia in the human eye,” Invest. Ophthalmol. Vis. Sci. 38(3), 569–578 (1997). [PubMed]  

6. D. A. Atchison, “Accommodation and presbyopia,” Ophthalmic Physiol. Opt. 15(4), 255–272 (1995). [CrossRef]   [PubMed]  

7. W. N. Charman, “The eye in focus: accommodation and presbyopia,” Clin. Exp. Optom. 91(3), 207–225 (2008). [CrossRef]   [PubMed]  

8. J. S. Wolffsohn and L. N. Davies, “Advances in anterior segment imaging,” Curr. Opin. Ophthalmol. 18(1), 32–38 (2007). [CrossRef]  

9. T. Kirschkamp, M. Dunne, and J. C. Barry, “Phakometric measurement of ocular surface radii of curvature, axial separations and alignment in relaxed and accommodated human eyes,” Ophthalmic Physiol. Opt. 24(2), 65–73 (2004). [CrossRef]   [PubMed]  

10. A. S. Vilupuru and A. Glasser, “Dynamic accommodative changes in rhesus monkey eyes assessed with A-scan ultrasound biometry,” Optom. Vis. Sci. 80(5), 383–394 (2003). [CrossRef]   [PubMed]  

11. H. Ishikawa and J. S. Schuman, “Anterior segment imaging: ultrasound biomicroscopy,” Ophthalmol. Clin. North Am. 17(1), 7–20 (2004). [CrossRef]   [PubMed]  

12. J. F. Koretz, S. A. Strenk, L. M. Strenk, and J. L. Semmlow, “Scheimpflug and high-resolution magnetic resonance imaging of the anterior segment: a comparative study,” J. Opt. Soc. Am. A 21(3), 346–354 (2004). [CrossRef]  

13. P. Rosales, M. Dubbelman, S. Marcos, and R. van der Heijde, “Crystalline lens radii of curvature from Purkinje and Scheimpflug imaging,” J. Vis. 6(10), 1057–1067 (2006). [CrossRef]   [PubMed]  

14. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991). [CrossRef]   [PubMed]  

15. A. F. Fercher, “Optical coherence tomography,” J. Biomed. Opt. 1(2), 157–173 (1996). [CrossRef]  

16. J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994). [CrossRef]   [PubMed]  

17. J. J. Kaluzny, M. Wojtkowski, and A. Kowalczyk, “Imaging of the anterior segment of the eye by Spectra Optical Coherence Tomography,” Optica Applicata 32, 581–589 (2002).

18. B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006). [PubMed]  

19. B. Baumann, M. Pircher, E. Götzinger, and C. K. Hitzenberger, “Full range complex spectral domain optical coherence tomography without additional phase shifters,” Opt. Express 15(20), 13375–13387 (2007). [CrossRef]   [PubMed]  

20. P. Targowski, I. Gorczynska, M. Szkulmowski, M. Wojtkowski, and A. Kowalczyk, “Improved complex spectral domain OCT for in vivo eye imaging,” Opt. Commun. 249(1-3), 357–362 (2005). [CrossRef]  

21. M. V. Sarunic, S. Asrani, and J. A. Izatt, “Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography,” Arch. Ophthalmol. 126(4), 537–542 (2008). [CrossRef]   [PubMed]  

22. I. Grulkowski, M. Gora, M. Szkulmowski, I. Gorczynska, D. Szlag, S. Marcos, A. Kowalczyk, and M. Wojtkowski, “Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera,” Opt. Express 17(6), 4842–4858 (2009). [CrossRef]   [PubMed]  

23. E. Gotzinger, M. Pircher, R. A. Leitgeb, B. Baumann, and C. K. Hitzenberger, “Quadruple depth range spectral domain optical coherence tomography for imaging of the anterior eye segment,” presented at the SPIE Photonics West on Bios, San Jose, CA, USA, 24–29 Jan. 2009.

24. Y. Yasuno, V. D. Madjarova, S. Makita, M. Akiba, A. Morosawa, C. Chong, T. Sakai, K. P. Chan, M. Itoh, and T. Yatagai, “Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments,” Opt. Express 13(26), 10652–10664 (2005). [CrossRef]   [PubMed]  

25. C. Kerbage, H. Lim, W. Sun, M. Mujat, and J. F. de Boer, “Large depth-high resolution full 3D imaging of the anterior segments of the eye using high speed optical frequency domain imaging,” Opt. Express 15(12), 7117–7125 (2007). [CrossRef]   [PubMed]  

26. B. Grajciar, M. Pircher, C. K. Hitzenberger, O. Findl, and A. F. Fercher, “High sensitive measurement of the human axial eye length in vivo with Fourier domain low coherence interferometry,” Opt. Express 16(4), 2405–2414 (2008). [CrossRef]   [PubMed]  

27. P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004). [CrossRef]  

28. E. Götzinger, M. Pircher, R. A. Leitgeb, and C. K. Hitzenberger, “High speed full range complex spectral domain optical coherence tomography,” Opt. Express 13, 583–594 (2005). [CrossRef]   [PubMed]  

29. A. Konstantopoulos, P. Hossain, and D. F. Anderson, “Recent advances in ophthalmic anterior segment imaging: a new era for ophthalmic diagnosis?” Br. J. Ophthalmol. 91(4), 551–557 (2007). [CrossRef]   [PubMed]  

30. W. Nolan, “Anterior segment imaging: ultrasound biomicroscopy and anterior segment optical coherence tomography,” Curr. Opin. Ophthalmol. 19(2), 115–121 (2008). [CrossRef]   [PubMed]  

31. J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005). [CrossRef]   [PubMed]  

32. G. Baikoff, E. Lutun, J. Wei, and C. Ferraz, “Anterior chamber optical coherence tomography study of human natural accommodation in a 19-year-old albino,” J. Cataract Refract. Surg. 30(3), 696–701 (2004). [CrossRef]   [PubMed]  

33. G. Baikoff, E. Lutun, C. Ferraz, and J. Wei, “Static and dynamic analysis of the anterior segment with optical coherence tomography,” J. Cataract Refract. Surg. 30(9), 1843–1850 (2004). [CrossRef]   [PubMed]  

34. K. Richdale, M. A. Bullimore, and K. Zadnik, “Lens thickness with age and accommodation by optical coherence tomography,” Ophthalmic Physiol. Opt. 28(5), 441–447 (2008). [CrossRef]   [PubMed]  

35. J. Holmes, S. Hattersley, N. Stone, F. Bazant-Hegemark, and H. Barr, “Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications,” Proc. SPIE 6847, 68470O (2008). [CrossRef]  

36. J. Holmes, “Theory and applications of multi-beam OCT,” Proc. SPIE 7139, 713908 (2008). [CrossRef]  

37. J. Holmes and S. Hattersley, “Image blending and speckle noise reduction in multi-beam OCT,” Proc. SPIE 7168, 71681N (2009). [CrossRef]  

38. V. Westphal, A. M. Rollins, S. Radhakrishnan, and J. A. Izatt, “Correction of geometrical and refractive image distortions in optical coherence tomography applying Fermat's principle,” Opt. Express 10, 397–403 (2002). [PubMed]  

References

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  1. H. Helmholtz, “Ueber die Accommodation des Auges,” Albrecht von Graefes Arch Ophthalmo 2(1), 1–74 (1855).
    [Crossref]
  2. R. A. Schachar, “Is Helmholtz’s theory of accommodation correct?” Ann. Ophthalmol. 31, 10–17 (1999).
  3. D. J. Coleman, “Unified model for accommodative mechanism,” Am. J. Ophthalmol. 69(6), 1063–1079 (1970).
    [PubMed]
  4. A. Glasser and P. L. Kaufman, “The mechanism of accommodation in primates,” Ophthalmology 106(5), 863–872 (1999).
    [Crossref] [PubMed]
  5. J. F. Koretz, C. A. Cook, and P. L. Kaufman, “Accommodation and presbyopia in the human eye,” Invest. Ophthalmol. Vis. Sci. 38(3), 569–578 (1997).
    [PubMed]
  6. D. A. Atchison, “Accommodation and presbyopia,” Ophthalmic Physiol. Opt. 15(4), 255–272 (1995).
    [Crossref] [PubMed]
  7. W. N. Charman, “The eye in focus: accommodation and presbyopia,” Clin. Exp. Optom. 91(3), 207–225 (2008).
    [Crossref] [PubMed]
  8. J. S. Wolffsohn and L. N. Davies, “Advances in anterior segment imaging,” Curr. Opin. Ophthalmol. 18(1), 32–38 (2007).
    [Crossref]
  9. T. Kirschkamp, M. Dunne, and J. C. Barry, “Phakometric measurement of ocular surface radii of curvature, axial separations and alignment in relaxed and accommodated human eyes,” Ophthalmic Physiol. Opt. 24(2), 65–73 (2004).
    [Crossref] [PubMed]
  10. A. S. Vilupuru and A. Glasser, “Dynamic accommodative changes in rhesus monkey eyes assessed with A-scan ultrasound biometry,” Optom. Vis. Sci. 80(5), 383–394 (2003).
    [Crossref] [PubMed]
  11. H. Ishikawa and J. S. Schuman, “Anterior segment imaging: ultrasound biomicroscopy,” Ophthalmol. Clin. North Am. 17(1), 7–20 (2004).
    [Crossref] [PubMed]
  12. J. F. Koretz, S. A. Strenk, L. M. Strenk, and J. L. Semmlow, “Scheimpflug and high-resolution magnetic resonance imaging of the anterior segment: a comparative study,” J. Opt. Soc. Am. A 21(3), 346–354 (2004).
    [Crossref]
  13. P. Rosales, M. Dubbelman, S. Marcos, and R. van der Heijde, “Crystalline lens radii of curvature from Purkinje and Scheimpflug imaging,” J. Vis. 6(10), 1057–1067 (2006).
    [Crossref] [PubMed]
  14. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
    [Crossref] [PubMed]
  15. A. F. Fercher, “Optical coherence tomography,” J. Biomed. Opt. 1(2), 157–173 (1996).
    [Crossref]
  16. J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
    [Crossref] [PubMed]
  17. J. J. Kaluzny, M. Wojtkowski, and A. Kowalczyk, “Imaging of the anterior segment of the eye by Spectra Optical Coherence Tomography,” Optica Applicata 32, 581–589 (2002).
  18. B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
    [PubMed]
  19. B. Baumann, M. Pircher, E. Götzinger, and C. K. Hitzenberger, “Full range complex spectral domain optical coherence tomography without additional phase shifters,” Opt. Express 15(20), 13375–13387 (2007).
    [Crossref] [PubMed]
  20. P. Targowski, I. Gorczynska, M. Szkulmowski, M. Wojtkowski, and A. Kowalczyk, “Improved complex spectral domain OCT for in vivo eye imaging,” Opt. Commun. 249(1-3), 357–362 (2005).
    [Crossref]
  21. M. V. Sarunic, S. Asrani, and J. A. Izatt, “Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography,” Arch. Ophthalmol. 126(4), 537–542 (2008).
    [Crossref] [PubMed]
  22. I. Grulkowski, M. Gora, M. Szkulmowski, I. Gorczynska, D. Szlag, S. Marcos, A. Kowalczyk, and M. Wojtkowski, “Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera,” Opt. Express 17(6), 4842–4858 (2009).
    [Crossref] [PubMed]
  23. E. Gotzinger, M. Pircher, R. A. Leitgeb, B. Baumann, and C. K. Hitzenberger, “Quadruple depth range spectral domain optical coherence tomography for imaging of the anterior eye segment,” presented at the SPIE Photonics West on Bios, San Jose, CA, USA, 24–29 Jan. 2009.
  24. Y. Yasuno, V. D. Madjarova, S. Makita, M. Akiba, A. Morosawa, C. Chong, T. Sakai, K. P. Chan, M. Itoh, and T. Yatagai, “Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments,” Opt. Express 13(26), 10652–10664 (2005).
    [Crossref] [PubMed]
  25. C. Kerbage, H. Lim, W. Sun, M. Mujat, and J. F. de Boer, “Large depth-high resolution full 3D imaging of the anterior segments of the eye using high speed optical frequency domain imaging,” Opt. Express 15(12), 7117–7125 (2007).
    [Crossref] [PubMed]
  26. B. Grajciar, M. Pircher, C. K. Hitzenberger, O. Findl, and A. F. Fercher, “High sensitive measurement of the human axial eye length in vivo with Fourier domain low coherence interferometry,” Opt. Express 16(4), 2405–2414 (2008).
    [Crossref] [PubMed]
  27. P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004).
    [Crossref]
  28. E. Götzinger, M. Pircher, R. A. Leitgeb, and C. K. Hitzenberger, “High speed full range complex spectral domain optical coherence tomography,” Opt. Express 13, 583–594 (2005).
    [Crossref] [PubMed]
  29. A. Konstantopoulos, P. Hossain, and D. F. Anderson, “Recent advances in ophthalmic anterior segment imaging: a new era for ophthalmic diagnosis?” Br. J. Ophthalmol. 91(4), 551–557 (2007).
    [Crossref] [PubMed]
  30. W. Nolan, “Anterior segment imaging: ultrasound biomicroscopy and anterior segment optical coherence tomography,” Curr. Opin. Ophthalmol. 19(2), 115–121 (2008).
    [Crossref] [PubMed]
  31. J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
    [Crossref] [PubMed]
  32. G. Baikoff, E. Lutun, J. Wei, and C. Ferraz, “Anterior chamber optical coherence tomography study of human natural accommodation in a 19-year-old albino,” J. Cataract Refract. Surg. 30(3), 696–701 (2004).
    [Crossref] [PubMed]
  33. G. Baikoff, E. Lutun, C. Ferraz, and J. Wei, “Static and dynamic analysis of the anterior segment with optical coherence tomography,” J. Cataract Refract. Surg. 30(9), 1843–1850 (2004).
    [Crossref] [PubMed]
  34. K. Richdale, M. A. Bullimore, and K. Zadnik, “Lens thickness with age and accommodation by optical coherence tomography,” Ophthalmic Physiol. Opt. 28(5), 441–447 (2008).
    [Crossref] [PubMed]
  35. J. Holmes, S. Hattersley, N. Stone, F. Bazant-Hegemark, and H. Barr, “Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications,” Proc. SPIE 6847, 68470O (2008).
    [Crossref]
  36. J. Holmes, “Theory and applications of multi-beam OCT,” Proc. SPIE 7139, 713908 (2008).
    [Crossref]
  37. J. Holmes and S. Hattersley, “Image blending and speckle noise reduction in multi-beam OCT,” Proc. SPIE 7168, 71681N (2009).
    [Crossref]
  38. V. Westphal, A. M. Rollins, S. Radhakrishnan, and J. A. Izatt, “Correction of geometrical and refractive image distortions in optical coherence tomography applying Fermat's principle,” Opt. Express 10, 397–403 (2002).
    [PubMed]

2009 (2)

2008 (7)

B. Grajciar, M. Pircher, C. K. Hitzenberger, O. Findl, and A. F. Fercher, “High sensitive measurement of the human axial eye length in vivo with Fourier domain low coherence interferometry,” Opt. Express 16(4), 2405–2414 (2008).
[Crossref] [PubMed]

M. V. Sarunic, S. Asrani, and J. A. Izatt, “Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography,” Arch. Ophthalmol. 126(4), 537–542 (2008).
[Crossref] [PubMed]

W. Nolan, “Anterior segment imaging: ultrasound biomicroscopy and anterior segment optical coherence tomography,” Curr. Opin. Ophthalmol. 19(2), 115–121 (2008).
[Crossref] [PubMed]

K. Richdale, M. A. Bullimore, and K. Zadnik, “Lens thickness with age and accommodation by optical coherence tomography,” Ophthalmic Physiol. Opt. 28(5), 441–447 (2008).
[Crossref] [PubMed]

J. Holmes, S. Hattersley, N. Stone, F. Bazant-Hegemark, and H. Barr, “Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications,” Proc. SPIE 6847, 68470O (2008).
[Crossref]

J. Holmes, “Theory and applications of multi-beam OCT,” Proc. SPIE 7139, 713908 (2008).
[Crossref]

W. N. Charman, “The eye in focus: accommodation and presbyopia,” Clin. Exp. Optom. 91(3), 207–225 (2008).
[Crossref] [PubMed]

2007 (4)

2006 (2)

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

P. Rosales, M. Dubbelman, S. Marcos, and R. van der Heijde, “Crystalline lens radii of curvature from Purkinje and Scheimpflug imaging,” J. Vis. 6(10), 1057–1067 (2006).
[Crossref] [PubMed]

2005 (4)

P. Targowski, I. Gorczynska, M. Szkulmowski, M. Wojtkowski, and A. Kowalczyk, “Improved complex spectral domain OCT for in vivo eye imaging,” Opt. Commun. 249(1-3), 357–362 (2005).
[Crossref]

Y. Yasuno, V. D. Madjarova, S. Makita, M. Akiba, A. Morosawa, C. Chong, T. Sakai, K. P. Chan, M. Itoh, and T. Yatagai, “Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments,” Opt. Express 13(26), 10652–10664 (2005).
[Crossref] [PubMed]

E. Götzinger, M. Pircher, R. A. Leitgeb, and C. K. Hitzenberger, “High speed full range complex spectral domain optical coherence tomography,” Opt. Express 13, 583–594 (2005).
[Crossref] [PubMed]

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

2004 (6)

G. Baikoff, E. Lutun, J. Wei, and C. Ferraz, “Anterior chamber optical coherence tomography study of human natural accommodation in a 19-year-old albino,” J. Cataract Refract. Surg. 30(3), 696–701 (2004).
[Crossref] [PubMed]

G. Baikoff, E. Lutun, C. Ferraz, and J. Wei, “Static and dynamic analysis of the anterior segment with optical coherence tomography,” J. Cataract Refract. Surg. 30(9), 1843–1850 (2004).
[Crossref] [PubMed]

P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004).
[Crossref]

H. Ishikawa and J. S. Schuman, “Anterior segment imaging: ultrasound biomicroscopy,” Ophthalmol. Clin. North Am. 17(1), 7–20 (2004).
[Crossref] [PubMed]

J. F. Koretz, S. A. Strenk, L. M. Strenk, and J. L. Semmlow, “Scheimpflug and high-resolution magnetic resonance imaging of the anterior segment: a comparative study,” J. Opt. Soc. Am. A 21(3), 346–354 (2004).
[Crossref]

T. Kirschkamp, M. Dunne, and J. C. Barry, “Phakometric measurement of ocular surface radii of curvature, axial separations and alignment in relaxed and accommodated human eyes,” Ophthalmic Physiol. Opt. 24(2), 65–73 (2004).
[Crossref] [PubMed]

2003 (1)

A. S. Vilupuru and A. Glasser, “Dynamic accommodative changes in rhesus monkey eyes assessed with A-scan ultrasound biometry,” Optom. Vis. Sci. 80(5), 383–394 (2003).
[Crossref] [PubMed]

2002 (2)

J. J. Kaluzny, M. Wojtkowski, and A. Kowalczyk, “Imaging of the anterior segment of the eye by Spectra Optical Coherence Tomography,” Optica Applicata 32, 581–589 (2002).

V. Westphal, A. M. Rollins, S. Radhakrishnan, and J. A. Izatt, “Correction of geometrical and refractive image distortions in optical coherence tomography applying Fermat's principle,” Opt. Express 10, 397–403 (2002).
[PubMed]

1999 (2)

R. A. Schachar, “Is Helmholtz’s theory of accommodation correct?” Ann. Ophthalmol. 31, 10–17 (1999).

A. Glasser and P. L. Kaufman, “The mechanism of accommodation in primates,” Ophthalmology 106(5), 863–872 (1999).
[Crossref] [PubMed]

1997 (1)

J. F. Koretz, C. A. Cook, and P. L. Kaufman, “Accommodation and presbyopia in the human eye,” Invest. Ophthalmol. Vis. Sci. 38(3), 569–578 (1997).
[PubMed]

1996 (1)

A. F. Fercher, “Optical coherence tomography,” J. Biomed. Opt. 1(2), 157–173 (1996).
[Crossref]

1995 (1)

D. A. Atchison, “Accommodation and presbyopia,” Ophthalmic Physiol. Opt. 15(4), 255–272 (1995).
[Crossref] [PubMed]

1994 (1)

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

1970 (1)

D. J. Coleman, “Unified model for accommodative mechanism,” Am. J. Ophthalmol. 69(6), 1063–1079 (1970).
[PubMed]

1855 (1)

H. Helmholtz, “Ueber die Accommodation des Auges,” Albrecht von Graefes Arch Ophthalmo 2(1), 1–74 (1855).
[Crossref]

Akiba, M.

Anderson, D. F.

A. Konstantopoulos, P. Hossain, and D. F. Anderson, “Recent advances in ophthalmic anterior segment imaging: a new era for ophthalmic diagnosis?” Br. J. Ophthalmol. 91(4), 551–557 (2007).
[Crossref] [PubMed]

Asrani, S.

M. V. Sarunic, S. Asrani, and J. A. Izatt, “Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography,” Arch. Ophthalmol. 126(4), 537–542 (2008).
[Crossref] [PubMed]

Atchison, D. A.

D. A. Atchison, “Accommodation and presbyopia,” Ophthalmic Physiol. Opt. 15(4), 255–272 (1995).
[Crossref] [PubMed]

Baikoff, G.

G. Baikoff, E. Lutun, J. Wei, and C. Ferraz, “Anterior chamber optical coherence tomography study of human natural accommodation in a 19-year-old albino,” J. Cataract Refract. Surg. 30(3), 696–701 (2004).
[Crossref] [PubMed]

G. Baikoff, E. Lutun, C. Ferraz, and J. Wei, “Static and dynamic analysis of the anterior segment with optical coherence tomography,” J. Cataract Refract. Surg. 30(9), 1843–1850 (2004).
[Crossref] [PubMed]

Bajraszewski, T.

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004).
[Crossref]

Barr, H.

J. Holmes, S. Hattersley, N. Stone, F. Bazant-Hegemark, and H. Barr, “Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications,” Proc. SPIE 6847, 68470O (2008).
[Crossref]

Barry, J. C.

T. Kirschkamp, M. Dunne, and J. C. Barry, “Phakometric measurement of ocular surface radii of curvature, axial separations and alignment in relaxed and accommodated human eyes,” Ophthalmic Physiol. Opt. 24(2), 65–73 (2004).
[Crossref] [PubMed]

Baumann, B.

Bazant-Hegemark, F.

J. Holmes, S. Hattersley, N. Stone, F. Bazant-Hegemark, and H. Barr, “Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications,” Proc. SPIE 6847, 68470O (2008).
[Crossref]

Bullimore, M. A.

K. Richdale, M. A. Bullimore, and K. Zadnik, “Lens thickness with age and accommodation by optical coherence tomography,” Ophthalmic Physiol. Opt. 28(5), 441–447 (2008).
[Crossref] [PubMed]

Chalita, M. R.

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

Chan, K. P.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Charman, W. N.

W. N. Charman, “The eye in focus: accommodation and presbyopia,” Clin. Exp. Optom. 91(3), 207–225 (2008).
[Crossref] [PubMed]

Chong, C.

Coleman, D. J.

D. J. Coleman, “Unified model for accommodative mechanism,” Am. J. Ophthalmol. 69(6), 1063–1079 (1970).
[PubMed]

Cook, C. A.

J. F. Koretz, C. A. Cook, and P. L. Kaufman, “Accommodation and presbyopia in the human eye,” Invest. Ophthalmol. Vis. Sci. 38(3), 569–578 (1997).
[PubMed]

Davies, L. N.

J. S. Wolffsohn and L. N. Davies, “Advances in anterior segment imaging,” Curr. Opin. Ophthalmol. 18(1), 32–38 (2007).
[Crossref]

de Boer, J. F.

Dubbelman, M.

P. Rosales, M. Dubbelman, S. Marcos, and R. van der Heijde, “Crystalline lens radii of curvature from Purkinje and Scheimpflug imaging,” J. Vis. 6(10), 1057–1067 (2006).
[Crossref] [PubMed]

Dunne, M.

T. Kirschkamp, M. Dunne, and J. C. Barry, “Phakometric measurement of ocular surface radii of curvature, axial separations and alignment in relaxed and accommodated human eyes,” Ophthalmic Physiol. Opt. 24(2), 65–73 (2004).
[Crossref] [PubMed]

Fercher, A. F.

Ferraz, C.

G. Baikoff, E. Lutun, J. Wei, and C. Ferraz, “Anterior chamber optical coherence tomography study of human natural accommodation in a 19-year-old albino,” J. Cataract Refract. Surg. 30(3), 696–701 (2004).
[Crossref] [PubMed]

G. Baikoff, E. Lutun, C. Ferraz, and J. Wei, “Static and dynamic analysis of the anterior segment with optical coherence tomography,” J. Cataract Refract. Surg. 30(9), 1843–1850 (2004).
[Crossref] [PubMed]

Findl, O.

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fujimoto, J. G.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Glasser, A.

A. S. Vilupuru and A. Glasser, “Dynamic accommodative changes in rhesus monkey eyes assessed with A-scan ultrasound biometry,” Optom. Vis. Sci. 80(5), 383–394 (2003).
[Crossref] [PubMed]

A. Glasser and P. L. Kaufman, “The mechanism of accommodation in primates,” Ophthalmology 106(5), 863–872 (1999).
[Crossref] [PubMed]

Goldsmith, J. A.

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

Gora, M.

Gorczynska, I.

I. Grulkowski, M. Gora, M. Szkulmowski, I. Gorczynska, D. Szlag, S. Marcos, A. Kowalczyk, and M. Wojtkowski, “Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera,” Opt. Express 17(6), 4842–4858 (2009).
[Crossref] [PubMed]

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

P. Targowski, I. Gorczynska, M. Szkulmowski, M. Wojtkowski, and A. Kowalczyk, “Improved complex spectral domain OCT for in vivo eye imaging,” Opt. Commun. 249(1-3), 357–362 (2005).
[Crossref]

P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004).
[Crossref]

Götzinger, E.

Grajciar, B.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Grulkowski, I.

Hattersley, S.

J. Holmes and S. Hattersley, “Image blending and speckle noise reduction in multi-beam OCT,” Proc. SPIE 7168, 71681N (2009).
[Crossref]

J. Holmes, S. Hattersley, N. Stone, F. Bazant-Hegemark, and H. Barr, “Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications,” Proc. SPIE 6847, 68470O (2008).
[Crossref]

Hee, M. R.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Helmholtz, H.

H. Helmholtz, “Ueber die Accommodation des Auges,” Albrecht von Graefes Arch Ophthalmo 2(1), 1–74 (1855).
[Crossref]

Hitzenberger, C. K.

Holmes, J.

J. Holmes and S. Hattersley, “Image blending and speckle noise reduction in multi-beam OCT,” Proc. SPIE 7168, 71681N (2009).
[Crossref]

J. Holmes, “Theory and applications of multi-beam OCT,” Proc. SPIE 7139, 713908 (2008).
[Crossref]

J. Holmes, S. Hattersley, N. Stone, F. Bazant-Hegemark, and H. Barr, “Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications,” Proc. SPIE 6847, 68470O (2008).
[Crossref]

Hossain, P.

A. Konstantopoulos, P. Hossain, and D. F. Anderson, “Recent advances in ophthalmic anterior segment imaging: a new era for ophthalmic diagnosis?” Br. J. Ophthalmol. 91(4), 551–557 (2007).
[Crossref] [PubMed]

Huang, D.

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Ishikawa, H.

H. Ishikawa and J. S. Schuman, “Anterior segment imaging: ultrasound biomicroscopy,” Ophthalmol. Clin. North Am. 17(1), 7–20 (2004).
[Crossref] [PubMed]

Itoh, M.

Izatt, J. A.

M. V. Sarunic, S. Asrani, and J. A. Izatt, “Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography,” Arch. Ophthalmol. 126(4), 537–542 (2008).
[Crossref] [PubMed]

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

V. Westphal, A. M. Rollins, S. Radhakrishnan, and J. A. Izatt, “Correction of geometrical and refractive image distortions in optical coherence tomography applying Fermat's principle,” Opt. Express 10, 397–403 (2002).
[PubMed]

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

Kaluzny, B. J.

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

Kaluzny, J. J.

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

J. J. Kaluzny, M. Wojtkowski, and A. Kowalczyk, “Imaging of the anterior segment of the eye by Spectra Optical Coherence Tomography,” Optica Applicata 32, 581–589 (2002).

Kaluzy, B. J.

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

Kaufman, P. L.

A. Glasser and P. L. Kaufman, “The mechanism of accommodation in primates,” Ophthalmology 106(5), 863–872 (1999).
[Crossref] [PubMed]

J. F. Koretz, C. A. Cook, and P. L. Kaufman, “Accommodation and presbyopia in the human eye,” Invest. Ophthalmol. Vis. Sci. 38(3), 569–578 (1997).
[PubMed]

Kerbage, C.

Kirschkamp, T.

T. Kirschkamp, M. Dunne, and J. C. Barry, “Phakometric measurement of ocular surface radii of curvature, axial separations and alignment in relaxed and accommodated human eyes,” Ophthalmic Physiol. Opt. 24(2), 65–73 (2004).
[Crossref] [PubMed]

Konstantopoulos, A.

A. Konstantopoulos, P. Hossain, and D. F. Anderson, “Recent advances in ophthalmic anterior segment imaging: a new era for ophthalmic diagnosis?” Br. J. Ophthalmol. 91(4), 551–557 (2007).
[Crossref] [PubMed]

Koretz, J. F.

Kowalczyk, A.

I. Grulkowski, M. Gora, M. Szkulmowski, I. Gorczynska, D. Szlag, S. Marcos, A. Kowalczyk, and M. Wojtkowski, “Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera,” Opt. Express 17(6), 4842–4858 (2009).
[Crossref] [PubMed]

P. Targowski, I. Gorczynska, M. Szkulmowski, M. Wojtkowski, and A. Kowalczyk, “Improved complex spectral domain OCT for in vivo eye imaging,” Opt. Commun. 249(1-3), 357–362 (2005).
[Crossref]

P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004).
[Crossref]

J. J. Kaluzny, M. Wojtkowski, and A. Kowalczyk, “Imaging of the anterior segment of the eye by Spectra Optical Coherence Tomography,” Optica Applicata 32, 581–589 (2002).

Leitgeb, R. A.

Li, Y.

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

Lim, H.

Lin, C. P.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Lutun, E.

G. Baikoff, E. Lutun, J. Wei, and C. Ferraz, “Anterior chamber optical coherence tomography study of human natural accommodation in a 19-year-old albino,” J. Cataract Refract. Surg. 30(3), 696–701 (2004).
[Crossref] [PubMed]

G. Baikoff, E. Lutun, C. Ferraz, and J. Wei, “Static and dynamic analysis of the anterior segment with optical coherence tomography,” J. Cataract Refract. Surg. 30(9), 1843–1850 (2004).
[Crossref] [PubMed]

Madjarova, V. D.

Makita, S.

Marcos, S.

Morosawa, A.

Mujat, M.

Nolan, W.

W. Nolan, “Anterior segment imaging: ultrasound biomicroscopy and anterior segment optical coherence tomography,” Curr. Opin. Ophthalmol. 19(2), 115–121 (2008).
[Crossref] [PubMed]

Patil, C. A.

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

Pircher, M.

Puliafito, C. A.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Radhakrishnan, S.

Richdale, K.

K. Richdale, M. A. Bullimore, and K. Zadnik, “Lens thickness with age and accommodation by optical coherence tomography,” Ophthalmic Physiol. Opt. 28(5), 441–447 (2008).
[Crossref] [PubMed]

Rollins, A. M.

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

V. Westphal, A. M. Rollins, S. Radhakrishnan, and J. A. Izatt, “Correction of geometrical and refractive image distortions in optical coherence tomography applying Fermat's principle,” Opt. Express 10, 397–403 (2002).
[PubMed]

Rosales, P.

P. Rosales, M. Dubbelman, S. Marcos, and R. van der Heijde, “Crystalline lens radii of curvature from Purkinje and Scheimpflug imaging,” J. Vis. 6(10), 1057–1067 (2006).
[Crossref] [PubMed]

Sakai, T.

Sarunic, M. V.

M. V. Sarunic, S. Asrani, and J. A. Izatt, “Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography,” Arch. Ophthalmol. 126(4), 537–542 (2008).
[Crossref] [PubMed]

Schachar, R. A.

R. A. Schachar, “Is Helmholtz’s theory of accommodation correct?” Ann. Ophthalmol. 31, 10–17 (1999).

Schuman, J. S.

H. Ishikawa and J. S. Schuman, “Anterior segment imaging: ultrasound biomicroscopy,” Ophthalmol. Clin. North Am. 17(1), 7–20 (2004).
[Crossref] [PubMed]

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Semmlow, J. L.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Stone, N.

J. Holmes, S. Hattersley, N. Stone, F. Bazant-Hegemark, and H. Barr, “Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications,” Proc. SPIE 6847, 68470O (2008).
[Crossref]

Strenk, L. M.

Strenk, S. A.

Sun, W.

Swanson, E. A.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Szkulmowska, A.

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

Szkulmowski, M.

I. Grulkowski, M. Gora, M. Szkulmowski, I. Gorczynska, D. Szlag, S. Marcos, A. Kowalczyk, and M. Wojtkowski, “Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera,” Opt. Express 17(6), 4842–4858 (2009).
[Crossref] [PubMed]

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

P. Targowski, I. Gorczynska, M. Szkulmowski, M. Wojtkowski, and A. Kowalczyk, “Improved complex spectral domain OCT for in vivo eye imaging,” Opt. Commun. 249(1-3), 357–362 (2005).
[Crossref]

P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004).
[Crossref]

Szlag, D.

Targowski, P.

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

P. Targowski, I. Gorczynska, M. Szkulmowski, M. Wojtkowski, and A. Kowalczyk, “Improved complex spectral domain OCT for in vivo eye imaging,” Opt. Commun. 249(1-3), 357–362 (2005).
[Crossref]

P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004).
[Crossref]

van der Heijde, R.

P. Rosales, M. Dubbelman, S. Marcos, and R. van der Heijde, “Crystalline lens radii of curvature from Purkinje and Scheimpflug imaging,” J. Vis. 6(10), 1057–1067 (2006).
[Crossref] [PubMed]

Vilupuru, A. S.

A. S. Vilupuru and A. Glasser, “Dynamic accommodative changes in rhesus monkey eyes assessed with A-scan ultrasound biometry,” Optom. Vis. Sci. 80(5), 383–394 (2003).
[Crossref] [PubMed]

Wei, J.

G. Baikoff, E. Lutun, C. Ferraz, and J. Wei, “Static and dynamic analysis of the anterior segment with optical coherence tomography,” J. Cataract Refract. Surg. 30(9), 1843–1850 (2004).
[Crossref] [PubMed]

G. Baikoff, E. Lutun, J. Wei, and C. Ferraz, “Anterior chamber optical coherence tomography study of human natural accommodation in a 19-year-old albino,” J. Cataract Refract. Surg. 30(3), 696–701 (2004).
[Crossref] [PubMed]

Westphal, V.

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

V. Westphal, A. M. Rollins, S. Radhakrishnan, and J. A. Izatt, “Correction of geometrical and refractive image distortions in optical coherence tomography applying Fermat's principle,” Opt. Express 10, 397–403 (2002).
[PubMed]

Wojtkowski, M.

I. Grulkowski, M. Gora, M. Szkulmowski, I. Gorczynska, D. Szlag, S. Marcos, A. Kowalczyk, and M. Wojtkowski, “Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera,” Opt. Express 17(6), 4842–4858 (2009).
[Crossref] [PubMed]

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

P. Targowski, I. Gorczynska, M. Szkulmowski, M. Wojtkowski, and A. Kowalczyk, “Improved complex spectral domain OCT for in vivo eye imaging,” Opt. Commun. 249(1-3), 357–362 (2005).
[Crossref]

P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004).
[Crossref]

J. J. Kaluzny, M. Wojtkowski, and A. Kowalczyk, “Imaging of the anterior segment of the eye by Spectra Optical Coherence Tomography,” Optica Applicata 32, 581–589 (2002).

Wolffsohn, J. S.

J. S. Wolffsohn and L. N. Davies, “Advances in anterior segment imaging,” Curr. Opin. Ophthalmol. 18(1), 32–38 (2007).
[Crossref]

Yasuno, Y.

Yatagai, T.

Zadnik, K.

K. Richdale, M. A. Bullimore, and K. Zadnik, “Lens thickness with age and accommodation by optical coherence tomography,” Ophthalmic Physiol. Opt. 28(5), 441–447 (2008).
[Crossref] [PubMed]

Albrecht von Graefes Arch Ophthalmo (1)

H. Helmholtz, “Ueber die Accommodation des Auges,” Albrecht von Graefes Arch Ophthalmo 2(1), 1–74 (1855).
[Crossref]

Am. J. Ophthalmol. (1)

D. J. Coleman, “Unified model for accommodative mechanism,” Am. J. Ophthalmol. 69(6), 1063–1079 (1970).
[PubMed]

Ann. Ophthalmol. (1)

R. A. Schachar, “Is Helmholtz’s theory of accommodation correct?” Ann. Ophthalmol. 31, 10–17 (1999).

Arch. Ophthalmol. (2)

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994).
[Crossref] [PubMed]

M. V. Sarunic, S. Asrani, and J. A. Izatt, “Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography,” Arch. Ophthalmol. 126(4), 537–542 (2008).
[Crossref] [PubMed]

Br. J. Ophthalmol. (1)

A. Konstantopoulos, P. Hossain, and D. F. Anderson, “Recent advances in ophthalmic anterior segment imaging: a new era for ophthalmic diagnosis?” Br. J. Ophthalmol. 91(4), 551–557 (2007).
[Crossref] [PubMed]

Clin. Exp. Optom. (1)

W. N. Charman, “The eye in focus: accommodation and presbyopia,” Clin. Exp. Optom. 91(3), 207–225 (2008).
[Crossref] [PubMed]

Cornea (1)

B. J. Kaluzny, B. J. Kaluzy, J. J. Kałuzny, A. Szkulmowska, I. Gorczyńska, M. Szkulmowski, T. Bajraszewski, M. Wojtkowski, and P. Targowski, “Spectral optical coherence tomography: a novel technique for cornea imaging,” Cornea 25(8), 960–965 (2006).
[PubMed]

Curr. Opin. Ophthalmol. (2)

W. Nolan, “Anterior segment imaging: ultrasound biomicroscopy and anterior segment optical coherence tomography,” Curr. Opin. Ophthalmol. 19(2), 115–121 (2008).
[Crossref] [PubMed]

J. S. Wolffsohn and L. N. Davies, “Advances in anterior segment imaging,” Curr. Opin. Ophthalmol. 18(1), 32–38 (2007).
[Crossref]

Invest. Ophthalmol. Vis. Sci. (1)

J. F. Koretz, C. A. Cook, and P. L. Kaufman, “Accommodation and presbyopia in the human eye,” Invest. Ophthalmol. Vis. Sci. 38(3), 569–578 (1997).
[PubMed]

J. Biomed. Opt. (1)

A. F. Fercher, “Optical coherence tomography,” J. Biomed. Opt. 1(2), 157–173 (1996).
[Crossref]

J. Cataract Refract. Surg. (2)

G. Baikoff, E. Lutun, J. Wei, and C. Ferraz, “Anterior chamber optical coherence tomography study of human natural accommodation in a 19-year-old albino,” J. Cataract Refract. Surg. 30(3), 696–701 (2004).
[Crossref] [PubMed]

G. Baikoff, E. Lutun, C. Ferraz, and J. Wei, “Static and dynamic analysis of the anterior segment with optical coherence tomography,” J. Cataract Refract. Surg. 30(9), 1843–1850 (2004).
[Crossref] [PubMed]

J. Opt. Soc. Am. A (1)

J. Vis. (1)

P. Rosales, M. Dubbelman, S. Marcos, and R. van der Heijde, “Crystalline lens radii of curvature from Purkinje and Scheimpflug imaging,” J. Vis. 6(10), 1057–1067 (2006).
[Crossref] [PubMed]

Ophthalmic Physiol. Opt. (3)

D. A. Atchison, “Accommodation and presbyopia,” Ophthalmic Physiol. Opt. 15(4), 255–272 (1995).
[Crossref] [PubMed]

T. Kirschkamp, M. Dunne, and J. C. Barry, “Phakometric measurement of ocular surface radii of curvature, axial separations and alignment in relaxed and accommodated human eyes,” Ophthalmic Physiol. Opt. 24(2), 65–73 (2004).
[Crossref] [PubMed]

K. Richdale, M. A. Bullimore, and K. Zadnik, “Lens thickness with age and accommodation by optical coherence tomography,” Ophthalmic Physiol. Opt. 28(5), 441–447 (2008).
[Crossref] [PubMed]

Ophthalmol. Clin. North Am. (1)

H. Ishikawa and J. S. Schuman, “Anterior segment imaging: ultrasound biomicroscopy,” Ophthalmol. Clin. North Am. 17(1), 7–20 (2004).
[Crossref] [PubMed]

Ophthalmology (2)

A. Glasser and P. L. Kaufman, “The mechanism of accommodation in primates,” Ophthalmology 106(5), 863–872 (1999).
[Crossref] [PubMed]

J. A. Goldsmith, Y. Li, M. R. Chalita, V. Westphal, C. A. Patil, A. M. Rollins, J. A. Izatt, and D. Huang, “Anterior chamber width measurement by high-speed optical coherence tomography,” Ophthalmology 112(2), 238–244 (2005).
[Crossref] [PubMed]

Opt. Commun. (2)

P. Targowski, I. Gorczynska, M. Szkulmowski, M. Wojtkowski, and A. Kowalczyk, “Improved complex spectral domain OCT for in vivo eye imaging,” Opt. Commun. 249(1-3), 357–362 (2005).
[Crossref]

P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczyńska, “Complex spectral OCT in human eye imaging in vivo,” Opt. Commun. 229(1-6), 79–84 (2004).
[Crossref]

Opt. Express (7)

E. Götzinger, M. Pircher, R. A. Leitgeb, and C. K. Hitzenberger, “High speed full range complex spectral domain optical coherence tomography,” Opt. Express 13, 583–594 (2005).
[Crossref] [PubMed]

Y. Yasuno, V. D. Madjarova, S. Makita, M. Akiba, A. Morosawa, C. Chong, T. Sakai, K. P. Chan, M. Itoh, and T. Yatagai, “Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments,” Opt. Express 13(26), 10652–10664 (2005).
[Crossref] [PubMed]

C. Kerbage, H. Lim, W. Sun, M. Mujat, and J. F. de Boer, “Large depth-high resolution full 3D imaging of the anterior segments of the eye using high speed optical frequency domain imaging,” Opt. Express 15(12), 7117–7125 (2007).
[Crossref] [PubMed]

B. Grajciar, M. Pircher, C. K. Hitzenberger, O. Findl, and A. F. Fercher, “High sensitive measurement of the human axial eye length in vivo with Fourier domain low coherence interferometry,” Opt. Express 16(4), 2405–2414 (2008).
[Crossref] [PubMed]

B. Baumann, M. Pircher, E. Götzinger, and C. K. Hitzenberger, “Full range complex spectral domain optical coherence tomography without additional phase shifters,” Opt. Express 15(20), 13375–13387 (2007).
[Crossref] [PubMed]

I. Grulkowski, M. Gora, M. Szkulmowski, I. Gorczynska, D. Szlag, S. Marcos, A. Kowalczyk, and M. Wojtkowski, “Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera,” Opt. Express 17(6), 4842–4858 (2009).
[Crossref] [PubMed]

V. Westphal, A. M. Rollins, S. Radhakrishnan, and J. A. Izatt, “Correction of geometrical and refractive image distortions in optical coherence tomography applying Fermat's principle,” Opt. Express 10, 397–403 (2002).
[PubMed]

Optica Applicata (1)

J. J. Kaluzny, M. Wojtkowski, and A. Kowalczyk, “Imaging of the anterior segment of the eye by Spectra Optical Coherence Tomography,” Optica Applicata 32, 581–589 (2002).

Optom. Vis. Sci. (1)

A. S. Vilupuru and A. Glasser, “Dynamic accommodative changes in rhesus monkey eyes assessed with A-scan ultrasound biometry,” Optom. Vis. Sci. 80(5), 383–394 (2003).
[Crossref] [PubMed]

Proc. SPIE (3)

J. Holmes, S. Hattersley, N. Stone, F. Bazant-Hegemark, and H. Barr, “Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications,” Proc. SPIE 6847, 68470O (2008).
[Crossref]

J. Holmes, “Theory and applications of multi-beam OCT,” Proc. SPIE 7139, 713908 (2008).
[Crossref]

J. Holmes and S. Hattersley, “Image blending and speckle noise reduction in multi-beam OCT,” Proc. SPIE 7168, 71681N (2009).
[Crossref]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Other (1)

E. Gotzinger, M. Pircher, R. A. Leitgeb, B. Baumann, and C. K. Hitzenberger, “Quadruple depth range spectral domain optical coherence tomography for imaging of the anterior eye segment,” presented at the SPIE Photonics West on Bios, San Jose, CA, USA, 24–29 Jan. 2009.

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Figures (4)

Fig. 1
Fig. 1 Schematic of the dual channel OCT experimental system. The inserted is the enlargement of the dual focus configuration of two sample beams.
Fig. 2
Fig. 2 The simultaneously acquired raw images using the dual channel dual focus OCT show the anterior chamber (a) and the posterior surface of the lens (b), respectively. These two images have a distance of 3.325mm in air in the depth direction. Pixels: 2048 × 2048; Imaging range: 5.2 (depth) × 12 (width) mm (a) and 2.5 (depth) × 12 (width) mm (b); White bar: 0.5mm.
Fig. 3
Fig. 3 The simultaneously acquired images were constructed in scale, but with optical correction. All the surfaces of the anterior segment of the eye including the cornea, anterior chamber, anterior and posterior surfaces of crystalline lens and capsule were clearly visualized. The white bar: 0.5mm.
Fig. 4
Fig. 4 The right eye (−3.50D myopic) of the subject was imaged without accommodation (a) and with 5.5 D accommodation (b). The white bar: 0.5mm.

Tables (1)

Tables Icon

Table 1 Dimensions of the anterior segment in relaxed and accommodated eye. The accommodation amplitude is 2.00D in test session 1 and 5.50D in test session 2, respectively.

Metrics