Abstract

Optofluidic time-stretch quantitative phase imaging (OTS-QPI) is a powerful tool as it enables high-throughput (>10,000 cell/s) QPI of single live cells. OTS-QPI is based on decoding temporally stretched spectral interferograms that carry the spatial profiles of cells flowing on a microfluidic chip. However, the utility of OTS-QPI is troubled by difficulties in phase retrieval from the high-frequency region of the temporal interferograms, such as phase-unwrapping errors, high instrumentation cost, and large data volume. To overcome these difficulties, we propose and experimentally demonstrate frequency-shifted OTS-QPI by bringing the phase information to the baseband region. Furthermore, to show its boosted utility, we use it to demonstrate image-based classification of leukemia cells with high accuracy over 96% and evaluation of drug-treated leukemia cells via deep learning.

© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Full Article  |  PDF Article
OSA Recommended Articles
High-throughput time-stretch imaging flow cytometry for multi-class classification of phytoplankton

Queenie T. K. Lai, Kelvin C. M. Lee, Anson H. L. Tang, Kenneth K. Y. Wong, Hayden K. H. So, and Kevin K. Tsia
Opt. Express 24(25) 28170-28184 (2016)

Cytopathological image analysis using deep-learning networks in microfluidic microscopy

G. Gopakumar, K. Hari Babu, Deepak Mishra, Sai Siva Gorthi, and Gorthi. R. K. Sai Subrahmanyam
J. Opt. Soc. Am. A 34(1) 111-121 (2017)

Differentiation of normal and leukemic cells by 2D light scattering label-free static cytometry

Linyan Xie, Qiao Liu, Changshun Shao, and Xuantao Su
Opt. Express 24(19) 21700-21707 (2016)

References

  • View by:
  • |
  • |
  • |

  1. C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
    [Crossref]
  2. B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
    [Crossref]
  3. B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
    [Crossref]
  4. K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
    [Crossref]
  5. A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
    [Crossref]
  6. A. Mahjoubfar, C. Chen, K. R. Niazi, S. Rabizadeh, and B. Jalali, “Label-free high-throughput cell screening in flow,” Biomed. Opt. Express 4(9), 1618–1625 (2013).
    [Crossref]
  7. K. Goda, K. Tsia, and B. Jalali, “Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena,” Nature 458(7242), 1145–1149 (2009).
    [Crossref]
  8. K. Goda and B. Jalali, “Dispersive Fourier transformation for fast continuous single-shot measurements,” Nat. Photonics 7(2), 102–112 (2013).
    [Crossref]
  9. K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
    [Crossref]
  10. Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
    [Crossref]
  11. H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
    [Crossref]
  12. H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
    [Crossref]
  13. H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
    [Crossref]
  14. C. Lei, B. Guo, Z. Cheng, and K. Goda, “Optical time-stretch imaging: Principles and applications,” Appl. Phys. Rev. 3(1), 011102 (2016).
    [Crossref]
  15. A. K. Lau, H. C. Shum, K. K. Wong, and K. K. Tsia, “Optofluidic time-stretch imaging–an emerging tool for high-throughput imaging flow cytometry,” Lab Chip 16(10), 1743–1756 (2016).
    [Crossref]
  16. T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
    [Crossref]
  17. T. T. Wong, A. K. Lau, K. K. Wong, and K. K. Tsia, “Optical time-stretch confocal microscopy at 1 µm,” Opt. Lett. 37(16), 3330–3332 (2012).
    [Crossref]
  18. A. Mahjoubfar, D. V. Churkin, S. Barland, N. Broderick, S. K. Turitsyn, and B. Jalali, “Time stretch and its applications,” Nat. Photonics 11(6), 341–351 (2017).
    [Crossref]
  19. Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12(10), 578–589 (2018).
    [Crossref]
  20. T. H. Nguyen, M. E. Kandel, M. Rubessa, M. B. Wheeler, and G. Popescu, “Gradient light interference microscopy for 3D imaging of unlabeled specimens,” Nat. Commun. 8(1), 210 (2017).
    [Crossref]
  21. M. Shan, M. E. Kandel, and G. Popescu, “Refractive index variance of cells and tissues measured by quantitative phase imaging,” Opt. Express 25(2), 1573–1581 (2017).
    [Crossref]
  22. G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
    [Crossref]
  23. H. Majeed, T. H. Nguyen, M. E. Kandel, A. Kajdacsy-Balla, and G. Popescu, “Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM),” Sci. Rep. 8(1), 6875 (2018).
    [Crossref]
  24. B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
    [Crossref]
  25. K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
    [Crossref]
  26. S. Shin, K. Lee, Z. Yaqoob, P. T. C. So, and Y. Park, “Reference-free polarization-sensitive quantitative phase imaging using single-point optical phase conjugation,” Opt. Express 26(21), 26858–26865 (2018).
    [Crossref]
  27. S. Shin, D. Kim, K. Kim, and Y. Park, “Super-resolution three-dimensional fluorescence and optical diffraction tomography of live cells using structured illumination generated by a digital micromirror device,” Sci. Rep. 8(1), 9183 (2018).
    [Crossref]
  28. J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
    [Crossref]
  29. M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
    [Crossref]
  30. P. Wang, R. Bista, R. Bhargava, R. E. Brand, and Y. Liu, “Spatial-domain low-coherence quantitative phase microscopy for cancer diagnosis,” Opt. Lett. 35(17), 2840–2842 (2010).
    [Crossref]
  31. N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
    [Crossref]
  32. A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
    [Crossref]
  33. C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
    [Crossref]
  34. G. M. Whitesides, E. Ostuni, S. Takayama, X. Jiang, and D. E. Ingber, “Soft Lithography in Biology and Biochemistry,” Annu. Rev. Biomed. Eng. 3(1), 335–373 (2001).
    [Crossref]
  35. J. Schmidhuber, “Deep learning in neural networks: An overview,” Neural Networks 61, 85–117 (2015).
    [Crossref]
  36. A. Krizhevsky, I. Sutskever, and G. E. Hinton, “Imagenet classification with deep convolutional neural networks,” in Neural Information Processing Systems 2012, 2012, 1097–1105.
  37. F. Chollet, “Keras: Deep learning for humans” (Github repository, 2015), retrieved https://github.com/keras-team/keras .
  38. M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.
  39. L. v. d. Maaten and G. Hinton, “Visualizing data using t-SNE,” J. Mach. Learn. Res. 9, 2579–2605 (2008).
  40. P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
    [Crossref]

2019 (3)

K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

2018 (9)

S. Shin, K. Lee, Z. Yaqoob, P. T. C. So, and Y. Park, “Reference-free polarization-sensitive quantitative phase imaging using single-point optical phase conjugation,” Opt. Express 26(21), 26858–26865 (2018).
[Crossref]

S. Shin, D. Kim, K. Kim, and Y. Park, “Super-resolution three-dimensional fluorescence and optical diffraction tomography of live cells using structured illumination generated by a digital micromirror device,” Sci. Rep. 8(1), 9183 (2018).
[Crossref]

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12(10), 578–589 (2018).
[Crossref]

H. Majeed, T. H. Nguyen, M. E. Kandel, A. Kajdacsy-Balla, and G. Popescu, “Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM),” Sci. Rep. 8(1), 6875 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

2017 (6)

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

A. Mahjoubfar, D. V. Churkin, S. Barland, N. Broderick, S. K. Turitsyn, and B. Jalali, “Time stretch and its applications,” Nat. Photonics 11(6), 341–351 (2017).
[Crossref]

T. H. Nguyen, M. E. Kandel, M. Rubessa, M. B. Wheeler, and G. Popescu, “Gradient light interference microscopy for 3D imaging of unlabeled specimens,” Nat. Commun. 8(1), 210 (2017).
[Crossref]

M. Shan, M. E. Kandel, and G. Popescu, “Refractive index variance of cells and tissues measured by quantitative phase imaging,” Opt. Express 25(2), 1573–1581 (2017).
[Crossref]

2016 (3)

C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
[Crossref]

C. Lei, B. Guo, Z. Cheng, and K. Goda, “Optical time-stretch imaging: Principles and applications,” Appl. Phys. Rev. 3(1), 011102 (2016).
[Crossref]

A. K. Lau, H. C. Shum, K. K. Wong, and K. K. Tsia, “Optofluidic time-stretch imaging–an emerging tool for high-throughput imaging flow cytometry,” Lab Chip 16(10), 1743–1756 (2016).
[Crossref]

2015 (2)

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

J. Schmidhuber, “Deep learning in neural networks: An overview,” Neural Networks 61, 85–117 (2015).
[Crossref]

2014 (1)

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

2013 (3)

A. Mahjoubfar, C. Chen, K. R. Niazi, S. Rabizadeh, and B. Jalali, “Label-free high-throughput cell screening in flow,” Biomed. Opt. Express 4(9), 1618–1625 (2013).
[Crossref]

K. Goda and B. Jalali, “Dispersive Fourier transformation for fast continuous single-shot measurements,” Nat. Photonics 7(2), 102–112 (2013).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

2012 (4)

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref]

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Wong, and K. K. Tsia, “Optical time-stretch confocal microscopy at 1 µm,” Opt. Lett. 37(16), 3330–3332 (2012).
[Crossref]

2011 (1)

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

2010 (1)

2009 (1)

K. Goda, K. Tsia, and B. Jalali, “Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena,” Nature 458(7242), 1145–1149 (2009).
[Crossref]

2008 (1)

L. v. d. Maaten and G. Hinton, “Visualizing data using t-SNE,” J. Mach. Learn. Res. 9, 2579–2605 (2008).

2006 (1)

2001 (1)

G. M. Whitesides, E. Ostuni, S. Takayama, X. Jiang, and D. E. Ingber, “Soft Lithography in Biology and Biochemistry,” Annu. Rev. Biomed. Eng. 3(1), 335–373 (2001).
[Crossref]

Abadi, M.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Adam, J.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Aisaka, Y.

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

Arai, F.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Ayazi, A.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Balduzzi, D.

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref]

Barham, P.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Barland, S.

A. Mahjoubfar, D. V. Churkin, S. Barland, N. Broderick, S. K. Turitsyn, and B. Jalali, “Time stretch and its applications,” Nat. Photonics 11(6), 341–351 (2017).
[Crossref]

Bhaduri, B.

Bhargava, R.

Bista, R.

Blaby, I. K.

C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
[Crossref]

Brackbilla, N.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Brain, G.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Brand, R. E.

Broderick, N.

A. Mahjoubfar, D. V. Churkin, S. Barland, N. Broderick, S. K. Turitsyn, and B. Jalali, “Time stretch and its applications,” Nat. Photonics 11(6), 341–351 (2017).
[Crossref]

Chan, A. C.

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

Chan, G. C.

K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

Chang, G.

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Cheah, K. S.

K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
[Crossref]

Chen, C.

Chen, C. L.

C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
[Crossref]

Chen, J.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Chen, Z.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Cheng, Z.

C. Lei, B. Guo, Z. Cheng, and K. Goda, “Optical time-stretch imaging: Principles and applications,” Appl. Phys. Rev. 3(1), 011102 (2016).
[Crossref]

Cho, S.

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Chollet, F.

F. Chollet, “Keras: Deep learning for humans” (Github repository, 2015), retrieved https://github.com/keras-team/keras .

Churkin, D. V.

A. Mahjoubfar, D. V. Churkin, S. Barland, N. Broderick, S. K. Turitsyn, and B. Jalali, “Time stretch and its applications,” Nat. Photonics 11(6), 341–351 (2017).
[Crossref]

Dasari, R. R.

Davis, A.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Dean, J.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Depeursinge, C.

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12(10), 578–589 (2018).
[Crossref]

Devin, M.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Di Carlo, D.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Endo, T.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Fang, T. Y.

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

Fard, A. M.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Feld, M. S.

Ferraro, P.

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref]

Finizio, A.

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref]

Fujiwaki, Y.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Fukuzawa, H.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Galli, A.

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref]

Ghemawat, S.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Goda, K.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

C. Lei, B. Guo, Z. Cheng, and K. Goda, “Optical time-stretch imaging: Principles and applications,” Appl. Phys. Rev. 3(1), 011102 (2016).
[Crossref]

K. Goda and B. Jalali, “Dispersive Fourier transformation for fast continuous single-shot measurements,” Nat. Photonics 7(2), 102–112 (2013).
[Crossref]

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

K. Goda, K. Tsia, and B. Jalali, “Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena,” Nature 458(7242), 1145–1149 (2009).
[Crossref]

Gossett, D. R.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Guo, B.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

C. Lei, B. Guo, Z. Cheng, and K. Goda, “Optical time-stretch imaging: Principles and applications,” Appl. Phys. Rev. 3(1), 011102 (2016).
[Crossref]

Hase, M.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Hayakawa, T.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Heo, J.

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Hinton, G.

L. v. d. Maaten and G. Hinton, “Visualizing data using t-SNE,” J. Mach. Learn. Res. 9, 2579–2605 (2008).

Hinton, G. E.

A. Krizhevsky, I. Sutskever, and G. E. Hinton, “Imagenet classification with deep convolutional neural networks,” in Neural Information Processing Systems 2012, 2012, 1097–1105.

Hiraki, K.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Hiramatsu, K.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Ho, K. K.

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

Hong, S.-J.

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

Hoshino, Y.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Hosokawa, Y.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Huang, A.

C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
[Crossref]

Huang, C.-J.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

Hur, S. C.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Iino, T.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Ikeda, T.

Inaba, M.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Ingber, D. E.

G. M. Whitesides, E. Ostuni, S. Takayama, X. Jiang, and D. E. Ingber, “Soft Lithography in Biology and Biochemistry,” Annu. Rev. Biomed. Eng. 3(1), 335–373 (2001).
[Crossref]

Irving, G.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Isard, M.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Isozaki, A.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

Ito, T.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

Jalali, B.

A. Mahjoubfar, D. V. Churkin, S. Barland, N. Broderick, S. K. Turitsyn, and B. Jalali, “Time stretch and its applications,” Nat. Photonics 11(6), 341–351 (2017).
[Crossref]

C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
[Crossref]

K. Goda and B. Jalali, “Dispersive Fourier transformation for fast continuous single-shot measurements,” Nat. Photonics 7(2), 102–112 (2013).
[Crossref]

A. Mahjoubfar, C. Chen, K. R. Niazi, S. Rabizadeh, and B. Jalali, “Label-free high-throughput cell screening in flow,” Biomed. Opt. Express 4(9), 1618–1625 (2013).
[Crossref]

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

K. Goda, K. Tsia, and B. Jalali, “Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena,” Nature 458(7242), 1145–1149 (2009).
[Crossref]

Jian, N.

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

Jian, P.

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

Jian, W.

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

Jiang, X.

G. M. Whitesides, E. Ostuni, S. Takayama, X. Jiang, and D. E. Ingber, “Soft Lithography in Biology and Biochemistry,” Annu. Rev. Biomed. Eng. 3(1), 335–373 (2001).
[Crossref]

Jiang, Y.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

Jo, Y.

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Jona, M.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

Jung, J.

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Kajdacsy-Balla, A.

H. Majeed, T. H. Nguyen, M. E. Kandel, A. Kajdacsy-Balla, and G. Popescu, “Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM),” Sci. Rep. 8(1), 6875 (2018).
[Crossref]

Kandel, M. E.

H. Majeed, T. H. Nguyen, M. E. Kandel, A. Kajdacsy-Balla, and G. Popescu, “Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM),” Sci. Rep. 8(1), 6875 (2018).
[Crossref]

T. H. Nguyen, M. E. Kandel, M. Rubessa, M. B. Wheeler, and G. Popescu, “Gradient light interference microscopy for 3D imaging of unlabeled specimens,” Nat. Commun. 8(1), 210 (2017).
[Crossref]

M. Shan, M. E. Kandel, and G. Popescu, “Refractive index variance of cells and tissues measured by quantitative phase imaging,” Opt. Express 25(2), 1573–1581 (2017).
[Crossref]

Karakawa, H.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Kasai, Y.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Kim, D.

S. Shin, D. Kim, K. Kim, and Y. Park, “Super-resolution three-dimensional fluorescence and optical diffraction tomography of live cells using structured illumination generated by a digital micromirror device,” Sci. Rep. 8(1), 9183 (2018).
[Crossref]

Kim, D.-J.

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

Kim, G.

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

Kim, H.-B.

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

Kim, K.

S. Shin, D. Kim, K. Kim, and Y. Park, “Super-resolution three-dimensional fluorescence and optical diffraction tomography of live cells using structured illumination generated by a digital micromirror device,” Sci. Rep. 8(1), 9183 (2018).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Kobayashi, H.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

Koizumi, K.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Krizhevsky, A.

A. Krizhevsky, I. Sutskever, and G. E. Hinton, “Imagenet classification with deep convolutional neural networks,” in Neural Information Processing Systems 2012, 2012, 1097–1105.

Kudlur, M.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Kutsuna, N.

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

Lam, E. Y.

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

Lau, A. K.

A. K. Lau, H. C. Shum, K. K. Wong, and K. K. Tsia, “Optofluidic time-stretch imaging–an emerging tool for high-throughput imaging flow cytometry,” Lab Chip 16(10), 1743–1756 (2016).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Wong, and K. K. Tsia, “Optical time-stretch confocal microscopy at 1 µm,” Opt. Lett. 37(16), 3330–3332 (2012).
[Crossref]

Lee, C.-G.

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

Lee, K.

S. Shin, K. Lee, Z. Yaqoob, P. T. C. So, and Y. Park, “Reference-free polarization-sensitive quantitative phase imaging using single-point optical phase conjugation,” Opt. Express 26(21), 26858–26865 (2018).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Lee, K. C.

K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
[Crossref]

Lee, M.

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

Lee, S.

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Lei, C.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

C. Lei, B. Guo, Z. Cheng, and K. Goda, “Optical time-stretch imaging: Principles and applications,” Appl. Phys. Rev. 3(1), 011102 (2016).
[Crossref]

Levenberg, J.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Li, M.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

Li, W.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

Li, Z. W.

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

Liu, Y.

Lonappan, C. K.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Maeno, T.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Mahjoubfar, A.

A. Mahjoubfar, D. V. Churkin, S. Barland, N. Broderick, S. K. Turitsyn, and B. Jalali, “Time stretch and its applications,” Nat. Photonics 11(6), 341–351 (2017).
[Crossref]

C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
[Crossref]

A. Mahjoubfar, C. Chen, K. R. Niazi, S. Rabizadeh, and B. Jalali, “Label-free high-throughput cell screening in flow,” Biomed. Opt. Express 4(9), 1618–1625 (2013).
[Crossref]

Majeed, H.

H. Majeed, T. H. Nguyen, M. E. Kandel, A. Kajdacsy-Balla, and G. Popescu, “Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM),” Sci. Rep. 8(1), 6875 (2018).
[Crossref]

Mao, A.

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

Matsusaka, S.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Mei, L. X.

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

Memmolo, P.

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref]

Mikami, H.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

Mir, M.

Monga, R.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Moore, S.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Murakami, D.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Murray, C.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Murray, D. G.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Nakagawa, A.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

Nguyen, T. H.

H. Majeed, T. H. Nguyen, M. E. Kandel, A. Kajdacsy-Balla, and G. Popescu, “Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM),” Sci. Rep. 8(1), 6875 (2018).
[Crossref]

T. H. Nguyen, M. E. Kandel, M. Rubessa, M. B. Wheeler, and G. Popescu, “Gradient light interference microscopy for 3D imaging of unlabeled specimens,” Nat. Commun. 8(1), 210 (2017).
[Crossref]

Niazi, K. R.

C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
[Crossref]

A. Mahjoubfar, C. Chen, K. R. Niazi, S. Rabizadeh, and B. Jalali, “Label-free high-throughput cell screening in flow,” Biomed. Opt. Express 4(9), 1618–1625 (2013).
[Crossref]

Nitta, N.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

Oguchi, Y.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Oikawa, M.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Ostuni, E.

G. M. Whitesides, E. Ostuni, S. Takayama, X. Jiang, and D. E. Ingber, “Soft Lithography in Biology and Biochemistry,” Annu. Rev. Biomed. Eng. 3(1), 335–373 (2001).
[Crossref]

Ota, T.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Ozeki, Y.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

Park, H.

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Park, Y.

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12(10), 578–589 (2018).
[Crossref]

S. Shin, D. Kim, K. Kim, and Y. Park, “Super-resolution three-dimensional fluorescence and optical diffraction tomography of live cells using structured illumination generated by a digital micromirror device,” Sci. Rep. 8(1), 9183 (2018).
[Crossref]

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

S. Shin, K. Lee, Z. Yaqoob, P. T. C. So, and Y. Park, “Reference-free polarization-sensitive quantitative phase imaging using single-point optical phase conjugation,” Opt. Express 26(21), 26858–26865 (2018).
[Crossref]

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Paturzo, M.

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref]

Pham, H.

Popescu, G.

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12(10), 578–589 (2018).
[Crossref]

H. Majeed, T. H. Nguyen, M. E. Kandel, A. Kajdacsy-Balla, and G. Popescu, “Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM),” Sci. Rep. 8(1), 6875 (2018).
[Crossref]

T. H. Nguyen, M. E. Kandel, M. Rubessa, M. B. Wheeler, and G. Popescu, “Gradient light interference microscopy for 3D imaging of unlabeled specimens,” Nat. Commun. 8(1), 210 (2017).
[Crossref]

M. Shan, M. E. Kandel, and G. Popescu, “Refractive index variance of cells and tissues measured by quantitative phase imaging,” Opt. Express 25(2), 1573–1581 (2017).
[Crossref]

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref]

Puglisi, R.

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref]

Rabizadeh, S.

Robles, J. D.

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

Rubessa, M.

T. H. Nguyen, M. E. Kandel, M. Rubessa, M. B. Wheeler, and G. Popescu, “Gradient light interference microscopy for 3D imaging of unlabeled specimens,” Nat. Commun. 8(1), 210 (2017).
[Crossref]

Sadasivam, J.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Sakuma, S.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Schmidhuber, J.

J. Schmidhuber, “Deep learning in neural networks: An overview,” Neural Networks 61, 85–117 (2015).
[Crossref]

Shan, M.

Shiba, K.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Shin, S.

S. Shin, D. Kim, K. Kim, and Y. Park, “Super-resolution three-dimensional fluorescence and optical diffraction tomography of live cells using structured illumination generated by a digital micromirror device,” Sci. Rep. 8(1), 9183 (2018).
[Crossref]

S. Shin, K. Lee, Z. Yaqoob, P. T. C. So, and Y. Park, “Reference-free polarization-sensitive quantitative phase imaging using single-point optical phase conjugation,” Opt. Express 26(21), 26858–26865 (2018).
[Crossref]

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

Shintaku, H.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Shirasaki, Y.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Shum, H. C.

A. K. Lau, H. C. Shum, K. K. Wong, and K. K. Tsia, “Optofluidic time-stretch imaging–an emerging tool for high-throughput imaging flow cytometry,” Lab Chip 16(10), 1743–1756 (2016).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

So, H. K.

K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
[Crossref]

So, P. T. C.

Sollier, E.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Steiner, B.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Suga, K.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Sugimura, T.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

Sun, C.-W.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

Sutskever, I.

A. Krizhevsky, I. Sutskever, and G. E. Hinton, “Imagenet classification with deep convolutional neural networks,” in Neural Information Processing Systems 2012, 2012, 1097–1105.

Suzuki, N.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Suzuki, Y.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Tai, L.-C.

C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
[Crossref]

Takayama, S.

G. M. Whitesides, E. Ostuni, S. Takayama, X. Jiang, and D. E. Ingber, “Soft Lithography in Biology and Biochemistry,” Annu. Rev. Biomed. Eng. 3(1), 335–373 (2001).
[Crossref]

Tanaka, Y.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

Tang, A. H.

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

Tang, M. Y.

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

Tezuka, H.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Toyokawa, C.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Tsia, K.

K. Goda, K. Tsia, and B. Jalali, “Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena,” Nature 458(7242), 1145–1149 (2009).
[Crossref]

Tsia, K. K.

K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
[Crossref]

A. K. Lau, H. C. Shum, K. K. Wong, and K. K. Tsia, “Optofluidic time-stretch imaging–an emerging tool for high-throughput imaging flow cytometry,” Lab Chip 16(10), 1743–1756 (2016).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Wong, and K. K. Tsia, “Optical time-stretch confocal microscopy at 1 µm,” Opt. Lett. 37(16), 3330–3332 (2012).
[Crossref]

Tucker, P.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Turitsyn, S. K.

A. Mahjoubfar, D. V. Churkin, S. Barland, N. Broderick, S. K. Turitsyn, and B. Jalali, “Time stretch and its applications,” Nat. Photonics 11(6), 341–351 (2017).
[Crossref]

Uemura, S.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

v. d. Maaten, L.

L. v. d. Maaten and G. Hinton, “Visualizing data using t-SNE,” J. Mach. Learn. Res. 9, 2579–2605 (2008).

Vasudevan, V.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Wang, C.

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Wang, M.

K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
[Crossref]

Wang, P.

Warden, P.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Wei, X.

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

Wheeler, M. B.

T. H. Nguyen, M. E. Kandel, M. Rubessa, M. B. Wheeler, and G. Popescu, “Gradient light interference microscopy for 3D imaging of unlabeled specimens,” Nat. Commun. 8(1), 210 (2017).
[Crossref]

Whitesides, G. M.

G. M. Whitesides, E. Ostuni, S. Takayama, X. Jiang, and D. E. Ingber, “Soft Lithography in Biology and Biochemistry,” Annu. Rev. Biomed. Eng. 3(1), 335–373 (2001).
[Crossref]

Wicke, M.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Wong, K. K.

K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
[Crossref]

A. K. Lau, H. C. Shum, K. K. Wong, and K. K. Tsia, “Optofluidic time-stretch imaging–an emerging tool for high-throughput imaging flow cytometry,” Lab Chip 16(10), 1743–1756 (2016).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Wong, and K. K. Tsia, “Optical time-stretch confocal microscopy at 1 µm,” Opt. Lett. 37(16), 3330–3332 (2012).
[Crossref]

Wong, T. T.

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Wong, and K. K. Tsia, “Optical time-stretch confocal microscopy at 1 µm,” Opt. Lett. 37(16), 3330–3332 (2012).
[Crossref]

Wu, Y.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

Yalikun, Y.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

Yamada, M.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

Yamagishi, M.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Yamano, T.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Yan, W. S.

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

Yaqoob, Z.

Yasumoto, A.

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

Yatomi, Y.

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

Yazawa, M.

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Yu, Y.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Zheng, X.

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Zhuan, Z.

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

Annu. Rev. Biomed. Eng. (1)

G. M. Whitesides, E. Ostuni, S. Takayama, X. Jiang, and D. E. Ingber, “Soft Lithography in Biology and Biochemistry,” Annu. Rev. Biomed. Eng. 3(1), 335–373 (2001).
[Crossref]

Appl. Phys. Rev. (1)

C. Lei, B. Guo, Z. Cheng, and K. Goda, “Optical time-stretch imaging: Principles and applications,” Appl. Phys. Rev. 3(1), 011102 (2016).
[Crossref]

Biomed. Opt. Express (1)

Cell (1)

N. Nitta, T. Sugimura, A. Isozaki, H. Mikami, K. Hiraki, S. Sakuma, T. Iino, F. Arai, T. Endo, Y. Fujiwaki, H. Fukuzawa, M. Hase, T. Hayakawa, K. Hiramatsu, Y. Hoshino, M. Inaba, T. Ito, H. Karakawa, Y. Kasai, K. Koizumi, S. Lee, C. Lei, M. Li, T. Maeno, S. Matsusaka, D. Murakami, A. Nakagawa, Y. Oguchi, M. Oikawa, T. Ota, K. Shiba, H. Shintaku, Y. Shirasaki, K. Suga, Y. Suzuki, N. Suzuki, Y. Tanaka, H. Tezuka, C. Toyokawa, Y. Yalikun, M. Yamada, M. Yamagishi, T. Yamano, A. Yasumoto, Y. Yatomi, M. Yazawa, D. Di Carlo, Y. Hosokawa, S. Uemura, Y. Ozeki, and K. Goda, “Intelligent image-activated cell sorting,” Cell 175(1), 266–276.e13 (2018).
[Crossref]

Chem (1)

H. Mikami, C. Lei, N. Nitta, T. Sugimura, T. Ito, Y. Ozeki, and K. Goda, “High-speed imaging meets single-cell analysis,” Chem 4(10), 2278–2300 (2018).
[Crossref]

Cytom. Part A (2)

B. Guo, C. Lei, H. Kobayashi, T. Ito, Y. Yalikun, Y. Jiang, Y. Tanaka, Y. Ozeki, and K. Goda, “High-throughput, label-free, single-cell, microalgal lipid screening by machine-learning-equipped optofluidic time-stretch quantitative phase microscopy,” Cytom. Part A 91(5), 494–502 (2017).
[Crossref]

K. C. Lee, M. Wang, K. S. Cheah, G. C. Chan, H. K. So, K. K. Wong, and K. K. Tsia, “Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping,” Cytom. Part A 95(5), 510–520 (2019).
[Crossref]

J. Biomed. Opt (1)

A. K. Lau, T. T. Wong, K. K. Ho, M. Y. Tang, A. C. Chan, X. Wei, E. Y. Lam, H. C. Shum, K. K. Wong, and K. K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1 µm,” J. Biomed. Opt 19(7), 076001 (2014).
[Crossref]

J. Hematol. Oncol. (1)

P. Jian, Z. W. Li, T. Y. Fang, W. Jian, Z. Zhuan, L. X. Mei, W. S. Yan, and N. Jian, “Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663,” J. Hematol. Oncol. 4(1), 20 (2011).
[Crossref]

J. Mach. Learn. Res. (1)

L. v. d. Maaten and G. Hinton, “Visualizing data using t-SNE,” J. Mach. Learn. Res. 9, 2579–2605 (2008).

Lab Chip (4)

Y. Jiang, C. Lei, A. Yasumoto, H. Kobayashi, Y. Aisaka, T. Ito, B. Guo, N. Nitta, N. Kutsuna, Y. Ozeki, A. Nakagawa, Y. Yatomi, and K. Goda, “Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy,” Lab Chip 17(14), 2426–2434 (2017).
[Crossref]

H. Kobayashi, C. Lei, Y. Wu, C.-J. Huang, A. Yasumoto, M. Jona, W. Li, Y. Wu, Y. Yalikun, Y. Jiang, B. Guo, C.-W. Sun, Y. Tanaka, M. Yamada, Y. Yatomi, and K. Goda, “Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemia,” Lab Chip 19(16), 2688–2698 (2019).
[Crossref]

A. K. Lau, H. C. Shum, K. K. Wong, and K. K. Tsia, “Optofluidic time-stretch imaging–an emerging tool for high-throughput imaging flow cytometry,” Lab Chip 16(10), 1743–1756 (2016).
[Crossref]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref]

Methods (1)

B. Guo, C. Lei, Y. Wu, H. Kobayashi, T. Ito, Y. Yalikun, S. Lee, A. Isozaki, M. Li, Y. Jiang, A. Yasumoto, D. Di Carlo, Y. Tanaka, Y. Yatomi, Y. Ozeki, and K. Goda, “Optofluidic time-stretch quantitative phase microscopy,” Methods 136, 116–125 (2018).
[Crossref]

Nat. Commun. (1)

T. H. Nguyen, M. E. Kandel, M. Rubessa, M. B. Wheeler, and G. Popescu, “Gradient light interference microscopy for 3D imaging of unlabeled specimens,” Nat. Commun. 8(1), 210 (2017).
[Crossref]

Nat. Photonics (3)

K. Goda and B. Jalali, “Dispersive Fourier transformation for fast continuous single-shot measurements,” Nat. Photonics 7(2), 102–112 (2013).
[Crossref]

A. Mahjoubfar, D. V. Churkin, S. Barland, N. Broderick, S. K. Turitsyn, and B. Jalali, “Time stretch and its applications,” Nat. Photonics 11(6), 341–351 (2017).
[Crossref]

Y. Park, C. Depeursinge, and G. Popescu, “Quantitative phase imaging in biomedicine,” Nat. Photonics 12(10), 578–589 (2018).
[Crossref]

Nat. Protoc. (2)

C. Lei, H. Kobayashi, Y. Wu, M. Li, A. Isozaki, A. Yasumoto, H. Mikami, T. Ito, N. Nitta, T. Sugimura, M. Yamada, Y. Yatomi, D. Di Carlo, Y. Ozeki, and K. Goda, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nat. Protoc. 13(7), 1603–1631 (2018).
[Crossref]

A. Isozaki, H. Mikami, K. Hiramatsu, S. Sakuma, Y. Kasai, T. Iino, T. Yamano, A. Yasumoto, Y. Oguchi, N. Suzuki, Y. Shirasaki, T. Endo, T. Ito, K. Hiraki, M. Yamada, S. Matsusaka, T. Hayakawa, H. Fukuzawa, Y. Yatomi, F. Arai, D. Di Carlo, A. Nakagawa, Y. Hoshino, Y. Hosokawa, S. Uemura, T. Sugimura, Y. Ozeki, N. Nitta, and K. Goda, “A practical guide to intelligent image-activated cell sorting,” Nat. Protoc. 14(8), 2370–2415 (2019).
[Crossref]

Nature (1)

K. Goda, K. Tsia, and B. Jalali, “Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena,” Nature 458(7242), 1145–1149 (2009).
[Crossref]

Neural Networks (1)

J. Schmidhuber, “Deep learning in neural networks: An overview,” Neural Networks 61, 85–117 (2015).
[Crossref]

Opt. Express (2)

Opt. Lett. (4)

Proc. Natl. Acad. Sci. U. S. A. (1)

K. Goda, A. Ayazi, D. R. Gossett, J. Sadasivam, C. K. Lonappan, E. Sollier, A. M. Fard, S. C. Hur, J. Adam, C. Murray, C. Wang, N. Brackbilla, D. Di Carlo, and B. Jalali, “High-throughput single-microparticle imaging flow analyzer,” Proc. Natl. Acad. Sci. U. S. A. 109(29), 11630–11635 (2012).
[Crossref]

Sci. Rep. (6)

H. Kobayashi, C. Lei, Y. Wu, A. Mao, Y. Jiang, B. Guo, Y. Ozeki, and K. Goda, “Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning,” Sci. Rep. 7(1), 12454 (2017).
[Crossref]

T. T. Wong, A. K. Lau, K. K. Ho, M. Y. Tang, J. D. Robles, X. Wei, A. C. Chan, A. H. Tang, E. Y. Lam, K. K. Wong, G. C. Chan, H. C. Shum, and K. K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Sci. Rep. 4(1), 3656 (2015).
[Crossref]

C. L. Chen, A. Mahjoubfar, L.-C. Tai, I. K. Blaby, A. Huang, K. R. Niazi, and B. Jalali, “Deep learning in label-free cell classification,” Sci. Rep. 6(1), 21471 (2016).
[Crossref]

H. Majeed, T. H. Nguyen, M. E. Kandel, A. Kajdacsy-Balla, and G. Popescu, “Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM),” Sci. Rep. 8(1), 6875 (2018).
[Crossref]

S. Shin, D. Kim, K. Kim, and Y. Park, “Super-resolution three-dimensional fluorescence and optical diffraction tomography of live cells using structured illumination generated by a digital micromirror device,” Sci. Rep. 8(1), 9183 (2018).
[Crossref]

J. Jung, S.-J. Hong, H.-B. Kim, G. Kim, M. Lee, S. Shin, S. Lee, D.-J. Kim, C.-G. Lee, and Y. Park, “Label-free non-invasive quantitative measurement of lipid contents in individual microalgal cells using refractive index tomography,” Sci. Rep. 8(1), 6524 (2018).
[Crossref]

Sensors (1)

K. Lee, K. Kim, J. Jung, J. Heo, S. Cho, S. Lee, G. Chang, Y. Jo, H. Park, and Y. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: From principles to applications,” Sensors 13(4), 4170–4191 (2013).
[Crossref]

Other (3)

A. Krizhevsky, I. Sutskever, and G. E. Hinton, “Imagenet classification with deep convolutional neural networks,” in Neural Information Processing Systems 2012, 2012, 1097–1105.

F. Chollet, “Keras: Deep learning for humans” (Github repository, 2015), retrieved https://github.com/keras-team/keras .

M. Abadi, P. Barham, J. Chen, Z. Chen, A. Davis, J. Dean, M. Devin, S. Ghemawat, G. Irving, M. Isard, M. Kudlur, J. Levenberg, R. Monga, S. Moore, D. G. Murray, B. Steiner, P. Tucker, V. Vasudevan, P. Warden, M. Wicke, Y. Yu, X. Zheng, and G. Brain, “Tensorflow: A system for large-scale machine learning,” in 12th USENIX Symposium on Operating Systems Design and Implementation, 2016), 265–283.

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)

Fig. 1.
Fig. 1. Frequency-shifted OTS-QPI. a. Schematic of the experimental setup of frequency-shifted OTS-QPI, including an OTS-QPI microscope and a microfluidic chip. b. Enlarged view of the microfluidic chip, where the cellular spatial profile is encoded into the intensity and phase of each pulse. c. Image recovery process. The temporal interferograms of four successive pulses are converted into one line of pixels in the bright-field and phase images. d. Architecture of the CNN. The CNN is constructed based on the autoencoder structure to extract key cellular features from the bottleneck layer during the reconstruction of the bright-field and phase images.
Fig. 2.
Fig. 2. Comparison of OTS-QPI and frequency-shifted OTS-QPI. a. Temporal interferograms of OTS-QPI that contain four successive pulses. b. Temporal interferograms of frequency-shifted OTS-QPI that contain four successive pulses. c. Detection bandwidth for intensity and phase measurements in OTS-QPI. A high-bandwidth photodetector is needed to acquire the phase information from the high-frequency region. d. Detection bandwidth for intensity and phase measurements in frequency-shifted OTS-QPI. A low-bandwidth photodetector is sufficient for acquiring both the intensity and phase information. e. Bright-field and phase images of a K562 cell obtained with OTS-QPI. The phase image is disturbed by high-frequency noise. f. Bright-field and phase images of a K562 cell obtained with frequency-shifted OTS-QPI. The phase image is clear and smooth due to the elimination of high-frequency noise. g. Phase images of a K562 cell recovered with different detection bandwidths. Frequency-shifted OTS-QPI can properly recover the phase images with a much lower detection bandwidth compared with conventional OTS-QPI. h. Phase images of a K562 cell recovered with different sampling rates. Frequency-shifted OTS-QPI can properly recover the phase images at a much lower sampling rate compared with conventional OTS-QPI. Scale bar, 10 µm.
Fig. 3.
Fig. 3. Intelligent detection of leukemia cells. a. Image library of the WBCs, HL-60 cells, Jurkat cells, and K562 cells. The arrow indicates the flowing direction. Scale bar, 10 µm. b. Confusion matrices of the classification results of the three models. c. t-SNE plots generated from the bottleneck layer, showing clear discrepancies between WBCs and leukemia cells. d. Predictions of the models on the corresponding spiked samples.
Fig. 4.
Fig. 4. Intelligent classification of leukemia cells. a. Confusion matrix of the model trained with both bright-field and phase images of 8,000 cells of each type. b. t-SNE plot of the model in a. c. Confusion matrix of the model trained with only bright-field images of 8,000 cells of each type of the same dataset. d. t-SNE plot of the model in c. e. Predictions of the model trained with bright-field and phase images on the spiked sample, which are close to the true values. f. Predictions of the model trained with only the bright-field images on the spiked sample, showing poor classification accuracies.
Fig. 5.
Fig. 5. Intelligent evaluation of leukemia treatment. a. Image library of the mononuclear cells, granulocytes, HL-60 cells in the control group, and HL-60 cells in the ATRA-treated group. The arrow indicates the flowing direction. MCs, mononuclear cells. Scale bar, 10 µm. b. Confusion matrix and t-SNE plot of the model trained with bright-field and phase images of mononuclear cells, granulocytes, and untreated HL-60 cells. c. Predictions of the model on the HL-60 cells in the control group. d. Predictions of the model on the HL-60 cells treated with ATRA.

Equations (8)

Equations on this page are rendered with MathJax. Learn more.

Δ ω = C Δ x .
Δ t = D Δ ω .
Δ t = C D Δ x ,
I ( t ) = I S ( t ) + I R ( t ) + 2 I S ( t ) I R ( t ) cos [ ( ω S ω R ) t + ϕ S ( t ) ] ,
I ( t ) = I S ( t ) + I R ( t ) + 2 I S ( t ) I R ( t ) cos [ ω r 4 t + ϕ S ( t ) ] ,
I k ( t ) = I S ( t ) + I R ( t ) + 2 I S ( t ) I R ( t ) cos [ ω r 4 t k 1 2 π + ϕ S ( t ) ]  for  k = 1 , 2 , 3 , 4.
I S ( x ) = 1 4 [ I 1 ( x ) + I 2 ( x ) + I 3 ( x ) + I 4 ( x ) ] I R ( x ) ,
ϕ S ( x ) = tan 1 [ I 2 ( x ) I 4 ( x ) I 1 ( x ) I 3 ( x ) ] + ω r C D x 4 ,