Abstract

We have developed a surgical microscope-integrated optical coherence tomography (MI-OCT) system based on an active feedback method to obtain uniform optimal OCT image contrast along the depth of focus (DOF) of a surgical microscope. Conventional MI-OCT systems use a shorter DOF objective lens than those of surgical microscopes for OCT imaging. The existing MI-OCT system was developed to overcome sensitivity roll-off by using an electrically tunable lens (ETL). However, active change in the focus position through the ETL cannot cope with the sensitivity decrease due to optical path length difference (OPD) mismatch. The proposed active feedback method was able to maintain high sensitivity by actively performing OPD matching using a linear motor in the reference arm while tuning the focal position in the sample arm using the ETL. The optical system designed to maintain the OCT resolution and a retroreflector used for ensuring regular reflection intensity in the reference arm during OPD compensation contributed to the uniform sensitivity and stable OCT imaging performance. The simultaneous and automatic actuation of the ETL and linear motor provided sensitivity variation of 3 dB from 17 dB for 10-mm sample displacement corresponding to the DOF of the surgical microscope used in the MI-OCT system. By using an infrared detection card and a mouse brain tumor model, it was demonstrated that the proposed MI-OCT system could acquire OCT images with optimal sensitivity without the limitations due to short OCT DOF.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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2018 (1)

2017 (1)

2016 (1)

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

2015 (2)

P. Hahn, O. Carrasco-Zevallos, D. Cunefare, J. Migacz, S. Farsiu, J. A. Izatt, and C. A. Toth, “Intrasurgical human retinal imaging with manual instrument tracking using a microscope-integrated spectral-domain optical coherence tomography device,” Transl. Vis. Sci. Technol. 4(4), 1–9 (2015).
[Crossref] [PubMed]

J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
[Crossref] [PubMed]

2014 (7)

J. P. Ehlers, P. K. Kaiser, and S. K. Srivastava, “Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study,” Br. J. Ophthalmol. 98(10), 1329–1332 (2014).
[Crossref] [PubMed]

N. H. Cho, J. H. Jang, W. Jung, and J. Kim, “In vivo imaging of middle-ear and inner-ear microstructures of a mouse guided by SD-OCT combined with a surgical microscope,” Opt. Express 22(8), 8985–8995 (2014).
[Crossref] [PubMed]

Y. K. Tao, S. K. Srivastava, and J. P. Ehlers, “Microscope-integrated intraoperative OCT with electrically tunable focus and heads-up display for imaging of ophthalmic surgical maneuvers,” Biomed. Opt. Express 5(6), 1877–1885 (2014).
[Crossref] [PubMed]

J. P. Ehlers, S. K. Srivastava, D. Feiler, A. I. Noonan, A. M. Rollins, and Y. K. Tao, “Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback,” PLoS One 9(8), e105224 (2014).
[Crossref] [PubMed]

I. Grulkowski, K. Szulzycki, and M. Wojtkowski, “Microscopic OCT imaging with focus extension by ultrahigh-speed acousto-optic tunable lens and stroboscopic illumination,” Opt. Express 22(26), 31746–31760 (2014).
[Crossref] [PubMed]

M. Singh and A. Saxena, “Microsurgery: A useful and versatile tool in surgical field,” Surgery Curr. Res. 4(4), 9–11 (2014).

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

2013 (3)

P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
[Crossref] [PubMed]

H. Neshat, D. W. Cool, K. Barker, L. Gardi, N. Kakani, and A. Fenster, “A 3D ultrasound scanning system for image guided liver interventions,” Med. Phys. 40(11), 112903 (2013).
[Crossref] [PubMed]

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

2012 (2)

2011 (2)

N. Sanai, L. A. Snyder, N. J. Honea, S. W. Coons, J. M. Eschbacher, K. A. Smith, and R. F. Spetzler, “Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas,” J. Neurosurg. 115(4), 740–748 (2011).
[Crossref] [PubMed]

C. Senft, A. Bink, K. Franz, H. Vatter, T. Gasser, and V. Seifert, “Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial,” Lancet Oncol. 12(11), 997–1003 (2011).
[Crossref] [PubMed]

2009 (1)

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

2007 (1)

D. J. Brenner and E. J. Hall, “Computed tomography--an increasing source of radiation exposure,” N. Engl. J. Med. 357(22), 2277–2284 (2007).
[Crossref] [PubMed]

2003 (1)

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

2001 (2)

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

M. Hadani, R. Spiegelman, Z. Feldman, H. Berkenstadt, and Z. Ram, “Novel, compact, intraoperative magnetic resonance imaging-guided system for conventional neurosurgical operating rooms,” Neurosurgery 48(4), 799–809 (2001).
[PubMed]

2000 (1)

R. M. Comeau, A. F. Sadikot, A. Fenster, and T. M. Peters, “Intraoperative ultrasound for guidance and tissue shift correction in image-guided neurosurgery,” Med. Phys. 27(4), 787–800 (2000).
[Crossref] [PubMed]

1999 (1)

J. M. Schmitt, “Optical coherence tomography (OCT): A review,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1205–1215 (1999).
[Crossref]

1997 (1)

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

1995 (1)

S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
[Crossref] [PubMed]

1994 (1)

D. Goutallier, J. M. Postel, J. Bernageau, L. Lavau, and M. C. Voisin, “Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan,” Clin. Orthop. Relat. Res. 304, 78–83 (1994).
[PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

1974 (1)

J. M. Parel, R. Machemer, and W. Aumayr, “A new concept for vitreous surgery. 5. An automated operating microscope,” Am. J. Ophthalmol. 77(2), 161–168 (1974).
[Crossref] [PubMed]

Albert, F. K.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Artal, P.

Aumayr, W.

J. M. Parel, R. Machemer, and W. Aumayr, “A new concept for vitreous surgery. 5. An automated operating microscope,” Am. J. Ophthalmol. 77(2), 161–168 (1974).
[Crossref] [PubMed]

Barker, K.

H. Neshat, D. W. Cool, K. Barker, L. Gardi, N. Kakani, and A. Fenster, “A 3D ultrasound scanning system for image guided liver interventions,” Med. Phys. 40(11), 112903 (2013).
[Crossref] [PubMed]

Bellafiore, F. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Berkenstadt, H.

M. Hadani, R. Spiegelman, Z. Feldman, H. Berkenstadt, and Z. Ram, “Novel, compact, intraoperative magnetic resonance imaging-guided system for conventional neurosurgical operating rooms,” Neurosurgery 48(4), 799–809 (2001).
[PubMed]

Berkovic, S. F.

S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
[Crossref] [PubMed]

Bernageau, J.

D. Goutallier, J. M. Postel, J. Bernageau, L. Lavau, and M. C. Voisin, “Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan,” Clin. Orthop. Relat. Res. 304, 78–83 (1994).
[PubMed]

Bink, A.

C. Senft, A. Bink, K. Franz, H. Vatter, T. Gasser, and V. Seifert, “Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial,” Lancet Oncol. 12(11), 997–1003 (2011).
[Crossref] [PubMed]

Bladin, P. F.

S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
[Crossref] [PubMed]

Böckler, D.

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

Bonsanto, M. M.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Boppart, S. A.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Borsato, S.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Brazenor, G. A.

S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
[Crossref] [PubMed]

Brenner, D. J.

D. J. Brenner and E. J. Hall, “Computed tomography--an increasing source of radiation exposure,” N. Engl. J. Med. 357(22), 2277–2284 (2007).
[Crossref] [PubMed]

Büchler, M. W.

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

Cable, A. E.

Carrasco-Zevallos, O.

P. Hahn, O. Carrasco-Zevallos, D. Cunefare, J. Migacz, S. Farsiu, J. A. Izatt, and C. A. Toth, “Intrasurgical human retinal imaging with manual instrument tracking using a microscope-integrated spectral-domain optical coherence tomography device,” Transl. Vis. Sci. Technol. 4(4), 1–9 (2015).
[Crossref] [PubMed]

Carrasco-Zevallos, O. M.

O. M. Carrasco-Zevallos, C. Viehland, B. Keller, M. Draelos, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Review of intraoperative optical coherence tomography: technology and applications [Invited],” Biomed. Opt. Express 8(3), 1607–1637 (2017).
[Crossref] [PubMed]

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
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F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
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Comeau, R. M.

R. M. Comeau, A. F. Sadikot, A. Fenster, and T. M. Peters, “Intraoperative ultrasound for guidance and tissue shift correction in image-guided neurosurgery,” Med. Phys. 27(4), 787–800 (2000).
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Cool, D. W.

H. Neshat, D. W. Cool, K. Barker, L. Gardi, N. Kakani, and A. Fenster, “A 3D ultrasound scanning system for image guided liver interventions,” Med. Phys. 40(11), 112903 (2013).
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Coons, S. W.

N. Sanai, L. A. Snyder, N. J. Honea, S. W. Coons, J. M. Eschbacher, K. A. Smith, and R. F. Spetzler, “Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas,” J. Neurosurg. 115(4), 740–748 (2011).
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G. Cserni, “Intraoperative analysis of sentinel lymph nodes in breast cancer by one-step nucleic acid amplification,” J. Clin. Pathol. 65(3), 193–199 (2012).
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Cursiefen, C.

P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
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Cwiklinski, L.

Day, S.

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
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J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Draelos, M.

Duker, J. S.

Dupps, W. J.

J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
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J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
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J. P. Ehlers, P. K. Kaiser, and S. K. Srivastava, “Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study,” Br. J. Ophthalmol. 98(10), 1329–1332 (2014).
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J. P. Ehlers, S. K. Srivastava, D. Feiler, A. I. Noonan, A. M. Rollins, and Y. K. Tao, “Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback,” PLoS One 9(8), e105224 (2014).
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Y. K. Tao, S. K. Srivastava, and J. P. Ehlers, “Microscope-integrated intraoperative OCT with electrically tunable focus and heads-up display for imaging of ophthalmic surgical maneuvers,” Biomed. Opt. Express 5(6), 1877–1885 (2014).
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J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
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N. Sanai, L. A. Snyder, N. J. Honea, S. W. Coons, J. M. Eschbacher, K. A. Smith, and R. F. Spetzler, “Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas,” J. Neurosurg. 115(4), 740–748 (2011).
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S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
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Farsiu, S.

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

P. Hahn, O. Carrasco-Zevallos, D. Cunefare, J. Migacz, S. Farsiu, J. A. Izatt, and C. A. Toth, “Intrasurgical human retinal imaging with manual instrument tracking using a microscope-integrated spectral-domain optical coherence tomography device,” Transl. Vis. Sci. Technol. 4(4), 1–9 (2015).
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J. P. Ehlers, S. K. Srivastava, D. Feiler, A. I. Noonan, A. M. Rollins, and Y. K. Tao, “Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback,” PLoS One 9(8), e105224 (2014).
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P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
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M. Hadani, R. Spiegelman, Z. Feldman, H. Berkenstadt, and Z. Ram, “Novel, compact, intraoperative magnetic resonance imaging-guided system for conventional neurosurgical operating rooms,” Neurosurgery 48(4), 799–809 (2001).
[PubMed]

Fenster, A.

H. Neshat, D. W. Cool, K. Barker, L. Gardi, N. Kakani, and A. Fenster, “A 3D ultrasound scanning system for image guided liver interventions,” Med. Phys. 40(11), 112903 (2013).
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R. M. Comeau, A. F. Sadikot, A. Fenster, and T. M. Peters, “Intraoperative ultrasound for guidance and tissue shift correction in image-guided neurosurgery,” Med. Phys. 27(4), 787–800 (2000).
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H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
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H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
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Gans, R.

J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
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Gardi, L.

H. Neshat, D. W. Cool, K. Barker, L. Gardi, N. Kakani, and A. Fenster, “A 3D ultrasound scanning system for image guided liver interventions,” Med. Phys. 40(11), 112903 (2013).
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C. Senft, A. Bink, K. Franz, H. Vatter, T. Gasser, and V. Seifert, “Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial,” Lancet Oncol. 12(11), 997–1003 (2011).
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P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
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H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
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J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
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[Crossref] [PubMed]

Grulkowski, I.

Hadani, M.

M. Hadani, R. Spiegelman, Z. Feldman, H. Berkenstadt, and Z. Ram, “Novel, compact, intraoperative magnetic resonance imaging-guided system for conventional neurosurgical operating rooms,” Neurosurgery 48(4), 799–809 (2001).
[PubMed]

Hahn, P.

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

P. Hahn, O. Carrasco-Zevallos, D. Cunefare, J. Migacz, S. Farsiu, J. A. Izatt, and C. A. Toth, “Intrasurgical human retinal imaging with manual instrument tracking using a microscope-integrated spectral-domain optical coherence tomography device,” Transl. Vis. Sci. Technol. 4(4), 1–9 (2015).
[Crossref] [PubMed]

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
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P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
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Honea, N. J.

N. Sanai, L. A. Snyder, N. J. Honea, S. W. Coons, J. M. Eschbacher, K. A. Smith, and R. F. Spetzler, “Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas,” J. Neurosurg. 115(4), 740–748 (2011).
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S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
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Hüttmann, G.

P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
[Crossref] [PubMed]

Izatt, J. A.

O. M. Carrasco-Zevallos, C. Viehland, B. Keller, M. Draelos, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Review of intraoperative optical coherence tomography: technology and applications [Invited],” Biomed. Opt. Express 8(3), 1607–1637 (2017).
[Crossref] [PubMed]

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

P. Hahn, O. Carrasco-Zevallos, D. Cunefare, J. Migacz, S. Farsiu, J. A. Izatt, and C. A. Toth, “Intrasurgical human retinal imaging with manual instrument tracking using a microscope-integrated spectral-domain optical coherence tomography device,” Transl. Vis. Sci. Technol. 4(4), 1–9 (2015).
[Crossref] [PubMed]

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

Jackson, G. D.

S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
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Jang, J. H.

Jayaraman, V.

Jiang, J.

Johnson, P. A.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Jung, W.

Kahn, T.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Kaiser, P. K.

J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
[Crossref] [PubMed]

J. P. Ehlers, P. K. Kaiser, and S. K. Srivastava, “Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study,” Br. J. Ophthalmol. 98(10), 1329–1332 (2014).
[Crossref] [PubMed]

Kakani, N.

H. Neshat, D. W. Cool, K. Barker, L. Gardi, N. Kakani, and A. Fenster, “A 3D ultrasound scanning system for image guided liver interventions,” Med. Phys. 40(11), 112903 (2013).
[Crossref] [PubMed]

Kalnins, R. M.

S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
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Karnowski, K.

Keller, B.

O. M. Carrasco-Zevallos, C. Viehland, B. Keller, M. Draelos, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Review of intraoperative optical coherence tomography: technology and applications [Invited],” Biomed. Opt. Express 8(3), 1607–1637 (2017).
[Crossref] [PubMed]

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

Kellermann, S.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

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H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
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Knauth, M.

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F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
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Krug, M.

P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
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Kunze, S.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
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Kuo, A.

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

Kuo, A. N.

O. M. Carrasco-Zevallos, C. Viehland, B. Keller, M. Draelos, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Review of intraoperative optical coherence tomography: technology and applications [Invited],” Biomed. Opt. Express 8(3), 1607–1637 (2017).
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O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

Kuth, R.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Lankenau, E.

P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
[Crossref] [PubMed]

Laufer, M.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

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D. Goutallier, J. M. Postel, J. Bernageau, L. Lavau, and M. C. Voisin, “Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan,” Clin. Orthop. Relat. Res. 304, 78–83 (1994).
[PubMed]

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P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
[Crossref] [PubMed]

Lee, A.

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
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Lenz, G.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Lieberenz, S.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Lin, P.

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
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C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
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Liu, J. J.

Lu, C. D.

Machemer, R.

J. M. Parel, R. Machemer, and W. Aumayr, “A new concept for vitreous surgery. 5. An automated operating microscope,” Am. J. Ophthalmol. 77(2), 161–168 (1974).
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Manzanera, S.

McIntosh, A. M.

S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
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H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
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Migacz, J.

P. Hahn, O. Carrasco-Zevallos, D. Cunefare, J. Migacz, S. Farsiu, J. A. Izatt, and C. A. Toth, “Intrasurgical human retinal imaging with manual instrument tracking using a microscope-integrated spectral-domain optical coherence tomography device,” Transl. Vis. Sci. Technol. 4(4), 1–9 (2015).
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P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

Mocellin, S.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Montesco, C.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
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Mruthyunjaya, P.

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

Müller-Stich, B. P.

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

Neshat, H.

H. Neshat, D. W. Cool, K. Barker, L. Gardi, N. Kakani, and A. Fenster, “A 3D ultrasound scanning system for image guided liver interventions,” Med. Phys. 40(11), 112903 (2013).
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Nguyen, F. T.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Nickel, F.

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

Nolden, M.

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

Noonan, A. I.

J. P. Ehlers, S. K. Srivastava, D. Feiler, A. I. Noonan, A. M. Rollins, and Y. K. Tao, “Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback,” PLoS One 9(8), e105224 (2014).
[Crossref] [PubMed]

O’Donnell, R.

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

Oelckers, S.

P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
[Crossref] [PubMed]

Oliphant, U. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Parel, J. M.

J. M. Parel, R. Machemer, and W. Aumayr, “A new concept for vitreous surgery. 5. An automated operating microscope,” Am. J. Ophthalmol. 77(2), 161–168 (1974).
[Crossref] [PubMed]

Pastyr, O.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Peters, T. M.

R. M. Comeau, A. F. Sadikot, A. Fenster, and T. M. Peters, “Intraoperative ultrasound for guidance and tissue shift correction in image-guided neurosurgery,” Med. Phys. 27(4), 787–800 (2000).
[Crossref] [PubMed]

Pilati, P.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Postel, E. A.

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

Postel, J. M.

D. Goutallier, J. M. Postel, J. Bernageau, L. Lavau, and M. C. Voisin, “Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan,” Clin. Orthop. Relat. Res. 304, 78–83 (1994).
[PubMed]

Potsaid, B.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Ram, Z.

M. Hadani, R. Spiegelman, Z. Feldman, H. Berkenstadt, and Z. Ram, “Novel, compact, intraoperative magnetic resonance imaging-guided system for conventional neurosurgical operating rooms,” Neurosurgery 48(4), 799–809 (2001).
[PubMed]

Rollins, A. M.

J. P. Ehlers, S. K. Srivastava, D. Feiler, A. I. Noonan, A. M. Rollins, and Y. K. Tao, “Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback,” PLoS One 9(8), e105224 (2014).
[Crossref] [PubMed]

Rossi, C. R.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Rowland, K. M.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Rubaltelli, L.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Rubello, D.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Sadikot, A. F.

R. M. Comeau, A. F. Sadikot, A. Fenster, and T. M. Peters, “Intraoperative ultrasound for guidance and tissue shift correction in image-guided neurosurgery,” Med. Phys. 27(4), 787–800 (2000).
[Crossref] [PubMed]

Sanai, N.

N. Sanai, L. A. Snyder, N. J. Honea, S. W. Coons, J. M. Eschbacher, K. A. Smith, and R. F. Spetzler, “Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas,” J. Neurosurg. 115(4), 740–748 (2011).
[Crossref] [PubMed]

Sartor, K.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Saxena, A.

M. Singh and A. Saxena, “Microsurgery: A useful and versatile tool in surgical field,” Surgery Curr. Res. 4(4), 9–11 (2014).

Scagnet, B.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Schaffranietz, L.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Schlegel, W.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Schmidt, F.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Schmitt, J. M.

J. M. Schmitt, “Optical coherence tomography (OCT): A review,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1205–1215 (1999).
[Crossref]

Schneider, J. P.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Schober, R.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Schulz, T.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Seifert, V.

C. Senft, A. Bink, K. Franz, H. Vatter, T. Gasser, and V. Seifert, “Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial,” Lancet Oncol. 12(11), 997–1003 (2011).
[Crossref] [PubMed]

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Senft, C.

C. Senft, A. Bink, K. Franz, H. Vatter, T. Gasser, and V. Seifert, “Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial,” Lancet Oncol. 12(11), 997–1003 (2011).
[Crossref] [PubMed]

Shen, L.

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

Shieh, C.

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

Singh, M.

M. Singh and A. Saxena, “Microsurgery: A useful and versatile tool in surgical field,” Surgery Curr. Res. 4(4), 9–11 (2014).

Singh, R. P.

J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
[Crossref] [PubMed]

Smith, K. A.

N. Sanai, L. A. Snyder, N. J. Honea, S. W. Coons, J. M. Eschbacher, K. A. Smith, and R. F. Spetzler, “Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas,” J. Neurosurg. 115(4), 740–748 (2011).
[Crossref] [PubMed]

Snyder, L. A.

N. Sanai, L. A. Snyder, N. J. Honea, S. W. Coons, J. M. Eschbacher, K. A. Smith, and R. F. Spetzler, “Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas,” J. Neurosurg. 115(4), 740–748 (2011).
[Crossref] [PubMed]

Sobczuk, F.

Speidel, S.

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

Spetzler, R. F.

N. Sanai, L. A. Snyder, N. J. Honea, S. W. Coons, J. M. Eschbacher, K. A. Smith, and R. F. Spetzler, “Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas,” J. Neurosurg. 115(4), 740–748 (2011).
[Crossref] [PubMed]

Spiegelman, R.

M. Hadani, R. Spiegelman, Z. Feldman, H. Berkenstadt, and Z. Ram, “Novel, compact, intraoperative magnetic resonance imaging-guided system for conventional neurosurgical operating rooms,” Neurosurgery 48(4), 799–809 (2001).
[PubMed]

Srivastava, S. K.

J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
[Crossref] [PubMed]

J. P. Ehlers, P. K. Kaiser, and S. K. Srivastava, “Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study,” Br. J. Ophthalmol. 98(10), 1329–1332 (2014).
[Crossref] [PubMed]

J. P. Ehlers, S. K. Srivastava, D. Feiler, A. I. Noonan, A. M. Rollins, and Y. K. Tao, “Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback,” PLoS One 9(8), e105224 (2014).
[Crossref] [PubMed]

Y. K. Tao, S. K. Srivastava, and J. P. Ehlers, “Microscope-integrated intraoperative OCT with electrically tunable focus and heads-up display for imaging of ophthalmic surgical maneuvers,” Biomed. Opt. Express 5(6), 1877–1885 (2014).
[Crossref] [PubMed]

Staubert, A.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Steven, P.

P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
[Crossref] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Stramare, R.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Szulzycki, K.

Tao, Y. K.

Y. K. Tao, S. K. Srivastava, and J. P. Ehlers, “Microscope-integrated intraoperative OCT with electrically tunable focus and heads-up display for imaging of ophthalmic surgical maneuvers,” Biomed. Opt. Express 5(6), 1877–1885 (2014).
[Crossref] [PubMed]

J. P. Ehlers, S. K. Srivastava, D. Feiler, A. I. Noonan, A. M. Rollins, and Y. K. Tao, “Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback,” PLoS One 9(8), e105224 (2014).
[Crossref] [PubMed]

Todorich, B.

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

Toth, C. A.

O. M. Carrasco-Zevallos, C. Viehland, B. Keller, M. Draelos, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Review of intraoperative optical coherence tomography: technology and applications [Invited],” Biomed. Opt. Express 8(3), 1607–1637 (2017).
[Crossref] [PubMed]

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

P. Hahn, O. Carrasco-Zevallos, D. Cunefare, J. Migacz, S. Farsiu, J. A. Izatt, and C. A. Toth, “Intrasurgical human retinal imaging with manual instrument tracking using a microscope-integrated spectral-domain optical coherence tomography device,” Transl. Vis. Sci. Technol. 4(4), 1–9 (2015).
[Crossref] [PubMed]

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

Trantakis, C.

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Tregnaghi, A.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Tronnier, V. M.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Vann, R.

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

Vatter, H.

C. Senft, A. Bink, K. Franz, H. Vatter, T. Gasser, and V. Seifert, “Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial,” Lancet Oncol. 12(11), 997–1003 (2011).
[Crossref] [PubMed]

Vecchiato, A.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Velten, K.

P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
[Crossref] [PubMed]

Viehland, C.

O. M. Carrasco-Zevallos, C. Viehland, B. Keller, M. Draelos, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Review of intraoperative optical coherence tomography: technology and applications [Invited],” Biomed. Opt. Express 8(3), 1607–1637 (2017).
[Crossref] [PubMed]

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

Voisin, M. C.

D. Goutallier, J. M. Postel, J. Bernageau, L. Lavau, and M. C. Voisin, “Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan,” Clin. Orthop. Relat. Res. 304, 78–83 (1994).
[PubMed]

Wagner, M.

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

Waterman, G.

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

Weitz, J.

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

Wirtz, C. R.

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

Wojtkowski, M.

Zavagno, G.

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

Zysk, A. M.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

AJNR Am. J. Neuroradiol. (1)

J. P. Schneider, T. Schulz, F. Schmidt, J. Dietrich, S. Lieberenz, C. Trantakis, V. Seifert, S. Kellermann, R. Schober, L. Schaffranietz, M. Laufer, and T. Kahn, “Gross-total surgery of supratentorial low-grade gliomas under intraoperative MR guidance,” AJNR Am. J. Neuroradiol. 22(1), 89–98 (2001).
[PubMed]

Am. J. Ophthalmol. (1)

J. M. Parel, R. Machemer, and W. Aumayr, “A new concept for vitreous surgery. 5. An automated operating microscope,” Am. J. Ophthalmol. 77(2), 161–168 (1974).
[Crossref] [PubMed]

Biomed. Opt. Express (3)

Br. J. Ophthalmol. (1)

J. P. Ehlers, P. K. Kaiser, and S. K. Srivastava, “Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study,” Br. J. Ophthalmol. 98(10), 1329–1332 (2014).
[Crossref] [PubMed]

Cancer Res. (1)

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Clin. Orthop. Relat. Res. (1)

D. Goutallier, J. M. Postel, J. Bernageau, L. Lavau, and M. C. Voisin, “Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan,” Clin. Orthop. Relat. Res. 304, 78–83 (1994).
[PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

J. M. Schmitt, “Optical coherence tomography (OCT): A review,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1205–1215 (1999).
[Crossref]

J. Clin. Pathol. (1)

G. Cserni, “Intraoperative analysis of sentinel lymph nodes in breast cancer by one-step nucleic acid amplification,” J. Clin. Pathol. 65(3), 193–199 (2012).
[Crossref] [PubMed]

J. Neurosurg. (1)

N. Sanai, L. A. Snyder, N. J. Honea, S. W. Coons, J. M. Eschbacher, K. A. Smith, and R. F. Spetzler, “Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas,” J. Neurosurg. 115(4), 740–748 (2011).
[Crossref] [PubMed]

J. Surg. Oncol. (1)

C. R. Rossi, S. Mocellin, B. Scagnet, M. Foletto, A. Vecchiato, P. Pilati, A. Tregnaghi, G. Zavagno, R. Stramare, L. Rubaltelli, C. Montesco, S. Borsato, D. Rubello, and M. Lise, “The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients,” J. Surg. Oncol. 83(2), 80–84 (2003).
[Crossref] [PubMed]

JAMA Ophthalmol. (2)

P. Steven, C. Le Blanc, K. Velten, E. Lankenau, M. Krug, S. Oelckers, L. M. Heindl, U. Gehlsen, G. Hüttmann, and C. Cursiefen, “Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography,” JAMA Ophthalmol. 131(9), 1135–1142 (2013).
[Crossref] [PubMed]

J. P. Ehlers, J. Goshe, W. J. Dupps, P. K. Kaiser, R. P. Singh, R. Gans, J. Eisengart, and S. K. Srivastava, “Determination of feasibility and utility of microscope-integrated optical coherence tomography during ophthalmic surgery: the DISCOVER Study RESCAN Results,” JAMA Ophthalmol. 133(10), 1124–1132 (2015).
[Crossref] [PubMed]

Lancet Oncol. (1)

C. Senft, A. Bink, K. Franz, H. Vatter, T. Gasser, and V. Seifert, “Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial,” Lancet Oncol. 12(11), 997–1003 (2011).
[Crossref] [PubMed]

Med. Phys. (2)

R. M. Comeau, A. F. Sadikot, A. Fenster, and T. M. Peters, “Intraoperative ultrasound for guidance and tissue shift correction in image-guided neurosurgery,” Med. Phys. 27(4), 787–800 (2000).
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H. Neshat, D. W. Cool, K. Barker, L. Gardi, N. Kakani, and A. Fenster, “A 3D ultrasound scanning system for image guided liver interventions,” Med. Phys. 40(11), 112903 (2013).
[Crossref] [PubMed]

N. Engl. J. Med. (1)

D. J. Brenner and E. J. Hall, “Computed tomography--an increasing source of radiation exposure,” N. Engl. J. Med. 357(22), 2277–2284 (2007).
[Crossref] [PubMed]

Neurology (1)

S. F. Berkovic, A. M. McIntosh, R. M. Kalnins, G. D. Jackson, G. C. Fabinyi, G. A. Brazenor, P. F. Bladin, and J. L. Hopper, “Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis,” Neurology 45(7), 1358–1363 (1995).
[Crossref] [PubMed]

Neurosurgery (2)

V. M. Tronnier, C. R. Wirtz, M. Knauth, G. Lenz, O. Pastyr, M. M. Bonsanto, F. K. Albert, R. Kuth, A. Staubert, W. Schlegel, K. Sartor, and S. Kunze, “Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery,” Neurosurgery 40(5), 891–902 (1997).
[Crossref] [PubMed]

M. Hadani, R. Spiegelman, Z. Feldman, H. Berkenstadt, and Z. Ram, “Novel, compact, intraoperative magnetic resonance imaging-guided system for conventional neurosurgical operating rooms,” Neurosurgery 48(4), 799–809 (2001).
[PubMed]

Opt. Express (2)

Optica (1)

PLoS One (1)

J. P. Ehlers, S. K. Srivastava, D. Feiler, A. I. Noonan, A. M. Rollins, and Y. K. Tao, “Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback,” PLoS One 9(8), e105224 (2014).
[Crossref] [PubMed]

Retina (1)

P. Hahn, J. Migacz, R. O’Donnell, S. Day, A. Lee, P. Lin, R. Vann, A. Kuo, S. Fekrat, P. Mruthyunjaya, E. A. Postel, J. A. Izatt, and C. A. Toth, “Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device,” Retina 33(7), 1328–1337 (2013).
[Crossref] [PubMed]

Sci. Rep. (1)

O. M. Carrasco-Zevallos, B. Keller, C. Viehland, L. Shen, G. Waterman, B. Todorich, C. Shieh, P. Hahn, S. Farsiu, A. N. Kuo, C. A. Toth, and J. A. Izatt, “Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography,” Sci. Rep. 6(1), 31689 (2016).
[Crossref] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et al.., “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Surg. Endosc. (1)

H. G. Kenngott, M. Wagner, M. Gondan, F. Nickel, M. Nolden, A. Fetzer, J. Weitz, L. Fischer, S. Speidel, H.-P. Meinzer, D. Böckler, M. W. Büchler, and B. P. Müller-Stich, “Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging,” Surg. Endosc. 28(3), 933–940 (2014).
[Crossref] [PubMed]

Surgery Curr. Res. (1)

M. Singh and A. Saxena, “Microsurgery: A useful and versatile tool in surgical field,” Surgery Curr. Res. 4(4), 9–11 (2014).

Transl. Vis. Sci. Technol. (1)

P. Hahn, O. Carrasco-Zevallos, D. Cunefare, J. Migacz, S. Farsiu, J. A. Izatt, and C. A. Toth, “Intrasurgical human retinal imaging with manual instrument tracking using a microscope-integrated spectral-domain optical coherence tomography device,” Transl. Vis. Sci. Technol. 4(4), 1–9 (2015).
[Crossref] [PubMed]

Supplementary Material (1)

NameDescription
» Visualization 1       OCT image of tumor in mouse brain (a) before and (a) after application of the proposed feedback method. Red dashed circle indicates the tumor.

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Figures (11)

Fig. 1
Fig. 1 (a) Schematics and (b) photographs of the surgical MI-OCT system with the ETL and linear motor. SS, swept source; BD, balanced detector; ETL, electrically tunable lens; Mems, MEMS scanner; TL, tube lens; OL, objective lens; DM, dichromatic mirror.
Fig. 2
Fig. 2 Sensitivity roll-off of the developed MI-OCT system.
Fig. 3
Fig. 3 Simulation results of focal positions of OL1 at current of (a) 150 mA, (b) 100 mA, and (c) 50 mA.
Fig. 4
Fig. 4 Simulation results of beam diameter incident on OL1 at current of (a) 150 mA, (b) 100 mA, and (c) 50 mA.
Fig. 5
Fig. 5 Simulation results of spot size at focal position at current of (a) 150 mA, (b) 100 mA, and (c) 50 mA.
Fig. 6
Fig. 6 Focus shift effect on OCT images. (a) The OCT image when the focus position of the objective lens disagrees in the lower region. (b) Contrast-enhanced OCT image after focus change upward using the ETL. (c) The OCT image when the focus position of the objective lens disagrees in the upper region (d) Contrast-enhanced OCT image after downward focus change using the ETL. The red dotted line indicates the focal positions.
Fig. 7
Fig. 7 OCT resolution target images obtained under different OPD conditions. (a) OCT image without any feedback, (b) OCT image after OPD compensation by linear motor, and (c) OCT image after OPD compensation and successive focus adjustment using ETL control.
Fig. 8
Fig. 8 Flowchart of feedback algorithm for maintaining sensitivity.
Fig. 9
Fig. 9 (a) OCT images recorded for every 1-mm movement of the sample backward from the objective lens, (b) OCT images obtained with decreasing current applied to ETL, and (c) OCT images obtained under proposed feedback method. Scale bar: 1 mm.
Fig. 10
Fig. 10 Sensitivity curves of (a) original OCT images without any feedback, (b) OCT images under tuning of focal positions only, and (c) OCT images under simultaneous tuning of focal positions and with OPD feedback.
Fig. 11
Fig. 11 OCT image of tumor in mouse brain (a) before and (a) after application of the proposed feedback method. Red dashed circle indicates the tumor. Visualization 1 shows the performance of the MI-OCT system with the proposed real-time feedback method.

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