Abstract

We present a novel method used to implement tiling lattice light sheets (LLS) in lattice light sheet microscopy (LLSM) on regular LLS microscopes without changing the LLS microscope hardware. A LLS is tiled by applying binary phase maps acquired from off-center cross-sections of the corresponding optical lattice to the binary SLM used in LLS microscopes, by which a thin LLS can be tiled to image large specimens while maintaining the 3D imaging ability in the entire field of view. We investigate the method via numerical simulations and experiments, and demonstrate the method by imaging fluorescent particles embedded in agarose gel and expanded cells in the dithered mode of LLSM.

© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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  1. B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
    [Crossref] [PubMed]
  2. J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
    [Crossref] [PubMed]
  3. N. Trivedi, D. R. Stabley, B. Cain, D. Howell, C. Laumonnerie, J. S. Ramahi, J. Temirov, R. A. Kerekes, P. R. Gordon-Weeks, and D. J. Solecki, “Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection,” Nat. Commun. 8, 14484 (2017).
    [Crossref] [PubMed]
  4. L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
    [Crossref] [PubMed]
  5. N. D. Condon, J. M. Heddleston, T.-L. Chew, L. Luo, P. S. McPherson, M. S. Ioannou, L. Hodgson, J. L. Stow, and A. A. Wall, “Macropinosome formation by tent pole ruffling in macrophages,” J. Cell Biol. 217(11), 3873–3885 (2018).
    [Crossref] [PubMed]
  6. K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).
  7. M. G. L. Gustafsson, L. Shao, P. M. Carlton, C. J. R. Wang, I. N. Golubovskaya, W. Z. Cande, D. A. Agard, and J. W. Sedat, “Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination,” Biophys. J. 94(12), 4957–4970 (2008).
    [Crossref] [PubMed]
  8. L. Gao, L. Shao, C. D. Higgins, J. S. Poulton, M. Peifer, M. W. Davidson, X. Wu, B. Goldstein, and E. Betzig, “Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens,” Cell 151(6), 1370–1385 (2012).
    [Crossref] [PubMed]
  9. L. Gao, L. Shao, B.-C. Chen, and E. Betzig, “3D live fluorescence imaging of cellular dynamics using Bessel beam plane illumination microscopy,” Nat. Protoc. 9(5), 1083–1101 (2014).
    [Crossref] [PubMed]
  10. J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
    [Crossref] [PubMed]
  11. P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. K. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
    [Crossref] [PubMed]
  12. T. A. Planchon, L. Gao, D. E. Milkie, M. W. Davidson, J. A. Galbraith, C. G. Galbraith, and E. Betzig, “Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination,” Nat. Methods 8(5), 417–423 (2011).
    [Crossref] [PubMed]
  13. F. O. Fahrbach, P. Simon, and A. Rohrbach, “Microscopy with self-reconstructing beams,” Nat. Photonics 4(11), 780–785 (2010).
    [Crossref]
  14. Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
    [Crossref] [PubMed]
  15. L. Gao, “Optimization of the excitation light sheet in selective plane illumination microscopy,” Biomed. Opt. Express 6(3), 881–890 (2015).
    [Crossref] [PubMed]
  16. T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).
  17. L. Gao, “Extend the field of view of selective plan illumination microscopy by tiling the excitation light sheet,” Opt. Express 23(5), 6102–6111 (2015).
    [Crossref] [PubMed]
  18. Q. Fu, B. L. Martin, D. Q. Matus, and L. Gao, “Imaging multicellular specimens with real-time optimized tiling light-sheet selective plane illumination microscopy,” Nat. Commun. 7(1), 11088 (2016).
    [Crossref] [PubMed]
  19. D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
    [Crossref] [PubMed]
  20. W. Zong, J. Zhao, X. Chen, Y. Lin, H. Ren, Y. Zhang, M. Fan, Z. Zhou, H. Cheng, Y. Sun, and L. Chen, “Large-field high-resolution two-photon digital scanned light-sheet microscopy,” Cell Res. 25(2), 254–257 (2015).
    [Crossref] [PubMed]
  21. K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free subcellular imaging with axially swept light sheet microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
    [Crossref] [PubMed]
  22. A. K. Chmielewski, A. Kyrsting, P. Mahou, M. T. Wayland, L. Muresan, J. F. Evers, and C. F. Kaminski, “Fast imaging of live organisms with sculpted light sheets,” Sci. Rep. 5(1), 9385 (2015).
    [Crossref] [PubMed]
  23. F. Chen, P. W. Tillberg, and E. S. Boyden, “Expansion microscopy,” Science 347(6221), 543–548 (2015).
    [Crossref] [PubMed]
  24. Z. Zhang, Y. Nishimura, and P. Kanchanawong, “Extracting microtubule networks from superresolution single-molecule localization microscopy data,” Mol. Biol. Cell 28(2), 333–345 (2017).
    [Crossref] [PubMed]
  25. P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
    [Crossref] [PubMed]

2018 (4)

N. D. Condon, J. M. Heddleston, T.-L. Chew, L. Luo, P. S. McPherson, M. S. Ioannou, L. Hodgson, J. L. Stow, and A. A. Wall, “Macropinosome formation by tent pole ruffling in macrophages,” J. Cell Biol. 217(11), 3873–3885 (2018).
[Crossref] [PubMed]

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
[Crossref] [PubMed]

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

2017 (3)

Z. Zhang, Y. Nishimura, and P. Kanchanawong, “Extracting microtubule networks from superresolution single-molecule localization microscopy data,” Mol. Biol. Cell 28(2), 333–345 (2017).
[Crossref] [PubMed]

N. Trivedi, D. R. Stabley, B. Cain, D. Howell, C. Laumonnerie, J. S. Ramahi, J. Temirov, R. A. Kerekes, P. R. Gordon-Weeks, and D. J. Solecki, “Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection,” Nat. Commun. 8, 14484 (2017).
[Crossref] [PubMed]

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
[Crossref] [PubMed]

2016 (3)

J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
[Crossref] [PubMed]

P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
[Crossref] [PubMed]

Q. Fu, B. L. Martin, D. Q. Matus, and L. Gao, “Imaging multicellular specimens with real-time optimized tiling light-sheet selective plane illumination microscopy,” Nat. Commun. 7(1), 11088 (2016).
[Crossref] [PubMed]

2015 (6)

L. Gao, “Optimization of the excitation light sheet in selective plane illumination microscopy,” Biomed. Opt. Express 6(3), 881–890 (2015).
[Crossref] [PubMed]

L. Gao, “Extend the field of view of selective plan illumination microscopy by tiling the excitation light sheet,” Opt. Express 23(5), 6102–6111 (2015).
[Crossref] [PubMed]

W. Zong, J. Zhao, X. Chen, Y. Lin, H. Ren, Y. Zhang, M. Fan, Z. Zhou, H. Cheng, Y. Sun, and L. Chen, “Large-field high-resolution two-photon digital scanned light-sheet microscopy,” Cell Res. 25(2), 254–257 (2015).
[Crossref] [PubMed]

K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free subcellular imaging with axially swept light sheet microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
[Crossref] [PubMed]

A. K. Chmielewski, A. Kyrsting, P. Mahou, M. T. Wayland, L. Muresan, J. F. Evers, and C. F. Kaminski, “Fast imaging of live organisms with sculpted light sheets,” Sci. Rep. 5(1), 9385 (2015).
[Crossref] [PubMed]

F. Chen, P. W. Tillberg, and E. S. Boyden, “Expansion microscopy,” Science 347(6221), 543–548 (2015).
[Crossref] [PubMed]

2014 (2)

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

L. Gao, L. Shao, B.-C. Chen, and E. Betzig, “3D live fluorescence imaging of cellular dynamics using Bessel beam plane illumination microscopy,” Nat. Protoc. 9(5), 1083–1101 (2014).
[Crossref] [PubMed]

2012 (1)

L. Gao, L. Shao, C. D. Higgins, J. S. Poulton, M. Peifer, M. W. Davidson, X. Wu, B. Goldstein, and E. Betzig, “Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens,” Cell 151(6), 1370–1385 (2012).
[Crossref] [PubMed]

2011 (2)

T. A. Planchon, L. Gao, D. E. Milkie, M. W. Davidson, J. A. Galbraith, C. G. Galbraith, and E. Betzig, “Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination,” Nat. Methods 8(5), 417–423 (2011).
[Crossref] [PubMed]

Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
[Crossref] [PubMed]

2010 (1)

F. O. Fahrbach, P. Simon, and A. Rohrbach, “Microscopy with self-reconstructing beams,” Nat. Photonics 4(11), 780–785 (2010).
[Crossref]

2008 (2)

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. K. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
[Crossref] [PubMed]

M. G. L. Gustafsson, L. Shao, P. M. Carlton, C. J. R. Wang, I. N. Golubovskaya, W. Z. Cande, D. A. Agard, and J. W. Sedat, “Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination,” Biophys. J. 94(12), 4957–4970 (2008).
[Crossref] [PubMed]

2004 (1)

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[Crossref] [PubMed]

Agard, D. A.

M. G. L. Gustafsson, L. Shao, P. M. Carlton, C. J. R. Wang, I. N. Golubovskaya, W. Z. Cande, D. A. Agard, and J. W. Sedat, “Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination,” Biophys. J. 94(12), 4957–4970 (2008).
[Crossref] [PubMed]

Bao, Z.

Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
[Crossref] [PubMed]

Bembenek, J. N.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Betzig, E.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
[Crossref] [PubMed]

J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
[Crossref] [PubMed]

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

L. Gao, L. Shao, B.-C. Chen, and E. Betzig, “3D live fluorescence imaging of cellular dynamics using Bessel beam plane illumination microscopy,” Nat. Protoc. 9(5), 1083–1101 (2014).
[Crossref] [PubMed]

L. Gao, L. Shao, C. D. Higgins, J. S. Poulton, M. Peifer, M. W. Davidson, X. Wu, B. Goldstein, and E. Betzig, “Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens,” Cell 151(6), 1370–1385 (2012).
[Crossref] [PubMed]

T. A. Planchon, L. Gao, D. E. Milkie, M. W. Davidson, J. A. Galbraith, C. G. Galbraith, and E. Betzig, “Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination,” Nat. Methods 8(5), 417–423 (2011).
[Crossref] [PubMed]

Blackstone, C.

J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
[Crossref] [PubMed]

Böhme, R.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Boyden, E. S.

P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
[Crossref] [PubMed]

F. Chen, P. W. Tillberg, and E. S. Boyden, “Expansion microscopy,” Science 347(6221), 543–548 (2015).
[Crossref] [PubMed]

Bugde, A.

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
[Crossref] [PubMed]

Cai, D.

P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
[Crossref] [PubMed]

Cain, B.

N. Trivedi, D. R. Stabley, B. Cain, D. Howell, C. Laumonnerie, J. S. Ramahi, J. Temirov, R. A. Kerekes, P. R. Gordon-Weeks, and D. J. Solecki, “Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection,” Nat. Commun. 8, 14484 (2017).
[Crossref] [PubMed]

Cande, W. Z.

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K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Chen, B.-C.

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
[Crossref] [PubMed]

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

L. Gao, L. Shao, B.-C. Chen, and E. Betzig, “3D live fluorescence imaging of cellular dynamics using Bessel beam plane illumination microscopy,” Nat. Protoc. 9(5), 1083–1101 (2014).
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Chen, F.

P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
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F. Chen, P. W. Tillberg, and E. S. Boyden, “Expansion microscopy,” Science 347(6221), 543–548 (2015).
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W. Zong, J. Zhao, X. Chen, Y. Lin, H. Ren, Y. Zhang, M. Fan, Z. Zhou, H. Cheng, Y. Sun, and L. Chen, “Large-field high-resolution two-photon digital scanned light-sheet microscopy,” Cell Res. 25(2), 254–257 (2015).
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Chen, X.

W. Zong, J. Zhao, X. Chen, Y. Lin, H. Ren, Y. Zhang, M. Fan, Z. Zhou, H. Cheng, Y. Sun, and L. Chen, “Large-field high-resolution two-photon digital scanned light-sheet microscopy,” Cell Res. 25(2), 254–257 (2015).
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Cheng, H.

W. Zong, J. Zhao, X. Chen, Y. Lin, H. Ren, Y. Zhang, M. Fan, Z. Zhou, H. Cheng, Y. Sun, and L. Chen, “Large-field high-resolution two-photon digital scanned light-sheet microscopy,” Cell Res. 25(2), 254–257 (2015).
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K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

N. D. Condon, J. M. Heddleston, T.-L. Chew, L. Luo, P. S. McPherson, M. S. Ioannou, L. Hodgson, J. L. Stow, and A. A. Wall, “Macropinosome formation by tent pole ruffling in macrophages,” J. Cell Biol. 217(11), 3873–3885 (2018).
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A. K. Chmielewski, A. Kyrsting, P. Mahou, M. T. Wayland, L. Muresan, J. F. Evers, and C. F. Kaminski, “Fast imaging of live organisms with sculpted light sheets,” Sci. Rep. 5(1), 9385 (2015).
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Christensen, R.

Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
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Collins, Z. M.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Colón-Ramos, D.

Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
[Crossref] [PubMed]

Condon, N. D.

N. D. Condon, J. M. Heddleston, T.-L. Chew, L. Luo, P. S. McPherson, M. S. Ioannou, L. Hodgson, J. L. Stow, and A. A. Wall, “Macropinosome formation by tent pole ruffling in macrophages,” J. Cell Biol. 217(11), 3873–3885 (2018).
[Crossref] [PubMed]

Cunniff, B.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Dambournet, D.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Danuser, G.

K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free subcellular imaging with axially swept light sheet microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
[Crossref] [PubMed]

Davidson, M. W.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

L. Gao, L. Shao, C. D. Higgins, J. S. Poulton, M. Peifer, M. W. Davidson, X. Wu, B. Goldstein, and E. Betzig, “Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens,” Cell 151(6), 1370–1385 (2012).
[Crossref] [PubMed]

T. A. Planchon, L. Gao, D. E. Milkie, M. W. Davidson, J. A. Galbraith, C. G. Galbraith, and E. Betzig, “Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination,” Nat. Methods 8(5), 417–423 (2011).
[Crossref] [PubMed]

Davidson, S.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Dean, K. M.

K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free subcellular imaging with axially swept light sheet microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
[Crossref] [PubMed]

DeGennaro, E. M.

P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
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Del Bene, F.

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
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Desimone, R.

P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
[Crossref] [PubMed]

Dewson, G.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Dramicanin, M.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Drubin, D. G.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Du, Z.

Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
[Crossref] [PubMed]

English, B. P.

P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
[Crossref] [PubMed]

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Evers, J. F.

A. K. Chmielewski, A. Kyrsting, P. Mahou, M. T. Wayland, L. Muresan, J. F. Evers, and C. F. Kaminski, “Fast imaging of live organisms with sculpted light sheets,” Sci. Rep. 5(1), 9385 (2015).
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F. O. Fahrbach, P. Simon, and A. Rohrbach, “Microscopy with self-reconstructing beams,” Nat. Photonics 4(11), 780–785 (2010).
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Fan, M.

W. Zong, J. Zhao, X. Chen, Y. Lin, H. Ren, Y. Zhang, M. Fan, Z. Zhou, H. Cheng, Y. Sun, and L. Chen, “Large-field high-resolution two-photon digital scanned light-sheet microscopy,” Cell Res. 25(2), 254–257 (2015).
[Crossref] [PubMed]

Feng, J. Q.

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
[Crossref] [PubMed]

Ferrin, T. E.

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
[Crossref] [PubMed]

Fiolka, R.

K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free subcellular imaging with axially swept light sheet microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
[Crossref] [PubMed]

Forster, R.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Fritz-Laylin, L.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Fritz-Laylin, L. K.

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
[Crossref] [PubMed]

Fu, Q.

Q. Fu, B. L. Martin, D. Q. Matus, and L. Gao, “Imaging multicellular specimens with real-time optimized tiling light-sheet selective plane illumination microscopy,” Nat. Commun. 7(1), 11088 (2016).
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Galbraith, C. G.

T. A. Planchon, L. Gao, D. E. Milkie, M. W. Davidson, J. A. Galbraith, C. G. Galbraith, and E. Betzig, “Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination,” Nat. Methods 8(5), 417–423 (2011).
[Crossref] [PubMed]

Galbraith, J. A.

T. A. Planchon, L. Gao, D. E. Milkie, M. W. Davidson, J. A. Galbraith, C. G. Galbraith, and E. Betzig, “Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination,” Nat. Methods 8(5), 417–423 (2011).
[Crossref] [PubMed]

Gao, L.

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
[Crossref] [PubMed]

Q. Fu, B. L. Martin, D. Q. Matus, and L. Gao, “Imaging multicellular specimens with real-time optimized tiling light-sheet selective plane illumination microscopy,” Nat. Commun. 7(1), 11088 (2016).
[Crossref] [PubMed]

P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
[Crossref] [PubMed]

L. Gao, “Optimization of the excitation light sheet in selective plane illumination microscopy,” Biomed. Opt. Express 6(3), 881–890 (2015).
[Crossref] [PubMed]

L. Gao, “Extend the field of view of selective plan illumination microscopy by tiling the excitation light sheet,” Opt. Express 23(5), 6102–6111 (2015).
[Crossref] [PubMed]

L. Gao, L. Shao, B.-C. Chen, and E. Betzig, “3D live fluorescence imaging of cellular dynamics using Bessel beam plane illumination microscopy,” Nat. Protoc. 9(5), 1083–1101 (2014).
[Crossref] [PubMed]

L. Gao, L. Shao, C. D. Higgins, J. S. Poulton, M. Peifer, M. W. Davidson, X. Wu, B. Goldstein, and E. Betzig, “Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens,” Cell 151(6), 1370–1385 (2012).
[Crossref] [PubMed]

T. A. Planchon, L. Gao, D. E. Milkie, M. W. Davidson, J. A. Galbraith, C. G. Galbraith, and E. Betzig, “Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination,” Nat. Methods 8(5), 417–423 (2011).
[Crossref] [PubMed]

Gao, X.

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
[Crossref] [PubMed]

Ge, W. P.

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
[Crossref] [PubMed]

Geoghegan, N. D.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Ghitani, A.

Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
[Crossref] [PubMed]

Goddard, T. D.

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
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Goldstein, B.

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B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
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N. D. Condon, J. M. Heddleston, T.-L. Chew, L. Luo, P. S. McPherson, M. S. Ioannou, L. Hodgson, J. L. Stow, and A. A. Wall, “Macropinosome formation by tent pole ruffling in macrophages,” J. Cell Biol. 217(11), 3873–3885 (2018).
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Hess, H. F.

J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
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L. Gao, L. Shao, C. D. Higgins, J. S. Poulton, M. Peifer, M. W. Davidson, X. Wu, B. Goldstein, and E. Betzig, “Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens,” Cell 151(6), 1370–1385 (2012).
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Higgs, H.

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
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T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Hockemeyer, D.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Hodgson, L.

N. D. Condon, J. M. Heddleston, T.-L. Chew, L. Luo, P. S. McPherson, M. S. Ioannou, L. Hodgson, J. L. Stow, and A. A. Wall, “Macropinosome formation by tent pole ruffling in macrophages,” J. Cell Biol. 217(11), 3873–3885 (2018).
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N. D. Condon, J. M. Heddleston, T.-L. Chew, L. Luo, P. S. McPherson, M. S. Ioannou, L. Hodgson, J. L. Stow, and A. A. Wall, “Macropinosome formation by tent pole ruffling in macrophages,” J. Cell Biol. 217(11), 3873–3885 (2018).
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B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Jing, D.

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
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L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
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Kaminski, C. F.

A. K. Chmielewski, A. Kyrsting, P. Mahou, M. T. Wayland, L. Muresan, J. F. Evers, and C. F. Kaminski, “Fast imaging of live organisms with sculpted light sheets,” Sci. Rep. 5(1), 9385 (2015).
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P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. K. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
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Kerekes, R. A.

N. Trivedi, D. R. Stabley, B. Cain, D. Howell, C. Laumonnerie, J. S. Ramahi, J. Temirov, R. A. Kerekes, P. R. Gordon-Weeks, and D. J. Solecki, “Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection,” Nat. Commun. 8, 14484 (2017).
[Crossref] [PubMed]

Kiehart, D. P.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Kile, B. T.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Kirchhausen, T.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Kohrman, A. Q.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Koyama, M.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Kyrsting, A.

A. K. Chmielewski, A. Kyrsting, P. Mahou, M. T. Wayland, L. Muresan, J. F. Evers, and C. F. Kaminski, “Fast imaging of live organisms with sculpted light sheets,” Sci. Rep. 5(1), 9385 (2015).
[Crossref] [PubMed]

Lane, R. M.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Laumonnerie, C.

N. Trivedi, D. R. Stabley, B. Cain, D. Howell, C. Laumonnerie, J. S. Ramahi, J. Temirov, R. A. Kerekes, P. R. Gordon-Weeks, and D. J. Solecki, “Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection,” Nat. Commun. 8, 14484 (2017).
[Crossref] [PubMed]

Lazarou, M.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Legant, W. R.

J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
[Crossref] [PubMed]

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Lessene, G.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Lessene, R.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Li, D.

J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
[Crossref] [PubMed]

Li, L.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Lin, Y.

W. Zong, J. Zhao, X. Chen, Y. Lin, H. Ren, Y. Zhang, M. Fan, Z. Zhou, H. Cheng, Y. Sun, and L. Chen, “Large-field high-resolution two-photon digital scanned light-sheet microscopy,” Cell Res. 25(2), 254–257 (2015).
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Lippincott-Schwartz, J.

J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
[Crossref] [PubMed]

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Liu, T.-L.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Liu, X.

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
[Crossref] [PubMed]

Liu, Z.

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Lord, S. J.

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
[Crossref] [PubMed]

Luo, L.

N. D. Condon, J. M. Heddleston, T.-L. Chew, L. Luo, P. S. McPherson, M. S. Ioannou, L. Hodgson, J. L. Stow, and A. A. Wall, “Macropinosome formation by tent pole ruffling in macrophages,” J. Cell Biol. 217(11), 3873–3885 (2018).
[Crossref] [PubMed]

Luo, W.

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
[Crossref] [PubMed]

Ma, C.

D. Jing, S. Zhang, W. Luo, X. Gao, Y. Men, C. Ma, X. Liu, Y. Yi, A. Bugde, B. O. Zhou, Z. Zhao, Q. Yuan, J. Q. Feng, L. Gao, W. P. Ge, and H. Zhao, “Tissue clearing of both hard and soft tissue organs with the PEGASOS method,” Cell Res. 28(8), 803–818 (2018).
[Crossref] [PubMed]

Mahou, P.

A. K. Chmielewski, A. Kyrsting, P. Mahou, M. T. Wayland, L. Muresan, J. F. Evers, and C. F. Kaminski, “Fast imaging of live organisms with sculpted light sheets,” Sci. Rep. 5(1), 9385 (2015).
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Martin, B. L.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Q. Fu, B. L. Martin, D. Q. Matus, and L. Gao, “Imaging multicellular specimens with real-time optimized tiling light-sheet selective plane illumination microscopy,” Nat. Commun. 7(1), 11088 (2016).
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Martorell, A.

P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
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T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

Q. Fu, B. L. Martin, D. Q. Matus, and L. Gao, “Imaging multicellular specimens with real-time optimized tiling light-sheet selective plane illumination microscopy,” Nat. Commun. 7(1), 11088 (2016).
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K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

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Megason, S. G.

T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

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T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Mullins, R. D.

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
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B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Z. Zhang, Y. Nishimura, and P. Kanchanawong, “Extracting microtubule networks from superresolution single-molecule localization microscopy data,” Mol. Biol. Cell 28(2), 333–345 (2017).
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K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

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K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

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J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
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P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
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Riel-Mehan, M.

L. K. Fritz-Laylin, M. Riel-Mehan, B.-C. Chen, S. J. Lord, T. D. Goddard, T. E. Ferrin, S. M. Nicholson-Dykstra, H. Higgs, G. T. Johnson, E. Betzig, and R. D. Mullins, “Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes,” eLife 6, 26990 (2017).
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B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
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P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
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Ryan, M. T.

K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

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M. G. L. Gustafsson, L. Shao, P. M. Carlton, C. J. R. Wang, I. N. Golubovskaya, W. Z. Cande, D. A. Agard, and J. W. Sedat, “Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination,” Biophys. J. 94(12), 4957–4970 (2008).
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P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
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B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
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N. Trivedi, D. R. Stabley, B. Cain, D. Howell, C. Laumonnerie, J. S. Ramahi, J. Temirov, R. A. Kerekes, P. R. Gordon-Weeks, and D. J. Solecki, “Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection,” Nat. Commun. 8, 14484 (2017).
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P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. K. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
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P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
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J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
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P. W. Tillberg, F. Chen, K. D. Piatkevich, Y. Zhao, C.-C. Yu, B. P. English, L. Gao, A. Martorell, H.-J. Suk, F. Yoshida, E. M. DeGennaro, D. H. Roossien, G. Gong, U. Seneviratne, S. R. Tannenbaum, R. Desimone, D. Cai, and E. S. Boyden, “Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies,” Nat. Biotechnol. 34(9), 987–992 (2016).
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K. McArthur, L. W. Whitehead, J. M. Heddleston, L. Li, B. S. Padman, V. Oorschot, N. D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R. M. Lane, M. Dramicanin, T. L. Saunders, C. Sugiana, R. Lessene, L. D. Osellame, T.-L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M. T. Ryan, K. L. Rogers, M. F. van Delft, and B. T. Kile, “BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis,” Science 359(6378), 6047 (2018).

Wall, A. A.

N. D. Condon, J. M. Heddleston, T.-L. Chew, L. Luo, P. S. McPherson, M. S. Ioannou, L. Hodgson, J. L. Stow, and A. A. Wall, “Macropinosome formation by tent pole ruffling in macrophages,” J. Cell Biol. 217(11), 3873–3885 (2018).
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M. G. L. Gustafsson, L. Shao, P. M. Carlton, C. J. R. Wang, I. N. Golubovskaya, W. Z. Cande, D. A. Agard, and J. W. Sedat, “Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination,” Biophys. J. 94(12), 4957–4970 (2008).
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B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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T.-L. Liu, S. Upadhyayula, D. E. Milkie, V. Singh, K. Wang, I. A. Swinburne, K. R. Mosaliganti, Z. M. Collins, T. W. Hiscock, J. Shea, A. Q. Kohrman, T. N. Medwig, D. Dambournet, R. Forster, B. Cunniff, Y. Ruan, H. Yashiro, S. Scholpp, E. M. Meyerowitz, D. Hockemeyer, D. G. Drubin, B. L. Martin, D. Q. Matus, M. Koyama, S. G. Megason, T. Kirchhausen, and E. Betzig, “Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms,” Science,  360(6386), 1392 (2018).

B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Wittbrodt, J.

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. K. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
[Crossref] [PubMed]

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. K. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
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L. Gao, L. Shao, C. D. Higgins, J. S. Poulton, M. Peifer, M. W. Davidson, X. Wu, B. Goldstein, and E. Betzig, “Noninvasive imaging beyond the diffraction limit of 3D dynamics in thickly fluorescent specimens,” Cell 151(6), 1370–1385 (2012).
[Crossref] [PubMed]

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B.-C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Y. Wu, A. Ghitani, R. Christensen, A. Santella, Z. Du, G. Rondeau, Z. Bao, D. Colón-Ramos, and H. Shroff, “Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans,” Proc. Natl. Acad. Sci. U.S.A. 108(43), 17708–17713 (2011).
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J. Nixon-Abell, C. J. Obara, A. V. Weigel, D. Li, W. R. Legant, C. S. Xu, H. A. Pasolli, K. Harvey, H. F. Hess, E. Betzig, C. Blackstone, and J. Lippincott-Schwartz, “Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER,” Science 354(6311), 3928 (2016).
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W. Zong, J. Zhao, X. Chen, Y. Lin, H. Ren, Y. Zhang, M. Fan, Z. Zhou, H. Cheng, Y. Sun, and L. Chen, “Large-field high-resolution two-photon digital scanned light-sheet microscopy,” Cell Res. 25(2), 254–257 (2015).
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W. Zong, J. Zhao, X. Chen, Y. Lin, H. Ren, Y. Zhang, M. Fan, Z. Zhou, H. Cheng, Y. Sun, and L. Chen, “Large-field high-resolution two-photon digital scanned light-sheet microscopy,” Cell Res. 25(2), 254–257 (2015).
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Supplementary Material (1)

NameDescription
» Visualization 1       An expanded mitotic cell imaged using Tiling lattice light sheet microscopy. Different frames display different depth ortho slides in xy and yz imaging plane.

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Figures (6)

Fig. 1
Fig. 1 The method used to tile LLSs in typical LLS microscopes. (a) A simplified optical configuration of the LLS microscope illumination path. (b) The amplitude and phase profile at the center cross section of a simulated optical lattice, and the corresponding binary phase map acquired from either of them to generate the optical lattice in LLS microscopes. (c) The amplitude and phase profile at an off-center cross section of the same simulated optical lattice in (b), and the corresponding binary phase map acquired from either of them to tile the optical lattice in LLS microscopes. (d-f) 3D volume renderings of simulated optical lattices generated by modulating the illumination light of the given amplitude profile using the given phase profiles at the image plane where the SLM locates in the LLS microscope. The white frames indicate the detection FOV.
Fig. 2
Fig. 2 Simulation results of tiling optical lattices generated by applying binary phase maps to the binary SLM used in typical LLS microscopes. (a-d) Four binary phase maps acquired from different off-center cross sections of the same optical lattice (NAOD = 0.4, NAID = 0.22) used to tile the optical lattice, and the intensity profiles of the corresponding tiling optical lattices and LLSs at the indicated cross sections. NAOD and NAID are the illumination numerical apertures (NA) corresponding to the outer and inner diameter of the transparent optical annulus used to create the optical lattice. Scales bars, 5 µm in (a) XZ panel, and 10 µm in (a) YZ panel.
Fig. 3
Fig. 3 The tiling distance limitation caused by the illumination light beam width. (a) A binary phase map applied to the binary SLM to modulate the illumination light with different beam widths of amp1 to amp3. (b-d) The intensity profiles of the tiling optical lattices and the indicated cross sections obtained by modulating the illuminating light of different beam widths with the same binary phase map shown in (a), demonstrating the tiling distance limitation caused by beam width of the illumination light. Scales bars, 5 µm in (b) XZ panel, and 10 µm in (b) YZ panel.
Fig. 4
Fig. 4 Schematic diagram of the experimental lattice light sheet microscope.
Fig. 5
Fig. 5 Characterization of tiling LLSs on a LLS microscope. (a) Images of an optical lattice tiled in dye solution. Tile 1 represents the regular LLS. (b) XY and YZ maximum intensity projections of a group of fluorescent particles embedded in agarose gel imaged using the tiling LLSs in (a), and zoom-in views of the marked areas. Scale bars, 10 µm. 1 µm in zoom-in views.
Fig. 6
Fig. 6 An expanded mitotic cell imaged using tiling LLSs on a LLS microscope. (a) XY and YZ maximum intensity projections of the cell imaged with a regular LLS, and zoom-in views of the marked areas. (b-c) XY and YZ maximum intensity projections of the expanded cell imaged using tiling LLSs at different tiling positions, and zoom-in views of the marked areas. The arrows indicate the waist positions of the tiling LLSs. (d) XY and YZ maximum intensity projections of the reconstruction result, and zoom-in views of the selected areas. (e) XY and YZ maximum intensity projections of the deconvolved reconstruction result, and zoom-in views of the marked areas. Scale bars, 20 µm.

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