Abstract

We demonstrated a fiber-based synchronously pumped optical parametric oscillator (SPOPO) with flexible repetition rates while retaining the cavity length. In contrast to conventional free-space SPOPO, the repetition rate of output signal pulses was solely determined by the repetition rate of the pump source in harmonic, fractional and rational operations. The relevant mechanism relies on synchronous pumping and intrinsic losses in our fiber resonator. The novel scheme enabled us to flexibly tune the repetition rate from 0.5 to 6.0 MHz without altering the resonator configuration. The resulting pulse properties were systematically analyzed at various operation conditions, and particularly showed that a wavelength tuning range of 157 nm was obtained. Such rational harmonic resonance implemented in our SPOPO provides not only a simple yet effective way to tune the repetition rate, but also a feasible approach to narrow down the spectral bandwidth. The presented SPOPO could be useful in nonlinear biomedical imaging by offering a convenient approach to optimize the pulse repetition rate for different biomedical samples with minimum photodamage.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Full Article  |  PDF Article
OSA Recommended Articles
Low-repetition-rate all-fiber integrated optical parametric oscillator for coherent anti-Stokes Raman spectroscopy

Kangwen Yang, Shikai Zheng, Yuxing Wu, Pengbo Ye, Kun Huang, Qiang Hao, and Heping Zeng
Opt. Express 26(13) 17519-17528 (2018)

Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy

Thomas Gottschall, Tobias Meyer, Martin Baumgartl, Benjamin Dietzek, Jürgen Popp, Jens Limpert, and Andreas Tünnermann
Opt. Express 22(18) 21921-21928 (2014)

Multimodal fiber source for nonlinear microscopy based on a dissipative soliton laser

Erin S. Lamb and Frank W. Wise
Biomed. Opt. Express 6(9) 3248-3255 (2015)

References

  • View by:
  • |
  • |
  • |

  1. C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
    [Crossref] [PubMed]
  2. M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
    [Crossref] [PubMed]
  3. R. He, Y. Xu, L. Zhang, S. Ma, X. Wang, D. Ye, and M. Ji, “Dual-phase stimulated Raman scattering microscopy for real-time two-color imaging,” Optica 4(1), 44–47 (2017).
    [Crossref]
  4. J. X. Cheng and X. S. Xie, “Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine,” Science 350(6264), aaa8870 (2015).
    [Crossref] [PubMed]
  5. A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
    [Crossref]
  6. C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
    [Crossref] [PubMed]
  7. T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
    [Crossref] [PubMed]
  8. N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
    [Crossref] [PubMed]
  9. J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
    [Crossref]
  10. W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
    [Crossref] [PubMed]
  11. C. Zhang and J. Cheng, “Perspective: Coherent Raman scattering microscopy, the future is bright,” APL Photonics 3(9), 90901 (2018).
    [Crossref]
  12. C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
    [Crossref] [PubMed]
  13. K. Charan, B. Li, M. Wang, C. P. Lin, and C. Xu, “Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy,” Biomed. Opt. Express 9(5), 2304–2311 (2018).
    [Crossref] [PubMed]
  14. Y. Fu, H. Wang, R. Shi, and J. X. Cheng, “Characterization of photodamage in coherent anti-Stokes Raman scattering microscopy,” Opt. Express 14(9), 3942–3951 (2006).
    [Crossref] [PubMed]
  15. T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
    [Crossref]
  16. J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
    [Crossref]
  17. S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
    [Crossref] [PubMed]
  18. C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
    [Crossref]
  19. K. Chen, T. Wu, H. Wei, and Y. Li, “Dual-soliton Stokes-based background-free coherent anti-Stokes Raman scattering spectroscopy and microscopy,” Opt. Lett. 41(11), 2628–2631 (2016).
    [Crossref] [PubMed]
  20. K. Yang, P. Ye, S. Zheng, J. Jiang, K. Huang, Q. Hao, and H. Zeng, “Polarization switch of four-wave mixing in a lawtunable fiber optical parametric oscillator,” Opt. Express 26(3), 2995–3003 (2018).
    [Crossref] [PubMed]
  21. E. S. Lamb, S. Lefrancois, M. Ji, W. J. Wadsworth, X. S. Xie, and F. W. Wise, “Fiber optical parametric oscillator for coherent anti-Stokes Raman scattering microscopy,” Opt. Lett. 38(20), 4154–4157 (2013).
    [Crossref] [PubMed]
  22. T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
    [Crossref] [PubMed]
  23. M. Brinkmann, S. Janfrüchte, T. Hellwig, S. Dobner, and C. Fallnich, “Electronically and rapidly tunable fiber-integrable optical parametric oscillator for nonlinear microscopy,” Opt. Lett. 41(10), 2193–2196 (2016).
    [Crossref] [PubMed]
  24. C. Wu and N. K. Dutta, “High-repetition-rate optical pulse generation using a rational harmonic mode-locked fiber laser,” IEEE J. Quantum Electron. 36, 145–150 (2002).
  25. P. Wang, L. Zhan, Z. Gu, Q. Ye, X. Hu, and Y. Xia, “Arbitrary numerator rational-harmonic mode locking in fiber ring lasers,” J. Opt. Soc. Am. B 21(10), 1781–1783 (2004).
    [Crossref]
  26. G. Zhu and N. K. Dutta, “Eighth-order rational harmonic mode-locked fiber laser with amplitude-equalized output operating at 80 Gbits/s,” Opt. Lett. 30(17), 2212–2214 (2005).
    [Crossref] [PubMed]
  27. J. Jiang and T. Hasama, “Synchronously pumped femtosecond optical parametric oscillator based on an improved pumping concept,” Opt. Commun. 220(1-3), 193–202 (2003).
    [Crossref]
  28. J. Li, T. Huang, and L. R. Chen, “Rational harmonic mode-locking of a fiber optical parametric oscillator at 30 GHz,” IEEE Photonics J. 3(3), 468–475 (2011).
    [Crossref]
  29. K. A. Ingold, A. Marandi, C. W. Rudy, K. L. Vodopyanov, and R. L. Byer, “Fractional-length sync-pumped degenerate optical parametric oscillator for 500-MHz 3-μm mid-infrared frequency comb generation,” Opt. Lett. 39(4), 900–903 (2014).
    [Crossref] [PubMed]
  30. K. Yang, S. Zheng, Y. Wu, P. Ye, K. Huang, Q. Hao, and H. Zeng, “Low-repetition-rate all-fiber integrated optical parametric oscillator for coherent anti-Stokes Raman spectroscopy,” Opt. Express 26(13), 17519–17528 (2018).
    [Crossref] [PubMed]
  31. K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable femtosecond laser from 965 to 1025 nm in fiber optical parametric oscillator,” IEEE Photonic. Tech. L. 30, 607–610 (2018).
  32. M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
    [PubMed]

2018 (7)

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

C. Zhang and J. Cheng, “Perspective: Coherent Raman scattering microscopy, the future is bright,” APL Photonics 3(9), 90901 (2018).
[Crossref]

K. Charan, B. Li, M. Wang, C. P. Lin, and C. Xu, “Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy,” Biomed. Opt. Express 9(5), 2304–2311 (2018).
[Crossref] [PubMed]

K. Yang, P. Ye, S. Zheng, J. Jiang, K. Huang, Q. Hao, and H. Zeng, “Polarization switch of four-wave mixing in a lawtunable fiber optical parametric oscillator,” Opt. Express 26(3), 2995–3003 (2018).
[Crossref] [PubMed]

K. Yang, S. Zheng, Y. Wu, P. Ye, K. Huang, Q. Hao, and H. Zeng, “Low-repetition-rate all-fiber integrated optical parametric oscillator for coherent anti-Stokes Raman spectroscopy,” Opt. Express 26(13), 17519–17528 (2018).
[Crossref] [PubMed]

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable femtosecond laser from 965 to 1025 nm in fiber optical parametric oscillator,” IEEE Photonic. Tech. L. 30, 607–610 (2018).

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

2017 (5)

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
[Crossref]

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

R. He, Y. Xu, L. Zhang, S. Ma, X. Wang, D. Ye, and M. Ji, “Dual-phase stimulated Raman scattering microscopy for real-time two-color imaging,” Optica 4(1), 44–47 (2017).
[Crossref]

2016 (2)

2015 (3)

J. X. Cheng and X. S. Xie, “Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine,” Science 350(6264), aaa8870 (2015).
[Crossref] [PubMed]

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

2014 (4)

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

K. A. Ingold, A. Marandi, C. W. Rudy, K. L. Vodopyanov, and R. L. Byer, “Fractional-length sync-pumped degenerate optical parametric oscillator for 500-MHz 3-μm mid-infrared frequency comb generation,” Opt. Lett. 39(4), 900–903 (2014).
[Crossref] [PubMed]

2013 (4)

E. S. Lamb, S. Lefrancois, M. Ji, W. J. Wadsworth, X. S. Xie, and F. W. Wise, “Fiber optical parametric oscillator for coherent anti-Stokes Raman scattering microscopy,” Opt. Lett. 38(20), 4154–4157 (2013).
[Crossref] [PubMed]

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
[Crossref]

2011 (2)

S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
[Crossref] [PubMed]

J. Li, T. Huang, and L. R. Chen, “Rational harmonic mode-locking of a fiber optical parametric oscillator at 30 GHz,” IEEE Photonics J. 3(3), 468–475 (2011).
[Crossref]

2006 (1)

2005 (1)

2004 (1)

2003 (1)

J. Jiang and T. Hasama, “Synchronously pumped femtosecond optical parametric oscillator based on an improved pumping concept,” Opt. Commun. 220(1-3), 193–202 (2003).
[Crossref]

2002 (1)

C. Wu and N. K. Dutta, “High-repetition-rate optical pulse generation using a rational harmonic mode-locked fiber laser,” IEEE J. Quantum Electron. 36, 145–150 (2002).

Andresen, E. R.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Arbel, M.

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

Bacskai, B. J.

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

Baumgartl, M.

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

Bentley, R. T.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Bernhardt, B.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Billaudeau, C.

S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
[Crossref] [PubMed]

Bocklitz, T.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Brasselet, S.

S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
[Crossref] [PubMed]

Brinkmann, M.

Brustlein, S.

S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
[Crossref] [PubMed]

Byer, R. L.

Camelo-Piragua, S.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Camp, C. H.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Charan, K.

Chen, K.

Chen, L.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Chen, L. R.

J. Li, T. Huang, and L. R. Chen, “Rational harmonic mode-locking of a fiber optical parametric oscillator at 30 GHz,” IEEE Photonics J. 3(3), 468–475 (2011).
[Crossref]

Chen, X.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Cheng, H.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Cheng, J.

C. Zhang and J. Cheng, “Perspective: Coherent Raman scattering microscopy, the future is bright,” APL Photonics 3(9), 90901 (2018).
[Crossref]

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
[Crossref]

Cheng, J. X.

J. X. Cheng and X. S. Xie, “Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine,” Science 350(6264), aaa8870 (2015).
[Crossref] [PubMed]

Y. Fu, H. Wang, R. Shi, and J. X. Cheng, “Characterization of photodamage in coherent anti-Stokes Raman scattering microscopy,” Opt. Express 14(9), 3942–3951 (2006).
[Crossref] [PubMed]

Cialla-May, D.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Cicerone, M. T.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Clark, C. G.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Dearden, G.

J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
[Crossref]

Dietzek, B.

Dobner, S.

Dutta, N. K.

G. Zhu and N. K. Dutta, “Eighth-order rational harmonic mode-locked fiber laser with amplitude-equalized output operating at 80 Gbits/s,” Opt. Lett. 30(17), 2212–2214 (2005).
[Crossref] [PubMed]

C. Wu and N. K. Dutta, “High-repetition-rate optical pulse generation using a rational harmonic mode-locked fiber laser,” IEEE J. Quantum Electron. 36, 145–150 (2002).

Eakins, G.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Fabert, M.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Fallnich, C.

Fan, M.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Ferrand, P.

S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
[Crossref] [PubMed]

Fisher-Hubbard, A.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Freudiger, C. W.

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Fu, D.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Fu, Y.

Garrard, M.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Gottschall, T.

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

Gu, Z.

Guelachvili, G.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Guo, Z.

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable femtosecond laser from 965 to 1025 nm in fiber optical parametric oscillator,” IEEE Photonic. Tech. L. 30, 607–610 (2018).

Hänsch, T. W.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Hao, Q.

Hartshorn, C. M.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Hasama, T.

J. Jiang and T. Hasama, “Synchronously pumped femtosecond optical parametric oscillator based on an improved pumping concept,” Opt. Commun. 220(1-3), 193–202 (2003).
[Crossref]

He, J.

J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
[Crossref]

He, R.

Heddleston, J. M.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Hellwig, T.

Heth, J. A.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Hight Walker, A. R.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Holtom, G. R.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Holzner, S.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Horton, N. G.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Hou, S. S.

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

Hu, X.

Hu, Y.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Huang, C. Y.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Huang, K.

Huang, T.

J. Li, T. Huang, and L. R. Chen, “Rational harmonic mode-locking of a fiber optical parametric oscillator at 30 GHz,” IEEE Photonics J. 3(3), 468–475 (2011).
[Crossref]

Ideguchi, T.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Ingold, K. A.

Janfrüchte, S.

Jauregui, C.

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

Ji, M.

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

R. He, Y. Xu, L. Zhang, S. Ma, X. Wang, D. Ye, and M. Ji, “Dual-phase stimulated Raman scattering microscopy for real-time two-color imaging,” Optica 4(1), 44–47 (2017).
[Crossref]

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

E. S. Lamb, S. Lefrancois, M. Ji, W. J. Wadsworth, X. S. Xie, and F. W. Wise, “Fiber optical parametric oscillator for coherent anti-Stokes Raman scattering microscopy,” Opt. Lett. 38(20), 4154–4157 (2013).
[Crossref] [PubMed]

Jia, H.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Jiang, J.

K. Yang, P. Ye, S. Zheng, J. Jiang, K. Huang, Q. Hao, and H. Zeng, “Polarization switch of four-wave mixing in a lawtunable fiber optical parametric oscillator,” Opt. Express 26(3), 2995–3003 (2018).
[Crossref] [PubMed]

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable femtosecond laser from 965 to 1025 nm in fiber optical parametric oscillator,” IEEE Photonic. Tech. L. 30, 607–610 (2018).

J. Jiang and T. Hasama, “Synchronously pumped femtosecond optical parametric oscillator based on an improved pumping concept,” Opt. Commun. 220(1-3), 193–202 (2003).
[Crossref]

Johnson, T. D.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Joly, N.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Kieu, K. Q.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Kobat, D.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Krafft, C.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Kudlinski, A.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Lamb, E. S.

Lathia, J. D.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Lee, Y. J.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Lefrancois, S.

Lewis, S.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Li, B.

Li, J.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

J. Li, T. Huang, and L. R. Chen, “Rational harmonic mode-locking of a fiber optical parametric oscillator at 30 GHz,” IEEE Photonics J. 3(3), 468–475 (2011).
[Crossref]

Li, M.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Li, Y.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

K. Chen, T. Wu, H. Wei, and Y. Li, “Dual-soliton Stokes-based background-free coherent anti-Stokes Raman scattering spectroscopy and microscopy,” Opt. Lett. 41(11), 2628–2631 (2016).
[Crossref] [PubMed]

Liang, R.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Liao, C.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Limpert, J.

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

Lin, C. P.

Lin, D.

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

Lin, P.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Liu, C. S.

J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
[Crossref]

Liu, D.

J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
[Crossref]

Liu, H.

J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
[Crossref]

Lombardini, A.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Louradour, F.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Lu, Y.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Ma, S.

Maher, C. O.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Marandi, A.

Marguet, D.

S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
[Crossref] [PubMed]

Matthäus, C.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Meyer, T.

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

Mytskaniuk, V.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Orringer, D. A.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Perrie, W.

J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
[Crossref]

Peyghambarian, N.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Picqué, N.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Popp, J.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

Qiu, P.

J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
[Crossref]

Ramkissoon, S. H.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Rich, J. N.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Rigneault, H.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
[Crossref] [PubMed]

Rong, H.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Rudy, C. W.

Sagher, O.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Sanai, N.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Schaffer, C. B.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Schie, I. W.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

Schmitt, M.

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

Shang, S.

J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
[Crossref]

Shi, R.

Sivankutty, S.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Snuderl, M.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Tünnermann, A.

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

T. Gottschall, T. Meyer, M. Baumgartl, B. Dietzek, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy,” Opt. Express 22(18), 21921–21928 (2014).
[Crossref] [PubMed]

Venneti, S.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Vodopyanov, K. L.

Wadsworth, W. J.

Walther, N.

S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
[Crossref] [PubMed]

Wang, A.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Wang, A. C.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Wang, H.

Wang, K.

J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
[Crossref]

J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
[Crossref]

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Wang, M.

Wang, P.

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

P. Wang, L. Zhan, Z. Gu, Q. Ye, X. Hu, and Y. Xia, “Arbitrary numerator rational-harmonic mode locking in fiber ring lasers,” J. Opt. Soc. Am. B 21(10), 1781–1783 (2004).
[Crossref]

Wang, X.

Wang, Y.

J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
[Crossref]

Watkins, K.

J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
[Crossref]

Wei, H.

Wen, W.

J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
[Crossref]

Wenger, J.

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Wise, F. W.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

E. S. Lamb, S. Lefrancois, M. Ji, W. J. Wadsworth, X. S. Xie, and F. W. Wise, “Fiber optical parametric oscillator for coherent anti-Stokes Raman scattering microscopy,” Opt. Lett. 38(20), 4154–4157 (2013).
[Crossref] [PubMed]

Wu, C.

C. Wu and N. K. Dutta, “High-repetition-rate optical pulse generation using a rational harmonic mode-locked fiber laser,” IEEE J. Quantum Electron. 36, 145–150 (2002).

Wu, H.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Wu, R.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Wu, T.

Wu, Y.

Xia, Y.

Xie, X. S.

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

J. X. Cheng and X. S. Xie, “Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine,” Science 350(6264), aaa8870 (2015).
[Crossref] [PubMed]

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

E. S. Lamb, S. Lefrancois, M. Ji, W. J. Wadsworth, X. S. Xie, and F. W. Wise, “Fiber optical parametric oscillator for coherent anti-Stokes Raman scattering microscopy,” Opt. Lett. 38(20), 4154–4157 (2013).
[Crossref] [PubMed]

Xu, C.

K. Charan, B. Li, M. Wang, C. P. Lin, and C. Xu, “Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy,” Biomed. Opt. Express 9(5), 2304–2311 (2018).
[Crossref] [PubMed]

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Xu, Y.

R. He, Y. Xu, L. Zhang, S. Ma, X. Wang, D. Ye, and M. Ji, “Dual-phase stimulated Raman scattering microscopy for real-time two-color imaging,” Optica 4(1), 44–47 (2017).
[Crossref]

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Yang, K.

Yang, W.

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

Yang, X.

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

Ye, D.

Ye, P.

Ye, Q.

Zeng, H.

Zhan, L.

Zhang, C.

C. Zhang and J. Cheng, “Perspective: Coherent Raman scattering microscopy, the future is bright,” APL Photonics 3(9), 90901 (2018).
[Crossref]

Zhang, L.

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

R. He, Y. Xu, L. Zhang, S. Ma, X. Wang, D. Ye, and M. Ji, “Dual-phase stimulated Raman scattering microscopy for real-time two-color imaging,” Optica 4(1), 44–47 (2017).
[Crossref]

Zhang, Y.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Zheng, S.

Zhou, Z.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Zhu, G.

Zong, W.

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

ACS Photonics (1)

C. Liao, P. Wang, C. Y. Huang, P. Lin, G. Eakins, R. T. Bentley, R. Liang, and J. Cheng, “In vivo and in situ spectroscopic imaging by a handheld stimulated Raman scattering microscope,” ACS Photonics 5(3), 947–954 (2017).
[Crossref]

Angew. Chem. Int. Ed. Engl. (1)

C. Krafft, M. Schmitt, I. W. Schie, D. Cialla-May, C. Matthäus, T. Bocklitz, and J. Popp, “Label-free molecular imaging of biological cells and tissues by linear and nonlinear Raman spectroscopic approaches,” Angew. Chem. Int. Ed. Engl. 56(16), 4392–4430 (2017).
[Crossref] [PubMed]

APL Photonics (1)

C. Zhang and J. Cheng, “Perspective: Coherent Raman scattering microscopy, the future is bright,” APL Photonics 3(9), 90901 (2018).
[Crossref]

Appl. Phys. Lett. (1)

J. He, Y. Wang, W. Wen, K. Wang, H. Liu, P. Qiu, and K. Wang, “Polarization multiplexing in large-mode-area waveguides and its application to signal enhancement in multiphoton microscopy,” Appl. Phys. Lett. 110(4), 041101 (2017).
[Crossref]

Biomed. Opt. Express (1)

IEEE J. Quantum Electron. (1)

C. Wu and N. K. Dutta, “High-repetition-rate optical pulse generation using a rational harmonic mode-locked fiber laser,” IEEE J. Quantum Electron. 36, 145–150 (2002).

IEEE Photonic. Tech. L. (1)

K. Yang, J. Jiang, Z. Guo, Q. Hao, and H. Zeng, “Tunable femtosecond laser from 965 to 1025 nm in fiber optical parametric oscillator,” IEEE Photonic. Tech. L. 30, 607–610 (2018).

IEEE Photonics J. (1)

J. Li, T. Huang, and L. R. Chen, “Rational harmonic mode-locking of a fiber optical parametric oscillator at 30 GHz,” IEEE Photonics J. 3(3), 468–475 (2011).
[Crossref]

J. Biomed. Opt. (1)

S. Brustlein, P. Ferrand, N. Walther, S. Brasselet, C. Billaudeau, D. Marguet, and H. Rigneault, “Optical parametric oscillator-based light source for coherent Raman scattering microscopy: practical overview,” J. Biomed. Opt. 16(2), 021106 (2011).
[Crossref] [PubMed]

J. Opt. Soc. Am. B (1)

Laser Photonics Rev. (1)

T. Gottschall, T. Meyer, M. Baumgartl, C. Jauregui, M. Schmitt, J. Popp, J. Limpert, and A. Tünnermann, “Fiber-based light sources for biomedical applications of coherent anti-Stokes Raman scattering microscopy,” Laser Photonics Rev. 9(5), 435–451 (2015).
[Crossref]

Light Sci. Appl. (1)

A. Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, “High-resolution multimodal flexible coherent Raman endoscope,” Light Sci. Appl. 7(1), 10 (2018).
[Crossref]

Nat. Methods (1)

W. Zong, R. Wu, M. Li, Y. Hu, Y. Li, J. Li, H. Rong, H. Wu, Y. Xu, Y. Lu, H. Jia, M. Fan, Z. Zhou, Y. Zhang, A. Wang, L. Chen, and H. Cheng, “Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice,” Nat. Methods 14(7), 713–719 (2017).
[Crossref] [PubMed]

Nat. Photonics (3)

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

C. W. Freudiger, W. Yang, G. R. Holtom, N. Peyghambarian, X. S. Xie, and K. Q. Kieu, “Stimulated Raman scattering microscopy with a robust fibre laser source,” Nat. Photonics 8(2), 153–159 (2014).
[Crossref] [PubMed]

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Nature (1)

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Opt. Commun. (1)

J. Jiang and T. Hasama, “Synchronously pumped femtosecond optical parametric oscillator based on an improved pumping concept,” Opt. Commun. 220(1-3), 193–202 (2003).
[Crossref]

Opt. Express (4)

Opt. Laser Technol. (1)

J. Cheng, C. S. Liu, S. Shang, D. Liu, W. Perrie, G. Dearden, and K. Watkins, “A review of ultrafast laser materials micromachining,” Opt. Laser Technol. 46, 88–102 (2013).
[Crossref]

Opt. Lett. (5)

Optica (1)

Sci. Adv. (1)

M. Ji, M. Arbel, L. Zhang, C. W. Freudiger, S. S. Hou, D. Lin, X. Yang, B. J. Bacskai, and X. S. Xie, “Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy,” Sci. Adv. 4(11), t7715 (2018).
[PubMed]

Sci. Transl. Med. (1)

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Science (1)

J. X. Cheng and X. S. Xie, “Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine,” Science 350(6264), aaa8870 (2015).
[Crossref] [PubMed]

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)

Fig. 1
Fig. 1 Schematic diagram for illustrating the generation of pulse train with a fourth-order harmonic repetition rate from a rational harmonic resonant OPO. The fundamental repetition rate of the OPO cavity and the repetition rate of the output pulse train satisfies 3 × fc = 4 × fp .
Fig. 2
Fig. 2 Experimental setup of synchronously pumped OPO with rational harmonic resonance. LD: laser diode; WDM: wavelength division multiplex; PCF: photonic crystal fiber; HWP: half-wave plate; PBS: polarization beam splitter; Yb: ytterbium-doped fiber; SMF: single mode fiber; Pre-Amp: pre-amplifier; FAOM: fiber-coupled acoustic optical modulator; FPGA: field programmable gate array; PD: photodiode.
Fig. 3
Fig. 3 (a) Oscilloscope traces of signal pulse trains for various orders of rational harmonic resonance. (b)-(c) Output power at 985 nm as a function of the pump power. (d) Pump peak power range depending on the harmonic orders. (e) Wavelength tuning by changing the delay line inside the OPO cavity.
Fig. 4
Fig. 4 Average power of the signal versus output center wavelength for various harmonic orders. (a) M = 1, 2, 3, 4, N = 1; (b) Group I, one lap: M = 1, N = 1, 2, 3; (c) Group II, two laps: M = 2, N = 1, 3; (d) Group III, three laps: M = 3, N = 1, 2; and (e) Group IV, four laps: M = 4, N = 1, 3.
Fig. 5
Fig. 5 Output spectra of signal pulses at 985 nm for various harmonic orders. (a) M = 1, 2, 3, 4, N = 1; (b) Group I, one lap: M = 1, N = 1, 2, 3; (c) Group II, two laps: M = 2, N = 1, 3; (d) Group III, three laps: M = 3, N = 1, 2; and (e) Group IV, four laps: M = 4, N = 1, 3.

Metrics