Abstract

Three-dimensional (3D) photoacoustic imaging can be achieved by a two-dimensional (2D) ultrasound array matrix. However, the 2D matrix consisting of hundreds or thousands of transducer elements makes it not only expensive, but also a big technical challenge for both probe manufacturing and parallel data acquisition. In this study, we performed the photoacoustic imaging by scanning an unfocused linear ultrasound array probe over a planar geometry, resulting in an equivalent 2D matrix probe. The phantom study demonstrated that this method substantially increased imaging quality, which has great potential for animal and clinical photoacoustic imaging.

© 2017 Optical Society of America

Full Article  |  PDF Article
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References

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2016 (1)

2014 (4)

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light in and sound out: emerging translational strategies for photoacoustic imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

T. Kitai, M. Torii, T. Sugie, S. Kanao, Y. Mikami, T. Shiina, and M. Toi, “Photoacoustic mammography: initial clinical results,” Breast Cancer 21(2), 146–153 (2014).
[Crossref] [PubMed]

A. Dima, N. C. Burton, and V. Ntziachristos, “Multispectral optoacoustic tomography at 64, 128, and 256 channels,” J. Biomed. Opt. 19(3), 036021 (2014).
[Crossref] [PubMed]

S. Y. Nam and S. Y. Emelianov, “Array-based real-time ultrasound and photoacoustic ocular imaging,” J. Opt. Soc. Korea 18(2), 151–155 (2014).
[Crossref]

2013 (2)

Z. Xie, F. M. Hooi, J. B. Fowlkes, R. W. Pinsky, X. Wang, and P. L. Carson, “Combined photoacoustic and acoustic imaging of human breast specimens in the mammographic geometry,” Ultrasound Med. Biol. 39(11), 2176–2184 (2013).
[Crossref] [PubMed]

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Med. Phys. 40(11), 113301 (2013).
[Crossref] [PubMed]

2012 (3)

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J.-L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

J. Xia, M. R. Chatni, K. Maslov, Z. Guo, K. Wang, M. Anastasio, and L. V. Wang, “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17(5), 050506 (2012).
[Crossref] [PubMed]

2011 (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

2010 (2)

D. Piras, W. Wenfeng Xia, T. G. Steenbergen, van Leeuwen, and S. G. Manohar, “Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

2009 (5)

L. Song, C. Kim, K. Maslov, K. K. Shung, and L. V. Wang, “High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array,” Med. Phys. 36(8), 3724–3729 (2009).
[Crossref] [PubMed]

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[Crossref] [PubMed]

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[Crossref] [PubMed]

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

2005 (2)

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

M. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 71(1), 016706 (2005).
[Crossref] [PubMed]

Aguirre, A.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

Anastasio, M.

J. Xia, M. R. Chatni, K. Maslov, Z. Guo, K. Wang, M. Anastasio, and L. V. Wang, “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17(5), 050506 (2012).
[Crossref] [PubMed]

Beard, P.

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

Brecht, H.-P.

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

Burton, N. C.

A. Dima, N. C. Burton, and V. Ntziachristos, “Multispectral optoacoustic tomography at 64, 128, and 256 channels,” J. Biomed. Opt. 19(3), 036021 (2014).
[Crossref] [PubMed]

Carson, P. L.

Z. Xie, F. M. Hooi, J. B. Fowlkes, R. W. Pinsky, X. Wang, and P. L. Carson, “Combined photoacoustic and acoustic imaging of human breast specimens in the mammographic geometry,” Ultrasound Med. Biol. 39(11), 2176–2184 (2013).
[Crossref] [PubMed]

Chatni, M. R.

J. Xia, M. R. Chatni, K. Maslov, Z. Guo, K. Wang, M. Anastasio, and L. V. Wang, “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17(5), 050506 (2012).
[Crossref] [PubMed]

Conjusteau, A.

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

David, G.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J.-L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

De La Zerda, A.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Del Rio, S. P.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Med. Phys. 40(11), 113301 (2013).
[Crossref] [PubMed]

Dima, A.

A. Dima, N. C. Burton, and V. Ntziachristos, “Multispectral optoacoustic tomography at 64, 128, and 256 channels,” J. Biomed. Opt. 19(3), 036021 (2014).
[Crossref] [PubMed]

Emelianov, S. Y.

Ermilov, S. A.

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

Erpelding, T. N.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J.-L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

Fowlkes, J. B.

Z. Xie, F. M. Hooi, J. B. Fowlkes, R. W. Pinsky, X. Wang, and P. L. Carson, “Combined photoacoustic and acoustic imaging of human breast specimens in the mammographic geometry,” Ultrasound Med. Biol. 39(11), 2176–2184 (2013).
[Crossref] [PubMed]

Frenz, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Fronheiser, M.

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

Furukawa, Y.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Gambhir, S. S.

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light in and sound out: emerging translational strategies for photoacoustic imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Gamelin, J.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

Geng, J.

Guo, Z.

J. Xia, M. R. Chatni, K. Maslov, Z. Guo, K. Wang, M. Anastasio, and L. V. Wang, “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17(5), 050506 (2012).
[Crossref] [PubMed]

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J.-L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

Hooi, F. M.

Z. Xie, F. M. Hooi, J. B. Fowlkes, R. W. Pinsky, X. Wang, and P. L. Carson, “Combined photoacoustic and acoustic imaging of human breast specimens in the mammographic geometry,” Ultrasound Med. Biol. 39(11), 2176–2184 (2013).
[Crossref] [PubMed]

Hu, S.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Jaeger, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Jankovic, L.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J.-L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

Jeffrey, R. B.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Kamaya, A.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Kanao, S.

T. Kitai, M. Torii, T. Sugie, S. Kanao, Y. Mikami, T. Shiina, and M. Toi, “Photoacoustic mammography: initial clinical results,” Breast Cancer 21(2), 146–153 (2014).
[Crossref] [PubMed]

Khuri-Yakub, B. T.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Kim, C.

L. Song, C. Kim, K. Maslov, K. K. Shung, and L. V. Wang, “High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array,” Med. Phys. 36(8), 3724–3729 (2009).
[Crossref] [PubMed]

Kitai, T.

T. Kitai, M. Torii, T. Sugie, S. Kanao, Y. Mikami, T. Shiina, and M. Toi, “Photoacoustic mammography: initial clinical results,” Breast Cancer 21(2), 146–153 (2014).
[Crossref] [PubMed]

Kruger, R. A.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Med. Phys. 40(11), 113301 (2013).
[Crossref] [PubMed]

Kuzmiak, C. M.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Med. Phys. 40(11), 113301 (2013).
[Crossref] [PubMed]

Lam, R. B.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Med. Phys. 40(11), 113301 (2013).
[Crossref] [PubMed]

Lemor, R.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Li, C.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[Crossref] [PubMed]

Lovell, J. F.

Ma, T. J.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Manohar, S. G.

D. Piras, W. Wenfeng Xia, T. G. Steenbergen, van Leeuwen, and S. G. Manohar, “Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

Maslov, K.

J. Xia, M. R. Chatni, K. Maslov, Z. Guo, K. Wang, M. Anastasio, and L. V. Wang, “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17(5), 050506 (2012).
[Crossref] [PubMed]

L. Song, C. Kim, K. Maslov, K. K. Shung, and L. V. Wang, “High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array,” Med. Phys. 36(8), 3724–3729 (2009).
[Crossref] [PubMed]

Maurudis, A.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

Mikami, Y.

T. Kitai, M. Torii, T. Sugie, S. Kanao, Y. Mikami, T. Shiina, and M. Toi, “Photoacoustic mammography: initial clinical results,” Breast Cancer 21(2), 146–153 (2014).
[Crossref] [PubMed]

Nam, S. Y.

Niederhauser, J. J.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Ntziachristos, V.

A. Dima, N. C. Burton, and V. Ntziachristos, “Multispectral optoacoustic tomography at 64, 128, and 256 channels,” J. Biomed. Opt. 19(3), 036021 (2014).
[Crossref] [PubMed]

Oraevsky, A. A.

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

Oralkan, O.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Pinsky, R. W.

Z. Xie, F. M. Hooi, J. B. Fowlkes, R. W. Pinsky, X. Wang, and P. L. Carson, “Combined photoacoustic and acoustic imaging of human breast specimens in the mammographic geometry,” Ultrasound Med. Biol. 39(11), 2176–2184 (2013).
[Crossref] [PubMed]

Piras, D.

D. Piras, W. Wenfeng Xia, T. G. Steenbergen, van Leeuwen, and S. G. Manohar, “Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

Reinecke, D. R.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Med. Phys. 40(11), 113301 (2013).
[Crossref] [PubMed]

Robert, J.-L.

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J.-L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

Shiina, T.

T. Kitai, M. Torii, T. Sugie, S. Kanao, Y. Mikami, T. Shiina, and M. Toi, “Photoacoustic mammography: initial clinical results,” Breast Cancer 21(2), 146–153 (2014).
[Crossref] [PubMed]

Shung, K. K.

L. Song, C. Kim, K. Maslov, K. K. Shung, and L. V. Wang, “High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array,” Med. Phys. 36(8), 3724–3729 (2009).
[Crossref] [PubMed]

Song, L.

L. Song, C. Kim, K. Maslov, K. K. Shung, and L. V. Wang, “High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array,” Med. Phys. 36(8), 3724–3729 (2009).
[Crossref] [PubMed]

Steed, D.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Med. Phys. 40(11), 113301 (2013).
[Crossref] [PubMed]

Steenbergen, T. G.

D. Piras, W. Wenfeng Xia, T. G. Steenbergen, van Leeuwen, and S. G. Manohar, “Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

Su, R.

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

Sugie, T.

T. Kitai, M. Torii, T. Sugie, S. Kanao, Y. Mikami, T. Shiina, and M. Toi, “Photoacoustic mammography: initial clinical results,” Breast Cancer 21(2), 146–153 (2014).
[Crossref] [PubMed]

Toi, M.

T. Kitai, M. Torii, T. Sugie, S. Kanao, Y. Mikami, T. Shiina, and M. Toi, “Photoacoustic mammography: initial clinical results,” Breast Cancer 21(2), 146–153 (2014).
[Crossref] [PubMed]

Torii, M.

T. Kitai, M. Torii, T. Sugie, S. Kanao, Y. Mikami, T. Shiina, and M. Toi, “Photoacoustic mammography: initial clinical results,” Breast Cancer 21(2), 146–153 (2014).
[Crossref] [PubMed]

Vaithilingam, S.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

van de Ven, S. M. W. Y.

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light in and sound out: emerging translational strategies for photoacoustic imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

van Leeuwen,

D. Piras, W. Wenfeng Xia, T. G. Steenbergen, van Leeuwen, and S. G. Manohar, “Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

Wang, D.

Wang, K.

J. Xia, M. R. Chatni, K. Maslov, Z. Guo, K. Wang, M. Anastasio, and L. V. Wang, “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17(5), 050506 (2012).
[Crossref] [PubMed]

Wang, L. V.

J. Xia, M. R. Chatni, K. Maslov, Z. Guo, K. Wang, M. Anastasio, and L. V. Wang, “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17(5), 050506 (2012).
[Crossref] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J.-L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[Crossref] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[Crossref] [PubMed]

L. Song, C. Kim, K. Maslov, K. K. Shung, and L. V. Wang, “High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array,” Med. Phys. 36(8), 3724–3729 (2009).
[Crossref] [PubMed]

M. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 71(1), 016706 (2005).
[Crossref] [PubMed]

Wang, X.

Z. Xie, F. M. Hooi, J. B. Fowlkes, R. W. Pinsky, X. Wang, and P. L. Carson, “Combined photoacoustic and acoustic imaging of human breast specimens in the mammographic geometry,” Ultrasound Med. Biol. 39(11), 2176–2184 (2013).
[Crossref] [PubMed]

Wang, Y.

Y. Wang, D. Wang, Y. Zhang, J. Geng, J. F. Lovell, and J. Xia, “Slit-enabled linear-array photoacoustic tomography with near isotropic spatial resolution in three dimensions,” Opt. Lett. 41(1), 127–130 (2016).
[Crossref] [PubMed]

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J.-L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

Weber, P.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Wenfeng Xia, W.

D. Piras, W. Wenfeng Xia, T. G. Steenbergen, van Leeuwen, and S. G. Manohar, “Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

Wygant, I. O.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Xia, J.

Y. Wang, D. Wang, Y. Zhang, J. Geng, J. F. Lovell, and J. Xia, “Slit-enabled linear-array photoacoustic tomography with near isotropic spatial resolution in three dimensions,” Opt. Lett. 41(1), 127–130 (2016).
[Crossref] [PubMed]

J. Xia, M. R. Chatni, K. Maslov, Z. Guo, K. Wang, M. Anastasio, and L. V. Wang, “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17(5), 050506 (2012).
[Crossref] [PubMed]

Xie, Z.

Z. Xie, F. M. Hooi, J. B. Fowlkes, R. W. Pinsky, X. Wang, and P. L. Carson, “Combined photoacoustic and acoustic imaging of human breast specimens in the mammographic geometry,” Ultrasound Med. Biol. 39(11), 2176–2184 (2013).
[Crossref] [PubMed]

Xu, M.

M. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 71(1), 016706 (2005).
[Crossref] [PubMed]

Zackrisson, S.

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light in and sound out: emerging translational strategies for photoacoustic imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

Zhang, Y.

Zhu, Q.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

Zhuang, X.

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Breast Cancer (1)

T. Kitai, M. Torii, T. Sugie, S. Kanao, Y. Mikami, T. Shiina, and M. Toi, “Photoacoustic mammography: initial clinical results,” Breast Cancer 21(2), 146–153 (2014).
[Crossref] [PubMed]

Cancer Res. (1)

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light in and sound out: emerging translational strategies for photoacoustic imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

D. Piras, W. Wenfeng Xia, T. G. Steenbergen, van Leeuwen, and S. G. Manohar, “Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

IEEE Trans. Med. Imaging (1)

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control (1)

S. Vaithilingam, T. J. Ma, Y. Furukawa, I. O. Wygant, X. Zhuang, A. De La Zerda, O. Oralkan, A. Kamaya, S. S. Gambhir, R. B. Jeffrey, and B. T. Khuri-Yakub, “Three-dimensional photoacoustic imaging using a two-dimensional CMUT array,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2411–2419 (2009).
[Crossref] [PubMed]

Interface Focus (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

J. Biomed. Opt. (5)

Y. Wang, T. N. Erpelding, L. Jankovic, Z. Guo, J.-L. Robert, G. David, and L. V. Wang, “In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe,” J. Biomed. Opt. 17(6), 061208 (2012).
[Crossref] [PubMed]

A. Dima, N. C. Burton, and V. Ntziachristos, “Multispectral optoacoustic tomography at 64, 128, and 256 channels,” J. Biomed. Opt. 19(3), 036021 (2014).
[Crossref] [PubMed]

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

J. Xia, M. R. Chatni, K. Maslov, Z. Guo, K. Wang, M. Anastasio, and L. V. Wang, “Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo,” J. Biomed. Opt. 17(5), 050506 (2012).
[Crossref] [PubMed]

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

J. Opt. Soc. Korea (1)

Med. Phys. (2)

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Med. Phys. 40(11), 113301 (2013).
[Crossref] [PubMed]

L. Song, C. Kim, K. Maslov, K. K. Shung, and L. V. Wang, “High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array,” Med. Phys. 36(8), 3724–3729 (2009).
[Crossref] [PubMed]

Nat. Photonics (1)

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[Crossref] [PubMed]

Opt. Lett. (1)

Phys. Med. Biol. (1)

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[Crossref] [PubMed]

Phys. Rev. E Stat. Nonlin. Soft Matter Phys. (1)

M. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 71(1), 016706 (2005).
[Crossref] [PubMed]

Science (1)

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Ultrasound Med. Biol. (1)

Z. Xie, F. M. Hooi, J. B. Fowlkes, R. W. Pinsky, X. Wang, and P. L. Carson, “Combined photoacoustic and acoustic imaging of human breast specimens in the mammographic geometry,” Ultrasound Med. Biol. 39(11), 2176–2184 (2013).
[Crossref] [PubMed]

Other (1)

M. Kuniyil Ajith Singh, W. Steenbergen, and S. Manohar, “Handheld Probe-Based Dual Mode Ultrasound/Photoacoustics for Biomedical Imaging,” in Frontiers in Biophotonics for Translational Medicine: In the Celebration of Year of Light (2015), M. Olivo and U. S. Dinish, eds. (Springer Singapore, Singapore, 2016), pp. 209–247.

Supplementary Material (2)

NameDescription
» Visualization 1: AVI (8392 KB)      animation for two carbon phantom
» Visualization 2: AVI (9549 KB)      animation for helixes phantom

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Figures (8)

Fig. 1
Fig. 1 The detected angle of the focused transducer and the unfocused transducer. (a) and (b) represented the focused and unfocused transducer elements, respectively.
Fig. 2
Fig. 2 (a) Simulation schematic diagram; (b) Cross-section of reconstructed images by two probes, respectively.
Fig. 3
Fig. 3 Schematic diagram of our method: scanning a linear ultrasound probe is equivalent to a 2D ultrasound matrix for PAT. (a) Scanning of a linear ultrasound probe (48 elements); (b) an equivalent 2D matrix with n × 48 elements.
Fig. 4
Fig. 4 The scheme of experimental device.
Fig. 5
Fig. 5 (a) PA signal by one element. (b) The spectral of PA signal.
Fig. 6
Fig. 6 (a) The cross section of the PAT result of hair; (b) (c) the normalized reconstructed PA values along horizontal and vertical white lines, respectively.
Fig. 7
Fig. 7 (a) The photograph of carbon rods in scattering medium during phantom process; (b) the 3D PAT of two carbon rods (see Visualization 1).
Fig. 8
Fig. 8 (a) The photograph of double helixes sample; (b) the 3D PAT of double helixes (see Visualization 2).

Equations (2)

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p 0 ( b ) ( r ) = 1 Ω 0 s d Ω [ 2 p ( r d , t ) 2 t p ( r d , t ) t ] | | t = | r d r | / c 0 ,
I ( r ) = | p 0 ( b ) ( r ) | 2 .

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