Abstract

Nucleic acid detection with label-free biosensors circumvents the need for costly fluorophore functionalization steps associated with conventional assays by utilizing optical fiber transducers. In spite of their technological prowess, however, these biosensors’ sensitivity is limited by the design/configuration of their transducers. Therefore, it is imperative to integrate novel optical fiber transducers with existing label-free approaches to overcome those limitations. Herein, we present a high sensitivity label-free fiber optic biosensor that employs polarimetric interference of a high-birefringence (Hi-Bi) microfiber to specifically detect DNA molecules. A slight target DNA concentration change is converted into an optical wavelength shift of polarimetric interference generated by the microfiber Sagnac interferometer. The sensor provides a log-linear response to target ssDNA concentrations range from 100 pM to 1 μM and a minimum detectable concentration of 75 pM.

© 2017 Optical Society of America

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  8. X. Tang, S. Bansaruntip, N. Nakayama, E. Yenilmez, Y. L. Chang, and Q. Wang, “Carbon nanotube DNA sensor and sensing mechanism,” Nano Lett. 6(8), 1632–1636 (2006).
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    [Crossref] [PubMed]
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    [Crossref]
  23. W. Yu, T. Lang, J. Bian, and W. Kong, “Label-free fiber optic biosensor based on thin-core modal interferometer,” Sens. Actuators B Chem. 228, 322–329 (2016).
    [Crossref]
  24. D. Sun, T. Guo, Y. Ran, Y. Huang, and B. O. Guan, “In-situ DNA hybridization detection with a reflective microfiber grating biosensor,” Biosens. Bioelectron. 61, 541–546 (2014).
    [Crossref] [PubMed]
  25. B. Song, H. Zhang, B. Liu, W. Lin, and J. Wu, “Label-free in-situ real-time DNA hybridization kinetics detection employing microfiber-assisted Mach-Zehnder interferometer,” Biosens. Bioelectron. 81, 151–158 (2016).
    [Crossref] [PubMed]
  26. W. B. Ji, H. H. Liu, S. C. Tjin, K. K. Chow, and A. Lim, “Ultrahigh Sensitivity Refractive Index Sensor Based on Optical Microfiber,” IEEE Photonics Technol. Lett. 24(20), 1872–1874 (2012).
    [Crossref]
  27. Y. Huang, Z. Tian, L. P. Sun, D. Sun, J. Li, Y. Ran, and B. O. Guan, “High-sensitivity DNA biosensor based on optical fiber taper interferometer coated with conjugated polymer tentacle,” Opt. Express 23(21), 26962–26968 (2015).
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  29. G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
    [Crossref]
  30. J. Lou, Y. Wang, and L. Tong, “Microfiber Optical Sensors: A Review,” Sensors (Basel) 14(4), 5823–5844 (2014).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  32. K. Li, G. Liu, Y. Wu, P. Hao, W. Zhou, and Z. Zhang, “Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum,” Talanta 120, 419–424 (2014).
    [Crossref] [PubMed]
  33. L. P. Sun, J. Li, S. Gao, L. Jin, Y. Ran, and B. O. Guan, “Fabrication of elliptic microfibers with CO2 laser for high-sensitivity refractive index sensing,” Opt. Lett. 39(12), 3531–3534 (2014).
    [Crossref] [PubMed]
  34. J. Li, L. P. Sun, S. Gao, Z. Quan, Y. L. Chang, Y. Ran, L. Jin, and B. O. Guan, “Ultrasensitive refractive-index sensors based on rectangular silica microfibers,” Opt. Lett. 36(18), 3593–3595 (2011).
    [Crossref] [PubMed]

2017 (1)

Y. Huang, B. Yu, T. Guo, and B. O. Guan, “Ultrasensitive and in situ DNA detection in various pH environments based on a microfiber with a graphene oxide linking layer,” RSC Advances 7(22), 13177–13183 (2017).
[Crossref]

2016 (3)

W. Yu, T. Lang, J. Bian, and W. Kong, “Label-free fiber optic biosensor based on thin-core modal interferometer,” Sens. Actuators B Chem. 228, 322–329 (2016).
[Crossref]

B. Song, H. Zhang, B. Liu, W. Lin, and J. Wu, “Label-free in-situ real-time DNA hybridization kinetics detection employing microfiber-assisted Mach-Zehnder interferometer,” Biosens. Bioelectron. 81, 151–158 (2016).
[Crossref] [PubMed]

H. M. R. Gonçalves, L. Moreira, L. Pereira, P. Jorge, C. Gouveia, P. Martins-Lopes, and J. R. A. Fernandes, “Biosensor for label-free DNA quantification based on functionalized LPGs,” Biosens. Bioelectron. 84, 30–36 (2016).
[Crossref] [PubMed]

2015 (1)

2014 (6)

D. Sun, T. Guo, Y. Ran, Y. Huang, and B. O. Guan, “In-situ DNA hybridization detection with a reflective microfiber grating biosensor,” Biosens. Bioelectron. 61, 541–546 (2014).
[Crossref] [PubMed]

J. Lou, Y. Wang, and L. Tong, “Microfiber Optical Sensors: A Review,” Sensors (Basel) 14(4), 5823–5844 (2014).
[Crossref] [PubMed]

K. Li, G. Liu, Y. Wu, P. Hao, W. Zhou, and Z. Zhang, “Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum,” Talanta 120, 419–424 (2014).
[Crossref] [PubMed]

L. P. Sun, J. Li, S. Gao, L. Jin, Y. Ran, and B. O. Guan, “Fabrication of elliptic microfibers with CO2 laser for high-sensitivity refractive index sensing,” Opt. Lett. 39(12), 3531–3534 (2014).
[Crossref] [PubMed]

Y. Wu, D. Y. Zhang, P. Yin, and F. Vollmer, “Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity,” Small 10(10), 2067–2076 (2014).
[Crossref] [PubMed]

E. Heydari, J. Buller, E. Wischerhoff, A. Laschewsky, S. Döring, and J. Stumpe, “Label‐Free Biosensor Based on an All‐Polymer DFB Laser,” Adv. Opt. Mater. 2(2), 137–141 (2014).
[Crossref]

2013 (2)

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

M. J. Yin, C. Wu, L. Y. Shao, W. K. Chan, A. P. Zhang, C. Lu, and H. Y. Tam, “Label-free, disposable fiber-optic biosensors for DNA hybridization detection,” Analyst (Lond.) 138(7), 1988–1994 (2013).
[Crossref] [PubMed]

2012 (2)

L. V. Nguyen, S. C. Warren-Smith, A. Cooper, and T. M. Monro, “Molecular beacons immobilized within suspended core optical fiber for specific DNA detection,” Opt. Express 20(28), 29378–29385 (2012).
[Crossref] [PubMed]

W. B. Ji, H. H. Liu, S. C. Tjin, K. K. Chow, and A. Lim, “Ultrahigh Sensitivity Refractive Index Sensor Based on Optical Microfiber,” IEEE Photonics Technol. Lett. 24(20), 1872–1874 (2012).
[Crossref]

2011 (1)

2009 (3)

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

S. Y. Niu, Q. Y. Li, R. Ren, and S. S. Zhang, “Enzyme-enhanced fluorescence detection of DNA on etched optical fibers,” Biosens. Bioelectron. 24(9), 2943–2946 (2009).
[Crossref] [PubMed]

J. Liu, Z. Cao, and Y. Lu, “Functional nucleic acid sensors,” Chem. Rev. 109(5), 1948–1998 (2009).
[Crossref] [PubMed]

2008 (4)

A. Sassolas, B. D. Leca-Bouvier, and L. J. Blum, “DNA biosensors and microarrays,” Chem. Rev. 108(1), 109–139 (2008).
[Crossref] [PubMed]

F. R. R. Teles and L. P. Fonseca, “Trends in DNA biosensors,” Talanta 77(2), 606–623 (2008).
[Crossref]

J. D. Suter, I. M. White, H. Zhu, H. Shi, C. W. Caldwell, and X. Fan, “Label-free quantitative DNA detection using the liquid core optical ring resonator,” Biosens. Bioelectron. 23(7), 1003–1009 (2008).
[Crossref] [PubMed]

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta 620(1-2), 8–26 (2008).
[Crossref] [PubMed]

2006 (2)

X. Tang, S. Bansaruntip, N. Nakayama, E. Yenilmez, Y. L. Chang, and Q. Wang, “Carbon nanotube DNA sensor and sensing mechanism,” Nano Lett. 6(8), 1632–1636 (2006).
[Crossref] [PubMed]

X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, and Z. Tu, “Label-free DNA sequence detection using oligonucleotide functionalized optical fiber,” Appl. Phys. Lett. 89(16), 163901 (2006).
[Crossref]

2005 (2)

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87(20), 201107 (2005).
[Crossref]

A. N. Chryssis, S. S. Saini, S. M. Lee, and H. Yi, “Detecting hybridization of DNA by highly sensitive evanescent field etched core fiber Bragg grating sensors,” IEEE J. Sel. Top. Quantum Electron. 11(4), 864–872 (2005).
[Crossref]

2004 (1)

J. I. Hahm and C. M. Lieber, “Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors,” Nano Lett. 4(1), 51–54 (2004).
[Crossref]

2003 (2)

T. G. Drummond, M. G. Hill, and J. K. Barton, “Electrochemical DNA sensors,” Nat. Biotechnol. 21(10), 1192–1199 (2003).
[Crossref] [PubMed]

L. Tong, R. R. Gattass, J. B. Ashcom, S. He, J. Lou, M. Shen, I. Maxwell, and E. Mazur, “Subwavelength-diameter silica wires for low-loss optical wave guiding,” Nature 426(6968), 816–819 (2003).
[Crossref] [PubMed]

2001 (1)

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, “Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays,” Anal. Chem. 73(1), 1–7 (2001).
[Crossref] [PubMed]

2000 (1)

L. He, M. D. Musick, S. R. Nicewarner, F. G. Salinas, S. J. Benkovic, M. J. Natan, and C. D. Keating, “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” J. Am. Chem. Soc. 122(38), 9071–9077 (2000).
[Crossref]

1999 (2)

J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
[Crossref]

X. Liu and W. Tan, “A fiber-optic evanescent wave DNA biosensor based on novel molecular beacons,” Anal. Chem. 71(22), 5054–5059 (1999).
[Crossref] [PubMed]

Ashcom, J. B.

L. Tong, R. R. Gattass, J. B. Ashcom, S. He, J. Lou, M. Shen, I. Maxwell, and E. Mazur, “Subwavelength-diameter silica wires for low-loss optical wave guiding,” Nature 426(6968), 816–819 (2003).
[Crossref] [PubMed]

Bansaruntip, S.

X. Tang, S. Bansaruntip, N. Nakayama, E. Yenilmez, Y. L. Chang, and Q. Wang, “Carbon nanotube DNA sensor and sensing mechanism,” Nano Lett. 6(8), 1632–1636 (2006).
[Crossref] [PubMed]

Barton, J. K.

T. G. Drummond, M. G. Hill, and J. K. Barton, “Electrochemical DNA sensors,” Nat. Biotechnol. 21(10), 1192–1199 (2003).
[Crossref] [PubMed]

Benkovic, S. J.

L. He, M. D. Musick, S. R. Nicewarner, F. G. Salinas, S. J. Benkovic, M. J. Natan, and C. D. Keating, “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” J. Am. Chem. Soc. 122(38), 9071–9077 (2000).
[Crossref]

Bertucci, A.

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

Bian, J.

W. Yu, T. Lang, J. Bian, and W. Kong, “Label-free fiber optic biosensor based on thin-core modal interferometer,” Sens. Actuators B Chem. 228, 322–329 (2016).
[Crossref]

Blum, L. J.

A. Sassolas, B. D. Leca-Bouvier, and L. J. Blum, “DNA biosensors and microarrays,” Chem. Rev. 108(1), 109–139 (2008).
[Crossref] [PubMed]

Brambilla, G.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Buller, J.

E. Heydari, J. Buller, E. Wischerhoff, A. Laschewsky, S. Döring, and J. Stumpe, “Label‐Free Biosensor Based on an All‐Polymer DFB Laser,” Adv. Opt. Mater. 2(2), 137–141 (2014).
[Crossref]

Caldwell, C. W.

J. D. Suter, I. M. White, H. Zhu, H. Shi, C. W. Caldwell, and X. Fan, “Label-free quantitative DNA detection using the liquid core optical ring resonator,” Biosens. Bioelectron. 23(7), 1003–1009 (2008).
[Crossref] [PubMed]

Candiani, A.

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

Cao, Z.

J. Liu, Z. Cao, and Y. Lu, “Functional nucleic acid sensors,” Chem. Rev. 109(5), 1948–1998 (2009).
[Crossref] [PubMed]

Chan, W. K.

M. J. Yin, C. Wu, L. Y. Shao, W. K. Chan, A. P. Zhang, C. Lu, and H. Y. Tam, “Label-free, disposable fiber-optic biosensors for DNA hybridization detection,” Analyst (Lond.) 138(7), 1988–1994 (2013).
[Crossref] [PubMed]

Chang, Y. L.

J. Li, L. P. Sun, S. Gao, Z. Quan, Y. L. Chang, Y. Ran, L. Jin, and B. O. Guan, “Ultrasensitive refractive-index sensors based on rectangular silica microfibers,” Opt. Lett. 36(18), 3593–3595 (2011).
[Crossref] [PubMed]

X. Tang, S. Bansaruntip, N. Nakayama, E. Yenilmez, Y. L. Chang, and Q. Wang, “Carbon nanotube DNA sensor and sensing mechanism,” Nano Lett. 6(8), 1632–1636 (2006).
[Crossref] [PubMed]

Chow, K. K.

W. B. Ji, H. H. Liu, S. C. Tjin, K. K. Chow, and A. Lim, “Ultrahigh Sensitivity Refractive Index Sensor Based on Optical Microfiber,” IEEE Photonics Technol. Lett. 24(20), 1872–1874 (2012).
[Crossref]

Chryssis, A. N.

A. N. Chryssis, S. S. Saini, S. M. Lee, and H. Yi, “Detecting hybridization of DNA by highly sensitive evanescent field etched core fiber Bragg grating sensors,” IEEE J. Sel. Top. Quantum Electron. 11(4), 864–872 (2005).
[Crossref]

Cooper, A.

Cooper, K. L.

X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, and Z. Tu, “Label-free DNA sequence detection using oligonucleotide functionalized optical fiber,” Appl. Phys. Lett. 89(16), 163901 (2006).
[Crossref]

Corn, R. M.

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, “Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays,” Anal. Chem. 73(1), 1–7 (2001).
[Crossref] [PubMed]

Corradini, R.

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

Cucinotta, A.

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

Döring, S.

E. Heydari, J. Buller, E. Wischerhoff, A. Laschewsky, S. Döring, and J. Stumpe, “Label‐Free Biosensor Based on an All‐Polymer DFB Laser,” Adv. Opt. Mater. 2(2), 137–141 (2014).
[Crossref]

Drummond, T. G.

T. G. Drummond, M. G. Hill, and J. K. Barton, “Electrochemical DNA sensors,” Nat. Biotechnol. 21(10), 1192–1199 (2003).
[Crossref] [PubMed]

Fan, X.

J. D. Suter, I. M. White, H. Zhu, H. Shi, C. W. Caldwell, and X. Fan, “Label-free quantitative DNA detection using the liquid core optical ring resonator,” Biosens. Bioelectron. 23(7), 1003–1009 (2008).
[Crossref] [PubMed]

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta 620(1-2), 8–26 (2008).
[Crossref] [PubMed]

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87(20), 201107 (2005).
[Crossref]

Feng, X.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Fernandes, J. R. A.

H. M. R. Gonçalves, L. Moreira, L. Pereira, P. Jorge, C. Gouveia, P. Martins-Lopes, and J. R. A. Fernandes, “Biosensor for label-free DNA quantification based on functionalized LPGs,” Biosens. Bioelectron. 84, 30–36 (2016).
[Crossref] [PubMed]

Fonseca, L. P.

F. R. R. Teles and L. P. Fonseca, “Trends in DNA biosensors,” Talanta 77(2), 606–623 (2008).
[Crossref]

Gao, S.

Gattass, R. R.

L. Tong, R. R. Gattass, J. B. Ashcom, S. He, J. Lou, M. Shen, I. Maxwell, and E. Mazur, “Subwavelength-diameter silica wires for low-loss optical wave guiding,” Nature 426(6968), 816–819 (2003).
[Crossref] [PubMed]

Gauglitz, G.

J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
[Crossref]

Giannetti, S.

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

Gonçalves, H. M. R.

H. M. R. Gonçalves, L. Moreira, L. Pereira, P. Jorge, C. Gouveia, P. Martins-Lopes, and J. R. A. Fernandes, “Biosensor for label-free DNA quantification based on functionalized LPGs,” Biosens. Bioelectron. 84, 30–36 (2016).
[Crossref] [PubMed]

Goodman, R. M.

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, “Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays,” Anal. Chem. 73(1), 1–7 (2001).
[Crossref] [PubMed]

Gouveia, C.

H. M. R. Gonçalves, L. Moreira, L. Pereira, P. Jorge, C. Gouveia, P. Martins-Lopes, and J. R. A. Fernandes, “Biosensor for label-free DNA quantification based on functionalized LPGs,” Biosens. Bioelectron. 84, 30–36 (2016).
[Crossref] [PubMed]

Grimsrud, T. E.

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, “Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays,” Anal. Chem. 73(1), 1–7 (2001).
[Crossref] [PubMed]

Guan, B. O.

Guo, T.

Y. Huang, B. Yu, T. Guo, and B. O. Guan, “Ultrasensitive and in situ DNA detection in various pH environments based on a microfiber with a graphene oxide linking layer,” RSC Advances 7(22), 13177–13183 (2017).
[Crossref]

D. Sun, T. Guo, Y. Ran, Y. Huang, and B. O. Guan, “In-situ DNA hybridization detection with a reflective microfiber grating biosensor,” Biosens. Bioelectron. 61, 541–546 (2014).
[Crossref] [PubMed]

Hahm, J. I.

J. I. Hahm and C. M. Lieber, “Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors,” Nano Lett. 4(1), 51–54 (2004).
[Crossref]

Hanumegowda, N. M.

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87(20), 201107 (2005).
[Crossref]

Hao, P.

K. Li, G. Liu, Y. Wu, P. Hao, W. Zhou, and Z. Zhang, “Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum,” Talanta 120, 419–424 (2014).
[Crossref] [PubMed]

He, L.

L. He, M. D. Musick, S. R. Nicewarner, F. G. Salinas, S. J. Benkovic, M. J. Natan, and C. D. Keating, “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” J. Am. Chem. Soc. 122(38), 9071–9077 (2000).
[Crossref]

He, S.

L. Tong, R. R. Gattass, J. B. Ashcom, S. He, J. Lou, M. Shen, I. Maxwell, and E. Mazur, “Subwavelength-diameter silica wires for low-loss optical wave guiding,” Nature 426(6968), 816–819 (2003).
[Crossref] [PubMed]

Heydari, E.

E. Heydari, J. Buller, E. Wischerhoff, A. Laschewsky, S. Döring, and J. Stumpe, “Label‐Free Biosensor Based on an All‐Polymer DFB Laser,” Adv. Opt. Mater. 2(2), 137–141 (2014).
[Crossref]

Hill, M. G.

T. G. Drummond, M. G. Hill, and J. K. Barton, “Electrochemical DNA sensors,” Nat. Biotechnol. 21(10), 1192–1199 (2003).
[Crossref] [PubMed]

Homola, J.

J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
[Crossref]

Horak, P.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Huang, Y.

Y. Huang, B. Yu, T. Guo, and B. O. Guan, “Ultrasensitive and in situ DNA detection in various pH environments based on a microfiber with a graphene oxide linking layer,” RSC Advances 7(22), 13177–13183 (2017).
[Crossref]

Y. Huang, Z. Tian, L. P. Sun, D. Sun, J. Li, Y. Ran, and B. O. Guan, “High-sensitivity DNA biosensor based on optical fiber taper interferometer coated with conjugated polymer tentacle,” Opt. Express 23(21), 26962–26968 (2015).
[Crossref] [PubMed]

D. Sun, T. Guo, Y. Ran, Y. Huang, and B. O. Guan, “In-situ DNA hybridization detection with a reflective microfiber grating biosensor,” Biosens. Bioelectron. 61, 541–546 (2014).
[Crossref] [PubMed]

Ji, W. B.

W. B. Ji, H. H. Liu, S. C. Tjin, K. K. Chow, and A. Lim, “Ultrahigh Sensitivity Refractive Index Sensor Based on Optical Microfiber,” IEEE Photonics Technol. Lett. 24(20), 1872–1874 (2012).
[Crossref]

Jin, L.

Jorge, P.

H. M. R. Gonçalves, L. Moreira, L. Pereira, P. Jorge, C. Gouveia, P. Martins-Lopes, and J. R. A. Fernandes, “Biosensor for label-free DNA quantification based on functionalized LPGs,” Biosens. Bioelectron. 84, 30–36 (2016).
[Crossref] [PubMed]

Jung, Y.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Keating, C. D.

L. He, M. D. Musick, S. R. Nicewarner, F. G. Salinas, S. J. Benkovic, M. J. Natan, and C. D. Keating, “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” J. Am. Chem. Soc. 122(38), 9071–9077 (2000).
[Crossref]

Koizumi, F.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Kong, W.

W. Yu, T. Lang, J. Bian, and W. Kong, “Label-free fiber optic biosensor based on thin-core modal interferometer,” Sens. Actuators B Chem. 228, 322–329 (2016).
[Crossref]

Konstantaki, M.

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

Koukharenko, E.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Lang, T.

W. Yu, T. Lang, J. Bian, and W. Kong, “Label-free fiber optic biosensor based on thin-core modal interferometer,” Sens. Actuators B Chem. 228, 322–329 (2016).
[Crossref]

Laschewsky, A.

E. Heydari, J. Buller, E. Wischerhoff, A. Laschewsky, S. Döring, and J. Stumpe, “Label‐Free Biosensor Based on an All‐Polymer DFB Laser,” Adv. Opt. Mater. 2(2), 137–141 (2014).
[Crossref]

Leca-Bouvier, B. D.

A. Sassolas, B. D. Leca-Bouvier, and L. J. Blum, “DNA biosensors and microarrays,” Chem. Rev. 108(1), 109–139 (2008).
[Crossref] [PubMed]

Lee, S. M.

A. N. Chryssis, S. S. Saini, S. M. Lee, and H. Yi, “Detecting hybridization of DNA by highly sensitive evanescent field etched core fiber Bragg grating sensors,” IEEE J. Sel. Top. Quantum Electron. 11(4), 864–872 (2005).
[Crossref]

Li, J.

Li, K.

K. Li, G. Liu, Y. Wu, P. Hao, W. Zhou, and Z. Zhang, “Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum,” Talanta 120, 419–424 (2014).
[Crossref] [PubMed]

Li, Q. Y.

S. Y. Niu, Q. Y. Li, R. Ren, and S. S. Zhang, “Enzyme-enhanced fluorescence detection of DNA on etched optical fibers,” Biosens. Bioelectron. 24(9), 2943–2946 (2009).
[Crossref] [PubMed]

Lieber, C. M.

J. I. Hahm and C. M. Lieber, “Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors,” Nano Lett. 4(1), 51–54 (2004).
[Crossref]

Liles, M. R.

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, “Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays,” Anal. Chem. 73(1), 1–7 (2001).
[Crossref] [PubMed]

Lim, A.

W. B. Ji, H. H. Liu, S. C. Tjin, K. K. Chow, and A. Lim, “Ultrahigh Sensitivity Refractive Index Sensor Based on Optical Microfiber,” IEEE Photonics Technol. Lett. 24(20), 1872–1874 (2012).
[Crossref]

Lin, W.

B. Song, H. Zhang, B. Liu, W. Lin, and J. Wu, “Label-free in-situ real-time DNA hybridization kinetics detection employing microfiber-assisted Mach-Zehnder interferometer,” Biosens. Bioelectron. 81, 151–158 (2016).
[Crossref] [PubMed]

Liu, B.

B. Song, H. Zhang, B. Liu, W. Lin, and J. Wu, “Label-free in-situ real-time DNA hybridization kinetics detection employing microfiber-assisted Mach-Zehnder interferometer,” Biosens. Bioelectron. 81, 151–158 (2016).
[Crossref] [PubMed]

Liu, G.

K. Li, G. Liu, Y. Wu, P. Hao, W. Zhou, and Z. Zhang, “Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum,” Talanta 120, 419–424 (2014).
[Crossref] [PubMed]

Liu, H. H.

W. B. Ji, H. H. Liu, S. C. Tjin, K. K. Chow, and A. Lim, “Ultrahigh Sensitivity Refractive Index Sensor Based on Optical Microfiber,” IEEE Photonics Technol. Lett. 24(20), 1872–1874 (2012).
[Crossref]

Liu, J.

J. Liu, Z. Cao, and Y. Lu, “Functional nucleic acid sensors,” Chem. Rev. 109(5), 1948–1998 (2009).
[Crossref] [PubMed]

Liu, X.

X. Liu and W. Tan, “A fiber-optic evanescent wave DNA biosensor based on novel molecular beacons,” Anal. Chem. 71(22), 5054–5059 (1999).
[Crossref] [PubMed]

Lou, J.

J. Lou, Y. Wang, and L. Tong, “Microfiber Optical Sensors: A Review,” Sensors (Basel) 14(4), 5823–5844 (2014).
[Crossref] [PubMed]

L. Tong, R. R. Gattass, J. B. Ashcom, S. He, J. Lou, M. Shen, I. Maxwell, and E. Mazur, “Subwavelength-diameter silica wires for low-loss optical wave guiding,” Nature 426(6968), 816–819 (2003).
[Crossref] [PubMed]

Lu, C.

M. J. Yin, C. Wu, L. Y. Shao, W. K. Chan, A. P. Zhang, C. Lu, and H. Y. Tam, “Label-free, disposable fiber-optic biosensors for DNA hybridization detection,” Analyst (Lond.) 138(7), 1988–1994 (2013).
[Crossref] [PubMed]

Lu, Y.

J. Liu, Z. Cao, and Y. Lu, “Functional nucleic acid sensors,” Chem. Rev. 109(5), 1948–1998 (2009).
[Crossref] [PubMed]

Manicardi, A.

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

Martins-Lopes, P.

H. M. R. Gonçalves, L. Moreira, L. Pereira, P. Jorge, C. Gouveia, P. Martins-Lopes, and J. R. A. Fernandes, “Biosensor for label-free DNA quantification based on functionalized LPGs,” Biosens. Bioelectron. 84, 30–36 (2016).
[Crossref] [PubMed]

Maxwell, I.

L. Tong, R. R. Gattass, J. B. Ashcom, S. He, J. Lou, M. Shen, I. Maxwell, and E. Mazur, “Subwavelength-diameter silica wires for low-loss optical wave guiding,” Nature 426(6968), 816–819 (2003).
[Crossref] [PubMed]

Mazur, E.

L. Tong, R. R. Gattass, J. B. Ashcom, S. He, J. Lou, M. Shen, I. Maxwell, and E. Mazur, “Subwavelength-diameter silica wires for low-loss optical wave guiding,” Nature 426(6968), 816–819 (2003).
[Crossref] [PubMed]

Monro, T. M.

Moreira, L.

H. M. R. Gonçalves, L. Moreira, L. Pereira, P. Jorge, C. Gouveia, P. Martins-Lopes, and J. R. A. Fernandes, “Biosensor for label-free DNA quantification based on functionalized LPGs,” Biosens. Bioelectron. 84, 30–36 (2016).
[Crossref] [PubMed]

Murugan, G. S.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Musick, M. D.

L. He, M. D. Musick, S. R. Nicewarner, F. G. Salinas, S. J. Benkovic, M. J. Natan, and C. D. Keating, “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” J. Am. Chem. Soc. 122(38), 9071–9077 (2000).
[Crossref]

Nakayama, N.

X. Tang, S. Bansaruntip, N. Nakayama, E. Yenilmez, Y. L. Chang, and Q. Wang, “Carbon nanotube DNA sensor and sensing mechanism,” Nano Lett. 6(8), 1632–1636 (2006).
[Crossref] [PubMed]

Natan, M. J.

L. He, M. D. Musick, S. R. Nicewarner, F. G. Salinas, S. J. Benkovic, M. J. Natan, and C. D. Keating, “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” J. Am. Chem. Soc. 122(38), 9071–9077 (2000).
[Crossref]

Nelson, B. P.

B. P. Nelson, T. E. Grimsrud, M. R. Liles, R. M. Goodman, and R. M. Corn, “Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays,” Anal. Chem. 73(1), 1–7 (2001).
[Crossref] [PubMed]

Nguyen, L. V.

Nicewarner, S. R.

L. He, M. D. Musick, S. R. Nicewarner, F. G. Salinas, S. J. Benkovic, M. J. Natan, and C. D. Keating, “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” J. Am. Chem. Soc. 122(38), 9071–9077 (2000).
[Crossref]

Niu, S. Y.

S. Y. Niu, Q. Y. Li, R. Ren, and S. S. Zhang, “Enzyme-enhanced fluorescence detection of DNA on etched optical fibers,” Biosens. Bioelectron. 24(9), 2943–2946 (2009).
[Crossref] [PubMed]

Patel, B. C.

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87(20), 201107 (2005).
[Crossref]

Pereira, L.

H. M. R. Gonçalves, L. Moreira, L. Pereira, P. Jorge, C. Gouveia, P. Martins-Lopes, and J. R. A. Fernandes, “Biosensor for label-free DNA quantification based on functionalized LPGs,” Biosens. Bioelectron. 84, 30–36 (2016).
[Crossref] [PubMed]

Pissadakis, S.

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

Quan, Z.

Ran, Y.

Ren, R.

S. Y. Niu, Q. Y. Li, R. Ren, and S. S. Zhang, “Enzyme-enhanced fluorescence detection of DNA on etched optical fibers,” Biosens. Bioelectron. 24(9), 2943–2946 (2009).
[Crossref] [PubMed]

Richardson, D. J.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Saini, S. S.

A. N. Chryssis, S. S. Saini, S. M. Lee, and H. Yi, “Detecting hybridization of DNA by highly sensitive evanescent field etched core fiber Bragg grating sensors,” IEEE J. Sel. Top. Quantum Electron. 11(4), 864–872 (2005).
[Crossref]

Salinas, F. G.

L. He, M. D. Musick, S. R. Nicewarner, F. G. Salinas, S. J. Benkovic, M. J. Natan, and C. D. Keating, “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” J. Am. Chem. Soc. 122(38), 9071–9077 (2000).
[Crossref]

Sassolas, A.

A. Sassolas, B. D. Leca-Bouvier, and L. J. Blum, “DNA biosensors and microarrays,” Chem. Rev. 108(1), 109–139 (2008).
[Crossref] [PubMed]

Selleri, S.

A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
[Crossref] [PubMed]

Sessions, N. P.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Shao, L. Y.

M. J. Yin, C. Wu, L. Y. Shao, W. K. Chan, A. P. Zhang, C. Lu, and H. Y. Tam, “Label-free, disposable fiber-optic biosensors for DNA hybridization detection,” Analyst (Lond.) 138(7), 1988–1994 (2013).
[Crossref] [PubMed]

Shen, M.

L. Tong, R. R. Gattass, J. B. Ashcom, S. He, J. Lou, M. Shen, I. Maxwell, and E. Mazur, “Subwavelength-diameter silica wires for low-loss optical wave guiding,” Nature 426(6968), 816–819 (2003).
[Crossref] [PubMed]

Shi, H.

J. D. Suter, I. M. White, H. Zhu, H. Shi, C. W. Caldwell, and X. Fan, “Label-free quantitative DNA detection using the liquid core optical ring resonator,” Biosens. Bioelectron. 23(7), 1003–1009 (2008).
[Crossref] [PubMed]

Shopova, S. I.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta 620(1-2), 8–26 (2008).
[Crossref] [PubMed]

Song, B.

B. Song, H. Zhang, B. Liu, W. Lin, and J. Wu, “Label-free in-situ real-time DNA hybridization kinetics detection employing microfiber-assisted Mach-Zehnder interferometer,” Biosens. Bioelectron. 81, 151–158 (2016).
[Crossref] [PubMed]

Stica, C. J.

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87(20), 201107 (2005).
[Crossref]

Stumpe, J.

E. Heydari, J. Buller, E. Wischerhoff, A. Laschewsky, S. Döring, and J. Stumpe, “Label‐Free Biosensor Based on an All‐Polymer DFB Laser,” Adv. Opt. Mater. 2(2), 137–141 (2014).
[Crossref]

Sun, D.

Y. Huang, Z. Tian, L. P. Sun, D. Sun, J. Li, Y. Ran, and B. O. Guan, “High-sensitivity DNA biosensor based on optical fiber taper interferometer coated with conjugated polymer tentacle,” Opt. Express 23(21), 26962–26968 (2015).
[Crossref] [PubMed]

D. Sun, T. Guo, Y. Ran, Y. Huang, and B. O. Guan, “In-situ DNA hybridization detection with a reflective microfiber grating biosensor,” Biosens. Bioelectron. 61, 541–546 (2014).
[Crossref] [PubMed]

Sun, L. P.

Sun, Y.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta 620(1-2), 8–26 (2008).
[Crossref] [PubMed]

Suter, J. D.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta 620(1-2), 8–26 (2008).
[Crossref] [PubMed]

J. D. Suter, I. M. White, H. Zhu, H. Shi, C. W. Caldwell, and X. Fan, “Label-free quantitative DNA detection using the liquid core optical ring resonator,” Biosens. Bioelectron. 23(7), 1003–1009 (2008).
[Crossref] [PubMed]

Tam, H. Y.

M. J. Yin, C. Wu, L. Y. Shao, W. K. Chan, A. P. Zhang, C. Lu, and H. Y. Tam, “Label-free, disposable fiber-optic biosensors for DNA hybridization detection,” Analyst (Lond.) 138(7), 1988–1994 (2013).
[Crossref] [PubMed]

Tan, W.

X. Liu and W. Tan, “A fiber-optic evanescent wave DNA biosensor based on novel molecular beacons,” Anal. Chem. 71(22), 5054–5059 (1999).
[Crossref] [PubMed]

Tang, X.

X. Tang, S. Bansaruntip, N. Nakayama, E. Yenilmez, Y. L. Chang, and Q. Wang, “Carbon nanotube DNA sensor and sensing mechanism,” Nano Lett. 6(8), 1632–1636 (2006).
[Crossref] [PubMed]

Teles, F. R. R.

F. R. R. Teles and L. P. Fonseca, “Trends in DNA biosensors,” Talanta 77(2), 606–623 (2008).
[Crossref]

Tian, Z.

Tjin, S. C.

W. B. Ji, H. H. Liu, S. C. Tjin, K. K. Chow, and A. Lim, “Ultrahigh Sensitivity Refractive Index Sensor Based on Optical Microfiber,” IEEE Photonics Technol. Lett. 24(20), 1872–1874 (2012).
[Crossref]

Tong, L.

J. Lou, Y. Wang, and L. Tong, “Microfiber Optical Sensors: A Review,” Sensors (Basel) 14(4), 5823–5844 (2014).
[Crossref] [PubMed]

L. Tong, R. R. Gattass, J. B. Ashcom, S. He, J. Lou, M. Shen, I. Maxwell, and E. Mazur, “Subwavelength-diameter silica wires for low-loss optical wave guiding,” Nature 426(6968), 816–819 (2003).
[Crossref] [PubMed]

Tu, Z.

X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, and Z. Tu, “Label-free DNA sequence detection using oligonucleotide functionalized optical fiber,” Appl. Phys. Lett. 89(16), 163901 (2006).
[Crossref]

Vollmer, F.

Y. Wu, D. Y. Zhang, P. Yin, and F. Vollmer, “Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity,” Small 10(10), 2067–2076 (2014).
[Crossref] [PubMed]

Wang, A.

X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, and Z. Tu, “Label-free DNA sequence detection using oligonucleotide functionalized optical fiber,” Appl. Phys. Lett. 89(16), 163901 (2006).
[Crossref]

Wang, Q.

X. Tang, S. Bansaruntip, N. Nakayama, E. Yenilmez, Y. L. Chang, and Q. Wang, “Carbon nanotube DNA sensor and sensing mechanism,” Nano Lett. 6(8), 1632–1636 (2006).
[Crossref] [PubMed]

Wang, X.

X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, and Z. Tu, “Label-free DNA sequence detection using oligonucleotide functionalized optical fiber,” Appl. Phys. Lett. 89(16), 163901 (2006).
[Crossref]

Wang, Y.

J. Lou, Y. Wang, and L. Tong, “Microfiber Optical Sensors: A Review,” Sensors (Basel) 14(4), 5823–5844 (2014).
[Crossref] [PubMed]

Wang, Z.

X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, and Z. Tu, “Label-free DNA sequence detection using oligonucleotide functionalized optical fiber,” Appl. Phys. Lett. 89(16), 163901 (2006).
[Crossref]

Warren-Smith, S. C.

White, I.

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87(20), 201107 (2005).
[Crossref]

White, I. M.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta 620(1-2), 8–26 (2008).
[Crossref] [PubMed]

J. D. Suter, I. M. White, H. Zhu, H. Shi, C. W. Caldwell, and X. Fan, “Label-free quantitative DNA detection using the liquid core optical ring resonator,” Biosens. Bioelectron. 23(7), 1003–1009 (2008).
[Crossref] [PubMed]

Wilkinson, J. S.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Wischerhoff, E.

E. Heydari, J. Buller, E. Wischerhoff, A. Laschewsky, S. Döring, and J. Stumpe, “Label‐Free Biosensor Based on an All‐Polymer DFB Laser,” Adv. Opt. Mater. 2(2), 137–141 (2014).
[Crossref]

Wu, C.

M. J. Yin, C. Wu, L. Y. Shao, W. K. Chan, A. P. Zhang, C. Lu, and H. Y. Tam, “Label-free, disposable fiber-optic biosensors for DNA hybridization detection,” Analyst (Lond.) 138(7), 1988–1994 (2013).
[Crossref] [PubMed]

Wu, J.

B. Song, H. Zhang, B. Liu, W. Lin, and J. Wu, “Label-free in-situ real-time DNA hybridization kinetics detection employing microfiber-assisted Mach-Zehnder interferometer,” Biosens. Bioelectron. 81, 151–158 (2016).
[Crossref] [PubMed]

Wu, Y.

Y. Wu, D. Y. Zhang, P. Yin, and F. Vollmer, “Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity,” Small 10(10), 2067–2076 (2014).
[Crossref] [PubMed]

K. Li, G. Liu, Y. Wu, P. Hao, W. Zhou, and Z. Zhang, “Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum,” Talanta 120, 419–424 (2014).
[Crossref] [PubMed]

Xu, F.

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

Xu, J.

X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, and Z. Tu, “Label-free DNA sequence detection using oligonucleotide functionalized optical fiber,” Appl. Phys. Lett. 89(16), 163901 (2006).
[Crossref]

Yee, S. S.

J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
[Crossref]

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X. Tang, S. Bansaruntip, N. Nakayama, E. Yenilmez, Y. L. Chang, and Q. Wang, “Carbon nanotube DNA sensor and sensing mechanism,” Nano Lett. 6(8), 1632–1636 (2006).
[Crossref] [PubMed]

Yi, H.

A. N. Chryssis, S. S. Saini, S. M. Lee, and H. Yi, “Detecting hybridization of DNA by highly sensitive evanescent field etched core fiber Bragg grating sensors,” IEEE J. Sel. Top. Quantum Electron. 11(4), 864–872 (2005).
[Crossref]

Yin, M. J.

M. J. Yin, C. Wu, L. Y. Shao, W. K. Chan, A. P. Zhang, C. Lu, and H. Y. Tam, “Label-free, disposable fiber-optic biosensors for DNA hybridization detection,” Analyst (Lond.) 138(7), 1988–1994 (2013).
[Crossref] [PubMed]

Yin, P.

Y. Wu, D. Y. Zhang, P. Yin, and F. Vollmer, “Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity,” Small 10(10), 2067–2076 (2014).
[Crossref] [PubMed]

Yu, B.

Y. Huang, B. Yu, T. Guo, and B. O. Guan, “Ultrasensitive and in situ DNA detection in various pH environments based on a microfiber with a graphene oxide linking layer,” RSC Advances 7(22), 13177–13183 (2017).
[Crossref]

Yu, W.

W. Yu, T. Lang, J. Bian, and W. Kong, “Label-free fiber optic biosensor based on thin-core modal interferometer,” Sens. Actuators B Chem. 228, 322–329 (2016).
[Crossref]

Zhang, A. P.

M. J. Yin, C. Wu, L. Y. Shao, W. K. Chan, A. P. Zhang, C. Lu, and H. Y. Tam, “Label-free, disposable fiber-optic biosensors for DNA hybridization detection,” Analyst (Lond.) 138(7), 1988–1994 (2013).
[Crossref] [PubMed]

Zhang, D. Y.

Y. Wu, D. Y. Zhang, P. Yin, and F. Vollmer, “Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity,” Small 10(10), 2067–2076 (2014).
[Crossref] [PubMed]

Zhang, H.

B. Song, H. Zhang, B. Liu, W. Lin, and J. Wu, “Label-free in-situ real-time DNA hybridization kinetics detection employing microfiber-assisted Mach-Zehnder interferometer,” Biosens. Bioelectron. 81, 151–158 (2016).
[Crossref] [PubMed]

Zhang, S. S.

S. Y. Niu, Q. Y. Li, R. Ren, and S. S. Zhang, “Enzyme-enhanced fluorescence detection of DNA on etched optical fibers,” Biosens. Bioelectron. 24(9), 2943–2946 (2009).
[Crossref] [PubMed]

Zhang, Y.

X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, and Z. Tu, “Label-free DNA sequence detection using oligonucleotide functionalized optical fiber,” Appl. Phys. Lett. 89(16), 163901 (2006).
[Crossref]

Zhang, Z.

K. Li, G. Liu, Y. Wu, P. Hao, W. Zhou, and Z. Zhang, “Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum,” Talanta 120, 419–424 (2014).
[Crossref] [PubMed]

Zhou, W.

K. Li, G. Liu, Y. Wu, P. Hao, W. Zhou, and Z. Zhang, “Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum,” Talanta 120, 419–424 (2014).
[Crossref] [PubMed]

Zhu, H.

X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta 620(1-2), 8–26 (2008).
[Crossref] [PubMed]

J. D. Suter, I. M. White, H. Zhu, H. Shi, C. W. Caldwell, and X. Fan, “Label-free quantitative DNA detection using the liquid core optical ring resonator,” Biosens. Bioelectron. 23(7), 1003–1009 (2008).
[Crossref] [PubMed]

Adv. Opt. Mater. (1)

E. Heydari, J. Buller, E. Wischerhoff, A. Laschewsky, S. Döring, and J. Stumpe, “Label‐Free Biosensor Based on an All‐Polymer DFB Laser,” Adv. Opt. Mater. 2(2), 137–141 (2014).
[Crossref]

Adv. Opt. Photonics (1)

G. Brambilla, F. Xu, P. Horak, Y. Jung, F. Koizumi, N. P. Sessions, E. Koukharenko, X. Feng, G. S. Murugan, J. S. Wilkinson, and D. J. Richardson, “Optical fiber nanowires and microwires: fabrication and applications,” Adv. Opt. Photonics 1(1), 107–161 (2009).
[Crossref]

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X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta 620(1-2), 8–26 (2008).
[Crossref] [PubMed]

Analyst (Lond.) (1)

M. J. Yin, C. Wu, L. Y. Shao, W. K. Chan, A. P. Zhang, C. Lu, and H. Y. Tam, “Label-free, disposable fiber-optic biosensors for DNA hybridization detection,” Analyst (Lond.) 138(7), 1988–1994 (2013).
[Crossref] [PubMed]

Appl. Phys. Lett. (2)

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87(20), 201107 (2005).
[Crossref]

X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, and Z. Tu, “Label-free DNA sequence detection using oligonucleotide functionalized optical fiber,” Appl. Phys. Lett. 89(16), 163901 (2006).
[Crossref]

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D. Sun, T. Guo, Y. Ran, Y. Huang, and B. O. Guan, “In-situ DNA hybridization detection with a reflective microfiber grating biosensor,” Biosens. Bioelectron. 61, 541–546 (2014).
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B. Song, H. Zhang, B. Liu, W. Lin, and J. Wu, “Label-free in-situ real-time DNA hybridization kinetics detection employing microfiber-assisted Mach-Zehnder interferometer,” Biosens. Bioelectron. 81, 151–158 (2016).
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H. M. R. Gonçalves, L. Moreira, L. Pereira, P. Jorge, C. Gouveia, P. Martins-Lopes, and J. R. A. Fernandes, “Biosensor for label-free DNA quantification based on functionalized LPGs,” Biosens. Bioelectron. 84, 30–36 (2016).
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S. Y. Niu, Q. Y. Li, R. Ren, and S. S. Zhang, “Enzyme-enhanced fluorescence detection of DNA on etched optical fibers,” Biosens. Bioelectron. 24(9), 2943–2946 (2009).
[Crossref] [PubMed]

J. D. Suter, I. M. White, H. Zhu, H. Shi, C. W. Caldwell, and X. Fan, “Label-free quantitative DNA detection using the liquid core optical ring resonator,” Biosens. Bioelectron. 23(7), 1003–1009 (2008).
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Chem. Rev. (2)

A. Sassolas, B. D. Leca-Bouvier, and L. J. Blum, “DNA biosensors and microarrays,” Chem. Rev. 108(1), 109–139 (2008).
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IEEE J. Sel. Top. Quantum Electron. (1)

A. N. Chryssis, S. S. Saini, S. M. Lee, and H. Yi, “Detecting hybridization of DNA by highly sensitive evanescent field etched core fiber Bragg grating sensors,” IEEE J. Sel. Top. Quantum Electron. 11(4), 864–872 (2005).
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IEEE Photonics Technol. Lett. (1)

W. B. Ji, H. H. Liu, S. C. Tjin, K. K. Chow, and A. Lim, “Ultrahigh Sensitivity Refractive Index Sensor Based on Optical Microfiber,” IEEE Photonics Technol. Lett. 24(20), 1872–1874 (2012).
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L. He, M. D. Musick, S. R. Nicewarner, F. G. Salinas, S. J. Benkovic, M. J. Natan, and C. D. Keating, “Colloidal Au-enhanced surface plasmon resonance for ultrasensitive detection of DNA hybridization,” J. Am. Chem. Soc. 122(38), 9071–9077 (2000).
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A. Candiani, A. Bertucci, S. Giannetti, M. Konstantaki, A. Manicardi, S. Pissadakis, A. Cucinotta, R. Corradini, and S. Selleri, “Label-free DNA biosensor based on a peptide nucleic acid-functionalized microstructured optical fiber-Bragg grating,” J. Biomed. Opt. 18(5), 57004 (2013).
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J. I. Hahm and C. M. Lieber, “Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors,” Nano Lett. 4(1), 51–54 (2004).
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T. G. Drummond, M. G. Hill, and J. K. Barton, “Electrochemical DNA sensors,” Nat. Biotechnol. 21(10), 1192–1199 (2003).
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Nature (1)

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RSC Advances (1)

Y. Huang, B. Yu, T. Guo, and B. O. Guan, “Ultrasensitive and in situ DNA detection in various pH environments based on a microfiber with a graphene oxide linking layer,” RSC Advances 7(22), 13177–13183 (2017).
[Crossref]

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W. Yu, T. Lang, J. Bian, and W. Kong, “Label-free fiber optic biosensor based on thin-core modal interferometer,” Sens. Actuators B Chem. 228, 322–329 (2016).
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J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
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Y. Wu, D. Y. Zhang, P. Yin, and F. Vollmer, “Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity,” Small 10(10), 2067–2076 (2014).
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K. Li, G. Liu, Y. Wu, P. Hao, W. Zhou, and Z. Zhang, “Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum,” Talanta 120, 419–424 (2014).
[Crossref] [PubMed]

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Figures (5)

Fig. 1
Fig. 1

(a) The schematic of the optical setup of Hi-Bi microfiber Sagnac interferometer. (b) Elliptical microfiber profiles and the transverse electric field amplitude distributions of the x- and y-polarized modes. (c) Relationship between the dip wavelength and the external refractive index. Error bars represent the standard deviations of ten independent measurements. The data in (d) show the wavelength stability within a shorter period of time. (e) The transmission spectrum of the interferometer after 34 days is similar to the initial profile.

Fig. 2
Fig. 2

(a) Sensorgram for Hi-Bi microfiber Sagnac interferometer surface activation and 1 μM complementary target DNA detection. (b) PLL modification. (c) Probe ssDNA incubation. (d) Target ssDNA hybridization. I-IV: Surface activation and hybridization performed in ultrapure water buffer. Insets show the AFM images of PLL coating on the microfiber surface, and the scheme of surface functionalization of microfiber biosensor.

Fig. 3
Fig. 3

Transmission spectrum of the high-birefringence microfiber Sagnac interferometer at each stage of surface activation.

Fig. 4
Fig. 4

Optical responses to different levels of complementary DNA concentrations (The result at zero concentration represents the result of blank trial). Error bars represent the standard deviations of three independent measurements with a single interferometer.

Fig. 5
Fig. 5

Measured responses to matched and mismatched (ssDNAA and ssDNAB) DNA with the same bulk concentration of 1 μM.

Tables (1)

Tables Icon

Table 1 Detection limits of various label-free DNA sensors.

Metrics